Mathematical modeling of corticosteroid pharmacogenomics in rat muscle following acute and chronic methylprednisolone dosing

Molecular Pharmaceutics

Volumn 5, Issue 2, 2008, Pages 328-339

  Yao, Zhenling ^a   Hoffman, Eric P ^b   Ghimbovschi, Svetlana ^b   DuBois, Debra C ^a   Almon, Richard R ^a   Jusko, William J ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

Computational biology; Mathematical models; Microarray studies; Pharmacodynamics; Pharmacokinetics

Indexed keywords

CORTICOSTEROID; METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE;

ADRENALECTOMY; ANIMAL TISSUE; ARTICLE; CLUSTER ANALYSIS; COMPARATIVE STUDY; DOWN REGULATION; DYNAMICS; GENE CONTROL; GENE EXPRESSION; GENOMICS; MALE; MATHEMATICAL MODEL; MICROARRAY ANALYSIS; MUSCLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHARMACOGENOMICS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RNA EXTRACTION; SKELETAL MUSCLE; UPREGULATION;

ANIMALS; CLUSTER ANALYSIS; GENE EXPRESSION REGULATION; MALE; METHYLPREDNISOLONE; MODELS, THEORETICAL; MUSCLE, SKELETAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHARMACOGENETICS; RATS; RATS, WISTAR;

EID: 42549101936     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp700094s     Document Type: Article

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