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Volumn 57, Issue 5, 2008, Pages 570-572

Nuclear factor-κB inhibition and non-alcoholic steatohepatitis: Inflammation as a target for therapy

Author keywords

[No Author keywords available]

Indexed keywords

1 [5 HYDROXY 2 (2 THIENYL) 4 QUINAZOLINYLAMINO] 3 METHYL 2,5 PYRROLEDIONE; ADIPOCYTOKINE; BORTEZOMIB; CHEMOKINE; FATTY ACID; GLUCOCORTICOID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SALAZOSULFAPYRIDINE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; THALIDOMIDE; BIOLOGICAL MARKER;

EID: 42549108683     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2007.141986     Document Type: Note
Times cited : (26)

References (30)
  • 1
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 2003;37:917-23.
    • (2003) Hepatology , vol.37 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3
  • 2
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002;346:1221-31.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 3
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M, Franzen LE, Mathiesen UL, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006;44:865-73.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 4
    • 0036302288 scopus 로고    scopus 로고
    • Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma
    • Bugianesi E, Leone N, Vanni E, et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002;123:134-40.
    • (2002) Gastroenterology , vol.123 , pp. 134-140
    • Bugianesi, E.1    Leone, N.2    Vanni, E.3
  • 5
    • 35348845091 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease: An open question
    • Loria P, Lonardo A, Bellentani S, et al. Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease: an open question. Nutr Metab Cardiovasc Dis 2007;17:684-98.
    • (2007) Nutr Metab Cardiovasc Dis , vol.17 , pp. 684-698
    • Loria, P.1    Lonardo, A.2    Bellentani, S.3
  • 6
    • 39549092421 scopus 로고    scopus 로고
    • Fatty Liver Italian Network. Rehavior therapy for nonalcoholic fatty liver disease: The need for a multidisciplinary approach
    • Bellentani S, Dalle Grave R, Suppini A, Marchesini G, Fatty Liver Italian Network. Rehavior therapy for nonalcoholic fatty liver disease: the need for a multidisciplinary approach. Hepatology 2008;47:746-54.
    • (2008) Hepatology , vol.47 , pp. 746-754
    • Bellentani, S.1    Dalle Grave, R.2    Suppini, A.3    Marchesini, G.4
  • 7
    • 33644547706 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: From steatosis to cirrhosis
    • Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006;43:S99-112.
    • (2006) Hepatology , vol.43
    • Farrell, G.C.1    Larter, C.Z.2
  • 8
    • 35948950834 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and liver injury
    • Kaplowitz N, Than TA, Shinohara M, et al. Endoplasmic reticulum stress and liver injury. Semin Liver Dis 2007;27:367-77.
    • (2007) Semin Liver Dis , vol.27 , pp. 367-377
    • Kaplowitz, N.1    Than, T.A.2    Shinohara, M.3
  • 9
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-kappa B System: A treasure trove for drug development
    • Karin M, Yamamoto Y, Wang QM. The IKK NF-kappa B System: a treasure trove for drug development. Nat Rev Drug Discov 2004;3:17-26.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 10
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis
    • Elsharkawy AM, Mann DA. Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 2007;46:590-7.
    • (2007) Hepatology , vol.46 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 11
    • 27744458510 scopus 로고    scopus 로고
    • NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis
    • Dela Pena A, Leclercq I, Field J, et al. NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. Gastroenterology 2005;129:1663-74.
    • (2005) Gastroenterology , vol.129 , pp. 1663-1674
    • Dela Pena, A.1    Leclercq, I.2    Field, J.3
  • 12
    • 4544335155 scopus 로고    scopus 로고
    • Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients
    • Ribeiro PS, Cortez-Pinto H, Sola S, et al. Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am J Gastroenterol 2004;99:1708-17.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1708-1717
    • Ribeiro, P.S.1    Cortez-Pinto, H.2    Sola, S.3
  • 13
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D, Yuan M, Frantz DF, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 2005;11:183-90.
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3
  • 14
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan MC, Hevener AL, Greten FR, et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 2005;11:191-8.
    • (2005) Nat Med , vol.11 , pp. 191-198
    • Arkan, M.C.1    Hevener, A.L.2    Greten, F.R.3
  • 15
    • 42549144094 scopus 로고    scopus 로고
    • Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic- steatohepatitis
    • Beraza N, Malato Y, Vander Borght S, et al. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic- steatohepatitis. Gut 2008;57:655-63
    • (2008) Gut , vol.57 , pp. 655-663
    • Beraza, N.1    Malato, Y.2    Vander Borght, S.3
  • 16
    • 34249746761 scopus 로고    scopus 로고
    • Pathogenesis of nonalcoholic steatohepatitis: Human data
    • Edmison J, McCullough AJ. Pathogenesis of nonalcoholic steatohepatitis: human data. Clin Liver Dis 2007;11:75-104, ix.
    • (2007) Clin Liver Dis , vol.11
    • Edmison, J.1    McCullough, A.J.2
  • 17
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007;132:2169-80.
    • (2007) Gastroenterology , vol.132 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 18
    • 33748111665 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance
    • Tilg H, Hotamisligil GS. Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology 2006;131:934-45.
    • (2006) Gastroenterology , vol.131 , pp. 934-945
    • Tilg, H.1    Hotamisligil, G.S.2
  • 19
    • 11144325650 scopus 로고    scopus 로고
    • Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
    • Oakley F, Meso M, Iredale JP, et al. Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis. Gastroenterology 2005;128:108-20.
    • (2005) Gastroenterology , vol.128 , pp. 108-120
    • Oakley, F.1    Meso, M.2    Iredale, J.P.3
  • 20
    • 33846253661 scopus 로고    scopus 로고
    • Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis
    • Ota T, Takamura T, Kurita S, et al. Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis. Gastroenterology 2007;132:282-93.
    • (2007) Gastroenterology , vol.132 , pp. 282-293
    • Ota, T.1    Takamura, T.2    Kurita, S.3
  • 21
    • 33749051213 scopus 로고    scopus 로고
    • Can NF-kappaB be a target for novel and efficient anti-cancer agents?
    • Olivier S, Robe P, Bours V. Can NF-kappaB be a target for novel and efficient anti-cancer agents? Biochem Pharmacol 2006;72:1054- 68.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1054-1068
    • Olivier, S.1    Robe, P.2    Bours, V.3
  • 22
    • 34249986360 scopus 로고    scopus 로고
    • Nuclear factor-kappaB in the liver: Friend or foe?
    • Schwabe RF, Brenner DA. Nuclear factor-kappaB in the liver: friend or foe? Gastroenterology 2007;132:2601-4.
    • (2007) Gastroenterology , vol.132 , pp. 2601-2604
    • Schwabe, R.F.1    Brenner, D.A.2
  • 23
    • 33846839443 scopus 로고    scopus 로고
    • Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma
    • Luedde T, Beraza N, Kotsikoris V, et al. Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma. Cancer Cell 2007;11:119-32.
    • (2007) Cancer Cell , vol.11 , pp. 119-132
    • Luedde, T.1    Beraza, N.2    Kotsikoris, V.3
  • 24
    • 34547605613 scopus 로고    scopus 로고
    • IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
    • Lee DF, Kuo HP, Chen CT, et al. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 2007;130:440-55.
    • (2007) Cell , vol.130 , pp. 440-455
    • Lee, D.F.1    Kuo, H.P.2    Chen, C.T.3
  • 25
    • 2342637066 scopus 로고    scopus 로고
    • Angiogenesis in chronic inflammatory liver disease
    • Medina J, Arroyo AG, Sanchez-Madrid F, et al. Angiogenesis in chronic inflammatory liver disease. Hepatology 2004;39:1185-95.
    • (2004) Hepatology , vol.39 , pp. 1185-1195
    • Medina, J.1    Arroyo, A.G.2    Sanchez-Madrid, F.3
  • 26
    • 34848851922 scopus 로고    scopus 로고
    • Angiogenesis modulates adipogenesis and obesity
    • Cao Y. Angiogenesis modulates adipogenesis and obesity. J Clin Invest 2007;117:2362-8.
    • (2007) J Clin Invest , vol.117 , pp. 2362-2368
    • Cao, Y.1
  • 27
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature 2002;420:333-6.
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3
  • 28
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H, Tateya S, Tamori Y, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006;116:1494-505.
    • (2006) J Clin Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3
  • 29
  • 30
    • 35948958955 scopus 로고    scopus 로고
    • TLR4 enhances TGF-beta signaling and hepatic fibrosis
    • Seki E, De Minicis S, Osterreicher CH, et al. TLR4 enhances TGF-beta signaling and hepatic fibrosis. Nat Med 2007;13:1324-32.
    • (2007) Nat Med , vol.13 , pp. 1324-1332
    • Seki, E.1    De Minicis, S.2    Osterreicher, C.H.3


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