메뉴 건너뛰기




Volumn 76, Issue 5, 2008, Pages 2130-2137

Interleukin-12 and host defense against murine Pneumocystis pneumonia

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; GAMMA INTERFERON; PROTEIN P35; RECOMBINANT INTERLEUKIN 12; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; FUNGAL RNA; INTERLEUKIN 12;

EID: 42949159328     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00065-08     Document Type: Article
Times cited : (36)

References (56)
  • 1
    • 0033401040 scopus 로고    scopus 로고
    • Intranasal interleukin-12 is a powerful adjuvant for protective mucosal immunity
    • Arulanandam, B. P., M. O'Toole, and D. W. Metzger. 1999. Intranasal interleukin-12 is a powerful adjuvant for protective mucosal immunity. J. Infect. Dis. 180:940-949.
    • (1999) J. Infect. Dis , vol.180 , pp. 940-949
    • Arulanandam, B.P.1    O'Toole, M.2    Metzger, D.W.3
  • 3
    • 0027510229 scopus 로고
    • Host defenses against Pneumocystis carinii in mice selectively depleted of CD4+ lymphocytes
    • Beck, J., M. Warnock, H. Kaltreider, and J. Shellito. 1993. Host defenses against Pneumocystis carinii in mice selectively depleted of CD4+ lymphocytes. Chest 103:116S-118S.
    • (1993) Chest , vol.103
    • Beck, J.1    Warnock, M.2    Kaltreider, H.3    Shellito, J.4
  • 4
    • 0032535760 scopus 로고    scopus 로고
    • The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12
    • Belyakov, I. M., J. D. Ahlers, B. Y. Brandwein, P. Earl, B. L. Kelsall, B. Moss, W. Strober, and J. A. Berzofsky. 1998. The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12. J. Clin. Investig. 102:2072-2081.
    • (1998) J. Clin. Investig , vol.102 , pp. 2072-2081
    • Belyakov, I.M.1    Ahlers, J.D.2    Brandwein, B.Y.3    Earl, P.4    Kelsall, B.L.5    Moss, B.6    Strober, W.7    Berzofsky, J.A.8
  • 5
    • 0020663062 scopus 로고
    • A severe combined immunodeficiency mutation in the mouse
    • Bosma, G. C., R. P. Custer, and M. J. Bosma. 1983. A severe combined immunodeficiency mutation in the mouse. Nature 301:527-530.
    • (1983) Nature , vol.301 , pp. 527-530
    • Bosma, G.C.1    Custer, R.P.2    Bosma, M.J.3
  • 6
    • 0030057511 scopus 로고    scopus 로고
    • Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: In vitro and in vivo production of biologically active interleukin-12
    • Bramson, J., M. Hitt, W. S. Gallichan, K. L. Rosenthal, J. Gauldie, and F. L. Graham. 1996. Construction of a double recombinant adenovirus vector expressing a heterodimeric cytokine: in vitro and in vivo production of biologically active interleukin-12. Hum. Gene Ther. 7:333-342.
    • (1996) Hum. Gene Ther , vol.7 , pp. 333-342
    • Bramson, J.1    Hitt, M.2    Gallichan, W.S.3    Rosenthal, K.L.4    Gauldie, J.5    Graham, F.L.6
  • 7
    • 0031298207 scopus 로고    scopus 로고
    • Biological properties of interleukin-12 and its therapeutic use in persistent hepatitis B virus and hepatitis C virus infection. I
    • Carreno, V., and J. A. Quiroga. 1997. Biological properties of interleukin-12 and its therapeutic use in persistent hepatitis B virus and hepatitis C virus infection. I. Viral Hepat. 4(Suppl. 2):83-86.
    • (1997) Viral Hepat , vol.4 , Issue.SUPPL. 2 , pp. 83-86
    • Carreno, V.1    Quiroga, J.A.2
  • 8
    • 0028538543 scopus 로고
    • Artificial infections of Pneumocystis carinii in the SCID mouse and their use in the in vivo evaluation of antipneumocystis drugs
    • Comley, J. C., and A. M. Sterling. 1994. Artificial infections of Pneumocystis carinii in the SCID mouse and their use in the in vivo evaluation of antipneumocystis drugs. J. Eukaryot. Microbiol. 41:540-546.
    • (1994) J. Eukaryot. Microbiol , vol.41 , pp. 540-546
    • Comley, J.C.1    Sterling, A.M.2
  • 9
    • 33845606612 scopus 로고    scopus 로고
    • IL-12p40: An inherently agonistic cytokine
    • Cooper, A. M., and S. A. Khader. 2007. IL-12p40: an inherently agonistic cytokine. Trends Immunol. 28:33-38.
    • (2007) Trends Immunol , vol.28 , pp. 33-38
    • Cooper, A.M.1    Khader, S.A.2
  • 10
    • 20644462376 scopus 로고    scopus 로고
    • Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations
    • Crothers, K., C. B. Beard, J. Turner, G. Groner, M. Fox, A. Morris, S. Eiser, and L. Huang. 2005. Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations. AIDS 19:801-805.
    • (2005) AIDS , vol.19 , pp. 801-805
    • Crothers, K.1    Beard, C.B.2    Turner, J.3    Groner, G.4    Fox, M.5    Morris, A.6    Eiser, S.7    Huang, L.8
  • 11
    • 0028670686 scopus 로고
    • Dysregulation of interleukin 8, interleukin 10, and interleukin 12 release by alveolar macrophages from HIV type 1-infected subjects
    • Denis, M., and E. Ghadirian. 1994. Dysregulation of interleukin 8, interleukin 10, and interleukin 12 release by alveolar macrophages from HIV type 1-infected subjects. AIDS Res. Hum. Retrovir. 10:1619-1627.
    • (1994) AIDS Res. Hum. Retrovir , vol.10 , pp. 1619-1627
    • Denis, M.1    Ghadirian, E.2
  • 12
    • 16244400432 scopus 로고    scopus 로고
    • Intranasal interleukin-12 treatment for protection against respiratory infection with the Francisella tularensis live vaccine strain
    • Ducken, N. S., S. Olmos, D. M. Durrant, and D. W. Metzger. 2005. Intranasal interleukin-12 treatment for protection against respiratory infection with the Francisella tularensis live vaccine strain. Infect. Immun. 73:2306-2311.
    • (2005) Infect. Immun , vol.73 , pp. 2306-2311
    • Ducken, N.S.1    Olmos, S.2    Durrant, D.M.3    Metzger, D.W.4
  • 13
    • 0029078676 scopus 로고
    • IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection
    • Flynn, J. L., M. M. Goldstein, K. J. Triebold, J. Sypek, S. Wolf, and B. R. Bloom. 1995. IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection. J. Immunol. 155:2515-2524.
    • (1995) J. Immunol , vol.155 , pp. 2515-2524
    • Flynn, J.L.1    Goldstein, M.M.2    Triebold, K.J.3    Sypek, J.4    Wolf, S.5    Bloom, B.R.6
  • 14
    • 0027264849 scopus 로고
    • Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts
    • Gazzinelli, R. T., S. Hieny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115-6119.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6115-6119
    • Gazzinelli, R.T.1    Hieny, S.2    Wynn, T.A.3    Wolf, S.4    Sher, A.5
  • 15
    • 0027939611 scopus 로고
    • Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii
    • Gazzinelli, R. T., M. Wysocka, S. Hayashi, E. Y. Denkers, S. Hieny, P. Caspar, G. Trinchieri, and A. Sher. 1994. Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii. J. Immunol. 153:2533-2543.
    • (1994) J. Immunol , vol.153 , pp. 2533-2543
    • Gazzinelli, R.T.1    Wysocka, M.2    Hayashi, S.3    Denkers, E.Y.4    Hieny, S.5    Caspar, P.6    Trinchieri, G.7    Sher, A.8
  • 16
    • 0034063151 scopus 로고    scopus 로고
    • Roles of interleukin-12 and gamma interferon in murine Chlamydia pneumoniae infection
    • Geng, Y., K. Berencsi, Z. Gyulai, T. Valyi-Nagy, E. Gonczol, and G. Trinchieri. 2000. Roles of interleukin-12 and gamma interferon in murine Chlamydia pneumoniae infection. Infect. Immun. 68:2245-2253.
    • (2000) Infect. Immun , vol.68 , pp. 2245-2253
    • Geng, Y.1    Berencsi, K.2    Gyulai, Z.3    Valyi-Nagy, T.4    Gonczol, E.5    Trinchieri, G.6
  • 17
    • 0343775765 scopus 로고    scopus 로고
    • Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection
    • Goebel, A., E. Kavanagh, A. Lyons, I. B. Saporoschetz, C. Soberg, J. A. Lederer, J. A. Mannick, and M. L. Rodrick. 2000. Injury induces deficient interleukin-12 production, but interleukin-12 therapy after injury restores resistance to infection. Ann. Surg. 231:253-261.
    • (2000) Ann. Surg , vol.231 , pp. 253-261
    • Goebel, A.1    Kavanagh, E.2    Lyons, A.3    Saporoschetz, I.B.4    Soberg, C.5    Lederer, J.A.6    Mannick, J.A.7    Rodrick, M.L.8
  • 19
    • 0030010968 scopus 로고    scopus 로고
    • Role of IL-12 in peripheral blood mononuclear cell responses to fungi in persons with and without HIV infection
    • Harrison, T. S., and S. M. Levitz. 1996. Role of IL-12 in peripheral blood mononuclear cell responses to fungi in persons with and without HIV infection. J. Immunol. 156:4492-4497.
    • (1996) J. Immunol , vol.156 , pp. 4492-4497
    • Harrison, T.S.1    Levitz, S.M.2
  • 20
    • 0029614851 scopus 로고
    • Immunoregulation of murine leishmaniasis by interleukin-12
    • Heinzel, F. P., F. Ahmed, A. M. Hujer, and R. M. Rerko. 1995. Immunoregulation of murine leishmaniasis by interleukin-12. Res. Immunol. 146: 575-581.
    • (1995) Res. Immunol , vol.146 , pp. 575-581
    • Heinzel, F.P.1    Ahmed, F.2    Hujer, A.M.3    Rerko, R.M.4
  • 21
    • 0027336689 scopus 로고
    • Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    • Hsieh, C. S., S. E. Macatonia, C. S. Tripp, S. F. Wolf, A. O'Garra, and K. M. Murphy. 1993. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549.
    • (1993) Science , vol.260 , pp. 547-549
    • Hsieh, C.S.1    Macatonia, S.E.2    Tripp, C.S.3    Wolf, S.F.4    O'Garra, A.5    Murphy, K.M.6
  • 24
    • 0029981459 scopus 로고    scopus 로고
    • IL-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans
    • Kawakami, K., M. Tohyama, Q. Xie, and A. Saito. 1996. IL-12 protects mice against pulmonary and disseminated infection caused by Cryptococcus neoformans. Clin. Exp. Immunol. 104:208-214.
    • (1996) Clin. Exp. Immunol , vol.104 , pp. 208-214
    • Kawakami, K.1    Tohyama, M.2    Xie, Q.3    Saito, A.4
  • 25
    • 2442562221 scopus 로고    scopus 로고
    • Increase in prevalence of Pneumocystis carinii mutations in patients with AIDS and P. carinii pneumonia, in the United States and China
    • Kazanjian, P. H., D. Fisk, W. Armstrong, Q. Shulin, H. Liwei, Z. Ke, and S. Meshnick. 2004. Increase in prevalence of Pneumocystis carinii mutations in patients with AIDS and P. carinii pneumonia, in the United States and China. J. Infect. Dis. 189:1684-1687.
    • (2004) J. Infect. Dis , vol.189 , pp. 1684-1687
    • Kazanjian, P.H.1    Fisk, D.2    Armstrong, W.3    Shulin, Q.4    Liwei, H.5    Ke, Z.6    Meshnick, S.7
  • 27
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
    • Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827-845.
    • (1989) J. Exp. Med , vol.170 , pp. 827-845
    • Kobayashi, M.1    Fitz, L.2    Ryan, M.3    Hewick, R.M.4    Clark, S.C.5    Chan, S.6    Loudon, R.7    Sherman, F.8    Perussia, B.9    Trinchieri, G.10
  • 28
    • 0037304350 scopus 로고    scopus 로고
    • Therapeutic effects of IL-12 combined with benzoylmesaconine, a non-toxic aconitine-hydrolysate, against herpes simplex virus type 1 infection in mice following thermal injury
    • Kobayashi, M., H. Takahashi, D. N. Herndon, R. B. Pollard, and F. Suzuki. 2003. Therapeutic effects of IL-12 combined with benzoylmesaconine, a non-toxic aconitine-hydrolysate, against herpes simplex virus type 1 infection in mice following thermal injury. Burns 29:37-42.
    • (2003) Burns , vol.29 , pp. 37-42
    • Kobayashi, M.1    Takahashi, H.2    Herndon, D.N.3    Pollard, R.B.4    Suzuki, F.5
  • 29
    • 0029875608 scopus 로고    scopus 로고
    • Transient CD4-lymphocyte depletion prolongs transgene expression of E1-deleted adenoviral vectors
    • Kolls, J., D. Lei, G. Odom, S. Nelson, W. Summer, M. Gerber, and J. Shellito. 1996. Transient CD4-lymphocyte depletion prolongs transgene expression of E1-deleted adenoviral vectors. Hum. Gene Ther. 7:489-497.
    • (1996) Hum. Gene Ther , vol.7 , pp. 489-497
    • Kolls, J.1    Lei, D.2    Odom, G.3    Nelson, S.4    Summer, W.5    Gerber, M.6    Shellito, J.7
  • 30
    • 0033106236 scopus 로고    scopus 로고
    • Interferon-gamma and CD8+ T-cells restore host defense against P. carinii in mice lacking CD4+ T-cells
    • Kolls, J., C. Vazquez, D. Lei, P. Schwarzenberger, P. Ye, S. Nelson, W. Summer, and J. Shellito. 1999. Interferon-gamma and CD8+ T-cells restore host defense against P. carinii in mice lacking CD4+ T-cells. J. Immunol. 162:2890-2894.
    • (1999) J. Immunol , vol.162 , pp. 2890-2894
    • Kolls, J.1    Vazquez, C.2    Lei, D.3    Schwarzenberger, P.4    Ye, P.5    Nelson, S.6    Summer, W.7    Shellito, J.8
  • 31
    • 0036932388 scopus 로고    scopus 로고
    • Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells
    • Lieberman, L. A., and C. A. Hunter. 2002. Regulatory pathways involved in the infection-induced production of IFN-gamma by NK cells. Microbes Infect. 4:1531-1538.
    • (2002) Microbes Infect , vol.4 , pp. 1531-1538
    • Lieberman, L.A.1    Hunter, C.A.2
  • 32
    • 0033747054 scopus 로고    scopus 로고
    • Epidemiology of Pneumocystis carinii pneumonia in an era of effective prophylaxis: The relative contribution of non-adherence and drug failure
    • Lundberg, B. E., A. J. Davidson, and W. J. Burman. 2000. Epidemiology of Pneumocystis carinii pneumonia in an era of effective prophylaxis: the relative contribution of non-adherence and drug failure. AIDS 14:2559-2566.
    • (2000) AIDS , vol.14 , pp. 2559-2566
    • Lundberg, B.E.1    Davidson, A.J.2    Burman, W.J.3
  • 34
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
    • Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199-1204.
    • (1993) J. Exp. Med , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3    Piccinni, M.P.4    Maggi, E.5    Trinchieri, G.6    Romagnani, S.7
  • 39
    • 0031926095 scopus 로고    scopus 로고
    • Role of interleukin-12 in primary influenza virus infection
    • Monteiro, J. M., C. Harvey, and G. Trinchieri. 1998. Role of interleukin-12 in primary influenza virus infection. J. Virol. 72:4825-4831.
    • (1998) J. Virol , vol.72 , pp. 4825-4831
    • Monteiro, J.M.1    Harvey, C.2    Trinchieri, G.3
  • 43
    • 0033556145 scopus 로고    scopus 로고
    • IL-12 is not required for induction of type 1 cytokine responses in viral infections
    • Oxenius, A., U. Karrer, R. M. Zinkernagel, and H. Hengartner. 1999. IL-12 is not required for induction of type 1 cytokine responses in viral infections. J. Immunol. 162:965-973.
    • (1999) J. Immunol , vol.162 , pp. 965-973
    • Oxenius, A.1    Karrer, U.2    Zinkernagel, R.M.3    Hengartner, H.4
  • 44
    • 9644307958 scopus 로고    scopus 로고
    • Intranasal interleukin-12 treatment promotes antimicrobial clearance and survival in pulmonary Francisella tularensis subsp. novicida infection
    • Pammit, M. A., V. N. Budhavarapu, E. K. Raulie, K. E. Klose, J. M. Teale, and B. P. Arulanandam. 2004. Intranasal interleukin-12 treatment promotes antimicrobial clearance and survival in pulmonary Francisella tularensis subsp. novicida infection. Antimicrob. Agents Chemother. 48:4513-4519.
    • (2004) Antimicrob. Agents Chemother , vol.48 , pp. 4513-4519
    • Pammit, M.A.1    Budhavarapu, V.N.2    Raulie, E.K.3    Klose, K.E.4    Teale, J.M.5    Arulanandam, B.P.6
  • 45
    • 0038580440 scopus 로고    scopus 로고
    • A multicenter study of recombinant human interleukin 12 for the treatment of chronic hepatitis C virus infection in patients nonresponsive to previous therapy
    • Pockros, P. J., K. Patel, C. O'Brien, M. Tong, C. Smith, V. Rustgi, R. L. Carithers, J. G. McHutchison, E. Olek, and M. F. Debruin. 2003. A multicenter study of recombinant human interleukin 12 for the treatment of chronic hepatitis C virus infection in patients nonresponsive to previous therapy. Hepatology 37:1368-1374.
    • (2003) Hepatology , vol.37 , pp. 1368-1374
    • Pockros, P.J.1    Patel, K.2    O'Brien, C.3    Tong, M.4    Smith, C.5    Rustgi, V.6    Carithers, R.L.7    McHutchison, J.G.8    Olek, E.9    Debruin, M.F.10
  • 46
    • 0038785538 scopus 로고    scopus 로고
    • Exogenous interleukin-12 protects against lethal infection with coxsackievirus B4
    • Potvin, D. M., D. W. Metzger, W. T. Lee, D. N. Collins, and A. I. Ramsingh. 2003. Exogenous interleukin-12 protects against lethal infection with coxsackievirus B4. J. Virol. 77:8272-8279.
    • (2003) J. Virol , vol.77 , pp. 8272-8279
    • Potvin, D.M.1    Metzger, D.W.2    Lee, W.T.3    Collins, D.N.4    Ramsingh, A.I.5
  • 47
    • 35748951920 scopus 로고    scopus 로고
    • Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells
    • Rothfuchs, A. G., A. Bafica, C. G. Feng, J. G. Egen, D. L. Williams, G. D. Brown, and A. Sher. 2007. Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. J. Immunol. 179:3463-3471.
    • (2007) J. Immunol , vol.179 , pp. 3463-3471
    • Rothfuchs, A.G.1    Bafica, A.2    Feng, C.G.3    Egen, J.G.4    Williams, D.L.5    Brown, G.D.6    Sher, A.7
  • 48
    • 34249869268 scopus 로고    scopus 로고
    • Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection
    • Rudner, X. L., K. I. Happel, E. A. Young, and J. E. Shellito. 2007. Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. Infect. Immun. 75:3055-3061.
    • (2007) Infect. Immun , vol.75 , pp. 3055-3061
    • Rudner, X.L.1    Happel, K.I.2    Young, E.A.3    Shellito, J.E.4
  • 49
    • 0025282012 scopus 로고
    • A new model of Pneumocystis carinii infection in mice selctively depleted of helper T lymphocytes
    • Shellito, J., V. Suzara, W. Blumenfeld, J. Beck, H. Steger, and T. Ermak. 1990. A new model of Pneumocystis carinii infection in mice selctively depleted of helper T lymphocytes. J. Clin. Investig. 85:1686-1693.
    • (1990) J. Clin. Investig , vol.85 , pp. 1686-1693
    • Shellito, J.1    Suzara, V.2    Blumenfeld, W.3    Beck, J.4    Steger, H.5    Ermak, T.6
  • 51
  • 52
    • 0033490502 scopus 로고    scopus 로고
    • Interleukin-12: A cytokine at the interface of inflammation and immunity
    • Trinchieri, G. 1998. Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv. Immunol. 70:83-243.
    • (1998) Adv. Immunol , vol.70 , pp. 83-243
    • Trinchieri, G.1
  • 53
    • 0031937388 scopus 로고    scopus 로고
    • Proinflammatory and immunoregulatory functions of interleukin-12
    • Trinchieri, G. 1998. Proinflammatory and immunoregulatory functions of interleukin-12. Int. Rev. Immunol. 16:365-396.
    • (1998) Int. Rev. Immunol , vol.16 , pp. 365-396
    • Trinchieri, G.1
  • 54
    • 0029557309 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions
    • Trinchieri, G., and P. Scott. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions. Res. Immunol. 146:423-431.
    • (1995) Res. Immunol , vol.146 , pp. 423-431
    • Trinchieri, G.1    Scott, P.2
  • 55
    • 0028068010 scopus 로고
    • Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection
    • Wagner, R. D., H. Steinberg, J. F. Brown, and C. J. Czuprynski. 1994. Recombinant interleukin-12 enhances resistance of mice to Listeria monocytogenes infection. Microb. Pathog. 17:175-186.
    • (1994) Microb. Pathog , vol.17 , pp. 175-186
    • Wagner, R.D.1    Steinberg, H.2    Brown, J.F.3    Czuprynski, C.J.4
  • 56
    • 0004252445 scopus 로고
    • Prentice-Hall, Inc, Englewood Cliffs, NJ
    • Zar, J. 1974. Biostatistical analysis. Prentice-Hall, Inc., Englewood Cliffs, NJ.
    • (1974) Biostatistical analysis
    • Zar, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.