Variants in the FFAR1 gene are associated with beta cell function

PLoS ONE

Volumn 2, Issue 11, 2007, Pages

  Kalis, Martins ^a   Levéen, Per ^a   Lyssenko, Valeriya ^a   Almgren, Peter ^a   Groop, Leif ^a   Cilio, Corrado M ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FREE FATTY ACID RECEPTOR 1; G PROTEIN COUPLED RECEPTOR; GLUCOSE; FFAR1 PROTEIN, HUMAN; PRIMER DNA; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; SINGLE NUCLEOTIDE POLYMORPHISM; AGED; GENETICS; GLUCOSE TOLERANCE TEST; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGED; BASE SEQUENCE; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; FEMALE; GENOTYPE; GLUCOSE TOLERANCE TEST; HUMANS; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, G-PROTEIN-COUPLED;

EID: 42549131357     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001090     Document Type: Article

References (46)

1. Groop L (2000) Pathogenesis of type 2 diabetes: the relative contribution of insulin resistance and impaired insulin secretion. Int J Clin Pract Suppl: 3-13.
2. LeRoith D (2002) Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalities. Am J Med 113 Suppl 6A: 3S-11S.
3. Del Prato S, Marchetti P (2004) Beta- and alpha-cell dysfunction in type 2 diabetes. Horm Metab Res 36: 775-781.
4. Ahren B (2005) Type 2 diabetes, insulin secretion and beta-cell mass. Curr Mol Med 5: 275-286.
5. Manco M, Calvani M, Mingrone G (2004) Effects of dietary fatty acids on insulin sensitivity and secretion. Diabetes Obes Metab 6: 402-413.
6. Steppel JH, Horton ES (2004) Beta-cell failure in the pathogenesis of type 2 diabetes mellitus. Curr Diab Rep 4: 169-175.
7. Robertson RP, Harmon J, Tran PO, Poitout V (2004) Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53 Suppl 1: S119-124.
8. Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, et al. (2003) Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 422: 173-176.
9. Ketarsky K, Nilsson NE, Flodgren E, Owman C, Olde B (2003) A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. Biochem Biophys Res Commun 301: 406-410.
10. Briscoe CP, Tadayyon M, Andrews JL, Benson WG, Chambers JK, et al. (2003) The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Cbem 278: 11303-11311.
11. van Tilburg JH, Sandkujil LA, Strengman E, van Someren H, Rigters-Aris CA, et al. (2003) A genome-wide scan in type 2 diabetes mellitus provides independent replication of a susceptibility locus on 18p11 and suggests the existence of novel Loci on 2q12 and 19q13. J Clin Endocrinol Metab 88: 2223-2230.
12. Mori Y, Otabe S, Dina C, Yasuda K, Populaire C, et al. (2002) Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. Diabetes 51: 1247-1255.
13. Panhuysen CI, Cupples LA, Wilson PW, Herbert AG, Myers RH, et al. (2003) A genome scan for loci linked to quantitative insulin traits in persons without diabetes: the Framingham Offspring Study. Diabetologia 46: 579-587.
14. Sawzdargo M, George SR, Nguyen T, Xu S, Kolakowski LF, et al. (1997) A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. Biochem Biophys Res Commun 239: 543-547.
15. Latour MG, Alquier T, Oseid E, Tremblay C, Jetton TL, et al. (2007) GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes 56: 1087-1094.
16. Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Erdlund H (2005) The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab 1: 245-258.
17. Groop L, Forsblom C, Lehtovirta M, Tuomi T, Karanko S, et al. (1996) Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes 46: 1585-1593.
18. Alberti KG, Zimmer PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part I: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15: 539-553.
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
20. National Center for Biotechnology Information (2007) NCBI. Available from http://www.ncbi.nlm.nih.gov, accessed 19 January, 2007.
21. Daly Lab at the Whitehead Institute, Cambridge, USA (2007) Haploview. Available from http://www.broad.mit edu/mpg/haploview/, accessed 15 April, 2007.
22. Barrett JC, Fry, B, Maller J, Daly MJ. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
23. Eskin E, Halperin E (2006) HAP haplotype analysis system. Available from http://research.calit2.net/hap, accessed 19 January, 2007.
24. Halperin E, Eskin E (2004) Haplotype reconstruction from genotype data using Imperfect Phylogeny. Bioinformatics 20: 1842-1849.
25. Purcell S, Sham P (2003) Genetic Power Calculator. Available from http://ibgwww.colorado.edu/~pshaun/gpc, accessed 19 January, 2007.
26. Purcell S, Cherny SS, Sham PC (2003) Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19: 149-150.
27. Itoh Y, Hinuma S (2005) GPR40, a free fatty acid receptor on pancreatic beta cells, regulates insulin secretion. Hepatol Res 33: 171-173.
28. Jachez B, Montecino-Rodriguez E, Fonteneau P, Loor F (1988) Partial expression of the lpr locus in the heterozygous state: presence of autoantibodies. Immunology 64: 31-36.
29. Hawkins RK, Jansen HG, Sanyal S (1985) Development and degeneration of retina in rds mutant mice: photoreceptor abnormalities in the heterozygotes. Exp Eye Res 41: 701-720.
30. Genomatix, Munich, Germany (2007) MatInspector. Available from http://www.genomatix.de/products/MatInspector/, accessed 15 April, 2007.
31. Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, et al. (2005) MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21: 2933-2942.
32. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, et al. (2005) Efficiency and power in genetic association studies. Nat Genet 37: 1217-1223.
33. Hevener A, Reichart D, Janez A, Olefsky J (2002) Female rats do not exhibit free fatty acid-induced insulin resistance. Diabetes 51: 1907-1912.
34. Ogawa T, Hirose H, Miyashita K, Saito I, Saruta T (2005) GPR40 gene Arg211 His polymorphism may contribute to the variation of insulin secretory capacity in Japanese men. Metabolism 54: 296-299.
35. Hamid YH, Vissing H, Holst B, Urhammer SA, Pyke C, et al. (2065) Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release. Diabet Med 22: 74-80.
36. Saxena R, Voight BF, Lyssenko V, Burtt NP, de Bakker PI, et al. (2007) Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 316: 1331-1336.
37. Malhotra A, Elbein SC, Ng MC, Duggirala R, Arya R, et al. (2007) Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetes. Diabetes 56: 890-896.
38. An P, Freedman BI, Hanis CL, Chen YD, Weder AB, et al. (2005) Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes 54: 909-914.
39. Guo YF, Shen H, Liu YJ, Wang W, Xiong DH, et al. (2006) Assessment of genetic linkage and parent-of-origin effects on obesity. J Clin Endocrinol Metab 91: 4001-4005.
40. Elbein SC, Hasstedt SJ (2002) Quantitative trait linkage analysis of lipid-related traits in familial type 2 diabetes: evidence for linkage of triglyceride levels to chromosome 19q. Diabetes 51: 528-535.
41. Lankat-Buttgereit B, Goke B (1997) Cloning and characterization of the 5′ flanking sequences (promoter region) of the human GLP-1 receptor gene. Peptides 18: 617-624.
42. Svoboda M, Portois L, Malaisse WJ (1999) Glucose regulation of the expression of the glucagon receptor gene. Mol Genet Metab 68: 258-267.
43. Chu WS, Das SK, Wang H, Chan JC, Delouka P, et al. (2007) Activating transcription factor 6 (ATF6) sequence polymorphisms in type 2 diabetes and pre-diabetic traits. Diabetes 56: 856-862.
44. Gierl MS, Karoulias N, Wende H, Strehle M, Birchmier C (2006) The zinc-finger factor Insm1 (IA-1) is essential for the developmemt of pancreatic beta cells and intestinal endocrine cells. Genes Dev 20: 2465-2478.
45. Ho E, Bray TM (1999) Antioxidants, NFkappaB activation, and diabetogenesis. Proc Soc Exp Biol Med 222: 205-213.
46. Tomita T, Masuzaki H, Iwakura H, Fujikura J, Noguchi M, et al. (2006) Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion. Diabetologia.