Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 9, 2008, Pages 2900-2904

  Park, Heuisul ^a   Min, Kyeongsik ^a   Kwak, Hyo Shin ^a   Koo, Ki Dong ^a   Lim, Dongchul ^a   Seo, Sang Won ^a   Choi, Jae Ung ^a   Platt, Bettina ^b   Choi, Deog Young ^a  

^a LG Chemical Ltd   (South Korea)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Alzheimer's disease; BACE 1; Cyclic urea

Indexed keywords

BETA SECRETASE 1 INHIBITOR; BETA SECRETASE INHIBITOR; CYCLIC UREA DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CELL LINE; CRYSTALLOGRAPHY, X-RAY; CYCLIZATION; ETHYLAMINES; HUMANS; HYDROXYLATION; INHIBITORY CONCENTRATION 50; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 43049114978     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.03.081     Document Type: Article

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