Evolution, expression and effectiveness in a cluster of novel bovine β-defensins

Immunogenetics

Volumn 60, Issue 3-4, 2008, Pages 147-156

  Cormican, Paul ^a   Meade, Kieran G ^a   Cahalane, Sarah ^a   Narciandi, Fernando ^a   Chapwanya, Aspinas ^a   Lloyd, Andrew T ^a   O'Farrelly, Cliona ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Anti microbial peptide; Bioinformatic; Bovine; Defensin

Indexed keywords

BETA DEFENSIN; BETA DEFENSIN 123; DNA; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BOS TAURUS; CATTLE; EFFECTOR CELL; EFFECTOR GENE; ESCHERICHIA COLI; GENE CLUSTER; GENE SEQUENCE; GENETIC CONSERVATION; INHIBITION KINETICS; LISTERIA MONOCYTOGENES; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS;

AMINO ACID SEQUENCE; ANIMALS; BACTERIA; BETA-DEFENSINS; CATTLE; EVOLUTION; MOLECULAR SEQUENCE DATA; RNA, MESSENGER;

BOS TAURUS; BOVINAE; ESCHERICHIA COLI; LISTERIA MONOCYTOGENES;

EID: 42449156664     PISSN: 00937711     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00251-007-0269-8     Document Type: Article

References (39)

1. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389-3402
2. Batoni G, Maisetta G, Esin S, Campa M (2006) Human beta-defensin-3: a promising antimicrobial peptide. Mini Rev Med Chem 6:1063-1073
3. Bauer F, Schweimer K, Kluver E, Conejo-Garcia JR, Forssmann WG, Rosch P, Adermann K, Sticht H (2001) Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. Protein Sci 10:2470-2479
4. Bettelheim KA, Bushrod FM, Chandler ME, Cooke EM, O'Farrell S, Shooter RA (1974) Escherichia coli serotype distribution in man and animals. J Hyg (Lond) 73:467-471
5. Boman HG (2003) Antibacterial peptides: basic facts and emerging concepts. J Intern Med 254:197-215
6. Brogden KA, Ackermann M, McCray PB Jr, Tack BF (2003) Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents 22:465-478
7. Burge C, Karlin S (1997) Prediction of complete gene structures in human genomic DNA. J Mol Biol 268:78-94
8. Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL (1991) Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci USA 88:3952-3956
9. Eddy SR (1998) Profile hidden Markov models. Bioinformatics 14:755-763
10. Elsbach P (2003) What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses? J Clin Invest 111:1643-1645
11. Ganz T (1999) Defensins and host defense. Science 286:420-421
12. Goldammer T, Zerbe H, Molenaar A, Schuberth HJ, Brunner RM, Kata SR, Seyfert HM (2004) Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Clin Diagn Lab Immunol 11:174-185
13. Higgs R, Lynn DJ, Gaines S, McMahon J, Tierney J, James T, Lloyd AT, Mulcahy G, O'Farrelly C (2005) The synthetic form of a novel chicken beta-defensin identified in silico is predominantly active against intestinal pathogens. Immunogenetics 57:90-98
14. Huttner KM, Lambeth MR, Burkin HR, Burkin DJ, Broad TE (1998) Localization and genomic organization of sheep antimicrobial peptide genes. Gene 206:85-91
15. Kent WJ (2002) BLAT-the BLAST-like alignment tool. Genome Res 12:656-664
16. Kumar S, Tamura K, Jakobsen IB, Nei M (2001) MEGA2: molecular evolutionary genetics analysis software. Bioinformatics 17:1244-1245
17. Lehrer RI, Ganz T (2002) Defensins of vertebrate animals. Curr Opin Immunol 14:96-102
18. Luenser K, Ludwig A (2005) Variability and evolution of bovine beta-defensin genes. Genes Immun 6:115-122
19. Lynn DJ, Bradley DG (2007) Discovery of alpha-defensins in basal mammals. Dev Comp Immunol 31:963-967
20. Motzkus D, Schulz-Maronde S, Heitland A, Schulz A, Forssmann WG, Jubner M, Maronde E (2006) The novel beta-defensin DEFB123 prevents lipopolysaccharide-mediated effects in vitro and in vivo. Faseb J 20:1701-1702
21. Murphy WJ, Eizirik E, O'Brien SJ, Madsen O, Scally M, Douady CJ, Teeling E, Ryder OA, Stanhope MJ, de Jong WW, Springer MS (2001) Resolution of the early placental mammal radiation using Bayesian phylogenetics. Science 294:2348-2351
22. Notredame C, Higgins DG, Heringa J (2000) T-Coffee: a novel method for fast and accurate multiple sequence alignment. J Mol Biol 302:205-217
23. Patil AA, Cai Y, Sang Y, Blecha F, Zhang G (2005) Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol Genomics 23:5-17
24. Radhakrishnan Y, Hamil KG, Yenugu S, Young SL, French FS, Hall SH (2005) Identification, characterization, and evolution of a primate beta-defensin gene cluster. Genes Immun 6:203-210
25. Radhakrishnan Y, Fares MA, French FS, Hall SH (2007) Comparative genomic analysis of a mammalian β-defensin gene cluster. Physiol Genomics 30:213-222
26. Roosen S, Exner K, Paul S, Schroder JM, Kalm E, Looft C (2004) Bovine beta-defensins: identification and characterization of novel bovine beta-defensin genes and their expression in mammary gland tissue. Mamm Genome 15:834-842
27. Russell JP, Diamond G, Tarver AP, Scanlin TF, Bevins CL (1996) Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect Immun 64:1565-1568
28. Sarikaya H, Werner-Misof C, Atzkern M, Bruckmaier RM (2005) Distribution of leucocyte populations, and milk composition, in milk fractions of healthy quarters in dairy cows. J Dairy Res 72:486-492
29. Schonwetter BS, Stolzenberg ED, Zasloff MA (1995) Epithelial antibiotics induced at sites of inflammation. Science 267:1645-1648
30. Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (2002) Discovery of five conserved beta-defensin gene clusters using a computational search strategy. Proc Natl Acad Sci USA 99:2129-2133
31. Selsted ME, Tang YQ, Morris WL, McGuire PA, Novotny MJ, Smith W, Henschen AH, Cullor JS (1993) Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils. J Biol Chem 268:6641-6648
32. Selsted ME, Ouellette AJ (2005) Mammalian defensins in the antimicrobial immune response. Nat Immunol 6:551-557
33. Semple CA, Gautier P, Taylor K, Dorin JR (2006) The changing of the guard: molecular diversity and rapid evolution of beta-defensins. Mol Divers 10:575-584
34. Swanson K, Gorodetsky S, Good L, Davis S, Musgrave D, Stelwagen K, Farr V, Molenaar A (2004) Expression of a beta-defensin mRNA, lingual antimicrobial peptide, in bovine mammary epithelial tissue is induced by mastitis. Infect Immun 72:7311-7314
35. Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME (1999) A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science 286:498-502
36. Tarver AP, Clark DP, Diamond G, Russell JP, Erdjument-Bromage H, Tempst P, Cohen KS, Jones DE, Sweeney RW, Wines M, Hwang S, Bevins CL (1998) Enteric beta-defensin: molecular cloning and characterization of a gene with inducible intestinal epithelial cell expression associated with Cryptosporidium parvum infection. Infect Immun 66:1045-1056
37. Ulmer AJ, Scholz W, Ernst M, Brandt E, Flad HD (1984) Isolation and subfractionation of human peripheral blood mononuclear cells (PBMC) by density gradient centrifugation on Percoll. Immunobiology 166:238-250
38. Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schroder JM, Wang JM, Howard OM, Oppenheim JJ (1999) Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286:525-528
39. Zasloff M (2002) Innate immunity, antimicrobial peptides, and protection of the oral cavity. Lancet 360:1116-1117