Inhibition of hydrogen sulfide synthesis attenuates chemokine production and protects mice against acute pancreatitis and associated lung injury

Pancreas

Volumn 36, Issue 4, 2008, Pages

  Tamizhselvi, Ramasamy ^a   Moore, Philip K ^a   Bhatia, Madhav ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Acute pancreatitis; H2S; MCP 1; MIP 1 ; MIP 2; RANTES

Indexed keywords

CERULETIDE; DEXTRO PROPARGYLGLYCINE; GLYCINE DERIVATIVE; HYDROGEN SULFIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; SODIUM DERIVATIVE; SODIUM HYDROSULFIDE;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG; LUNG INJURY; MALE; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

ACUTE DISEASE; ALKYNES; ANIMALS; CAERULEIN; CHEMOKINE CCL5; CHEMOKINES; CYSTATHIONINE GAMMA-LYASE; DNA PRIMERS; GLYCINE; HYDROGEN SULFIDE; MALE; MICE; PANCREATITIS; RESPIRATORY DISTRESS SYNDROME, ADULT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 42549151948     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31816857bb     Document Type: Article

References (40)

1. Wang R. Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter? FASEB J. 2002;16:1792-1798.
2. Stipanuk MH, Beck PW. Characterization of the enzymatic capacity for cysteine desulphhydration in liver and kidney of the rat. Biochem J. 1982;206:267-277.
3. Mester A, Fraser PE, Tice SV. Enzymatic desulphuration of b-mercapto-pyruvate to pyruvate. J Biol Chem. 1954;206:516-575.
4. Navarra P, Dello Russo C, Mancuso C, et al. Gaseous neuromodulators in the control of neuroendocrine stress axis. Ann N Y Acad Sci. 2000;917:638-646.
5. 2S as a novel endogenous gaseous KATP channel opener. EMBO J. 2001;20:6008-6016.
6. Qingyou Z, Junbao D, Weijin Z, et al. Impact of hydrogen sulfide on carbon monoxide/heme oxygenase pathway in the pathogenesis of hypoxic pulmonary hypertension. Biochem Biophys Res Commun. 2004;317:30-37.
7. Chunyu Z, Junbao D, Dingfang B, et al. The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats. Biochem Biophys Res Commun. 2003;302:810-816.
8. 2S) content during septic shock and endotoxin shock in rats. J Infect. 2003;47:155-160.
9. Bhatia M, Sidhapuriwala J, Moochhala SM, et al. Hydrogen sulfide is a mediator of carrageenan-induced hindpaw edema in the rat. Br J Pharmacol. 2005;145:141-144.
10. Bhatia M, Wong FL, Fu D, et al. Role of hydrogen sulfide in acute pancreatitis and associated lung injury. FASEB J. 2005;19:623-625.
11. Li L, Bhatia M, Zhu YZ, et al. Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB J. 2005;19:1196-1198.
12. Zhang H, Zhi L, Moore PK, et al. Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse. Am J Physiol Lung Cell Mol Physiol. 2006;290:L1193-L1201.
13. Zhang H, Zhi L, Moochhala SM, et al. Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture induced sepsis in mice by up-regulating the production of cytokines and chemokines via NF-{kappa}B. Am J Physiol Lung Cell Mol Physiol. 2007;292(4):L960-L971.
14. Grady T, Mah'Moud M, Otani T, et al. Zymogen proteolysis within the pancreatic acinar cell is associated with cellular injury. Am J Physiol. 1998;275:G1010-G1017.
15. Bhatia M. Novel therapeutic targets for acute pancreatitis and associated multiple organ dysfunction syndrome. Curr Drug Targets Inflamm Allergy. 2002;1:343-351.
16. Bhatia M. Novel therapeutic targets for acute pancreatitis and associated multiple organ dysfunction syndrome - an update. Med Chem Rev Online. 2004;1:25-26.
17. Bhatia M, Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol. 2004;202:145-156.
18. Bhatia M, Brady M, Shokuhi S, et al. Inflammatory mediators in acute pancreatitis. J Pathol. 2000;190:117-125.
19. Bhatia M, Neoptolemos JP, Slavin J. Inflammatory mediators as therapeutic targets in acute pancreatitis. Curr Opin Investig Drugs. 2001;2:496-501.
20. Bhatia M, Wong FL, Cao Y, et al. Pathophysiology of acute pancreatitis. Pancreatology. 2005;5:132-144.
21. Yang B, Demaine AG, Kingsnorth A. Chemokines MCP-1 and RANTES in isolated rat pancreatic acinar cells treated with CCK and ethanol in vitro. Pancreas. 2000;21:22-31.
22. Rossi D, Zlotnik A. The biology of chemokines and their receptors. Annu Rev Immunol. 2000;18:217-242.
23. Adams DH, Lloyd AR. Chemokines: leucocyte recruitment and activation cytokines. Lancet. 1997;349:490-495.
24. Bhatia M, Ramnath RD, Chevali L, et al. Treatment with bindarit, a blocker of MCP-1 synthesis, protects mice against acute pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2005;288:G1259-G1265.
25. Brady M, Bhatia M, Christmas S, et al. Expression of the chemokines MCP-1/JE and cytokine-induced neutrophil chemoattractant in early acute pancreatitis. Pancreas. 2002;25:260-269.
26. Grady T, Liang P, Ernst SA, et al. Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. Gastroenterology. 1997;113:1966-1975.
27. Sun J, Bhatia M. Blockade of neurokinin-1 receptor attenuates CC and CXC chemokine production in experimental acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 2007;292(1):G143-G153.
28. Bhatia M, Brady M, Kang YK, et al. MCP-1 but not CINC synthesis is increased in rat pancreatic acini in response to cerulean hyperstimulation. Am J Physiol Gastrointest Liver Physiol. 2002;282:G77-G85.
29. Tamizhselvi R, Moore PK, Bhatia M. The mechanism by which hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells. J Cell Mol Med. 2007;11(2):1-12.
30. Labarca C, Paigen K. A simple, rapid, and sensitive DNA assay procedure. Anal Biochem. 1980;102:344-352.
31. Bhatia M, Zhi L, Zhang H, et al. Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice. Am J Physiol Lung Mol Physiol. 2006;291:L896-L904.
32. Grady T, Liang P, Ernst SA, et al. Chemokine gene expression in rat pancreatic acinar cells is an early event associated with acute pancreatitis. Gastroenterology. 1997;113:1966-1975.
33. Bhatia M, Brady M, Christmas S, et al. Effect of caerulein on chemokine production from cultured rat pancreatic acini. Pancreas. 1999;19:415-422.
34. Ramnath RD, Bhatia M. Substance P treatment stimulates chemokine synthesis in pancreatic acinar cells via the activation of NF-kappaB. Am J Physiol Gastrointest Liver Physiol. 2006;291(6):G1113-G1119.
35. Rollins BJ. Chemokines. Blood. 1997;90:909-928.
36. Premark BA, Schall TJ. Chemokine receptors: gateway to inflammation and infection. Nat Med. 1996;11:1174-1178.
37. Rau B, Baumgart K, Kruger CM, et al. CC-chemokine activation in acute pancreatitis: enhanced release of monocyte chemoattractant protein-1 in patients with local and systemic complications. Intensive Care Med. 2003;29:622-629.
38. Pastor CM, Rubbia-Brandt L, Hadengue A, et al. Role of macrophage inflammatory peptide-2 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injury. Lab Invest. 2003;83:471-478.
39. Gerard C, Frossard JL, Bhatia M, et al. Targeted disruption of the beta-chemokine receptor CCR1 protects against pancreatitis-associated lung injury. J Clin Invest. 1997;100:2022-2027.
40. Zhi L, Ang AD, Zhang H, et al. Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-{kappa}B pathway. J Leukoc Biol. 2007;81:1322-1332.