Administering plasmid DNA encoding tumor vessel-anchored IFN-α for localizing gene product within or into tumors

Molecular Therapy

Volumn 16, Issue 5, 2008, Pages 901-906

  Craig, Ryan ^a   Cutrera, Jeffry ^a   Zhu, Shiguo ^a   Xia, Xueqing ^a   Lee, Yong Hwan ^a   Li, Shulin ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANYLCYSTEINYLASPARTYLCYSTEINYLARGINYLGLUTAMYLASPARTYLCYSTEINYLPHENYLALANYLCYSTEINYLGLYCINE; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; GENE PRODUCT; HYBRID PROTEIN; PLASMID DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GENE THERAPY; CANCER IMMUNOTHERAPY; CD8+ T LYMPHOCYTE; CIRCULATION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; DRUG EFFICACY; ELECTROPORATION; FEMALE; FUSION GENE; GENE EXPRESSION; GENE LOCATION; GENE TARGETING; GROWTH INHIBITION; IMMUNE RESPONSE; LYMPHOCYTIC INFILTRATION; MONOTHERAPY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; SYSTEMIC THERAPY; TUMOR; TUMOR VASCULARIZATION; TUMOR VOLUME; WILD TYPE;

EID: 42549132993     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.40     Document Type: Article

References (43)

1. WJ Fairbrother HW Christinger AG Cochran G Fuh CJ Keenan C Quan Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site Biochemistry 37 1998 17754 17764
2. MN Fukuda C Ohyama K Lowitz O Matsuo R Pasqualini E Ruoslahti A peptide mimic of E-selectin ligand inhibits sialyl Lewis X-dependent lung colonization of tumor cells Cancer Res 60 2000 450 456
3. R Pasqualini E Ruoslahti Organ targeting in vivo using phage display peptide libraries Nature 380 1996 364 366
4. P Laakkonen K Porkka JA Hoffman E Ruoslahti A tumor-homing peptide with a targeting specificity related to lymphatic vessels Nat Med 8 2002 751 755
5. v integrins as receptors for tumor targeting by circulating ligands Nat Biotechnol 15 1997 542 546
6. RO Hynes Integrins: versatility, modulation, and signaling in cell adhesion Cell 69 1992 11 25
7. N Assa-Munt X Jia P Laakkonen E Ruoslahti Solution structures and integrin binding activities of an RGD peptide with two isomers Biochemistry 40 2001 2373 2378
8. 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo Proc Natl Acad Sci USA 98 2001 119 124
9. v integrins during angiogenesis: insights into potential mechanisms of action and clinical development J Clin Invest 103 1999 1227 1230
10. M Yamamoto DT Curiel Cancer gene therapy Technol Cancer Res Treat 4 2005 315 330
11. v integrin ligands improves its antineoplastic activity Cancer Res 64 2004 565 571
12. FM de Groot HJ Broxterman HP Adams A van Vliet GI Tesser YW Elderkamp Design, synthesis, and biological evaluation of a dual tumor-specific motive containing integrin-targeted plasmin-cleavable doxorubicin prodrug Mol Cancer Ther 1 2002 901 911
13. K Hiroishi T Tuting MT Lotze IFN- α -expressing tumor cells enhance generation and promote survival of tumor-specific CTLs J Immunol 164 2000 567 572
14. Z von Marschall A Scholz T Cramer G Schafer M Schirner K Oberg Effects of interferon α on vascular endothelial growth factor gene transcription and tumor angiogenesis J Natl Cancer Inst 95 2003 437 448
15. L Thyrell S Erickson B Zhivotovsky K Pokrovskaja O Sangfelt J Castro Mechanisms of interferon- α induced apoptosis in malignant cells Oncogene 21 2002 1251 1262
16. M Coleman S Muller A Quezada SK Mendiratta J Wang NM Thull Nonviral interferon α gene therapy inhibits growth of established tumors by eliciting a systemic immune response Hum Gene Ther 9 1998 2223 2230
17. JF Zhang C Hu Y Geng LM Blatt MW Taylor Gene therapy with an adeno-associated virus carrying an interferon gene results in tumor growth suppression and regression Cancer Gene Ther 3 1996 31 38
18. JA Gollob JW Mier K Veenstra DF McDermott D Clancy M Clancy Phase I trial of twice-weekly intravenous interleukin 12 in patients with metastatic renal cell cancer or malignant melanoma: ability to maintain IFN-γ induction is associated with clinical response Clin Cancer Res 6 2000 1678 1692
19. SA Buechner Intralesional interferon α -2b in the treatment of basal cell carcinoma. Immunohistochemical study on cellular immune reaction leading to tumor regression J Am Acad Dermatol 24 1991 731 734
20. M Benasso M Merlano F Blengio M Cavallari R Rosso S Toma Concomitant α -interferon and chemotherapy in advanced squamous cell carcinoma of the head and neck Am J Clin Oncol 16 1993 465 468
21. S Salesse F Moreau-Gaudry V Pigeonnier-Lagarde F Mazurier H Chahine C Ged Retroviral vector-mediated transfer of the interferon- α gene in chronic myeloid leukemia cells Cancer Gene Ther 5 1998 390 400
22. G Alatrash TE Hutson L Molto A Richmond C Nemec T Mekhail Clinical and immunologic effects of subcutaneously administered interleukin-12 and interferon α -2b: phase I trial of patients with metastatic renal cell carcinoma or malignant melanoma J Clin Oncol 22 2004 2891 2900
23. PC Enzinger DH Ilson LB Saltz LK Martin DP Kelsen Phase II clinical trial of 13- cis -retinoic acid and interferon- α -2a in patients with advanced esophageal carcinoma Cancer 85 1999 1213 1217
24. M Ohashi K Yoshida M Kushida Y Miura S Ohnami Y Ikarashi Adenovirus-mediated interferon α gene transfer induces regional direct cytotoxicity and possible systemic immunity against pancreatic cancer Br J Cancer 93 2005 441 449
25. S Li L Zhang M Torrero M Cannon R Barret Administration route-and immune cell activation-dependent tumor eradication by IL12 electrotransfer Mol Ther 12 2005 942 949
26. MP Colombo M Vagliani F Spreafico M Parenza C Chiodoni C Melani Amount of interleukin 12 available at the tumor site is critical for tumor regression Cancer Res 56 1996 2531 2534
27. F Anizon FT Boyle J Fisher PJ Kocienski Synthesis and characterisation of a doxorubicin-CNGRC peptide conjugate that targets tumour vasculature Synthesis 18 2002 2733 2736
28. F Curnis G Arrigoni A Sacchi L Fischetti W Arap R Pasqualini Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells Cancer Res 62 2002 867 874
29. F Curnis A Sacchi A Corti Improving chemotherapeutic drug enetration in tumors by vascular targeting and barrier alteration J Clin Invest 110 2002 475 482
30. R Li RH Hoess JS Bennett WF DeGrado Use of phage display to probe the evolution of binding specificity and affinity in integrins Protein Eng 16 2003 65 72
31. LS Peng ML Penichet JS Dela Cruz SL Sampogna SL Morrison Mechanism of antitumor activity of a single-chain interleukin-12 IgG3 antibody fusion protein (mscIL-12.her2.IgG3) J Interferon Cytokine Res 21 2001 709 720
32. 3 integrin Mol Cancer Res 2 2004 663 673
33. W Arap R Pasqualini E Ruoslahti Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model Science 279 1998 377 380
34. P Di Matteo F Curnis R Longhi G Colombo A Sacchi L Crippa Immunogenic and structural properties of the Asn-Gly-Arg (NGR) tumor neovasculature-homing motif Mol Immunol 43 2006 1509 1518
35. A Sacchi A Gasparri F Curnis M Bellone A Corti Crucial role for interferon gamma in the synergism between tumor vasculature-targeted tumor necrosis factor α (NGR-TNF) and doxorubicin Cancer Res 64 2004 7150 7155
36. I Puisieux L Odin D Poujol P Moingeon J Tartaglia W Cox Canarypox virus-mediated interleukin 12 gene transfer into murine mammary adenocarcinoma induces tumor suppression and long-term antitumoral immunity Hum Gene Ther 9 1998 2481 2492
37. S Li X Xia X Zhang J Suen Regression of tumors by IFN- α electroporation gene therapy and analysis of the responsible genes by cDNA array Gene Ther 9 2002 390 397
38. S Li X Zhang X Xia Regression of tumor growth and induction of long-term antitumor memory by interleukin 12 electro-gene therapy J Natl Cancer Inst 94 2002 762 768
39. S Li X Zhang X Xia L Zhou R Breau J Suen Intramuscular electroporation delivery of IFN- α gene therapy for inhibition of tumor growth located at a distant site Gene Ther 8 2001 400 407
40. L Liu A Chahroudi G Silvestri ME Wernett WJ Kaiser JT Safrit Visualization and quantification of t cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates Nat Med 8 2002 185 189
41. S Li X Xia FM Mellieon J Liu S Steele Candidate genes associated with tumor regression mediated by intratumoral IL-12 electroporation gene therapy Mol Ther 9 2004 347 354
42. 3 Science 294 2001 339 345
43. NA Baker D Sept S Joseph MJ Holst JA McCammon Electrostatics of nanosystems: application to microtubules and the ribosome Proc Natl Acad Sci USA 98 2001 10037 10041