Synthesis, physicochemical and anticonvulsant properties of N-benzyl and N-aminophenyl derivatives of 2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione. Part I

Farmaco

Volumn 60, Issue 6-7, 2005, Pages 529-539

  Obniska, Jolanta ^a   Dzierzawska Majewska, Agnieszka ^b   Zagorska, Agnieszka ^a   Zajdel, Pawel ^a   Karolak Wojciechowska, Janina ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

2 Azaspiro 4.4 nonane 1,3 dione; 2 Azaspiro 4.5 decane 1,3 dione; Anticonvulsant activity; Pyrrolidine 2,5 diones; Spirosuccinimides; X ray structures

Indexed keywords

2 (2 METHOXYLBENZYL) 2 AZASPIRO[4.5]DECANE 1,3 DIONE; BENZENE DERIVATIVE; CARBENE; N (2 CHLOROBENZYL) 2 AZASPIRO[4.4]NONANE 1,3 DIONE; N (2 CHLOROBENZYL) 2 AZASPIRO[4.5]DECANE 1,3 DIONE; N (2 METHOXYLBENZYL) 2 AZASPIRO[4.4]NONANE 1,3 DIONE; N (2 METHYLBENZYL) 2 AZASPIRO[4.4]NONANE 1,3 DIONE; N (2 METHYLBENZYL) 2 AZASPIRO[4.5]DECANE 1,3 DIONE; N (2,4 DICHLOROBENZYL) 2 AZASPIRO[4.4]NONANE 1,3 DIONE; N (2,4 DICHLOROBENZYL) 2 AZASPIRO[4.5]DECANE 1,3 DIONE; N (3 CHLOROBENZYL) 2 AZASPIRO[4.4]NONANE 1,3 DIONE; N (3 CHLOROBENZYL) 2 AZASPIRO[4.5]DECANE 1,3 DIONE; N (4 CHLOROBENZYL) 2 AZASPIRO[4.4]NONANE 1,3 DIONE; N (4 CHLOROBENZYL) 2 AZASPIRO[4.5]DECANE 1,3 DIONE; N (4 METHOXYLBENZYL) 2 AZASPIRO[4.4]NONANE 1,3 DIONE; N (4 METHOXYLBENZYL) 2 AZASPIRO[4.5]DECANE 1,3 DIONE; N (4 METHYLBENZYL) 2 AZASPIRO[4.4]NONANE 1,3 DIONE; N (4 METHYLBENZYL) 2 AZASPIRO[4.5]DECANE 1,3 DIONE; N AMINOPHENYL 2 AZASPIRO[4.4]NONANE 1,3 DIONE; N AMINOPHENYL 2 AZASPIRO[4.5]DECANE 1,3 DIONE; N BENZYL 2 AZASPIRO[4.4]NONANE 1,3 DIONE; N BENZYL 2 AZASPIRO[4.5]DECANE 1,3 DIONE; PENTETRAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRIC SHOCK; MALE; NEUROTOXICITY; NONHUMAN; PHYSICAL CHEMISTRY; PROBLEM SOLVING; RAT; SEIZURE; STRUCTURE ACTIVITY RELATION; X RAY;

ALKANES; ANILINE COMPOUNDS; ANIMALS; ANTICONVULSANTS; AZA COMPOUNDS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROSHOCK; MALE; MICE; MOLECULAR STRUCTURE; PENTYLENETETRAZOLE; RATS; RATS, SPRAGUE-DAWLEY; ROTAROD PERFORMANCE TEST; SEIZURES; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21744441948     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.farmac.2005.05.006     Document Type: Article

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