Polarized secretion of CXC chemokines by human intestinal epithelial cells in response to Bacteroides fragilis enterotoxin: NF-κB plays a major role in the regulation of IL-8 expression

Clinical and Experimental Immunology

Volumn 123, Issue 3, 2001, Pages 421-427

  Kim, J M ^a   Oh, Y K ^a   Kim, Y J ^a   Oh, H B ^a  

^a Hanyang University   (South Korea)

Author keywords

Bacteroides fragilis; CXC chemokines; Epithelial cells; NF B

Indexed keywords

ALPHA CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MELANOMA GROWTH STIMULATORY ACTIVITY FACTOR;

ARTICLE; BACTEROIDES FRAGILIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; EPITHELIUM CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOREGULATION; INTESTINE EPITHELIUM; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

BACTERIAL TOXINS; CELL LINE; CELL POLARITY; CHEMOKINES, CXC; CHEMOTACTIC FACTORS; DNA-BINDING PROTEINS; GROWTH SUBSTANCES; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-8; INTESTINAL MUCOSA; METALLOENDOPEPTIDASES; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; RNA, MESSENGER;

EID: 0035073457     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01462.x     Document Type: Article

References (31)

1. Prevalence of enterotoxigenic Bacteroides fragilis in adult patients with diarrhea and healthy controls
2. Association of enterotoxigenic Bacteroides fragilis with childhood diarrhoea
3. Detection of toxin production by Bacteroides fragilis: Assay development and screening of extraintestinal clinical isolates
4. Detection of intestinal and extra-intestinal strains of enterotoxigenic Bacteroides fragilis by the HT-29 cytotoxicity assay
5. Bacteroides fragilis toxin exhibits polar activity on monolayers of human intestinal epithelial cells (T84 cells) in vitro
6. Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo
7. Diarrheal disease caused by enterotoxigenic Bacteroides fragilis in infant rabbits
8. Bacteroides fragilis enterotoxin induces the expression of IL-8 and transforming growth factor-beta (TGF-β) by human colonic epithelial cells
9. Chemokines
10. IP-10, a gamma-interferon-inducible protein related to interleukin-8, lacks neutrophil activating properties
11. Helicobacter pylori induces an array of pro-inflammatory cytokines in human gastric epithelial cells: Quantification of mRNA for interleukin-8, 1α/β, granulocyte-macrophage colony-stimulating factor, monocyte chemoattractant protein-1 and tumour necrosis factor-α
12. Cytokine genes are down-regulated when attachment of Entamoeba histolytica to HT-29 colon epithelial cells is prevented
13. Synergy between Entamoeba histolytica and Escherichia coli in the induction of cytokine gene expression in human colon epithelial cells
14. Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines
15. Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells
16. Epithelial cells as sensors for microbial infection
17. Apoptosis of human intestinal epithelial cells after bacterial invasion
18. Synthesis and regulation of accessory/proinflammatory cytokines by intestinal epithelial cells
19. Identification of a third metalloprotease toxin gene in extraintestinal isolates of Bacteroides fragilis
20. Mapping of the inducible IκB phosphorylation sites that signal its ubiquitination and degradation
21. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-kappa B activation
22. NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria
23. A chemiluminescent assay for quantitation of β-galactosidase in the femtogram range: Application to quantitation of β-galactosidase in lacZ-transfected cells
24. The NF-kappa B and I kappa B proteins: New discoveries and insights
25. From cytoskeleton to polarity and chemoreception in the gut epithelium
26. Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78)
27. Neutrophil-activating protein ENA-78 and IL-8 exhibit different patterns of expression in lipopolysaccharide- and cytokine-stimulated human monocytes
28. The epithelial cell response to rotavirus infection
29. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
30. Regulation of interleukin-8 gene expression
31. A specific sorting signal is not required for the polarized secretion of newly synthesized proteins from cultured intestinal epithelial cells