If bone is the answer, then what is the question?

Journal of Anatomy

Volumn 197, Issue 2, 2000, Pages 145-156

  Huiskes, R ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

'Wolff's law'; Biomechanics; Osteology

Indexed keywords

ADAPTATION; ANALYTIC METHOD; ANIMAL TISSUE; BIOMECHANICS; BONE; BONE REMODELING; BONE STRENGTH; BONE STRESS; BONE STRUCTURE; COMPUTER SIMULATION; CONTROLLED STUDY; DOG; FINITE ELEMENT ANALYSIS; MATHEMATICAL COMPUTING; MECHANICAL STRESS; MEDICAL RESEARCH; MORPHOLOGY; NONHUMAN; ORGAN WEIGHT; OSSIFICATION; OSTEOCYTE; PHYSIOLOGY; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; TRABECULAR BONE; WORKLOAD;

ANIMALS; BONE AND BONES; BONE REMODELING; COMPUTER SIMULATION; DOGS; ELASTICITY; FINITE ELEMENT ANALYSIS; HUMANS; MODELS, BIOLOGICAL; OSTEOCYTES; STRESS, MECHANICAL;

EID: 0033811529     PISSN: 00218782     EISSN: None     Source Type: Journal    
DOI: 10.1017/S002187829900638X     Document Type: Review

References (53)

1. Optimal design of material properties and material distribution for multiple loading conditions
2. Mechanical loading history and skeletal biology
3. Trabecular bone density and loading history: Regulation of connective tissue biology by mechanical energy
4. Relationships between loading history and femoral cancellous bone architecture
5. The false premise of Wolff's Law
6. Candidates for the mechanosensory system in bone
7. One Century of Wolff's Law
8. The direct examination of three-dimensional bone architecture in vitro by computed tomography
9. Vital biomechanics. Proposed general concepts for skeletal adaptation to mechanical usage
10. A unifying principle relating stress to trabecular bone morphology
11. Introduction to finite element based simulation of functional adaptation of cancellous bone
12. Towards a quantitative formulation of Wolff's Law in trabecular bone
13. Do bone ingrowth processes produce a globally optimized structure?
14. Human vertebral body apparent and hard tissue stiffness
15. The law of adaptive bone remodeling: A case for crying Newton?
16. Simulation of self-organization and functional adaptation in bone
17. A survey of finite flement analysis in orthopaedic biomechanics: The first decade
18. From structure to process, from organ to cell: Recent developments of FE-analysis in orthopaedic biomechanics
19. Adaptive bone remodeling in cyberspace: Tricks and treats
20. Effects of mechanical forces on maintenance and adaptation of form in trabecular bone
21. Adaptive bone remodeling incorporating simultaneous density and anisotropy considerations
22. The role of an effective isotropic tissue modulus in the elastic properties of cancellous bone
23. The third culture
24. Sensitivity of osteocytes to biomechanical stress in vitro
25. Finite-element modeling of trabecular bone: Comparison with mechanical testing and determination of tissue modulus
26. Osteocytes, strain detection, bone modeling and remodeling
27. Strain rate and strain as bone remodeling stimuli
28. Die Architektur der Spongiosa
29. A physiological approach to the simulation of bone remodeling as a self-organizational control process (Technical Note)
30. A proposal for the regulatory mechanism of Wolff's law
31. Osteocyte density changes in aging and osteoporosis
32. Osteocyte density and histomorphometric parameters in cancellous bone of the proximal femur in five mammalian species
33. Osteocyte and bone lining cells-which are the best candidates for mechano-sensors in cancellous bone?
34. Effect of mechanical set-point of bone cells on mechanical control of trabecular bone architecture
35. A direct method for fast three-dimensional reconstruction
36. Finite element models in tissue mechanics and orthopaedic implant design
37. The history of some fundamental concepts in bone Biomechanics
38. Der Kampf der Teile im Organismus. Leipzig: Engelmann.
39. A microtomographic system for the nondestructive evaluation of bone architecture
40. Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo
41. Review of Wolff's Law and its proposed means of operation
42. Three rules for bone adaptation to mechanical stimuli
43. Differentiation to plate-like or strut-like architectures in trabecular bone as a result of mechanical loading
44. A new method to determine trabecular bone elastic properties and loading using micro-mechanical finite-elements methods
45. Computational strategies for iterative solutions of large FEM applications employing voxel data
46. Tissue stress and strain in trabeculae of a canine proximal femur can be quantified from computer reconstructions
47. Trabecular bone tissue strains in the healthy and osteoporotic human femur
48. The behavior of adaptive bone-remodeling simulation models
49. Das Gesetz der Transformation der Knochen