Conjugated linoleic acids produced by Lactobacillus dissociates IKK-γ and Hsp90 complex in Helicobacter pylori-infected gastric epithelial cells

Laboratory Investigation

Volumn 88, Issue 5, 2008, Pages 541-552

  Kim, Jung M ^a,b   Kim, Joo S ^b   Kim, Yeong J ^c   Oh, Yu K ^d   Kim, In Y ^e   Chee, Young J ^e   Han, Joong S ^a   Jung, Hyun C ^b  

^a Hanyang University College of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Joongbu University   (South Korea)

^d Korea University   (South Korea)

^e Hanyang University   (South Korea)

Author keywords

Conjugated linoleic acids; Heat shock protein 90; Helicobacter pylori; I B kinase; NF B

Indexed keywords

CONJUGATED LINOLEIC ACID; HEAT SHOCK PROTEIN 90; I KAPPA B ALPHA; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; EPITHELIUM CELL; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; LACTOBACILLUS ACIDOPHILUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH ADENOCARCINOMA; STOMACH EPITHELIUM; SUPERNATANT; UPREGULATION;

CELL LINE; ENZYME ACTIVATION; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; I-KAPPA B KINASE; INTERLEUKIN-8; LACTOBACILLUS; LINOLEIC ACIDS, CONJUGATED; NF-KAPPA B; PHOSPHORYLATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 42549146006     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2008.16     Document Type: Article

References (42)

1. Correa P, Houghton J. Carcinogenesis of Helicobacter pylori. Gastroenterology 2007;133:659-672.
2. Makola D, Peura DA, Crowe SE. Helicobacter pylori infection and related gastrointestinal diseases. J Clin Gastroenterol 2007;41:548-558.
3. Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu Rev Immunol 2000;18:621-663.
4. Chen ZJ, Parent L, Maniatis T. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 1996;84:853-862.
5. Rothwarf DM, Zandi E, Natoli G, et al. IKK-gamma is an essential regulatory subunit of the IκB kinase complex. Nature 1998;395: 297-300.
6. Yamaoka S, Courtois G, Bessia C, et al. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 1998;93:1231-1240.
7. Chen ZJ, Parent L, Maniatis T. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 1996;84:853-862.
8. Rothwarf DM, Zandi E, Natoli G, et al. IKK-gamma is an essential regulatory subunit of the IκB kinase complex. Nature 1998;395: 297-300.
9. Broemer M, Krappmann D, Scheidereit C. Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation. Oncogene 2004;23:5378-5386.
10. Chen G, Cao P, Goeddel DV. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol Cell 2002;9:401-410.
11. Lewis J, Devin A, Miller A, et al. Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-κB activation. J Biol Chem 2000;275:10519-10526.
12. Scheibel T, Buchner J. The Hsp90 complex-a super-chaperone machine as a novel drug target. Biochem Pharmacol 1998;56:675-682.
13. Bouwmeester T, Bauch A, Ruffner H, et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol 2004;6:97-105.
14. Belury MA. Dietary conjugated linoleic acid in health: physiological effects and mechanisms of action. Annu Rev Nutr 2002;22:505-531.
15. Pariza MW, Park Y, Cook ME. Mechanisms of action of conjugated linoleic acid: evidence and speculation. Proc Soc Exp Biol Med 2000;223:8-13.
16. Bhattacharya A, Banu J, Rahman M, et al. Biological effects of conjugated linoleic acids in health and disease. J Nutr Biochem 2006;17:789-810.
17. Gotteland M, Brunser O, Cruchet S. Systematic review: are probiotics useful in controlling gastric colonization by Helicobacter pylori? Aliment Pharmacol Ther 2006;23:1077-1086.
18. Kim JM, Kim JS, Jung HC, et al. Helicobacter pylori infection activates the NF-κB signaling pathway to induce iNOS and protect human gastric epithelial cells from apoptosis. Am J Physiol - Gastrointest Liver 2003;285:G1171-G1180.
19. Kim JM, Kim JS, Lee LY, et al. Vacuolating cytotoxin in Helicobacter pylori water-soluble proteins upregulates chemokine expression in human eosinophils via Ca2+ influx, mitochondrial reactive oxygen intermediates, and NF-κB activation. Infect Immun 2007;75:3373-3381.
20. Ewaschuk JB, Walker JW, Diaz H, et al. Bioproduction of conjugated linoleic acid by probiotic bacteria occurs in vitro and in vivo in mice. J Nutr 2006;136:1483-1487.
21. Lee HY, Park JH, Seok SH, et al. Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochim Biophys Acta 2006;1761:736-744.
22. May MJ, D'Acquisto F, Madge LA, et al. Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science 2000;289:1550-1554.
23. Kim JM, Oh YK, Lee JH, et al. Induction of proinflammatory mediators requires activation of TRAF, NIK, IKK and NF-kappaB signal transduction pathway in astrocytes infected with Escherichia coli. Clin Exp Immunol 2005;140:450-460.
24. Elewaut D, DiDonato JA, Kim JM, et al. NF-kappaB is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria. J Immunol 1999;163:1457-1466.
25. Kim JM, Lee JY, Yoon YM, et al. Bacteroides fragilis enterotoxin induces cyclooxygenase-2 and fluid secretion in intestinal epithelial cells through NF-κB activation. Eur J Immunol 2006;36:2446-2456.
26. Kim JM, Oh YK, Kim YJ, et al. Polarized secretion of CXC chemokines by human intestinal epithelial cells in response to Bacteroides fragilis enterotoxin: NF-kappa B plays a major role in the regulation of IL-8 expression. Clin Exp Immunol 2001;123:421-427.
27. Hirata Y, Maeda S, Ohmae T, et al. Helicobacter pylori induces IκB kinase alpha nuclear translocation and chemokine production in gastric epithelial cells. Infect Immun 2006;74:1452-1461.
28. Kim JM, Jung HY, Lee JY, et al. Mitogen-activated protein kinase and activator protein-1 dependent signals are essential for Bacteroides fragilis enterotoxin-induced enteritis. Eur J Immunol 2005;35: 2648-2657.
29. Park KA, Byun HS, Won M, et al. Sustained activation of protein kinase C downregulates nuclear factor-κB signaling by dissociation of IKK-γ and Hsp90 complex in human colonic epithelial cells. Carcinogenesis 2007;28:71-80.
30. Lee JY, Park HR, Oh YK, et al. Effects of transcription factor activator protein-1 on interleukin-8 expression and enteritis in response to Clostridium difficile toxin A. J Mol Med 2007;85:1393-1404.
31. Cheon JH, Kim JS, Kim JM, et al. Plant sterol guggulsterone inhibits NF-κB signaling in intestinal epithelial cells by blocking IκB kinase and ameliorates acute murine colitis. Inflamm Bowel Dis 2006;12: 1152-1161.
32. Kim JM, Kim JS, Jung HC, et al. Inhibition of Helicobacter pylori-induced nuclear factor-κB activation and interleukin-8 gene expression by ecabet sodium in gastric epithelial cells. Helicobacter 2003;8:542-553.
33. Yeo M, Park HK, Lee KM, et al. Blockage of HSP 90 modulates Helicobacter pylori-induced IL-8 productions through the inactivation of transcriptional factors of AP-1 and NF-κB. Biochem Biophys Res Commun 2004;320:816-824.
34. Marteau P, Minekus M, Havenaar R, et al. Survival of lactic acid bacteria in a dynamic model of the stomach and small intestine: validation and the effects of bile. J Dairy Sci 1997;80:1031-1037.
35. Sgouras DN, Panayotopoulou EG, Martinez-Gonzalez B, et al. Lactobacillus johnsonii La1 attenuates Helicobacter pylori-associated gastritis and reduces levels of proinflammatory chemokines in C57BL/6 mice. Clin Diagn Lab Immunol 2005;12:1378-1386.
36. Tamura A, Kumai H, Nakamichi N, et al. Suppression of Helicobacter pylori-induced interleukin-8 production in vitro and within the gastric mucosa by a live Lactobacillus strain. J Gastroenterol Hepatol 2006;21:1399-1406.
37. Hahn JS. Regulation of Nod1 by Hsp90 chaperone complex. FEBS Lett 2005;579:4513-4519.
38. Viala J, Chaput C, Boneca IG, et al. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 2004;5:1166-1174.
39. Keates S, Sougioultzis S, Keates AC, et al. cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Biol Chem 2001;276:48127-48134.
40. Hamilton-Miller JMT. The role of probiotics in the treatment and prevention of Helicobacter pylori infection. Int J Antimicrob Agents 2003;22:360-366.
41. Conway PL, Gorbach SL, Goldin BR. Survival of lactic acid bacteria in the human stomach and adhesion to intestinal cells. J Dairy Sci 1987;70:1-12.
42. Malfertheiner P, Megraud F, O'Morain C, et al. Current concepts in the management of Helicobacter pylori infection-the Maastricht 2-2000 Consensus Report. Aliment Pharmacol Ther 2002;16:167-180.