Rational design, synthesis, and in vivo evaluation of the antileukemic activity of six new alkylating steroidal esters

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 9, 2008, Pages 5207-5215

  Koutsourea, Anna I ^a   Fousteris, Manolis A ^a   Arsenou, Evagelia S ^a   Papageorgiou, Athanasios ^b   Pairas, George N ^a   Nikolaropoulos, Sotiris S ^a  

^a UNIVERSITY OF PATRAS   (Greece)

^b THEAGENIO CANCER HOSPITAL   (Greece)

Author keywords

Antileukemic activity; Nitrogen mustards; SAR; Steroids

Indexed keywords

3BETA HYDROXY 17BETA ACETAMIDE ANDROST 5 EN 7 ONE 4 METHYL 3 N,N BIS(2 CHLOROETHYL) AMINO BENZOATE; 3BETA HYDROXY 17BETA ACETAMIDE ANDROST 5 EN 7 ONE 4 N,N BIS(2 CHLOROETHYL)AMINO PHENYLACETATE; 3BETA HYDROXY 17BETA ACETAMIDE ANDROST 5 EN 7 ONE 4 N,N BIS(2 CHLOROETHYL)AMINO PHENYLBUTYRATE; 3BETA HYDROXY 7ALPHA AZA B HOMO 17BETA ACETAMIDE ANDROST 5 EN 7 ONE 4 METHYL 3 N,N BIS(2 CHLOROETHYL)AMINO BENZOATE; 3BETA HYDROXY 7ALPHA AZA B HOMO 17BETA ACETAMIDE ANDROST 5 EN 7 ONE 4 N,N BIS(2 CHLOROETHYL)AMINO PHENYLACETATE; 3BETA HYDROXY 7ALPHA AZA B HOMO 17BETA ACETAMIDE ANDROST 5 EN 7 ONE 4 N,N BIS(2 CHLOROETHYL)AMINO PHENYLBUTYRATE; ANTILEUKEMIC AGENT; ESTER DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; LEUKEMIA L 1210; LEUKEMIA P 388; MALE; MOUSE; NONHUMAN; TUMOR;

ALKYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ESTERS; FEMALE; INJECTIONS, INTRAPERITONEAL; LEUKEMIA L1210; LEUKEMIA P388; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MOLECULAR STRUCTURE; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; STEREOISOMERISM; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

BRASSICACEAE;

EID: 43049088825     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.03.015     Document Type: Article

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