Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis

Tubercle and Lung Disease

Volumn 78, Issue 2, 1998, Pages 117-122

  Hirano, K ^a   Takahashi, M ^a   Kazumi, Y ^a   Fukasawa, Y ^a   Abe, C ^a  

^a RESEARCH INSTITUTE OF TUBERCULOSIS   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PYRAZINAMIDE; TUBERCULOSTATIC AGENT;

ARTICLE; ENZYME ACTIVITY; GENE MUTATION; GENE SEQUENCE; HUMAN; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; PRIORITY JOURNAL; TUBERCULOSIS;

EID: 0031424884     PISSN: 09628479     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0962-8479(98)80004-X     Document Type: Article

References (30)

1. Barnes PF Bloch AB Davidson PT Snider DE Jr Tuberculosis in patients with human immunodeficiency virus infection N Engl J Med 324 1991 1644 1650
2. Snider DE Roper WL The new tuberculosis N Engl J Med 326 1992 703 705
3. Zhang Y Heym B Allen B Young D Cole S The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis Nature 358 1992 591 593
4. Banergee A Dubnau E Quemard A inhA , a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis Science 263 1994 227 230
5. Telenti A Imboden P Marchesi F Detection of rifampicin resistance mutations in Mycobacterium tuberculosis Lancet 341 1993 647 650
6. Williams DL Waguespack C Eisenach K Characterization of rifampin resistance in pathogenic mycobacteria Antimicrob Agents Chemother 38 1994 2380 2386
7. Finken M Kirschner P Meier A Wrede A Bottger EC Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot Mol Microbiol 9 1993 1239 1246
8. Nair J Rouse DA Bai G-H Morris SL The rpsL gene and streptomycin resistance in single and multiple drug-resistant strains of Mycobacterium tuberculosis Mol Microbiol 10 1993 521 527
9. Cambau E Sougakoff W Besson M Truffot-Pernot C Grosset J Jarlier V Selection of a gyrA mutant of Mycobacterium tuberculosis resistant to fluoroquinolones during treatment with ofloxacin J Infect Dis 170 1994 479 483
10. Belanger AE Besra GS Ford ME The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol Proc Natl Acad Sci USA 93 1996 11919 11924
11. Telenti A Philipp WJ Sreevatsan S The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol Nat Med 3 1997 567 570
12. Sreevatsan S Stochbauer KE Pan X Ethambutol resistance in Mycobacterium tuberculosis : critical role of embB mutations Antimicrob Agents Chemother 41 1997 1677 1681
13. Heifets L Lindholm-Levy P Pyrazinamide sterilizing activity in vitro against semidormant Mycobacterium tuberculosis bacterial populations Am Rev Respir Dis 145 1992 1223 1225
14. Mitchison DA The action of antituberculosis drugs in short-course chemotherapy Tubercle 66 1985 219 225
15. Konno K Feldmann FM McDermott W Pyrazinamide susceptibility and amidase activity of tubercle bacilli Am Rev Respir Dis 95 1967 461 469
16. McClatchy JK Tsang AY Cernich MS Use of pyrazinamidase activity in Mycobacterium tuberculosis as a rapid method for determination of pyrazinamide susceptibility Antimicrob Agents Chemother 20 1981 556 557
17. Trivedi SS Desai SG Pyrazinamidase activity of Mycobacterium tuberculosis — a test of sensitivity to pyrazinamide Tubercle 68 1987 221 224
18. Butler WR Kilburn JO Susceptibility of Mycobacterium tuberculosis to pyrazinamide and its relationship to pyrazinamidase activity Antimicrob Agents Chemother 24 1983 600 601
19. Scorpio A Zhang Y Mutations in pncA , a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus Nat Med 2 1996 662 667
20. Wayne LG Simple pyrazinamide and urease tests for routine identification of mycobacteria Am Rev Respir Dis 109 1974 147 151
21. Sreevatsan S Pan X Zhang Y Kreiswirth BN Musser JM Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms Antimicrob Agents Chemother 41 1997 636 641
22. Mackanes GB The intracellular activation of pyrazinamide and nicotinamide American Review of Tuberculosis and Pulmonary Diseases 74 1956 718 728
23. McDermott W Tompsett R Activation of pyrazinamide and nicotinamide in acid environments in vitro American Review of Tuberculosis and Pulmonary Diseases 70 1954 748 754
24. Stottmeier KD Beam RE Kubica GP Determination of drug susceptibility of mycobacteria to pyrazinamide in 7H10 agar Am Rev Respir Dis 96 1967 1072 1075
25. Salfinger M Heifets LB Determination of pyrazinamide MICs for Mycobacterium tuberculosis at different pHs by the radiometric method Antimicrob Agents Chemother 32 1988 1002 1004
26. Kim SJ Hong YP Drug resistance of Mycobacterium tuberculosis in Korea Tubercle Lung Dis 73 1992 219 224
27. Bloch AB Cauthen GM Onorato IM Nationwide survey of drug-resistant tuberculosis in the United States JAMA 271 1994 665 671
28. Hirano K Kazumi Y Abe C Mori T Aoki M Aoyagi T Resistance to antituberculosis drugs in Japan Tubercle Lung Dis 77 1996 130 135
29. Cohn DL Bustreo F Raviglione MC Drug-resistant tuberculosis: review of the worldwide situation and the WHO/IUATLD Global Surveillance Project Clin Infect Dis 24 Suppl 1 1997 S121 S130
30. Scorpio A Lindholm-Levy P Heifets L Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis Antimicrob Agents Chemother 41 1997 540 543