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Volumn 82, Issue 9, 2008, Pages 4492-4501

Coronavirus infection modulates the unfolded protein response and mediates sustained translational repression

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; INITIATION FACTOR 2ALPHA; PROTEIN IRE1; PROTEIN P58; X BOX BINDING PROTEIN 1;

EID: 42449139748     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00017-08     Document Type: Article
Times cited : (83)

References (61)
  • 1
    • 0033808358 scopus 로고    scopus 로고
    • RNase L-independent specific 28S rRNA cleavage in murine coronavirus-infected cells
    • Banerjee, S., S. An, A. Zhou, R. H. Silverman, and S. Makino. 2000. RNase L-independent specific 28S rRNA cleavage in murine coronavirus-infected cells. J. Virol. 74:8793-8802.
    • (2000) J. Virol , vol.74 , pp. 8793-8802
    • Banerjee, S.1    An, S.2    Zhou, A.3    Silverman, R.H.4    Makino, S.5
  • 2
    • 0026519212 scopus 로고
    • Structural and functional characterization of the poliovirus replication complex
    • Bienz, K., D. Egger, T. Pfister, and M. Troxler. 1992. Structural and functional characterization of the poliovirus replication complex. J. Virol. 66:2740-2747.
    • (1992) J. Virol , vol.66 , pp. 2740-2747
    • Bienz, K.1    Egger, D.2    Pfister, T.3    Troxler, M.4
  • 4
    • 0037011917 scopus 로고    scopus 로고
    • IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
    • Calfon, M., H. Zeng, F. Urano, J. H. Till, S. R. Hubbard, H. P. Harding, S. G. Clark, and D. Ron. 2002. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415:92-96.
    • (2002) Nature , vol.415 , pp. 92-96
    • Calfon, M.1    Zeng, H.2    Urano, F.3    Till, J.H.4    Hubbard, S.R.5    Harding, H.P.6    Clark, S.G.7    Ron, D.8
  • 6
    • 33748502744 scopus 로고    scopus 로고
    • Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein
    • Chan, C. P., K. L. Siu, K. T. Chin, K. Y. Yuen, B. Zheng, and D. Y. Jin. 2006. Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein. J. Virol. 80:9279-9287.
    • (2006) J. Virol , vol.80 , pp. 9279-9287
    • Chan, C.P.1    Siu, K.L.2    Chin, K.T.3    Yuen, K.Y.4    Zheng, B.5    Jin, D.Y.6
  • 8
    • 36148979683 scopus 로고    scopus 로고
    • Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus
    • Devaraj, S. G., N. Wang, Z. Chen, M. Tseng, N. Barretto, R. Lin, C. J. Peters, C. T. Tseng, S. C. Baker, and K. Li. 2007. Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus. J. Biol. Chem. 282:32208-32221.
    • (2007) J. Biol. Chem , vol.282 , pp. 32208-32221
    • Devaraj, S.G.1    Wang, N.2    Chen, Z.3    Tseng, M.4    Barretto, N.5    Lin, R.6    Peters, C.J.7    Tseng, C.T.8    Baker, S.C.9    Li, K.10
  • 11
    • 40649098253 scopus 로고    scopus 로고
    • SARS coronavirus and innate immunity
    • Frieman, M., M. Heise, and R. Baric. 2008. SARS coronavirus and innate immunity. Virus Res. 133:101-112.
    • (2008) Virus Res , vol.133 , pp. 101-112
    • Frieman, M.1    Heise, M.2    Baric, R.3
  • 12
    • 0037073712 scopus 로고    scopus 로고
    • Activation of an unfolded protein response during differentiation of antibody-secreting B cells
    • Gass, J. N., N. M. Gifford, and J. W. Brewer. 2002. Activation of an unfolded protein response during differentiation of antibody-secreting B cells. J. Biol. Chem. 277:49047-49054.
    • (2002) J. Biol. Chem , vol.277 , pp. 49047-49054
    • Gass, J.N.1    Gifford, N.M.2    Brewer, J.W.3
  • 14
    • 0345144016 scopus 로고    scopus 로고
    • Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons
    • Gosert, R., D. Egger, V. Lohmann, R. Bartenschlager, H. E. Blum, K. Bienz, and D. Moradpour. 2003. Identification of the hepatitis C virus RNA replication complex in Huh-7 cells harboring subgenomic replicons. J. Virol. 77:5487-5492.
    • (2003) J. Virol , vol.77 , pp. 5487-5492
    • Gosert, R.1    Egger, D.2    Lohmann, V.3    Bartenschlager, R.4    Blum, H.E.5    Bienz, K.6    Moradpour, D.7
  • 15
    • 0036196634 scopus 로고    scopus 로고
    • RNA replication of mouse hepatitis virus takes place at double-membrane vesicles
    • Gosert, R., A. Kanjanahaluethai, D. Egger, K. Bienz, and S. C. Baker. 2002. RNA replication of mouse hepatitis virus takes place at double-membrane vesicles. J. Virol. 76:3697-3708.
    • (2002) J. Virol , vol.76 , pp. 3697-3708
    • Gosert, R.1    Kanjanahaluethai, A.2    Egger, D.3    Bienz, K.4    Baker, S.C.5
  • 16
    • 0033634654 scopus 로고    scopus 로고
    • Regulated translation initiation controls stress-induced gene expression in mammalian cells
    • Harding, H. P., I. Novoa, Y. Zhang, H. Zeng, R. Wek, M. Schapira, and D. Ron. 2000. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6:1099-1108.
    • (2000) Mol. Cell , vol.6 , pp. 1099-1108
    • Harding, H.P.1    Novoa, I.2    Zhang, Y.3    Zeng, H.4    Wek, R.5    Schapira, M.6    Ron, D.7
  • 19
    • 2942525412 scopus 로고    scopus 로고
    • Kinetic analysis and modeling of firefly luciferase as a quantitative reporter gene in live mammalian cells
    • Ignowski, J. M., and D. V. Schaffer. 2004. Kinetic analysis and modeling of firefly luciferase as a quantitative reporter gene in live mammalian cells. Biotechnol. Bioeng. 86:827-834.
    • (2004) Biotechnol. Bioeng , vol.86 , pp. 827-834
    • Ignowski, J.M.1    Schaffer, D.V.2
  • 20
    • 18844419215 scopus 로고    scopus 로고
    • Human cytomegalovirus infection activates and regulates the unfolded protein response
    • Isler, J. A., A. H. Skalet, and J. C. Alwine. 2005. Human cytomegalovirus infection activates and regulates the unfolded protein response. J. Virol. 79:6890-6899.
    • (2005) J. Virol , vol.79 , pp. 6890-6899
    • Isler, J.A.1    Skalet, A.H.2    Alwine, J.C.3
  • 21
    • 33748046163 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation
    • Kamitani, W., K. Narayanan, C. Huang, K. Lokugamage, T. Ikegami, N. Ito, H. Kubo, and S. Makino. 2006. Severe acute respiratory syndrome coronavirus nsp1 protein suppresses host gene expression by promoting host mRNA degradation. Proc. Natl. Acad. Sci. USA 103:12885-12890.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 12885-12890
    • Kamitani, W.1    Narayanan, K.2    Huang, C.3    Lokugamage, K.4    Ikegami, T.5    Ito, N.6    Kubo, H.7    Makino, S.8
  • 22
    • 33846104528 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists
    • Kopecky-Bromberg, S. A., L. Martinez-Sobrido, M. Frieman, R. A. Baric, and P. Palese. 2007. Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonists. J. Virol. 81:548-557.
    • (2007) J. Virol , vol.81 , pp. 548-557
    • Kopecky-Bromberg, S.A.1    Martinez-Sobrido, L.2    Frieman, M.3    Baric, R.A.4    Palese, P.5
  • 24
    • 0142059951 scopus 로고    scopus 로고
    • XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    • Lee, A. H., N. N. Iwakoshi, and L. H. Glimcher. 2003. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol. Cell. Biol. 23:7448-7459.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 7448-7459
    • Lee, A.H.1    Iwakoshi, N.N.2    Glimcher, L.H.3
  • 26
    • 84934436377 scopus 로고    scopus 로고
    • A previously unrecognized UNR stem-loop structure in the coronavirus 5′ untranslated region plays a functional role in replication
    • Liu, P., J. J. Millership, L. Li, D. P. Giedroc, and J. L. Leibowitz. 2006. A previously unrecognized UNR stem-loop structure in the coronavirus 5′ untranslated region plays a functional role in replication. Adv. Exp. Med. Biol. 581:25-30.
    • (2006) Adv. Exp. Med. Biol , vol.581 , pp. 25-30
    • Liu, P.1    Millership, J.J.2    Li, L.3    Giedroc, D.P.4    Leibowitz, J.L.5
  • 27
    • 0041315834 scopus 로고    scopus 로고
    • Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress
    • Ma, Y., and L. M. Hendershot. 2003. Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress. J. Biol. Chem. 278:34864-34873.
    • (2003) J. Biol. Chem , vol.278 , pp. 34864-34873
    • Ma, Y.1    Hendershot, L.M.2
  • 28
    • 36248949141 scopus 로고    scopus 로고
    • The endoplasmic reticulum and the unfolded protein response
    • Malhotra, J. D., and R. J. Kaufman. 2007. The endoplasmic reticulum and the unfolded protein response. Semin. Cell Dev. Biol. 18:716-731.
    • (2007) Semin. Cell Dev. Biol , vol.18 , pp. 716-731
    • Malhotra, J.D.1    Kaufman, R.J.2
  • 30
    • 33746317830 scopus 로고    scopus 로고
    • The molecular biology of coronaviruses
    • Masters, P. S. 2006. The molecular biology of coronaviruses. Adv. Virus Res. 66:193-292.
    • (2006) Adv. Virus Res , vol.66 , pp. 193-292
    • Masters, P.S.1
  • 31
    • 38349138566 scopus 로고    scopus 로고
    • Rotavirus infection induces the phosphorylation of eIF2α but prevents the formation of stress granules
    • Montero, H., M. Rojas, C. F. Arias, and S. Lopez. 2008. Rotavirus infection induces the phosphorylation of eIF2α but prevents the formation of stress granules. J. Virol. 82:1496-1504.
    • (2008) J. Virol , vol.82 , pp. 1496-1504
    • Montero, H.1    Rojas, M.2    Arias, C.F.3    Lopez, S.4
  • 32
    • 0037416211 scopus 로고    scopus 로고
    • Stress-induced gene expression requires programmed recovery from translational repression
    • Novoa, I., Y. Zhang, H. Zeng, R. Jungreis, H. P. Harding, and D. Ron. 2003. Stress-induced gene expression requires programmed recovery from translational repression. EMBO J. 22:1180-1187.
    • (2003) EMBO J , vol.22 , pp. 1180-1187
    • Novoa, I.1    Zhang, Y.2    Zeng, H.3    Jungreis, R.4    Harding, H.P.5    Ron, D.6
  • 34
    • 34547883878 scopus 로고    scopus 로고
    • Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies
    • Raaben, M., M. J. Groot Koerkamp, P. J. Rottier, and C. A. de Haan. 2007. Mouse hepatitis coronavirus replication induces host translational shutoff and mRNA decay, with concomitant formation of stress granules and processing bodies. Cell. Microbiol. 9:2218-2229.
    • (2007) Cell. Microbiol , vol.9 , pp. 2218-2229
    • Raaben, M.1    Groot Koerkamp, M.J.2    Rottier, P.J.3    de Haan, C.A.4
  • 35
    • 11344254375 scopus 로고    scopus 로고
    • Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B
    • Reimers, K., K. Buchholz, and H. Werchau. 2005. Respiratory syncytial virus M2-1 protein induces the activation of nuclear factor kappa B. Virology 331:260-268.
    • (2005) Virology , vol.331 , pp. 260-268
    • Reimers, K.1    Buchholz, K.2    Werchau, H.3
  • 37
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron, D., and P. Walter. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8:519-529.
    • (2007) Nat. Rev. Mol. Cell Biol , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 38
    • 34250836810 scopus 로고    scopus 로고
    • Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels
    • Roth-Cross, J. K., L. Martinez-Sobrido, E. P. Scott, A. Garcia-Sastre, and S. R. Weiss. 2007. Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels. J. Virol. 81:7189-7199.
    • (2007) J. Virol , vol.81 , pp. 7189-7199
    • Roth-Cross, J.K.1    Martinez-Sobrido, L.2    Scott, E.P.3    Garcia-Sastre, A.4    Weiss, S.R.5
  • 40
    • 33845750075 scopus 로고    scopus 로고
    • A contemporary view of coronavirus transcription
    • Sawicki, S. G., D. L. Sawicki, and S. G. Siddell. 2007. A contemporary view of coronavirus transcription. J. Virol. 81:20-29.
    • (2007) J. Virol , vol.81 , pp. 20-29
    • Sawicki, S.G.1    Sawicki, D.L.2    Siddell, S.G.3
  • 41
  • 43
    • 33744928372 scopus 로고    scopus 로고
    • Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex
    • Snijder, E. J., Y. van der Meer, J. Zevenhoven-Dobbe, J. J. Onderwater, J. van der Meulen, H. K. Koerten, and A. M. Mommaas. 2006. Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. J. Virol. 80:5927-5940.
    • (2006) J. Virol , vol.80 , pp. 5927-5940
    • Snijder, E.J.1    van der Meer, Y.2    Zevenhoven-Dobbe, J.3    Onderwater, J.J.4    van der Meulen, J.5    Koerten, H.K.6    Mommaas, A.M.7
  • 44
    • 0023485281 scopus 로고
    • Sequence and translation of the murine coronavirus 5′-end genomic RNA reveals the N-terminal structure of the putative RNA polymerase
    • Soe, L. H., C. K. Shieh, S. C. Baker, M. F. Chang, and M. M. Lai. 1987. Sequence and translation of the murine coronavirus 5′-end genomic RNA reveals the N-terminal structure of the putative RNA polymerase. J. Virol. 61:3968-3976.
    • (1987) J. Virol , vol.61 , pp. 3968-3976
    • Soe, L.H.1    Shieh, C.K.2    Baker, S.C.3    Chang, M.F.4    Lai, M.M.5
  • 45
    • 5444222234 scopus 로고    scopus 로고
    • XBP1: A link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum
    • Sriburi, R., S. Jackowski, K. Mori, and J. W. Brewer. 2004. XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum. J. Cell Biol. 167:35-41.
    • (2004) J. Cell Biol , vol.167 , pp. 35-41
    • Sriburi, R.1    Jackowski, S.2    Mori, K.3    Brewer, J.W.4
  • 47
    • 0015410395 scopus 로고
    • Enhanced growth of a murine coronavirus in transformed mouse cells
    • Sturman, L. S., and K. K. Takemoto. 1972. Enhanced growth of a murine coronavirus in transformed mouse cells. Infect. Immun. 6:501-507.
    • (1972) Infect. Immun , vol.6 , pp. 501-507
    • Sturman, L.S.1    Takemoto, K.K.2
  • 49
    • 2342435179 scopus 로고    scopus 로고
    • Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response
    • Tardif, K. D., K. Mori, R. J. Kaufman, and A. Siddiqui. 2004. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. J. Biol. Chem. 279:17158-17164.
    • (2004) J. Biol. Chem , vol.279 , pp. 17158-17164
    • Tardif, K.D.1    Mori, K.2    Kaufman, R.J.3    Siddiqui, A.4
  • 50
    • 0036314483 scopus 로고    scopus 로고
    • Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway
    • Tardif, K. D., K. Mori, and A. Siddiqui. 2002. Hepatitis C virus subgenomic replicons induce endoplasmic reticulum stress activating an intracellular signaling pathway. J. Virol. 76:7453-7459.
    • (2002) J. Virol , vol.76 , pp. 7453-7459
    • Tardif, K.D.1    Mori, K.2    Siddiqui, A.3
  • 51
    • 0037036412 scopus 로고    scopus 로고
    • Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16
    • Thuerauf, D. J., L. E. Morrison, H. Hoover, and C. C. Glembotski. 2002. Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16. J. Biol. Chem. 277:20734-20739.
    • (2002) J. Biol. Chem , vol.277 , pp. 20734-20739
    • Thuerauf, D.J.1    Morrison, L.E.2    Hoover, H.3    Glembotski, C.C.4
  • 52
    • 0021893229 scopus 로고
    • Infection of AtT20 murine pituitary tumour cells by mouse hepatitis virus strain A59: Virus budding is restricted to the Golgi region
    • Tooze, J., and S. A. Tooze. 1985. Infection of AtT20 murine pituitary tumour cells by mouse hepatitis virus strain A59: virus budding is restricted to the Golgi region. Eur. J. Cell Biol. 37:203-212.
    • (1985) Eur. J. Cell Biol , vol.37 , pp. 203-212
    • Tooze, J.1    Tooze, S.A.2
  • 53
    • 29944433224 scopus 로고    scopus 로고
    • Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation: A strategy to overcome the antiviral effect of protein kinase PKR
    • Ventoso, I., M. A. Sanz, S. Molina, J. J. Berlanga, L. Carrasco, and M. Esteban. 2006. Translational resistance of late alphavirus mRNA to eIF2alpha phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR. Genes Dev. 20:87-100.
    • (2006) Genes Dev , vol.20 , pp. 87-100
    • Ventoso, I.1    Sanz, M.A.2    Molina, S.3    Berlanga, J.J.4    Carrasco, L.5    Esteban, M.6
  • 54
    • 33745604908 scopus 로고    scopus 로고
    • Transcriptional profiling of acute cytopathic murine hepatitis virus infection in fibroblast-like cells
    • Versteeg, G. A., O. Slobodskaya, and W. J. Spaan. 2006. Transcriptional profiling of acute cytopathic murine hepatitis virus infection in fibroblast-like cells. J. Gen. Virol. 87:1961-1975.
    • (2006) J. Gen. Virol , vol.87 , pp. 1961-1975
    • Versteeg, G.A.1    Slobodskaya, O.2    Spaan, W.J.3
  • 55
    • 35148876973 scopus 로고    scopus 로고
    • The coronavirus spike protein induces endoplasmic reticulum stress and upregulation of intracellular chemokine mRNA concentrations
    • Versteeg, G. A., P. S. van de Nes, P. J. Bredenbeek, and W. J. Spaan. 2007. The coronavirus spike protein induces endoplasmic reticulum stress and upregulation of intracellular chemokine mRNA concentrations. J. Virol. 81:10981-10990.
    • (2007) J. Virol , vol.81 , pp. 10981-10990
    • Versteeg, G.A.1    van de Nes, P.S.2    Bredenbeek, P.J.3    Spaan, W.J.4
  • 56
    • 35448939321 scopus 로고    scopus 로고
    • Severe acute respiratory syndrome coronavirus evades antiviral signaling: Role of nsp1 and rational design of an attenuated strain
    • Wathelet, M. G., M. Orr, M. B. Frieman, and R. S. Baric. 2007. Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain. J. Virol. 81:11620-11633.
    • (2007) J. Virol , vol.81 , pp. 11620-11633
    • Wathelet, M.G.1    Orr, M.2    Frieman, M.B.3    Baric, R.S.4
  • 57
    • 33748667752 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with Borna disease virus
    • Williams, B. L., and W. I. Lipkin. 2006. Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with Borna disease virus. J. Virol. 80:8613-8626.
    • (2006) J. Virol , vol.80 , pp. 8613-8626
    • Williams, B.L.1    Lipkin, W.I.2
  • 59
    • 34548172495 scopus 로고    scopus 로고
    • Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1
    • Yamamoto, K., T. Sato, T. Matsui, M. Sato, T. Okada, H. Yoshida, A. Harada, and K. Mori. 2007. Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1. Dev. Cell 13:365-376.
    • (2007) Dev. Cell , vol.13 , pp. 365-376
    • Yamamoto, K.1    Sato, T.2    Matsui, T.3    Sato, M.4    Okada, T.5    Yoshida, H.6    Harada, A.7    Mori, K.8
  • 60
    • 33947387099 scopus 로고    scopus 로고
    • Mouse hepatitis coronavirus A59 nucleocapsid protein is a type I interferon antagonist
    • Ye, Y., K. Hauns, J. O. Langland, B. L. Jacobs, and B. G. Hogue. 2007. Mouse hepatitis coronavirus A59 nucleocapsid protein is a type I interferon antagonist. J. Virol. 81:2554-2563.
    • (2007) J. Virol , vol.81 , pp. 2554-2563
    • Ye, Y.1    Hauns, K.2    Langland, J.O.3    Jacobs, B.L.4    Hogue, B.G.5
  • 61
    • 34548425017 scopus 로고    scopus 로고
    • Coronavirus non-structural protein 1 is a major pathogenicity factor: Implications for the rational design of coronavirus vaccines
    • Zust, R., L. Cervantes-Barragan, T. Kuri, G. Blakqori, F. Weber, B. Ludewig, and V. Thiel. 2007. Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines. PLoS Pathog. 3:e109.
    • (2007) PLoS Pathog , vol.3
    • Zust, R.1    Cervantes-Barragan, L.2    Kuri, T.3    Blakqori, G.4    Weber, F.5    Ludewig, B.6    Thiel, V.7


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