Protective effect of Aloe vera L. gel against sulphur mustard-induced systemic toxicity and skin lesions

Indian Journal of Pharmacology

Volumn 37, Issue 2, 2005, Pages 103-110

  Anshoo, G ^a   Singh, S ^a   Kulkarni, A S ^a   Pant, S C ^a   Vijayaraghavan, R ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Aloe vera gel; Glutathione; Malondialdehyde; Oxidative stress

Indexed keywords

ALOE VERA EXTRACT; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEMOGLOBIN; MALONALDEHYDE; MUSTARD GAS;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLISTER; CONTROLLED STUDY; DRUG SCREENING; ERYTHROCYTE COUNT; FEMALE; HEMOGLOBIN DETERMINATION; HISTOPATHOLOGY; LD 50; LEUKOCYTE COUNT; LIVER INJURY; LIVER PROTECTION; MOUSE; NONHUMAN; OXIDATIVE STRESS; SKIN DEFECT; SKIN PROTECTION; SKIN SURFACE; SKIN TOXICITY; SPLEEN INJURY;

EID: 17444404152     PISSN: 02537613     EISSN: None     Source Type: Journal    
DOI: 10.4103/0253-7613.15110     Document Type: Article

References (31)

1. Eisenmenger W, Drasch G, Von Clarmann M, Kretschmer E, Roider G. Clinical and morphological findings on mustard gas (bis[2-chloroethyl] sulphide) poisoning. J Forensic Sci 1991;36:1688-98.
2. Papirmeister B, Feister AJ, Robinson SI, Ford RD. Medical defense against mustard gas: Toxic mechanisms and pharmacological implications. Boca Raton: CRC Press; 1991.
3. Somani SM, Babu SR. Toxicodynamics of sulfur mustard. Int J Clin Pharmacol Ther Toxicol 1989;27:419-35.
4. Pechura CM, Rall DP. Veterans at risk: The health effects of mustard gas and lewisite. Washington DC: National Academy Press; 1993.
5. Dacre JC, Goldman M. Toxicology and pharmacology of the chemical warfare agent sulfur mustard. Pharmacol Rev 1996;48:289-326.
6. Vijayaraghavan R, Sugendran K, Pant SC, Husain K, Malhotra RC. Dermal intoxication of mice with bis (2-chloroethyl) sulphide and the protective effect of flavonoids. Toxicology 1991;69:35-42.
7. Kumar O, Sugendran K, Vijayaraghavan R. Protective effect of various antioxidants on the toxicity of sulphur mustard administered to mice by inhalation or percutaneous routes. Chemical Biol Interact 2001;134:1-12.
8. Yagi A, Kabash A, Okamura N, Haraguchi H, Moustafa SM, Khalifa TI. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Planta Med 2002;68:957-60.
9. Kaufman T, Kalderon N, Ullmann Y, Berger J. Aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled study. J Burn Care Rehabil 1988;9:156-9.
10. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
11. Izzo AA, Sautebin L, Borrelli F, Longo R, Capasso F. The role of nitric oxide in Aloe-induced diarrhoea in the rat. Eur J Pharmacol 1999;368:43-8.
12. Gad SC, Weil CS. Statistics for toxicologists. In: Hayes AW, editor. Principles and Methods of Toxicology. 2nd ed. New York: Raven Press; 1989. p 463-7.
13. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978;52: 302-10.
14. Hisin PJ, Hilf R. A fluorometric method for determination of oxidised and reduced glutathione in tissues. Anal Biochem 1976;74:214-26.
15. Mcmanus FA, Mowry RW. Staining methods. In: Histology and Histochemistry. Hoeber PB, editor. New York: Harper and Brothers; 1965.
16. Vijayaraghavan R, Kumar P, Joshi U, Raza SK, Lakshmana Rao PV, Malhotra RC, et al. Prophylactic efficacy of amifostine and its analogues against sulphur mustard toxicity. Toxicology 2001;163:83-91.
17. Atkins KB, Lodhi IJ, Hurley IL, Hinshaw DB. N-acetylcysteine and endothelial cell injury by sulfur mustard. J Appl Toxicol 2000;20 Suppl 1:125-8.
18. Gross CL, Innace JK, Hovatter RC, Meier HL, Smith WJ. Biochemical manipulation of intracellular glutathione levels influences cytotoxicity to isolated human lymphocytes by sulfur mustard. Cell Biol Toxicol 1993;9:259-67.
19. Saada HN, Ussama ZS, Mahdy AM. Effectiveness of Aloe vera on the antioxidant status of different tissues in irradiated rats. Pharmazie. 2003;58:929-31.
20. Vijayaraghavan R, Kulkarni AS, Pant SC, Kumar P, Lakshmana Rao PV, Gupta N, et al. Differential toxicity of sulfur mustard administered through percutaneous, subcutaneous and oral routes. Toxicol Appl Pharmacol. In press, 2004.
21. Vijayaraghavan R, Kumar P, Dubey DK, Singh R. Evaluation of CC2 as a decontaminant in various hydrophilic and lipophilic formulations against sulphur mustard. Biomed Environ Sci 2001;15:25-35.
22. Vijayaraghavan R, Kumar P, Dubey DK, Singh R, Sachan AS, Kumar D, et al. Acute toxicity studies of CC2: An effective chemical decontaminant of sulphur mustard in hydrophilic formulation. Indian J Pharmacol 2002;34:321-31.
23. Sugendran K, Pravin Kumar, Vijayaraghavan R. Treatment of sulphur mustard poisoning - a review. Defence Sci J 1998;48:155-62.
24. Wormser U, Sintov A, Brodsky B, Casillas RP, Nyska A. Protective effect of topical iodine containing anti-inflammatory drugs aganist sulfur mustard induced skin lesions. Arch Toxicol 2004;78:156-66.
25. Hu Y, Xu J, Hu Q. Evaluation of antioxidant potential of Aloe vera (Aloe barbadensis miller) extracts. J Agric Food Chem 2003;51:7788-91.
26. Davis RH, Leitner MG, Russo JM, Byrne ME. Wound healing, oral and topical activity of Aloe vera. J Am Podiatr Med Assoc 1989;79:559-62.
27. Chauhan RS, Murthy LV, Pant SC. Electron microscopic study of guinea pig skin exposed to sulphur mustard. Bull Environ Contam Toxicol 1995;55:50-7.
28. Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Mol Cell Biochem 1998;181:71-6.
29. Somboonwong J, Thanamittramanee S, Jariyapongskul A, Patumraj S. Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. J Med Assoc Thai 2000;83:417-25.
30. Williams MS, Burk M, Loprinzi CL, Hill M, Schomberg PJ, Nearhood K, et al. Phase III double-blind evaluation of an Aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9.
31. Heggie S, Bryant GP, Tripcony L, Keller J, Rose P, Glendenning M, et al. A Phase III study on the efficacy of topical Aloe vera gel on irradiated breast tissue. Cancer Nurs 2002;25:442-51.