Multiparallel microfluidic high-performance liquid chromatography for high-throughput normal-phase chiral analysis

Journal of Chromatography A

Volumn 1145, Issue 1-2, 2007, Pages 149-154

  Sajonz, Peter ^a   Schafer, Wes ^a   Gong, Xiaoyi ^a   Shultz, Scott ^a   Rosner, Thorsten ^a   Welch, Christopher J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Asymmetric hydrogenation; Catalyst screening; Chromatography; High throughput; HPLC; Microfluidic; Multiparallel; Normal phase

Indexed keywords

ASYMMETRIC HYDROGENATION; CATALYST SCREENING; HIGH THROUGHPUT; MULTIPARALLEL; NORMAL PHASE;

CATALYSTS; ESTERS; HYDROGENATION; OPTIMIZATION; THROUGHPUT;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

BENZOIN; DIHYDROBENZOIN; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; CATALYST; CHIRALITY; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HYDROGENATION; MICROFLUIDIC ANALYSIS; PRIORITY JOURNAL; PROCESS OPTIMIZATION;

BENZOIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGENATION; MICROFLUIDICS; MOLECULAR STRUCTURE; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM;

EID: 33847280899     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.01.067     Document Type: Article

References (19)

1. Finn M.G. Chirality 14 (2002) 534
2. Nelson T.D., Welch C.J., Rosen J.D., Smitrovich J.H., Huffman M.A., McNamara J.M., and Mathre D.J. Chirality 16 (2004) 609
3. Welch C.J., Albaneze-Walker J., Leonard W.R., Biba M., DaSilva J., Henderson D., Laing B., Mathre D.J., Spencer S., Bu X., and Wang T. Org. Process Res. Dev. 9 (2005) 198
4. Reetz M.T., Kuhling K.M., Hinrichs H., and Deege A. Chirality 12 (2000) 479
5. Welch C.J., Grau B., Moore J., and Mathre D.J. J. Org. Chem. 66 (2001) 6836
6. Welch C.J., Pollard S.D., Mathre D.J., and Reider P.J. Org. Lett. 3 (2001) 95
7. Harre M., Tilstam U., and Weinmann H. Org. Process Res. Dev. 3 (1999) 304
8. Tao W.A., and Cooks R.G. Anal. Chem. 75 (2003) 25A
9. Schug K.A., Maier N.M., and Lindner W. Chem. Commun. 4 (2006) 414
10. Brewer B.N., Zu C., and Koscho M.E. Chirality 17 (2005) 456
11. Reetz M.T. Angew. Chem. Int. Ed. 40 (2001) 284
12. Anslyn E.V. Tetrahedron 60 (2004) 11055
13. Mei X., Martin R.M., and Wolf C. J. Org. Chem. 71 (2006) 2854
14. Welch C.J., Sajonz P., Biba M., Gouker J., and Fairchild J. J. Liq. Chromatogr. Related Technol. 29 (2006) 2185
15. Sajonz P., Gong X., Leonard W.R., Biba M., and Welch C.J. Chirality 18 (2006) 803
16. Hsiao Y., Rivera N.R., Rosner T., Krska S.W., Njolito E., Wang F., Sun Y., Armstrong J.D., Grabowski E.J.J., Tillyer R.D., Spindler F., and Malan C. J. Am. Chem. Soc. 126 (2004) 9918
17. Hansen K.B., Rosner T., Kubryk M., Dormer P.G., and Armstrong J.D. Org. Lett. 7 (2005) 4935
18. Ikemoto N., Tellers D.M., Dreher S.D., Liu J., Huang A., Rivera N.R., Njolito E., Hsiao Y., McWilliams J.C., Williams J.M., Armstrong J.D., Sun Y., Mathre D.J., Grabowski E.J.J., and Tillyer R.D. J. Am. Chem. Soc. 126 (2004) 3048
19. Maligres P.E., Krska S.W., and Humphrey G.R. Org. Lett. 6 (2004) 3147