The treatment of malaria with iron chelators

Journal of Pharmacy and Pharmacology

Volumn 49, Issue SUPPL. 2, 1997, Pages 59-64

  Hider, Robert C ^a   Liu, Zudong ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHELATING AGENT; DEFEROXAMINE; HYDROXYL RADICAL; PYRIMETHAMINE; QUININE DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; DRUG DESIGN; ENZYME INHIBITION; ERYTHROCYTE; HUMAN; IRON CHELATION; MALARIA;

EID: 0030990206     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06162.x     Document Type: Article

References (48)

1. Albert, A., Rees, C. W., Tomlinson, A. J. H. (1956) Why are metal binding substances anti-bacterial? Recueil 75: 819-824
2. Bunnag, D., Poltera, A. A., Viravan, C., Looareesuwan, S., Harinasuta, K. T., Schindlery, C. (1992) Plasmodicidal effect of desferrioxamine-β in human vivax or falciparum malaria from Thailand. Acta Trop. 52: 59-67
3. Cabantchik, Z. I. (1989) Altered membrane transport of malaria-infected erythrocytes: a possible pharmacological target. Blood 74: 1464-1471
4. Cabantchik, Z. I., Glickstein, H., Golenser, J., Loyevsky, M., Tsafack, A. (1996) Iron chelators: mode of action as antimalarials. Acta Haematol. 95: 70-77
5. Cooper, C. E., Lynagh, G. R., Hoyes, K. P., Hider, R. C., Cammack, R., Porter, J. B. (1996) The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase. J. Biol. Chem. 271: 20291-20299
6. Cory, J. G., Lasater, L., Sato, A. (1981) Effect of iron chelating agents on inhibitors of ribonucleotide reductase. Biochem. Pharmacol. 30: 979-984
7. Dobbin, P. S., Hider, R. C., Hall, A. D., Taylor, P. D., Sarpong, P., Porter, J. B., Xiao, G., Van Der Helm, D. (1993) Synthesis, physicochemical properties and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)pyridinones: orally active iron chelators with clinical potential. J. Med. Chem. 36: 2448-2548
8. Elford, B. C., Cowan, G. M., Ferguson, J. P. (1996) Parasite-regulated membrane transport processes and metabolic control in malaria-infected erythrocytes. Biochem. J. 308: 361-374
9. Fritsch, G., Sawatzki, G., Treumer, J., Jung, A., Spira, D. R. (1987) Plasmodium falciparum: inhibition in vitro with lactoferrin, desferrithiocin and desferricrocin. Exp. Parasitol. 63: 1
10. Ganeshaguru, K., Hoffbrand, A. V., Grady, R. W., Cerami, A. (1980) Effect of iron chelating agents on DNA synthesis in human cells. Biochem. Pharmacol. 29: 1275-1279
11. Goldberg, D. E., Slater, A. F. G., Cerami, A., Henderson, G. B. (1990) Haemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle. Proc. Natl Acad. Sci. USA 87: 2931-2935
12. Golenser, J., Tsafack, A., Amichai, Y., Libman, J., Shanzer, A., Cabantchik, Z. I. (1995) Antimalarial action of hydroxamate-based iron chelators and potentiation of desferrioxamine action by reversed siderophores. Antimicrob. Agents Chemother. 39: 61-65
13. Gordeuk, V., Thuma, P., Brittenham, G., McLaren, C., Parry, D., Backenstrose, A., Biemba, G., Msiska, R., Holmes, L., McKinlye, E., Vargas, L., Gilkeson, R., Poltera, A. A. (1992a) Effect of iron chelation therapy of recovery from deep coma in children with cerebral malaria. N. Engl. J. Med. 237: 1473-1477
14. Gordeuk, Y. R., Thuma, P. E., Brittenham, G. M., Zulu, S., Simwanza, G., Mhang, A., Flesch, G., Parry, D. (1992b) Iron chelation with desferrioxamine β in adults with asymptomatic Plasmodium falciparum parasitemia. Blood 79: 308-312
15. Heppner, D. G., Hallaway, P. E., Kontoghiorghes, G. J., Eaton, J. W. (1988) Antimalarial properties of orally active iron chelators. Blood 72: 358-361
16. Hershko, C., Peto, T. E. A. (1988) Desferrioxamine inhibition of malaria is independent of host iron status. J. Exp. Med. 168: 375
17. Hershko, C., Gordeuk, V. R., Thuma, P. E., Theanacho, E. N., Spira, D. T., Hider, R. C., Peto, T. E. A., Brittenham, G. M. (1992) The antimalarial effect of iron chelator studies in animal models and in humans with mild falciparum malaria. J. Inorg. Biochem. 47: 267-277
18. Hider, R. C., Porter, J. B., Singh, S. (1994) The design of therapeutically useful iron chelators. In: Bergeron, R. J., Brittenham, G. M. (eds) The Design of Therapeutically Useful Iron Chelators in the Development of Iron Chelators for Clinical Use. CRC Press, Ann Arbor, pp 353-371
19. Hider, R. C., Choudhury, R., Rai, B. I., Dehkordi, L. S., Singh, S. (1996) Design of orally active iron chelators. Eur. J. Drug Metab. Disposit. 95: 6-12
20. Hoyes, K. P., Hider, R. C., Porter, J. B. (1992) Cell cycle synchronisation and growth inhibition by 3-hydroxypyridin-4-one iron chelators in leukamia cell lines. Cancer Res. 52: 4591-4599
21. Kannani, J., Ginsburg, H. (1991) Transport of lactate in Plasmodium falciparum-infected human erythrocytes. J. Cell Physiol. 149: 469-476
22. Kannani, J., Ginsburg, H. (1992) Effect of cinnamic acid derivatives on in vitro growth of Plasmodium falciparum and on the permeability of the membrane of malaria-infected erythrocytes. Antimicrob. Agents Chemother. 36: 1102-1108
23. Kontoghiorghes, G. J., Goddard, J. G., Bartlet, A. N., Sheppard, L. (1990) Pharmacokinetic studies in humans with the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one. Clin. Pharmacol. Ther. 48: 255-261
24. Li, X.-M. (1986) Clinical analysis of the efficacy of daphnetin in the treatment of Bruger's disease in 112 cases. Jilin Med. 7: 28-29
25. Lytton, S. D., Mester, B., Dayan, I., Glickstein, H., Libman, J., Shanzer, A., Cabantchik, Z. I. (1993) Mode of action of iron(III) chelators as antimalarials: 1. Membrane permeation properties and cytotoxic activity. Blood 81: 214-221
26. Mabeza, G. F., Biemba, G., Gordeuk, V. R. (1996) Clinical studies of iron chelators in malaria. Acta Haematol. 95: 78-86
27. Meshnik, S. R., Yang, Y. Z., Lima, V., Kuypers, F., Kamchonwongpaisan, S., Yuthovong, Y. (1993) Iron-dependent free radical generation from the antimalarial agent artemisinin (Quinghasosu). Antimicrob. Agents Chemother. 37: 1108-1114
28. Nordlund, P., Sjoberg, B. M., Eklund, H. (1990) Three-dimensional structure of the free radical protein of ribonucleotide reductase. Nature 345: 593-598
29. Pasvol, G., Cough, B., Carlsson, J. (1992) Malaria and the red cell membrane. Blood Reviews 6: 183-192
30. Pattanapanyasat, K., Thaithong, S., Kyle, D. E., Udomsangpetch, R., Yongvanitchit, K., Hider, R. C., Webster, H. K. (1997) Flow cytometric assessment of hydroxypyridinone iron chelators on in vitro growth of drug-resistant malaria. Cytometry In press
31. Peto, T. E. A., Thompson, J. L. (1986) A reappraisal of the effects iron and desferrioxamine on the growth of Plasmodium falciparum in vitro: the unimportance of serum iron. Br. J. Haematol. 63: 273-280
32. Pollack, S., Rossan, R. N., Davidson, D. E., Escajadillo, A. (1987) Desferrioxamine suppresses Plasmodium falciparum in Aotus monkeys. Proc. Soc. Exp. Biol. Med. 184: 162-164
33. Porter, J. B. (1989) Oral iron chelators; prospects for future development. Eur. J. Haematol. 43: 271-285
34. Porter, J. B., Gyparaki, M., Burke, L. C., Huehns, E. R., Sarpong, P., Saez, V., Hider, R. C. (1988) Iron mobilization from hepatocyte monolayer cultures by chelators: the importance of membrane permeability and the iron-binding constant. Blood 72: 1497-1503
35. Porter, J. B., Morgan, J., Hoyes, K. P., Burke, L. C., Huehns, E. R., Hider, R. C. (1990) Relative efficacy and acute toxicity of hydroxypyridin-4-one iron chelators in mice. Blood 76: 2389-2396
36. Raventos-Suarez, C., Pollack, S., Nagal, R. L. (1982) Plasmodium falciparum: inhibition of in-vitro growth by deferoxamine. Am. J. Trop. Med. Hyg. 31: 919-922
37. Scheibel, L. W., Adler, A. (1980) Antimalarial activity of selected aromatic chelators. Mol. Pharmacol. 18: 320-325
38. Scheibel, L. W., Adler, A. (1982) III 8-Hydroxyquinolines (oxines) substituted in position 5 and 7 and oxines annelated in position 5, 6 by an aromatic ring. Mol. Pharmacol. 22: 140-144
39. Scott, M. D., Ranz, A., Kuypers, F. A., Lubin, B. H., Meshnick, S. R. (1990) Parasite uptake of desferrioxamine: a prerequisite for antimalarial activity. Br. J. Haematol. 75: 598-602
40. Shanzer, A., Libman, J., Lytton, S. D., Glickstein, H., Cabantchik, Z. I. (1991) Reversed siderophores act as antimalarial agents. Proc. Natl Acad. Sci. USA 88: 6585-6589
41. Singh, S., Epemolu, R. O., Dobbin, P. S., Tilbrook, G. S., Ellis, B. L., Damani, L. A., Hider, R. C. (1992) Urinary metabolic profiles in human and rat of 1,2-dimethyl- and 1,2-diethyl-substituted 3-hydroxypyridin-4-ones. Drug Metab. Dispos. 20: 256-261
42. Steck, E. (1971) The Chemotherapy of Protozoal Diseases. Walter Reed Army Institute of Research, Washington DC
43. Stubbe, J. (1990). Ribonucleotide reductases: amazing and confusing. J. Biol. Chem. 265: 5329-5332
44. Tsafack, A., Loyevsky, M., Ponka, P., Cabantchik, Z. I. (1996) Mode of action of iron (III) chelators as antimalarials. J. Lab. Clin. Med. 127: 574-582
45. Van Zyl, R. L., Havlik, I., Hemplemann, E., MacPhail, A. P., McNamaro, L. (1993) Malaria pigment and excellular iron. Possible target from iron chelating agents. Biochem. Pharmacol. 45: 1431-1436
46. Whitehead, S., Peto, T. E. A. (1990) Stage-dependent effect of desferrioxamine on growth of Plasmodium falciparum in vitro. Blood 76: 1250-1255
47. Yang, Y. Z., Ranz, A., Pan, H. Z., Zhang, Z. N., Lin, X. B., Meshnick, S. R. (1992) Daphnetin: a novel antimalarial agent with in vitro and in vivo activity. Am. J. Trop. Med. Hyg. 46: 15-20
48. Yinnan, A. M., Theanacho, E. N., Grady, R. W., Spira, D. T., Hershko, C. (1989) Antimalarial effect of HBED and other phenolic and catecholic iron chelators. Blood 74: 2166-2171