Improved understanding of the effect of food on drug absorption and bioavailability for lipophilic compounds using an intestinal pig perfusion model

European Journal of Pharmaceutical Sciences

Volumn 34, Issue 1, 2008, Pages 22-29

  Persson, E M ^a   Nordgren, A ^b   Forsell, P ^b   Knutson, L ^b   Ohgren C ^c   Forssen S ^c   Lennernas H ^a   Abrahamsson, B ^c  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Bioavailability; Biopharmaceutical classification system; Cyclosporine; Danazol; Food drug interaction effects; Intestinal absorption; Low soluble drugs; Nanoparticles; P glycoprotein; Permeability; Verapamil

Indexed keywords

CYCLOSPORIN; DANAZOL; NANOPARTICLE; VERAPAMIL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG INHIBITION; DRUG PENETRATION; FAT INTAKE; FOOD INTAKE; IN VIVO STUDY; INTESTINE PERFUSION; NONHUMAN; PRIORITY JOURNAL; SWINE;

ANIMALS; BIOLOGICAL AVAILABILITY; CYCLOSPORINE; DANAZOL; FOOD; INTESTINAL ABSORPTION; JEJUNUM; PARTICLE SIZE; PERFUSION; SOLUBILITY; SWINE;

EID: 42649119408     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.02.002     Document Type: Article

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