Nonviral interferon α gene therapy inhibits growth of established tumors by eliciting a systemic immune response

Human Gene Therapy

Volumn 9, Issue 15, 1998, Pages 2223-2230

  Coleman, Mike ^a   Muller, Susanne ^a   Quezada, Abraham ^a   Mendiratta, Sanjeev K ^a   Wang, Jijun ^a   Thull, Nikolyn M ^a   Bishop, Jeffrey ^a   Matar, Majed ^a   Mester, Joseph ^a   Pericle, Federica ^a  

^a GeneMedicine Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CD4 ANTIGEN; CD8 ANTIGEN; POVIDONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CANCER IMMUNOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION SYSTEM; GENE TARGETING; GENE THERAPY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; KIDNEY CARCINOMA; MOUSE; NONHUMAN; PLASMID; T LYMPHOCYTE; TUMOR IMMUNITY;

ANIMALIA; MURINAE;

EID: 17344373047     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.15-2223     Document Type: Article

References (31)

1. ALILA, H., COLEMAN, M., NTTTA, H., FRENCH, M., ANWER, K., LIU, Q., MEYER, T., WANG, J., MUMPER, R., OUBARI, D., LONG, S., NORDSTROM, J., and ROLLAND, A. (1997). Expression of biologically active human insulin-like growth factor-I following intramuscular injection of a formulated plasmic in rats. Hum. Gene Ther. 8, 1785-1795.
2. BELARDELLI, F., GRESSER, E., MAURY, C, and MAUNOURY, M.T. (1982). Antitumor effects of interferon in mice injected with interferon-sensitive and interferon-resistant Friend leukemia cells. Int. J. Cancer 30, 813.
3. BELLDEGRUN, A., TSO, C.L., SAKATA, T., DUCKETT, T., BRUNDA, M.J., BARSKY, S.H., CHAI, J., KABOO, R., LAVEY, R.S., and McBRIDE, W.H. (1993). Human renal carcinoma line transfected with interleukin-12 and/or interferon-α gene(s): Implication for live cancer vaccines. J. Natl. Cancer Inst. 85, 207.
4. BRAMSON, J.L., HITT, M., ADDISON, C.L., MULLER, W.J., GAULDIE, J., and GRAHAM, F.L. (1996). Direct intratumoral injection of an adenovirus expressing interleukin-12 induces regression and long-lasting immunity that is associated with highly localized expression of interleukin-12. Hum. Gene Ther. 7, 1995-2002.
5. COLOMBO, M.P., MODESTI, A., PARMIANI, G., and FORNI, G. (1992). Local cytokine availability elicits tumor rejection and systemic immunity through granulocyte-T-lymphocyte cross-talk. Cancer Res. 52, 4853-857.
6. FERRANTTNI, M., PROEETTI, E., SANTODONATO, L., GABREELE, L., PRETTI, M., PLAVEC, I., MEYER, F., KAIDO, T., GRESSER, I., and BELARDELLI, F. (1993). Interferon alpha-1 gene transfer into metastatic Friend leukemia cells abrogated tumorigenicity in immunocompetent mice: Antitumor therapy by means of interferon-producing cells. Cancer Res. S3, 1107-1615.
7. FERRANTINI, M., GIOVARELLI, M., MODESTI, A., MUSIANI, P., MODICA, A., VENDITTI, M., PERETTI, E., LOLLINI, P., NANNI, P., FORM, G., and BELARDELLI, F. (1994). IFN-αl gene expression into a metastatic murine adenocarcinoma (TS/A) results in CD8+ T cell-mediated tumor rejection and development of antitumor immunity. J. Immunol. 153, 4604-4615.
8. FORM, G., GIOVARELLI, M., SANTOM, A., MODESTI, A., and FORM, M. (1987). Interleukin-2 activated tumor inhibition in vivo depends on the systemic involvement of host immunoreactivity. J. Immunol. 138, 4033-1038.
9. FORM, G., GIOVARELLI, M., CAVALLO, F., CONSALVO, M., AL-LIONE, A., MODESTI, A., MUSIANI, P., and COLOMBO, M.P. (1993). Cytokine-induced immunogenicity: From exogenous cytokines to gene therapy. J. Immunother. 14, 253-257.
10. GABRIELE, L., KAIDO, T., WOODROW, D., et al. (1995). The local and systemic response of mice to interferon αl transfected Friend leukemia cells. Am. J. Pathol. 147, 445-160.
11. GRESSER, I. (1989). Antitumor effects of interferon. Acta Oncol. 28, 347-353.
12. MARTINOTTI, A., STOPPACCIARO, A., VAGLIAM, M., MELAM, C, SPREAFICO, F., WYSOCKA, M., PARMIAM, G., TRINCHIERI, G., and COLOMBO, M. (1995). CD4 T cells inhibit in vivo the CD8-mediated immune response against murine colon carcinoma cells transducted with interleukin-12 genes. Eur. J. Immunol. 25, 137-146.
13. MOSMANN, T.R., and COFFMAN, R.L. (1989). Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv. Immunol. 46, 111-147.
14. MUMPER, R.J., DUGUID, J.G., ANWER, K., BARRON, M.K., NTTTA, H., and ROLLAND, A.P. (1996). Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle. Pharm. Res. 5, 701-709.
15. MUMPER, R.J., WANG, J., KLAKAMP, S.L., NTTTA, H., ANSWER, K., TAGLIARFERRI, F., and ROLLAND, A.P. (1998). Protective interactive noncondensing (PINC) polymers for enhanced plasmid distribution and expression in rat skeletal muscle. J. Controlled Release (in press).
16. MUSIAM, P., MODESTI, A., GIOVARELLI, M., CAVALLO, F., COLOMBO, M.P., LOLLIM, P L., and FORM, G. (1997). Cytokines, tumor-cell death and immunogenicity: A question of choice. Immunol. Today 1, 32-36.
17. NANM, P., DE GIOVANM, C, LOLLIM, P.L., NICOLETTI, G., and PRODI, G. (1983). TS/A: A new metastasizing cell line originated from BALB/c spontaneous mammary adenocarcinoma. Clin. Exp. Metastasis 1, 373-380.
18. OGURA, H., TAM, K., OZAWA, K., NAGATA, S., ASANO, S., and TAKAKU, F. (1990). Implantation of genetically manipulated fibroblasts into mice as antitumor a-interferon therapy. Cancer Res. 50, 5102.
19. PARDOLL, D.M. (1994). Gene modified tumor vaccines. In Cytokine-induced Tumor Immunogenicity. G. Forni, R. Foa, A. Santoni, and L. Frati, eds. (Academic Press, London) pp. 71-86.
20. PARDOLL, D.M. (1995). Paracrine cytokine adjuvants in cancer immunotherapy. Annu. Rev. Immunol. 13, 399-415.
21. PERICLE, F., DIPIERO, F., and FORM, G. (1992). Clinical trials with local administration of haematopoietic growth factors. In Lympho-haematopoietic Growth Factors in Cancer Therapy, Vol. II. R. Mer-telsmann, ed. (Springer-Verlag, Berlin) pp. 234-244.
22. PERICLE, F., GIOVARELLI, M., COLOMBO, M.P., FERRARI, G., MUSIAM, P., MODESTI, A., CAVALLO, F., DI PIERO, F., NOVELLI, F., and FORM, G. (1994). An efficient Th2-type memory follows CD8+ lymphocyte-driven and eosinophil-mediated rejection of a spontaneous mouse mamary adenocarcinoma engineered to release IL-4. J. Immunol. 153, 5660-5673.
23. POWRIE, F., MENON, S., and COFFMAN, R.L. (1993). Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo. Eur. J. Immunol. 11, 3043-3049.
24. RAKHMILEVICH, A.L., and NORTH, R.J. (1994). Elimination of CD4+ T cells in mice bearing an advanced sarcoma augments the antitumor action of itnerleukin-12. Cancer Immunol. Immunother. 38, 107-112.
25. RAKHMILEVICH, A.L., TURNER, J., FORD, M.J., McCABE, D., SUN, W.H., SONDEL, P.M., GROTA, K., and YANG, N. (1996). Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors. Proc. Natl. Acad. Sci. U.S.A. 93, 6291-6296.
26. RAKHMILEVICH, A.L., JANSSEN, K., TURNER, J., CULP, J., and YANG, N. (1997). Cytokine gene therapy of cancer using gene gun technology: Superior antitumor activity of interleukin-12. Hum. Gene Ther. 8, 1303-1311.
27. RAO, J.B., CHAMBERLAIN, R.S., BRONTE, V., CARROL, M.W., IRVINE, K.R., MOSS, B., ROSEMBERG, S.A., and RESTTFO, N.P. (1996). IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines. J. Immunol. 156, 3357-3365.
28. SCARPA, S., GUIFFRIDA, A., PALUMBO, C, VASATURO, F., SIG-NORELLI, P., FORM, G., MODESTI, M., FERRANTTM, M., BEL-LARDELLI, F., MUSIAM, P., and MODESTI, A. (1997). Extracellular matrix remodelling in a murine mamary adenocarcinoma transfected with the interferon-alphal gene. J. Pathol. 181, 116-123.
29. SINGH, R.K., GUTMAN, M., BUCANA, CD., SANCHEZ, R., LLANSA, N., and FIDLER, I.J. (1995). Interferons α and β down-regulate the expression of basic fibroblast growth factor inhuman carcinomas. Proc. Natl. Acad. Sci. U.S.A. 92, 4562-4566.
30. TRAPMAN, J., VAN HEUVEL, M., DE JONGE, P., BOSVELD, I.J., KLAASSEN, P., and ZWARTHOFF, E.C. (1988). Structure-function analysis of mouse interferon alpha species: MuIFN-α 10, a subspecies with low antiviral activity. J. Gen. Virol. 69, 67-75.
31. VAN HEUVEL, M., BOSVELD, I.J., MOOREN, A.T.A., TRAPMAN, J., and ZWARTHOFF, E.C. (1986). Properties of natural and hybrid murine alpha interferons. J. Gen. Virol. 67, 2215-2222.