Modulation of murine embryonic stem cell-derived CD41+c-kit + hematopoietic progenitors by ectopic expression of Cdx genes

Blood

Volumn 111, Issue 10, 2008, Pages 4944-4953

  McKinney Freeman, Shannon L ^a,b,c   Lengerke, Claudia ^a,b,c,d   Jang, Ll Ho ^a,b,c   Schmitt, Sabine ^a,b,c   Wang, Yuan ^a,b,c,e   Philitas, Marsha ^a,b,c   Shea, Jessica ^a,b,c   Daley, George Q ^a,b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRINOGEN RECEPTOR; HOX PROTEIN; STEM CELL FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CDX1; TRANSCRIPTION FACTOR CDX2; TRANSCRIPTION FACTOR CDX4; UNCLASSIFIED DRUG; CDX1 PROTEIN, MOUSE; CDX2 PROTEIN, MOUSE; CDX4 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL POPULATION; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; ANIMAL; CYTOLOGY; GENETICS; LEUKEMIA; PHYSIOLOGY;

ANIMALS; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; LEUKEMIA; MICE; TRANSCRIPTION FACTORS;

EID: 42449154162     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-11-124644     Document Type: Article

References (41)

1. Davidson AJ; Ernst R Wang Y, et al. Cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 2003; 425:300-306.
2. Davidson AJ, Zon LI. The caudal-related ho- meobox genes cdxl a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis. Dev Biol. 2006;292: 506-518.
3. Subramanian V, Meyer BL Gruss P. Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell. 1995;83: 641-653.
4. van den Akker E, Forlani S. Chawengsaksophak K, et al. Gdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. Development. 2002:129:2181- 2193.
5. van Nes J, de Graaff W, Lebrin F, et al. The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice. Development. 2006;133:419-428.
6. Izraeli S. Leukaemia - a developmental perspective. Br J Haematol. 2004;126:3-10.
7. Bansal D, Scholl C, Frohling S. et al. Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis 1 a in a murine model. Proc Natl Acad Sci USA. 2006;103:16924-16929.
8. Chase A, Reiter A, Burci L, etal. Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13; q12). Blood. 1999;93:1025-1031.
9. Heckman CA, Mehew JW, Ying GG, et al. A-Myb up-regulates Bcl-2 through a Cdx binding site in t(14;18) lymphoma cells. J Biol Chem. 2000;275: 6499-6508.
10. Rawat VP. Cusan M. Deshpande A. et al. Ectopic expression of the homeobox gene Gdx2 is the transforming event in a mouse model of t(12; 13)(p13;q12) acute myeloid leukemia. Proc Natl Acad Sci USA. 2004;101:817-822.
11. Scholl C, Bansal D, Dohner K, et al. The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest. 2007;117: 1037-1048.
12. Wang Y, Yates F, Naveiras O, et al. Embryonic stem cell-derived hematopoietic stem cells. Proc Natl Acad Sci USA. 2005;102:19081-19086.
13. Ernst R Mabon M, Davidson AJ, etal. An Mil- dependent Hox program drives hematopoietic progenitor expansion. Curr Biol. 2004; 14:2063- 2069.
14. Keller G. Embryonic stem cell differentiation: emergence of a new era in biology and medicine. Genes Dev. 2005;19:1129-1155.
15. Lacaud G, Gore L, Kennedy M, et al. Runx 1 is essential for hematopoietic commitment at the hemangioblast stage of development in vitro. Blood. 2002;100:458-466.
16. Lugus JJ, Chung YS; Mills JC, et al. GATA2 functions at multiple steps in hemangioblast development and differentiation. Development. 2007;134: 393-405.
17. Melotti P, Galabretta B. The transcription factors c-myb and GATA-2 act independently in the regulation of normal hematopoiesis. Proc Natl Acad Sci U S A. 1996;93:5313-5318.
18. Park C, Afrikanova I, Ghung YS; et al. A hierarchical order of factors in the generation of FLK1 - and SCL-expressing hematopoietic and endothelial progenitors from embryonic stem cells. Development. 2004;131:2749-2762.
19. Porcher C, Swat W, Rockwell K, et al. The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages. Cell. 1996;86:47-57.
20. Simon MC; Pevny L Wiles MV, et al. Rescue of erythroid development in gene targeted GATA-1- mouse embryonic stem cells. Nat Genet. 1992:1: 92-98.
21. Tsai FY. Orkin SH. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood. 1997;89:3636-3643.
22. Lengerke C, Schmitt S, Bowman TV, et al. BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. Cell Stem Cell. 2008;2: 72-82.
23. Kyba M, Perlingeiro RC, Daley GQ. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell. 2002;109:29-37.
24. Lengerke C, Kim K, Lerou P, et al. Differentiation potential of histocompatible parthenogenetic embryonic stem cells. Ann N YAcad Sci. 2007;1106: 209-218.
25. Kennedy M, Firpo M, Ghoi K, et al. A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature. 1997;386:488-493.
26. Gupta P, Gurudutta GU, Verma YK, etal. PU. 1: An ETS family transcription factor that regulates leukemogenesis besides normal hematopoiesis. Stem Cells Dev. 2006;15:609-617.
27. Lowry JA, Mackay JP. GATA-1: one protein, many partners. Int J Biochem Cell Biol. 2006;38:6-11.
28. Ling KW. Ottersbach K, van Hamburg JP, et al. GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med. 2004;200:871-882.
29. Rodrigues NP, Janzen V, Forkert R, et al. Haplo- insufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis. Blood. 2005;106:477- 484.
30. Skromne I, Thorsen D, Hale M, et al. Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord. Development. 2007;134: 2147-2158.
31. Gruss P, Kessel M. Axial specification in higher vertebrates. Curr Opin Genet Dev. 1991 ;1:204- 210.
32. Krumlauf R. Hox genes in vertebrate development. Cell. 1994;78:191-201.
33. Lohnes D. The Cdx1 homeodomain protein: an integrator of posterior signaling in the mouse. Bioessays. 2003;25:971-980.
34. Mitjavila-Garcia MT, Cailleret M, Godin I, et al. Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development. 2002;129:2003-2013.
35. Mikkola HK, Fujiwara Y, Schlaeger TM, et al. Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood. 2003;101:508-516.
36. Bertrand JY Giroux S, Golub R, et al. Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin. Proc Natl Acad Sci U SA. 2005;102:134-139.
37. Delassus S. Tit ley I. Enver T Functional and molecular analysis of hematopoietic progenitors derived from the aorta-gonad-mesonephros region of the mouse embryo. Blood. 1999;94:1495- 1503.
38. Begley CG, Apian PD, Davey MP, et al. Chromosomal translocation in a human leukemic stem- cell line disrupts the T-cell antigen receptor delta- chain diversity region and results in a previously unreported fusion transcript. Proc Natl Acad Sci U SA. 1989;86:2031-2035.
39. Kubo A, Shinozaki K, Shannon JM, et al. Development of definitive endoderm from embryonic stem cells in culture. Development. 2004; 131: 1651-1662.
40. Ernst P, Fisher JK, Avery W, et al. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell. 2004;6:437-443.
41. Gross I, Lhermitte B, Domon-Dell C, et al. Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene. 2005;24: 7955-7963.