The protective effect of Nigella sativa on lung injury of sulfur mustard-exposed guinea pigs

Experimental Lung Research

Volumn 34, Issue 4, 2008, Pages 183-194

  Hossein, Boskabady Mohammad ^a,b   Nasim, Vahedi ^a   Sediqa, Amery ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b Medical School   (Iran)

Author keywords

Guinea pig; Lung inflammation; Nigella sativa; Sulfur mustard; Tracheal responsiveness

Indexed keywords

ALCOHOL; METHACHOLINE; MUSTARD GAS; NIGELLA SATIVA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLACK CUMIN; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG EFFECT; EXPOSURE; FEMALE; GUINEA PIG; LEUKOCYTE; LUNG INJURY; LUNG LAVAGE; MALE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; TRACHEA; WEIGHT CHANGE;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CHEMICAL WARFARE AGENTS; FEMALE; GUINEA PIGS; LEUKOCYTES; LUNG; LUNG DISEASES; MALE; METHACHOLINE CHLORIDE; MUSTARD GAS; NIGELLA SATIVA; PLANT EXTRACTS; SEEDS; TRACHEA;

EID: 42449136641     PISSN: 01902148     EISSN: 15210499     Source Type: Journal    
DOI: 10.1080/01902140801935082     Document Type: Article

References (39)

1. Dacre JC, Goldman M: Toxicology and pharmacology of the chemical warfare agent sulfur mustard. Pharmacol Rev. 1996;48:289-326.
2. Evison D, Hinsley D, Rice P: Chemical weapons. BMJ. 2002;324:332-335.
3. Bahadori M, Pishva N, Masjedi MR: History of pulmonary lesions in victims of chemical warfare. Ir J Med Sci. 1989;14:999-1005.
4. Emad AF, Rezaian GR: The diversity of the effects of sulfur mustard gas inhalation on respiratory system 10 years after a single, heavy exposure: analysis of 197 cases. Chest. 1997;112:734-738.
5. Emad AF, Rezaian GR, Hoseini K, Ghayyoomi SMA: Chronic pulmonary sequel of sulfur mustard exposure in man a report of 36 cases. Ir J Med Sci. 1995;20:1-4.
6. Briton JR, Burney PG, Chinn S, Paracosta A, Tattersfield AE: The relationship between change in airway reactivity and change in respiratory symptoms and medication in a community study. Am Rev Respir Dis. 1988;138:530-534.
7. Ramsdale EH, Morris MM, Roberts RS, Hargreave FE: Methacholine bronchial responsiveness in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness. Thorax. 1994;39:912-918.
8. Frew AJ: Advances in environmental and occupational disorders. J Allergy Clin Immunol. 2003;111:824-S828.
9. Padrid P, Snook S, Finucane T, Shiue P, Cozzi P, Solway J, Leff AR: Persistent airway hyperresponsiveness and histologic alteration after chronic antigen challenge in cats. Am J Respir Crit Care. 1995;151:184-193.
10. Mapp CE, Boniotti A, Papi A et al: The effect of phospho ramidon and epithelial removal on toluen diisocyanate-induced contraction in guinea pig bronchi. Eur Respir J. 1992;5:331-333.
11. Trigg CJ, Bennett JB, Tooly M, Sibbald B, D'souza MF, Davis RJ: A general practice based survey of bronchial hyperresponsiveness and its relations to symptoms, sex, age, atopy and smoking. Thorax. 1990;45:866-872.
12. Somani SM, Babu SR: Toxicodynamics of sulfur mustard. Int J Clin Pharm Ther Toxicol. 1989;27(9):419-435.
13. Hosseini K, Moradi A, Mansouri, Vesal K: Pulmonary manifestations of mustard gas injury; a review of 61 cases. Ir J Med Sci. 1989;14:20-25.
14. Hajhashemi V, Ghannadi A, Jafarabadi H: Black cumin seed essential oil, as a potent analgesic and anti-inflammatory drug. Phytother Res. 2004;18:195-199.
15. Kalus U, Pruss A, Bystron J, Jurecka M, Smekalova A, Lichius JJ, Kiesewetter H: Effect of Nigella sativa (black seed) on subjective feeling in patients with allergic diseases. Phytother Res. 2003;17:1209-1214.
16. Labib Salem M: Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005;5:1749-1770.
17. Boskabady MH, Shahabi M: Bronchodilatory and anticholinergic effects of Nigella sativa on isolated guinea-pig tracheal chains. Iran J Med Sci. 1997;22:127-133.
18. 1) receptors of isolated guinea pig tracheal chains. Eur Respir J. 2000;16(Suppl. 31):461s.
19. Boskabady MH, Shirmohammadi B: Effect ofNigella sativa on isolated guinea pig tracheal chains. Arch. Iram. Med. 2002;5:103-107.
20. Boskabady MH, Shirmohammadi B, Jandaghi P, Kiani S: Possible mechanisms for relaxant effect of aqueous and macerate extracts from Nigella sativa on tracheal chains of guinea pig. B M C Pharmacol. 2004;4:3.
21. 2-adronceptors of guinea pig tracheal chains. Med J I R Iran. 2004;18:153-158.
22. Boskabady MH, Kiani S, Jandaghi P, Ziaei T, Zarei A: Antitussive of Nigella sativa. Pak J Med Sci. 2004;20:224-228.
23. Vijayaraghavan R: Modifications of breathing pattern induced by inhaled sulphur mustard in mice. Arch Toxicol. 1997;71:157-164.
24. Holroyde MC: The influence of epithelium on the responsiveness of guinea-pig isolated trachea. Br J Pharmacol. 1986;87:501-507.
25. Calvet JH, Jarreau PH, Levame M, D'Ortho MP, Lorino H, Harf A: Acute and chronic respiratory effects of sulfur mustard intoxication in guinea pig. J Appl Physiol. 1994;76:681-688.
26. Mirsadraee M, Attaran D, Boskabady MH, Towhidi M: Airway hyperresponsiveness to methacholine in chemical war victims. Respiration. 2005;72:523-528.
27. Boskabady MH, Attaran D, Shafei. Airways hyperresponsiveness to salbutamol in chemical war victims. Thr (In Press: Respirol).
28. Eisenmenger W, Drasch G, von Clarmann M, Kretschmer E, Roider G: Clinical and morphological findings on mustard gas [bis(2-chloroethyl)sulfide] poisoning. J Forensic Sci. 1991;36:1688-1698.
29. Gautam A, Vijayaraghavan R, Sharma M, Ganesan KG: Comparative toxicity studies of sulfur mustard (2,2′Dichloro Diethyl Sulfide) and monofunctional sulfur mustard (2Chloroethyl Ethyl Sulfide), administered through various routes in mice. J Med CBR Def. 2006;4.
30. Guatum A, Singh S, Kulkarni AS, Pant SC, Vijayaraghavan R: Protective effect of Aloe vera L. gel against sulphur mustard-induced systemic toxicity and skin lesions. Indian J Pharmacol. 2005;37:103-110.
31. Freitag L, Firusian N, Stamatis G, Greschuchna D: The role of bronchoscopy in pulmonary complications due to mustard gas inhalation. Chest. 1991;100:1436-1441.
32. Houghton PJ, Zarka R, De las Heras B, Hoult JR: Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipidperoxidation. Planta Med. 1995;61:33-36.
33. Ali BH, Blunden G: Pharmacological and toxicological properties of Nigella sativa. Phytother Res. 2003;17:299-305.
34. Kumar O, Sugendran K, Vijayaraghavan R: Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes. Chem Biol Interact. 2001;134:1-12.
35. Mokry J, Mokra D, Antosova M, et al: Dexamethasone Alleviates Meconium-Induced Airway Hyperresponsiveness and Lung Inflammation in Rabbits. Pediatr Pulmonol. 2005;41:55-60.
36. Peng CT, Lin C, Lin YJ, et al: Early Dexamethasone Therapy and Blood Cell Count in Preterm Infants. Pediatr. 1999;104:476-481.
37. Wormser U, Brodsky B, Sintov A: Skin toxicokinetics of mustard gas in the guinea pig: effect of hypochlorite and safety aspects. Arch Toxicol. 2002;76:517-522.
38. Brennan RJ, Waeckerle JF, Sharp TW, Lillibridge SR: Chemical warfare agents: emergency medical and emergency public health issues. Ann Emerg Med. 1999;34:191-204.
39. Langenberg JP, Schans GP, Spruit HET: Toxicokinetics of sulfur mustard and its DNA-adducts in the hairless guinea pig. Drug Chem Toxicol. 1998;21:131-147.