Toxicology and pharmacology of the chemical warfare agent sulfur mustarda

Pharmacological Reviews

Volumn 48, Issue 2, 1996, Pages 289-326

  Dacre, Jack C ^a   Goldman, Max ^a  

^a U States Army Biomed R D Lab   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUSTARD GAS;

ARTICLE; CHEMICAL WARFARE; DRUG EFFECT; ENDOCRINE DISEASE; EYE TOXICITY; GASTROINTESTINAL TOXICITY; HUMAN; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT INJURY; SKIN TOXICITY; TOXICITY;

ALKYLATION; ANIMALS; ANTIDOTES; CARCINOGENS; CHEMICAL WARFARE AGENTS; DERMATOLOGIC AGENTS; DIGESTIVE SYSTEM; EMBRYONIC AND FETAL DEVELOPMENT; ENDOCRINE GLANDS; EYE; HUMANS; MUSTARD GAS; MUTATION; NEOPLASMS; NERVOUS SYSTEM; RESPIRATORY SYSTEM; SKIN; SKIN ABSORPTION;

EID: 0029931420     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (349)

1. AASTED, A., WULF, H. C., DARRE, E., AND NIEBUHR, E.: Fishermen exposed to mustard gas: clinical experience and assessment of risk of developing cancer. Ugeskr. Laeg. 147: 2213-2216, 1985.
2. ABELL, C. W., ROSINI, L. A., AND RAMSEUR, M. R.: Alkylation of polyribonucleotides: the biological, physical, and chemical properties of alkylated polyuridylic acid. Proc. Natl. Acad. Sci. USA 54: 608-614, 1965.
3. AINSWORTH, M.: The importance of the blink reflex in liquid mustard gas burns of the eye. Porton Report No. 2687: A.3004, Chemical Defence Experimental Station, Porton, Great Britain, May 31, 1945.
4. ALEKSANDROV, V. N.: Toxic agents. In Otravlyayushchiue veshchestva: order of the red banner of labor military publishing house of the ministry of defense USSR, Moscow, vol. 48748, pp. 92-122, Translated by the Joint Publication Research Service, JPRS, 1969.
5. ALEXANDER, P.: Comparison of the mode of action by which some alkylating agents and ionizing radiations kill mammalian cells. Ann. NY Acad. Sci. 163: 652-675, 1969.
6. ALEXANDER, S. F.: Medical report of the Bari Harbor mustard casualties. Mil. Surg. 101: 1-17, 1947.
7. ANDRZEJEWSKI, S., AND SCIANOWSKI, J.: Recovery pattern of lactate dehydrogenase (LDH) total activity changes induced with sulphur mustard in internal organ tissue and serum of rats. Bull. Acad. Pol. Sci. Series Sci. Biol. 23: 773-776, 1975.
8. ANDRZEJEWSKI, S., AND SCIANOWSKI, J.: Investigations on the toxic influence of sulphur yperite on selected internal rat organs and a histoautoradiographic assay of its distribution in internal organs damaged earlier with sulphur yperite. Patologia Polska 29: 51-60, 1978.
9. ANSLOW, W. P., JR., AND HOUCK, C. R.: Systemic pharmacology and pathology of sulfur and nitrogen mustards. In Chemical Warfare Agents and Related Chemical Problems. Chapter 22: Summary technical report of division 9, pp. 440-478, National Defense Research Committee, Washington, DC, 1946.
10. ANSLOW, W. P., JR., KARNOFSKY, D. A., JAGER, B. V., AND SMITH, H. W.: The intravenous, subcutaneous and cutaneous toxicity of bis(β-chloroethyl)sulfide (Mustard Gas) and of various derivaties. J. Pharmacol. Exp. Ther. 93: 1-9, 1948.
11. ATKINSON, W. S.: Delayed keratitis due to mustard gas (dichlorodiethyl sulfide burns): report of two cases. Arch. Ophthalmol. 40: 291-301, 1948.
12. AUERBACH, C.: The induction by mustard gas of chromosomal instabilities in Drosophila melanogaster. Proc. Roy. Soc. Edinb. Sect. B (Biol) B62: 307-320, 1947.
13. AUERBACH, C.: Mutagenic effects of alkylating agents. Ann. NY Acad. Sci. 68: 731-749, 1958.
14. AUERBACH, C., AND FALCONER, D. S.: A new mutant in the progeny of mice treated with nitrogen mustard. Nature (Lond.) 163: 678-679, 1949.
15. AUERBACH, C., AND MOSER, H.: Production of mutations by monochloro-mustards. Nature (Lond.) 116: 1019-1020, 1950.
16. AUERBACH, C., AND ROBSON, J. M.: Chemical production of mutations. Nature (Lond.) 157: 302, 1946.
17. AUERBACH, C., AND ROBSON, J. M.: The production of mutations by chemical substances. Proc. Roy. Soc. Edinb. Sect. B (Biol.) B62: 271-283, 1947a.
18. AUERBACH, C., AND ROBSON, J. M.: Tests of chemical substances for mutagenic action. Proc. Roy. Soc. Edinb. Sect. B. (Biol.) B62: 284-291, 1947b.
19. AUERBACH, C., ROBSON, J. M., AND CARR, J. G.: The chemical production of mutations. Science (Wash. DC) 105: 243-247, 1947.
20. AVERY, O. T., MACLEOD, C. M., AND MCCARTHY, M.: Studies on the chemical nature of the substance inducing transformation of pneumococcal types. Induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. J. Exp. Med. 79: 137-157, 1944.
21. BACQ, Z. M., AND ALEXANDER, P.: Importance of radioprotection of the reaction of cells to sulphydryl and disulfide compounds. Nature (Lond.) 203: 162-164, 1964.
22. BALL, E.: A study of the composition of the blood and urine of rabbits and rats as affected by the administration of H. National Defense Research Committee, Washington, DC, Division 9, OSRD 3923, June 1944.
23. BARRON, E. S. G., BARTLETT, G. R., AND MILLER. Z. B.: The effect of nitrogen mustards on enzymes and tissue metabolism, I: the effect on enzymes. J. Exper. Med. 87: 489-501, 1948.
24. BEEBE, G. W.: Lung cancer in World War I veterans: possible relation to mustard-gas injury and 1918 influenza epidemic. J. Nat. Cancer Inst. 25: 1231-1252, 1960.
25. 2+ sequestration by the plasma membrane fraction from rat liver. FEBS Lett. 163: 136-139, 1983.
26. BERENBAUM, M. C.: The effect of cytotoxic agents on the production of antibody to T.A.B. vaccine in the mouse. Biochem. Pharmacol. 11: 29-44, 1962.
27. BERENBLUM, I.: The modifying influence of dichloroethyl sulfur on the induction of tumors in mice by tar. J. Path. Bact. 32: 425-434, 1929.
28. BERENBLUM, I.: The anti-carcinogenic action of dichloroethylsulphide (mustard gas). J. Path. Bact. 34: 731-746, 1931.
29. BERENBLUM, I.: Experimental inhibition of tumor induction by mustard gas and other compounds. J. Path. Bact. 40: 549-558, 1935.
30. BERENBLUM, I. AND SCHOENTAL, R.: Action of mustard-gas (ββ′-dichlorodiethylsulphide) on nucleoproteins. Nature (Lond.) 159: 727-729, 1947.
31. BERENBLUM, I., KENDAL, L. P., AND ORR, J. W.: Tumor metabolism in the presence of anti-carcinogenic substances. Biochem. J. 30: 709-715, 1936.
32. BERENS, C., AND HARTMANN, E.: The effect of war gases and other chemicals on the eyes of the civilian population. Bull. NY Acad. Med. 19: 356-367, 1943.
33. BERGER, N. A., SIKORSKI, G. W., PETZOLD, S. J. AND KUROHARA, K. K.: Association of pol (adenosine diphosphorebase) syntheses with DNA damage and repair in normal human lymphoytes. J. Chem. Invest. 63: 1164-1171, 1979.
34. BLACK, S., AND THOMSON, J. F.: Some metabolic effects produced by large doses of di-β-chloroethyl sulfide in rats. J. Biol. Chem. 167: 283-289, 1947.
35. BLEWETT, W. K.: Tactical weapons: is mustard still king? Nuclear, Biological, Chemical Defense and Technology International 1: 64-66, 1986.
36. BODANSKY, O.: Contributions of medical research in chemical warfare to medicine. Science (Wash. DC) 102: 517-521, 1945.
37. BODENSTEIN, D.: The effect of nitrogen mustards on proliferating embryonic tissues. Cancer Res. 7: 49-50, 1947.
38. BODENSTEIN, D., AND KONDRITZER, A. A.: The effects of nitrogen mustards on nucleic acids during embryonic amphibian development. J. Exper. Zool. 107: 109-112, 1948.
39. BONADONNA, G. AND KARNOFSKY, D. A.: Protection studies with sodium thiosulfate against methyl bis (β-chloroethyl) amine hydrochloride (HN2) and its ethylenimonium derivative. Clin. Pharmacol. Ther. 6: 50-64, 1965.
40. BONNEFON, G.: L'oeil yperite' son traitement. Gaz. Hebd. D. Sc. Med. de Bordeaux 60: 168, 1939.
41. BOURSNELL, J. C., FRANCIS, G. E., AND WORMALL, A.: Studies on mustard gas (ββ′-dichlorodiethyl sulphide) and some related compounds. 2. The action of mustard gas, ββ′-dichlorodiethyl sulphone and divinyl sulphone on amino acids. Biochem. J. 40: 737-742, 1946a.
42. BOURSNELL, J. C., COHEN, J. A., DIXON, M., FRANCIS, G. E., GREVILLE, G. D., NEEDHAM, D. M., AND WORMALL, A.: Studies on mustard gas (ββ′-dichlorodiethyl sulphide) and some related compounds. 5. The fate of injected mustard-gas (containing radioactive sulphur) in the animal body. Biochem. J. 40: 756-764, 1946b.
43. BOURSNELL, J. C., FRANCIS, G. E., AND WORMALL, A.: Studies on mustard gas (ββ′-dichlorodiethyl sulphide) and some related compounds. 6. The fate of injected ββ′-dichlorodiethyl sulphone and ββ′-dichlorodiethyl sulphoxide (containing radioactive sulphur) in the animal body. Biochem. J. 40: 765-768, 1946c.
44. BOYLAND, E., AND HORNING, E. S.: The induction of tumors with nitrogen mustard. Br. J. Cancer 3: 118-123, 1949.
45. BRDAR, B.: Induction of plasminogen activator by alkylating agents in a repair defective human glioblastoma cell strain. Cancer Res. 46: 2282-2284, 1986.
46. BROOKES, P., AND LAWLEY, P. D.: The reaction of mono- and di-functional alkylating agents with nucleic acids. Biochem. J. 80: 496-503, 1961.
47. BROOKES, P., AND LAWLEY, P. D.: Effects of alkylating agents on T2 and T4 bacteriophages. Biochem. J. 89: 138-144, 1963.
48. BROWN, E. C., JR.: Pulmonary effects following chronic exposure to HS vapor. Medical Division Report No. 187, U. S. Army Chemical Center, MD: pp. 1-31, 1949.
49. BURCHENAL, J. H., AND RILEY, J. B.: Nitrogen mustards: the relationship between chemical structure and chemotherapeutic activity. Cancer Res. 9: 553-554, 1949.
50. BURCHENAL, J. H., LESTER, R. A., RILEY, J. B., AND RHOADS, C. P.: Studies on the chemotherapy of leukemia. I. Effect of certain nitrogen mustards and carbamates on transmitted mouse leukemia. Cancer 1: 399-411, 1948.
51. BURCHENAL, J. H., BURCHENAL, J. R., AND JOHNSTON, S. F.: Chemotherapy of leukemia. III. Further studies on the effect of nitrogen mustards and related compounds on transmitted mouse leukemia. Cancer 4: 353-356, 1951.
52. BURTON, N. K., AND AHERNE, G. W.: Sensitive measurement of glutathione using isocratic high-performance liquid chromatography with fluorescence detection. J. Chromatogr. 382: 253-257, 1986.
53. BUSCHER, H.: Green and yellow cross. R. Himmelheber and Co., Hamburg, Germany, 1931. Translated from the German by N. Conway, Kettering Laboratory of Applied Physiology, College of Medicine, University of Cincinnati, Cincinnati, OH, pp. i-xi, 1-156, 1944.
54. BUTLER, J. A. V., GILBERT, L. A., AND SMITH, K. A.: Radiomimetic action of sulfur and nitrogen 'mustards' on deoxyribonucleic acid. Nature (Lond.) 165: 714-716, 1950.
55. CALLAWAY, S., AND PEARCE, K. A.: Protection against systemic poisoning by mustard gas, di(2-chloroethyl) sulphide, by sodium thiosulphate and thiocit in the albino rat. Br. J. Pharmacol. 13: 395-398, 1958.
56. CANELLI, A. F.: Contributo alia conoscenza dell'intossicazione acuta da "yprite" ed in particolare del suo reperto anatomo-patologico. Rivista Ospedaliera Italiana 8: 2-7, 1918.
57. - murine leukemia. Mutation Res. 21: 6, 1973.
58. - murine leukemia in vitro and in a host-mediated assay. Cancer Res. 34: 3073-3082, 1974.
59. CARDOZO, R. H., AND EDELMAN, I. S.: The volume of distribution of sodium thiosulfate as a measure of the extracellular fluid space. J. Clin. Invest. 31: 280-290, 1952.
60. CASE, R. A. M., AND LEA, A. J.: Mustard gas poisoning, chronic bronchitis, and lung cancer. An investigation into the possibility that poisoning by mustard gas in the 1914-1918 war might be a factor in the production of neoplasia. Brit. J. Prev. Soc. Med. 9: 62-72, 1955.
61. CATALINE, N., GIBERTINI, G., MARGOTTA, V., AND FILONE, S.: Comparative study of the biological effects of x-rays and of mustard gas (ββ′-dichlorodiethylsulfide) on the thymus of young rats. Atti Acad. Naz. Lincei Rend. Cl. Sci. Fis. Mat. Nat. 51: 81-92, 1971.
62. CHANUTIN, A.: Physiological mechanisms of chemical warfare agents. Informal Progress Report No.2, Biochemical Laboratory, University of Virginia, Charlottesville, NC, Oct. 15, 1944.
63. CHANUTIN, A., AND LUDEWIG, S.: The effect of β-chloroethyl vesicants, thermal injury, and turpentine on plasma fibrin, cholesterol, and sugar of dogs and rats. J. Biol. Chem. 167: 313-320, 1947.
64. CHIESMAN, W. E.: Diagnosis and treatment of lesions due to vesicants. Brit. Med. J. 2: 109-112, 1944.
65. 35-labelled mustard gas in the body studied by means of whole body autoradiography in mice. Acta Radiologica 1: 3-7. 1963.
66. CONNORS, T. A.: Protection against the toxicity of all alkylating agents by thiols: the mechanism of protection and its relevance to cancer chemotherapy. Europ. J. Cancer 2: 293-305, 1966.
67. CONNORS, T. A., JENEY, A., AND JONES, M.: Reduction of the toxicity of 'radiomimetic' alkylating agents in rats by thiol pretreatment: the mechanism of the proctective action of thosulphate. Biochem. Pharmacol. 13: 1545-1550, 1964.
68. CORDIER, D., AND CORDIER, G.: Etude du mode d'action de l'yperite (sulfure d'ethyle dichlore) sur le systeme cardio-vasculaire: effet des produits d'hydrolyse de l'yperite. Compt. Rend. Soc. Biol. 144: 540-542, 1950.
69. COWLES, S. R.: Cancer of the larynx: occupational and environmental associations. South. Med. J. 76: 894-898, 1983.
70. CRATHORN, A. R., AND ROBERTS, J. J.: Mechanism of the cytotoxic action of alkylating agents in mammalian cells and evidence for the removal of alkylated groups from deoxyribonucleic acid. Nature (Lond.) 211: 150-153, 1966.
71. CULLUMBINE, H.: Medical aspects of mustard gas poisoning. Nature (Lond.) 159: 151-153, 1947.
72. CULLUMBINE, H.: The physiological and biochemical disturbances produced by war gases. Brit. Med. Bull. 10: 18-21, 1954.
73. DACRE, J. C., AND BURROWS, W. D.: Recommended field drinking water criteria for chemical agent sulfur mustard. Technical Report 8816. U.S. Army Biomedical Research and Development Laboratory, Fort Detrick, Frederick, MD, Dec. 1988.
74. DAHL, H., GLUUD, B., VANGSTED, P., AND NORN, M.: Eye lesions induced by mustard gas. Acta Ophthalmol. 63 (suppl. 173): 30-31, 1985.
75. DAILY, L. E., CLARK, J. W., STOLP, B. N. CONNER, J. C., BORGSTROM, P., AND VAN KEUREN, A. H.: A controlled laboratory experiment to compare lesions resulting from application of mustard, lewisite, and nitrogen mustards to the skin of the forearms of humans. NRL Report No. P-2364, Naval Research Laboratory, Naval Medical Research Institute, Bethesda, MD, 1944.
76. DANFORTH, C. H., AND CENTER, E.: Nitrogen mustard as a teratogenic agent in the mouse. Proc. Soc. Exper. Biol. Med. 86: 705-707, 1954.
77. DANNENBERG, A. M., JR.: Sulfur mustard (SM) lesions in organ-cultured human skin: markers of injury and inflammatory mediators. Annual Report prepared under U. S. Army Medical Research and Development Command, Contract No. DAMD17-87-C-7040, AD A202373, Mar. 1988.
78. DANNENBERG, A. M., JR., AND VOGT, R. F., JR.: Pathogenesis and treatment of skin lesions caused by sulfur mustard. DTIC Technical Report Program No. 3E162780A, U. S. Army Medical Research and Development Command, Contract No. DAMD17-80-C-0102, Aug. 1981.
79. DANNENBERG, A. M., JR., NAKAMURA, M., MOORE, K. G., AND PULA, P. J.: Basic research studies on the pathogenesis of dermal sulfur mustard lesions. In: Proceedings of the Sixth Medical Chemical Defense Bioscience Review, pp. 751-754, U. S. Army Medical Research and Development Command, (U. S. Army Medical Research Institute of Chemical Defense), Aug. 1987.
80. DARLINGTON, C. D., AND KOLLER, P. C.: The chemical breakage of chromosomes, Heredity 1: 187-221, 1947.
81. DAVISON, C., ROZMAN, R. S., BLISS, L., AND SMITH, P. K.: Studies on the metabolic fate of bis(2-chloromethyl)sulfide (mustard gas) in the mouse and human. Proc. Am. Assoc. Cancer Res. 2: 195, 1957.
82. DAVISON, C., ROZMAN, R. S., AND SMITH, P. K.: Metabolism of bis-β-chloroethyl sulfide (sulfur mustard gas). Biochem. Pharmacol. 7: 65-74, 1961.
83. DESPRETZ, M.: Des composes triples du chlore. Ann. Chem. Phys. 21: 438, 1822.
84. DICKMAN, S.: Nerve gas cloud hangs over West German farms. Nature (Lond.) 332: 573, 1988.
85. 2+ homeostasis. Arch. Biochem. Biophys. 253: 343-346, 1984.
86. DIXON, M., AND NEEDHAM, D. M.: Biochemical research on chemical warfare agents. Nature (Lond.) 158: 432-438, 1946.
87. DUSTIN, P.: Some new aspects of mitotic poisoning. Nature (Lond.) 159: 794-797, 1947.
88. DUTRA, F. A., HENRIQUES, F. C., JR., MORTIZ, A. R., BREYFOGLE, H. S., AND PATTERSON, L. A.: The mechanism of cutaneous injury by mustard gas an experimental study using mustard prepared with radioactive sulphur. National Defense Research Committee, Washington, DC, Division 9, OSRD 3620, May 9, 1944.
89. DZIEMIAN, A. J.: The effects of the intravenous administration of H on the carbohydrate metabolism of dogs. Medical Division Report No. 60, U.S. Army Service Forces, Office of the Chief, Chemical Warfare Service, Washington, DC, pp. 1-20, 14 Dec. 1945.
90. EASTON, D. F., PETO, J., AND DOLL, R.: Cancers of the respiratory tract in mustard gas workers. Brit. J. Indust. Med. 45: 652-659, 1988.
91. EKLOW, L., MOLDEUS, P., AND ORRENIUS, S.: Oxidation of glutathione during hydroperoxide metabolism: a study using isolated hepatocytes and glutathione reductase inhibitor 1,3-bis(2-chloroethyl)-1-nitrosurea. Eur. J. Biochem. 138: 459-463, 1984.
92. ELMORE, D. T., GULLAND, J. M., JORDAN, D. O., AND TAYLOR, H. F. W.: The reaction of nucleic acids with mustard gas. Biochem. J. 42: 308-316, 1948.
93. FAHMY, O. G., AND FAHMY, M. J.: Mutagenicity in the sperm of Drosophila and the structure of the nitrogen mustard molecule. Heredity 15: 115-128, 1960.
94. FAHMY, O. G., AND FAHMY, M. J.: Mutability at specific euchromatic and heterochromatic loci with alkylating and nitroso compounds in Drosophila melagogaster. Mutation Res. 13: 19-34, 1971.
95. FAHMY, O. G., AND FAHMY, M. J.: Mutagenic selectivity for the RNA-forming genes in relation to the carcinogenicity of alkylating agents and polycyclic aromatics. Cancer Res. 32: 550-557, 1972.
96. FAIRLEY, A.: Chemical Board Notes F 720-729 of the Physiological subcommittee held on Apr. 15, 1943, National Defense Research Commitee, Washington, DC, Division 9, B-3105, Y.4469, 1943.
97. FASTH, A., AND SORBO, B.: Protective effect of thiosulfate and metabolic thiosulfate precursors against toxicity of nitrogen mustard (HN2). Biochem. Pharmacol. 22: 1337-1351, 1973.
98. FELL, H. B., AND ALLSOPP, C. B.: The action of mustard gas (ββ′-dichlorodiethylsulphide) on living cells in vitro. I. The immediate cytological effects of mustard gas and its hydrolysis products. II. The effect on cell growth of adding small concentrations of mustard to the culture medium. Cancer Res. 8: 145-161, 1948a.
99. FELL, H. B., AND ALLSOPP, C. B.: The effect of repeated applications of minute quantities of mustard gas (ββ′-dichloroethylsulphide) on the skin of mice. Cancer Res. 8: 177-181, 1948b.
100. FOSTER, J. H., LEWIS, M. R., AND JACOBS, J. K.: Thiosulfate protection against the toxic effects of nitrogen mustard in perfusion of the liver. Am. Surg. 28: 461-464, 1962.
101. FOX, M., AND SCOTT, D.: The genetic toxicology of nitrogen and sulphur mustards. Mutation Res. 75: 131-168, 1980.
102. FRIEDBERG, K., MENGELAND, K. AND SCHLECK, E.: The action of azimexone of the cells of the hemopoietic system in mice especially after damage with x-rays, Radiat. Environ. 22: 117-131, 1983.
103. FRIEDENWALD, J. S., AND WOODS, A. C.: Studies on the physiology, biochemistry, and cytopathology of the cornea in relation to injury by mustard gas and allied toxic agents. I. Introduction and outline. Bull. Johns Hopkins Hosp. 82: 81-101, 1948.
104. FUJITA, M.: Study on the genetic effects of sulfur mustard gas exposure using variant proteins as indicators. Med. J. Hiroshima Univ. (Japanese, English Abstract), 35: 305-339, 1987.
105. FUJITA, M., GORIKI, K., SATOH, C., HAMILTON, H. B., YAMAKIDO, M., INAMIZU, T., ONARI, K., NISHIMOTO, Y., AND SHIGENOBU, T.: Study of genetic effects of occupational exposure to mustard gas (1). Jap. J. Human Genet. 28: 109, (Abstract A8), 1983.
106. GATES, M., AND MOORE, S.: Mustard gas and other sulfur mustards. In: Chemical Warfare Agents and Related Chemical Problems. Part 1. Summary technical report of Division 9, National Defense Research Committee, Washington, DC. pp. 30-58, 1946.
107. GEERAETS, W. J., ABEDI, S., AND BLANKE, R. V.: Acute corneal injury by mustard gas. South. Med. J. 70: 348-350, 1977.
108. GIBSON, P. B., BRINK, R. A., AND STAHMANN, M. A.: The mutagenic action of mustard gas on Zea mays. J. Hered. 41: 232-238, 1950.
109. GILLE, R.: Pathozenese, klinik und therepie der resorptivem allegemeinschadegung durch hautschadgende kampfstoffe. Zach. Militaermed. 2: 94-99, 1969.
110. GILMAN, A.: The initial Clinical trial of nitrogen mustard. Am. J. Surg. 105: 574-578, 1963.
111. GILMAN, A., AND PHILIPS, F. S.: The biological actions and therapeutic applications of the β-chloroethyl amines and sulfides. Science (Wash. DC) 103: 409-415, 436., 1946.
112. GILMAN, A., GOODMAN, L., AND PHILIPS, F. S.: Pharmacodynamics of #1330 and its transformation products and the antidotal value of sodium thiosulfate. OSRD Contract OEM-CMR-51, Technical Library, Edgewood Arsenal, Edgewood, MD, 1942.
113. GILMAN, A., PHILIPS, F. S., AND KOELLE, E. S.: The renal clearance of thiosulfate with obersvations on its volume distribution. Am. J. Physiol. 146: 348, 1946.
114. GIRAUD, A.: Les premiers symptomes de l'intoxication par les gaz "moutarde". J. Med. Chirurg. Prat. 78: 890-894, 1917.
115. GOLDACRE, R. J., LOVELACE, A., AND Ross, W. C. J.: Mode of production of chromosome abnormalities by the nitrogen mustards: the possible role of cross-linking. Nature (Lond.) 163: 667-669, 1949.
116. GOLDMAN, M., AND DACRE, J. C.: Lewisite: Its chemistry, toxicology, and biological effects. Rev. Environ. Contamin. Toxicol. 110: 75-115, 1989.
117. GRAEF, I., JAGER, V. B., KARNOFSKY, D. A., AND SMITH, H. W.: The comparative systemic effects of mustard and the nitrogen mustards (HN1, HN2, HN3) in rats. Formal Progress Report Contract OEM-556, Medical Division, Chemical Warfare Service, Division 9, National Defense Research Committee, Office of Scientific Research and Development, OSRD 5180, May 1, 1945.
118. GRAEF, I., KARNOFSKY, D. A., JAGER, V. B., KRICHESKY, B., AND SMITH, H. W.: The clinical and pathological effects of nitrogen and sulphur mustards in laboratory animals, Am. J. Path. 24: 1-47, 1948.
119. GRANT, V. M.: Toxicology of the Eye, 3rd ed. pp. 383, 562, 643-645. Charles C. Thomas Publishers, Springfield, IL, 1986.
120. GRIFFIN, A. C., BRANDT, E. L., AND TATUM, E. L.: Induction of tumors with nitrogen mustards. Cancer Res. 11: 253, 1951.
121. GROSS, C. L., WATSON, C. V., PETRALI, J., AND PAPIRMEISTER, B.: Effect of sulfur mustards on lysosomes from rat liver in vitro. Toxicol. Appl. Pharmacol. 61: 147-151, 1981.
122. GROSS, C. L., MEIER, H. L., PAPIRMEISTER, B., BRINKLEY, F. B., AND JOHNSON, J. B.: Sulfur mustard lowers nicotenamide adenine dinucleotide concentrations in human skin grafted to athymic nude mice. Toxicol. Appl. Pharmacol. 81: 85-90, 1985.
123. HABER, L.: The Poisonous Cloud, Clarendon Press, Oxford, England, 1986.
124. HACKETT, P. L., ROMMEREIM, R. L., BURTON, F. G., BUSCHBOM, R. L., AND SASSER, L. B.: Teratology studies on Lewisite and sulfur mustard agents: effects of sulfur mustard in rats and rabbits. Final Report. AD A187495, Pacific Northwest Laboratory, Richland, WA, Sept 1987.
125. HADDOW, A.: The chemical and genetic mechanisms of carcinogenesis. II. Biologic alkylating agents. In: The Physiopathology of cancer, Ed. by F. Homburger, 2nd ed., pp. 602-685, Hoeber-Harper, New York, 1959.
126. HADDOW, A.: On the biological alkylating agents. In: Perspectives in Biology and Medicine, vol. 16, pp. 503-524. The University of Chicago Press, Chicago, IL, 1973.
127. 35S-sulphur mustard in rat and comparison with human blood in vitro. Xenobiotica 23: 537-561, 1993.
128. HARRINGTON D. G.: Development of a safe and effective skin decontamination system: a progress report. In Proceedings of the vesicant workshop, Columbia, MD, Feb. 1987, USAMRICD-SP-87-03. U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, AD A188-222, pp. 85-90, 1987.
129. HASKIN, D.: Some effects of nitrogen mustard on the development of external body form in the fetal rat. Anat. Rec. 102: 493-511, 1948.
130. HASSETT, C. C.: Study of long-term human and ecological effects of chemical weapons systems. CRDL Special Publication 2-52. U.S. Army Chemical Research and Development Laboratories, Edgewood Arsenal, MD, Apr. 1963.
131. HATIBOGLU, I.: Prevention of the toxicity of nitrogen mustard (HN2) by sodium thiosulfate (ST). Proc. Am. Assoc. Cancer Res. 3: 117, (Abstract-105) 1960.
132. HAYES, A. W., CHAN, P. K., O'HARA, G. P., SMITH, J. M., AND KOPCHIK, R.: A toxicological program for evaluating the safety of a chemical warfare decontaminant. Fund. Appl. Toxicol. 4: S145-S149, 1984.
133. HELLMANN, U.: Katamnestische Studien an Kampfstoffgeschadigten Personen unter besonderer Berucksichtigung psychiatrischer spat-und Dauerschaden, Ph.D. thesis, University of Marburg, Marburg, Germany, 1970a.
134. HELLMANN, W.: Klinisch-genetische Untersuchungen an Familien von durch N- und S-Lost chemisch gewerblich Geschadigten, Ph.D. thesis, University of Marburg, Marburg, Germany, 1970b.
135. HERRIOTT, R. M.: Inactivation of viruses and cells by mustard gas. J. Gen. Physiol. 32: 231-239, 1948.
136. HESTON, W. E.: Induction of pulmary tumors in strain A mice with methylbis(β-chloroethyl)amine hydrochloride. J. Natl. Cancer Inst. 10: 125-130, 1949.
137. HESTON, W. E.: Carcinogenic action of the mustards. J. Natl. Cancer Inst. 11: 415-423, 1950.
138. HESTON, W. E.: Pulmonary tumors in strain A mice exposed to mustard gas. Proc. Soc. Exp. Biol. Med. 82: 457-460, 1953a.
139. HESTON, W. E.: Occurrence of tumors in mice injected subcutaneously with sulfur mustard and nitrogen mustard. J. Natl. Cancer Inst. 14: 131-140, 1953b.
140. HEYNDRICKX, A, AND HEYNDRICKX, B.: Treatment of Iranian soldiers attacked by chemical and microbiological war gases. Arch. Belg. Med. Soc., D. Hyg. Med. Trav. Med. Leg. (suppl.): 157-159, 1984.
141. HIGUCHI, K., KAJIKI, A., NAKAMURA, M., HARADA, S., PULA, P. J., SCOTT, A. L., AND DANNENBERG, A. M., JR.: Proteases released in oxygen culture by acute dermal inflammatory lesions produced in vivo in rabbit skin by sulfur mustard: hydrolysis of synthetic peptide substrates for trypsin-like and chymotrypsin-like enzymes. Inflammation 12: 311-334, 1988.
142. HIRONO, M., SUEHIRO, S., HIRAI, T., NIIMOTO, M., AND HATTORI, T.: Early gastric cancer with widespread lymph node metastasis; a case report. Jpn. J. Surgery 14: 143-145, 1984.
143. HOCKENHULL, D.: Mustard gas mutations in Aspergilius nedulans. Nature (Lond.) 161: 100, 1948.
144. HOROWITZ, N. H., HOULAHAN, M. B., HUNTGATE, M. G., AND WRIGHT, B.: Mustard gas mutations in Neurospora. Science (Wash. DC) 104: 233-234, 1946.
145. HOUCK, C. R., CRAWFORD, B., BANNON, J. H., AND SMITH, H. W.: Studies on the mechanism of death in dogs after systemic intoxication by the intravenous injection of methyl-bis(β-chloroethyl)amine or tris(β-chloroethyl)amine. J. Pharmacol. Exper. Therap. 91: 277-292, 1947.
146. HUEPER, W. C.: Public health hazards from environmental chemical carcinogens, mutagens and teratogens. Health Phys. 21: 689-707, 1971.
147. HUGHES, W. F., JR.: Mustard gas injuries to the eyes. Arch. Ophthalmol. 27: 582-601, 1942.
148. ILLIG, L.: Die behandling der psoriasis vulgaris mit schwefel lost extern unter besonderer berucksuhtegung-ihru megluchen carcinogenese resikoc. S. Hautkr. 52: 973-987, 1977.
149. INADA, S., HIRAGUN, K., UNEO, R., KANEMITAU, A., AND YAMURA, T.: Clinicopathological studies on skin tumors observed in former workers of a poison gas factory, with special reference to Bowen's disease. Jap. J. Dermatol. 87: 160-161, 1977.
150. INADA, S., HIRAGUN, K., SEO, K., AND YAMURA, T.: Multiple Bowen's disease observed in former workers of a poison gas factory in Japan, with special reference to mustard gas exposure. J. Dermatol. 5: 49-60, 1978.
151. INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (IARC): IARC monographs on the evauation of carcinogenic risk of chemicals in man. Some aziridines, N-, S- & O-mustards and Selenium. 9: 181-192, Lyon, France: International Agency for Research on Cancer, 1975.
152. INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (IARC): LARC monographs on the evaluation of the carcinogenic risk of chemicals to humans. Mustard gas, suppl. 4, pp. 163-164, Lyon, France, IARC, 1982.
153. JACKSON, K. E.: The history of mustard gas. J. Tenn. Acad. Sci. 11: 98-106, 1936.
154. JAGER, V.: The Oral Injection of 1070 by Humans. MRL(EA) Report No. 1, Medical Research Laboratory, Edgewood Arsenal, MD. pp. 1-14, May 18, 1946.
155. JANKOVICH, L.: Beitrage zur hutologic der experimentallon senfgarvergiftung. Internationaler Kongress fur Gerichtliche und Sozeale Medizin Verhandlungebericht. Bonn, 1938.
156. JAPAN TIMES: Toxic chemicals found In Iraqi soil samples, p. 6, 24 Nov. 1988.
157. JELENKO, C., III.: Chemicals that "burn." J. Trauma 14: 65-71, 1974.
158. JENSEN, K. A., KIRK, I., AND WESTERGAARD, M.: Mutagenic activity of some 'mustard gas' compounds. Nature (Lond.) 166: 1020-1021, 1950.
159. 2+ homeostasis. Science (Wash. DC) 217: 1257-1259, 1982.
160. JOHNSEN, B. A., AND BLANCH, J. H.: Analysis of snow samples contaminated with chemical warfare agents. Arch. Belg. Med. Soc. Hyg. Med. Trav. Med. Leg. (suppl.): 22-30, 1984.
161. JOHNSTONE, R. M.: Sulfhydryl agents: arsenicale. In Metabolic Inhibitors, ed. by R. M. Hochester and J. H. Quastel, vol. 2, pp. 99-118, Academic Press, New York, 1963.
162. 2. Arch. Biochem. Biophys. 210: 505-516, 1981.
163. JORGENSEN, B. S., OLESEN, B., BERNTSEN, O.: Accidents with mustard gas near Bornholm. Ugeskr Laeger 147: 2251-2254, 1985.
164. JUSTUS, C., MULLER, S., AND KRAMER, M. D.: A monoclonal antibody recognizing plasminogen and plasmin-altered reactivity in psoriatic lesions. Brit. J. Dermatol. 117: 687-694, 1987.
165. KARNOFSKY, D. A.: Chemotheraphy of neoplastic disease. I. Methods of approach. N. Eng. J. Med. 239: 226-231, 1948a.
166. KARNOFSKY, D. A.: Chemotheraphy of neoplastic disease. II. Trends in experimental cancer therapy. N. Eng. J. Med. 239: 260-270, 1948b.
167. KARNOFSKY, D. A.: Chemotheraphy of neoplastic disease. III. Agents of clinical value. N. Eng. J. Med. 239: 299-305, 1948c.
168. KINDRED, J. E.: Histologic changes occurring in the hemopoietic organs of albino rats after single injection of 2-chloroethyl vesicants: a quantitative study. Arch. Path. 43: 253-295, 1947.
169. KINDRED, J. E.: Nitrogen mustards. Statistical analysis of effects on sarcoma 180 and viscera of normal mice in relation to toxicity and structure. Cancer 2: 1083-1086, 1949a.
170. KINDRED, J. E.: The blood cells and the hemopoietic and other organs of dogs given intravenous injections of 2-chloroethyl vesicants. Arch. Path. 47: 378-398, 1949b.
171. KIRCHER, M., FLUR, R., RUHLAND, A., AND BRENDEL, M.: Biological and chemical effects of mustard gas on yeast. Mutation Res. 63: 273-289, 1979.
172. KLEHR, N. W.: Cutaneous late manifestations in former mustard gas workers. Z. Hantkr. 59: 1161-1170, 1984.
173. KOHLER, F.: Antidotes 6146 (Sodium thiosulphate), Alsbach-Bergstrasse, West Germany, 1989.
174. KOHN, K. W., STEIGBIGEL, N. H., AND SPEARS, C. L.: Cross-linking and repair of DNA in sensitive and resistant strains of E. coli treated with nitrogen mustard. Proc. Nat. Acad. Sci. 53: 1154-1161, 1965.
175. KRUMBHAAR, E. B.: Role of the blood and the bone marrow in certain forms of gas poisoning. I. Peripheral blood changes and their significance. JAMA 72: 39-41, 1919.
176. KRUMBHAAR, E. B., AND KRUMBHAAR, H. D.: The blood and bone marrow of yellow cross gas (mustard gas) poisoning: changes produced in the bone marrow of fetal cases. J. Med. Res. 40: 497-507, 1919.
177. LANDING, B. H., AND EISENBERG, F. F.: Statistical analysis of effects on sarcoma 180 and viscera of normal mice in relation to toxicity and structure. Cancer 2: 1083-1086, 1949.
178. LANDING, B. H., GOLDIN, A., AND NOE, H. A.: Testicular lesions in mice following parenteral administration of nitrogen mustards. Cancer 2: 1075-1082, 1949.
179. LANKS, K. W., TURNBULL, J. D., ALOYO, V. J., DORWIN, J., AND PAPIRMEISTER, B.: Sulfur mustards induce neurite extension and acetylcholinesterase synthesis in cultured neuroblastema cells. Expt. Cell Res. 93: 1-19, 1975.
180. LAUGHLIN, R. C.: Eye examination of factory workers handling H, CN and CG. MRL(EA) Report No. 18, Medical Research Laboratory, Edgewood Arsenal, Edgewood, MD, pp. 1-8, 14 April 1944a.
181. LAUGHLIN, R. C.: Correlation of eye changes in rabbits with CT exposure to H. MRL(EA) Report No. 23, Medical Research Laboratory, Edgewood Arsenal, Edgewood, MD, 12 June 1944b.
182. LAWLEY, P. D.: Effects of some chemical mutagens and carcinogens on nucleic acids. In Prog. Nucl. Acid. Res. Mol. Biol., ed. by J. N. Davidson and W. E. Cohn, vol. 5, pp. 89-131, Academic Press, New York and London, 1966.
183. LAWLEY, P. D., AND BROOKES, P.: Molecular mechanism of the cytotoxic action of difunctional alkylating agents and of resistance to this action. Nature (Lond.) 206: 480-483, 1965.
184. LAWLEY, P. D., LETHBRIDGE, J. H., EDWARDS, P. A., AND SHOOTER, K. V.: Inactivation of bacteriophage T7 by mono- and difunctional sulphur mustards in relation to cross-linking and depurination of bacteriophage DNA. J. Mol. Biol. 39: 181-198, 1969.
185. LAWRENCE, W., JR., TAYAO, M. S., MAHAJAN, D. R., PAGE, R., MILLER, D. G., AND CLAPP, P.: Systemic thiosulfate protection during fractionated regional nitrogen mustard therapy. J. Surg. Res. 4: 483-494, 1964.
186. LINDSTEN, D. C., AND SCHMITT, R. P.: Decontamination of water containing chemical warfare agents. Report 2125, U.S. Army Mobility Equipment Research and Development Center, Fort Belvoir, VA. AD A012630, 1975.
187. LITWINS, J., BOYD, L. J., AND GREENWALD, L.: The action of sodium thiosulphate on the blood. Exper. Med. Surg. 1: 252-259, 1943.
188. LIVINGSTON, P. C., WALKER, H. M.: A study of the effects of liquid mustard gas upon the eyes of rabbits and of certain methods of treatment. Brit. J. Ophthalmol. 24: 67-97, 1940.
189. LOHS, K.: Delayed toxic effects of chemical warfare agents. A SIPRI Monograph, Stockholm International Peace Research Institute (SIPRI), Stockholm, Sweden, 1975.
190. LOVELESS, A.: Qualitative aspects of the chemistry and biology of radiomimetic (mutagenic) substances. Nature (Lond.) 167; 338-342, 1951.
191. LOVELESS, A.: The influence of radiomimetic substances on deoxyribonucleic acid symthesis and function studied in Escherichia coli/phage systems. III. Mutation of T2 bacteriophage as a consequence of alkylation in vitro: the uniqueness of ethylation. Proc. Roy. Soc. Lond. B:150: 497-508, 1959.
192. LOVELESS, A., AND REVELL, S.: New evidence on the mode of action of 'mitotic poisons.' Nature (Lond.) 164: 938-944, 1949.
193. LUDEWIG, S., AND CHANUTIN, A.: The chemical changes in rat adrenals after injection of β-chloroethyl vesicants. Endocrinology 38: 376-384, 1946.
194. LYNCH, V., SMITH, H. W., AND MARSHALL, E. K., JR.: On dichlorethylsulphide (mustard gas). I. The systemic effects and mechanism of action. J. Pharmacol. Expl. Therap. 12: 265-290, 1918.
195. MACKEY, J.: The biological action of mustards on dormant seeds of barley and wheat. Acta Agr. Scand. 4: 412-429, 1954.
196. MAISONNEUVE, A., CALLEBAT, I., DEBORDES, L., AND COPPET, L.: Biological fate of sulphur mustard in rat: toxicokinetics and disposition. Xenobiotica 23: 771-780, 1993.
197. MANDEL, M., AND GIBSON, W. S.: Clinical manifestations and treatment of gas poisoning. JAMA 69: 1970-1971, 1917.
198. MANDL, H., AND FREILINGER, G.: First report on victims of chemical warfare in the Gulf-war treated in Vienna. Arch. Belg. Med. Soc. Hyg. Med. Trav. Med. Leg. 42: 330-340, 1984.
199. MANN, I.: A study of eighty-four cases of delayed mustard gas keratitis fitted with contact lenses. Brit. J. Ophthalmol. 28: 441-447, 1944.
200. MANN, I., AND PULLINGER, B. D.: Experiments on the effect of ascorbic acid in mustard gas burns of the eye. Brit. J. Ophthalmol. 24: 444, 1940.
201. MANN, I., AND PULLINGER, B. D.: A study of mustard gas lesions of the eyes of rabbits and men. Proc. Roy. Soc. Med. 35: 229-244, 1942.
202. MANNING, K. P., SKEGG, D. C. G., STELL, P. M., AND DOLL, R.: Cancer of the larynx and other occupational hazards of mustard gas workers. Clin. Otolaryngol. 6: 165-170, 1981.
203. MARSHALL, E.: Iraq's chemical warfare: case proved. Science (Wash. DC) 224: 130-132, 1984.
204. MARSHALL, E. K., JR.: Mustard gas. JAMA 73: 684-686, 1919.
205. MARSHALL, E. K., JR., AND WILLIAMS, J. W.: The toxicity and skin irritant effect of certain derivatives of dichloroethyl sulfide. J. Pharmacol. Exp. Therap. 16: 259-272, 1920.
206. MARSHALL, E. K., JR., LYNCH, V. AND SMITH, H, W.: On dichloroethylsulfide (mustard gas). II. Variations in susceptibility of the skin to dichloroethyl-sulfide. J. Pharmacol. Exp. Therap. 12: 291-302, 1918.
207. MAURO, F., AND ELKIND, M. M.: Sulfur mustard and x-rays: differences in expression of lethal damage. Science (Wash. DC). 155: 1561-1563, 1967.
208. MAYER, A., MAGNE, H. AND PLANTEFOL, L.: Toxic action of bis(β-chloroethyl) sulfide. Compt. Rend. 170: 1625-1628, 1920.
209. MCKINLEY, M. D., MCKINLEY, F. R., AND MCGOWN, E. L.: Thiosulfate as an antidote to mustard poisoning. A review of the literature. Letterman Army Institute of Research, Presidio of San Francisco, CA, Institute Report No. 127, AD A121877, Sep. 1982.
210. MCMASTER, P. D., AND HOGEBOOM, G.: The inhibition of vesiculation in mustard gas, H, lesions of human skin by BAL, Division 9, National Defense Research Committee, Office of Scientific Research and Development, Report OSRD No. 5027, May 3, 1945.
211. MCNAMARA, B. P.: Medical aspects of chemical warfare. U. S. Army Chemical Research and Development Laboratories, Army Chemical Center, Edgewood Arsenal, MD, AD 240713, 1960.
212. MCNAMARA, B. P., OWENS, E. J., CHRISTENSEN, M. K., VOCCI, F. J., FORD, D. F., AND ROZIMAREK, H. AND SEVENTEEN OTHERS: Toxicological basis for controlling levels of mustard in the environment. Edgewood Arsenal Biomedical Laboratory, Aberdeen Proving Ground, MD, Edgewood Arsenal Special Publication EB-SP-74030, AD A011260, 1975.
213. MEDEMA, J.: Mustard gas: the science of H. Nuclear, Biological, and Chemical Defense and Technology International 1: 66-71, 1986.
214. Medical Chemical Defense. Pathogenic mechanisms in cutaneous mustard injury. U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD., 3: (No. 1), 5-8, April 1989.
215. Medical Chemical Defense. Current controversies on the poly(ADP-ribose) polymerase hypothesis for sulfur-mustard-induced cytotoxicity. U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD., 4: (No. 2), 1-6, Aug. 1991.
216. MEYER, V.: Medicinisch-chemische Notizen. Ber. Deuts. Chem. Gess. 20: 1725-1731, 1887.
217. MILOVIDOV, P.: Influence of yperite and lewisite on the plant cell. Sb. Cesk. Aka. Zemed. 21: 12-26, 1949.
218. MIYAJI, T.: Pathology of lung cancer. Adv. Res. Pulm. Dis. 31: 21-47, (in Japanese), 1962.
219. MOORE, L., CHEN, T., KNAPP, H. R., AND LANDON, E.: Energy-dependent calcium sequestration activity in rat liver microsomes. J. Biol. Chem. 250: 4562-4568, 1975.
220. MORGENSTERN, P., KOSS, F. R., AND ALEXANDER, W. W.: Residual mustard gas bronchiti: effects of prolonged exposure to low concentrations of mustard gas. Ann. Inter. Med. 26: 27-40, 1947.
221. MURPHY, M. L., AND KARNOFSKY, D. A.: Effect of azaserine and other growth inhibiting agents on fetal development of the rat. Cancer 9: 955-962, 1956.
222. MURPHY, M. L., MORO, A. D., AND LACON, C.: The comparative effects of five polyfunctional alkylating agents on the rat fetus, with additional notes on the chick embryo. Ann. NY Acad. Sci. 68: 762-782, 1958.
223. NAGY, S. M., GOLUMBIC, C., STEIN, W. H., FRUTON, J. S., AND BERGMANN, M.: The penetration of vesicant vapors into human skin. J. Gen. Physiol. 29: 441-469, 1946.
224. NAKAMURA, T.: Studies on the warfare gas-injury in Japan. Report V: On the investigations of the cause of death of the workers. Hiroshima Med. J. 4: 1182-1189, 1956, (in Japanese).
225. NASRAT, G. E.: Some cytological observation on the delayed effect of mustard gas. Nature (Lond.) 174: 968-969, 1954.
226. NASRAT, G. E., KAPLAN, W. D., AND AUERBACH, C.: A quantitative study of mustard gas induced chromosome breaks and rearrangements in Drosophila melanogaster. Z. Vererbungsl. 86: 249-262, 1954.
227. NEEDHAM, D. M., COHEN, J. A., AND BARREIT, A. M.: The mechanism of damage to the bone marrow in systemic poisoning with mustard gas. Biochem. J. 41: 631-639, 1947.
228. NEEL, J. V., NISHIMOTO, Y., GORIKI, K., SOTOH, C., FUJITA, M., AND YOSHIMOTO, Y.: Epidemiological studies of germ cell mutation in human populations, with particular reference to groups with unusual chemical exposures. In Methods for estimating risk of chemical injury: human and non-human biota and ecosystems, ed. by V. B. Vouk, G. C. Butler, D. G. Hoel, and D. B. Peakall, John Wiley and Sons: New York, 1985.
229. NEW YORK TIMES, (BROWNE, M. W.), CHEMICAL WEAPONS: 'poor man's atomic bomb' is once again used in battle. p. E7, 17 April 1988.
230. NISHIMOTO, Y., BURROWS, B., MIYANISHI, M., KATSUTA, S., SHIGENOBU, T., AND KETTEL, L. J.: Chronic obstructive lung disease in Japanese poison gas workers. Am. Rev. Respir. Disease 102: 173-179, 1970.
231. NISHIMOTO, Y., YAMAKIDO, M., SHIGENOBU, T., ONARI, K. AND YUKUTAKE, M.: Long-term observation of poison gas workers with special reference to respiratory cancers. J. UOEH (suppl.) 5: 89-94, 1983.
232. NORMAN, J. E., JR.: Lung cancer mortality in World War I veterans with mustard gas injury: 1919-1965. J. Nat. Cancer Inst. 54: 311-317, 1975.
233. ORRENIUS, S.: Biochemical mechanisms of cytotoxicity. Trends Pharmacol. Sci. (FEST suppl.): pp. 15-20, 1985.
234. ORRENIUS, S., AND NICOTERA, P.: Biochemical mechanisms of oxidative liver cell injury. Bull. Eur. Physiopathol. Respir. 23: 291-295, 1987.
235. OWENS, G., AND HATIBOGLU, I.: Clinical evaluation of sodium thiosulfate as a systemic neutralizer of nitrogen mustard: report of 12 patients. Ann. Surg. 154: 895-897, 1961.
236. PAPIRMEISTER, B.: On the mechanisms of inhibition of T2 bacteriophage by mustard gas. CRDL Special Publications 2-45, U.S. Army Chemical Research and Development Laboratories, Army Chemical Center, MD, Oct. 1961.
237. PAPIRMEISTER, B.: International vesicant research. In: Proceedings of the Vesicant Workshop, Columbia, MD, Feb. 1987, pp. 101-119, AD A188222, USAMRICD-SP-87-03, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, Feb. 1987.
238. PAPIRMEISTER, B., AND DAVISON, C. L.: Elimination of sulfur mustard-induced products from DNA of Escherichia coli. Biochem. Biophys. Res. Comm. 17: 608-617, 1964.
239. PAPIRMEISTER, B., AND DAVISON, C. L.: Unbalanced growth and latent killing of Escherichia coli following exposure to sulfur mustard. Biochem. Biophys. Acta. 103: 70-92, 1965.
240. PAPIRMEISTER, B., WESTLING, A. W., AND SCHROER, J.: Mustard: the relevance of DNA damage to the development of the skin lesion. Edgewood Arsenal Technical Report EATR 4294, Edgewood Arsenal, Aberdeen Proving Ground, MD, 1969.
241. PAPIRMEISTER, B., GROSS, C. L., PETRALI, J. P., AND HIXSON, C. J.: Pathology produced by sulfur mustard in human skin grafs on athymic nude mice. I. Gross and light microscopic changes. J. Toxicol.-Cutaneous Ocul. Toxicol. 3: 371-391, 1984a.
242. PAPIRMEISTER, B., GROSS, C. L., PETRALI, J. P., AND MEIER, H. L.: Pathology produced by sulfur mustard in human skin grafs on athymic nude mice. II. Ultrastructural changes. J. Toxicol.-Cutaneous Ocul. Toxicol. 3: 393-408, 1984b.
243. PAPIRMEISTER, B., GROSS, C. L., MEIER, H. L., PETRALI, J. P., AND JOHNSON, J. B.: Molecular basis for mustard-induced vesication. Fund. Appl. Toxicol. 5: S134-S149, 1985.
244. PAPPENHEIMER, A. M., AND VANCE, M.: The effects of intravenous injections of dichlorethylsulfide in rabbits with special reference to its leukotoxic action. J. Exper. Med. 31: 71-94, 1920.
245. PAUSER, G., ALOY, A., CARVANA, M., GRANINGER, W., HAVEL, M., KOLLER, W., AND MUTZ, N.: Lethal intoxication by wargases on Iranian soldiers. Therapeutic interventions on survivors of mustard gas and mycotoxin inmersion. Arch Belg. Med. Soc. Hyg. Med. Trav. Med. Leg. (suppl.): 341-351, 1984.
246. PETERS, R. A.: Biochemical research at Oxford upon mustard gas. Nature (Lond.) 159: 149-151, 1947.
247. PETERS, R. A., SINCLAIR, H. M., AND THOMPSON, R. H. S.: An analysis of the inhibition of pyruvate oxidation by arsenicals in relation to the enzyme theory of vesication. Biochem. J. 40: 516-524, 1946.
248. PETRALI, J. P., OLGESBY, S. B., AND MEIER, H. L.: Ultrastructural correlates of the protection afforded by niacinamide against sulfur mustard-induced cytotoxicity of human lymphocytes in vitro. USAMRICD-TR-88-16, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, AD A203118, Dec. 1988.
249. PHILIPS, F. S.: Recent contributions to the pharmacology of bis(2-haloethyl)-amines and sulfides. J. Pharmacol. Exper. Therap. 99: 281-323, 1950.
250. PHILIPS, F. S., AND THIERSCH, J. B.: The nitrogen mustard-like actions of 2,4,6-tris(ethylene-imino)-s-triazine, and other bis(ethylenamines). J. Pharmacol. Exper. Therap. 100: 398-407, 1950.
251. PICKARD, H. L.: Ocular action of dichlorethylsulphide (mustard gas). Am. J. Ophthalmol. 2: 136-145, 1919.
252. PIERPONT, H., AND DAVISON, C.: Lung perfusion. Behavior of alkylating and antimetabolite cancer chemotherapeutic agents in dogs. JAMA 179: 421-423, 1962.
253. PRICE, C. C.: Fundamental mechanisms of alkylaton. Ann. NY Acad. Sci. 68: 663-668, 1958.
254. PRUIT, B. A.: Treatment of the cutaneous injury. In: Proceedings of the Vesicant Workshop, Columbia, MD, Feb. 1987, pp. 39-43, AD A188222, USAMRICD-SP-87-03, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, 1987.
255. PURNELL, M. R., AND WHISH, W. J. D.: Novel inhibitors of poly(ADP-ribose) synthetase. Biochem. J. 185: 775-777, 1980.
256. RANKIN, P. W., JACOBSON, M. K., MITCHELL, V. R., AND BUSBEE, D. L.: Reduction of nicotinamide adenine dinucleotide levels by ultimate carcinogens in human lymphocytes. Cancer Res. 40: 1803-1807, 1980.
257. REED, C. L.: The minimum concentration of dichloroethylsulphide (mustard gas) effective for the eyes of man. J. Pharmacol. Exp. Ther. 15: 77-80, 1920.
258. REID, B. D., AND WALKER, I. G.: The response of mammalian cells to alkylating agents. II. On the mechanisms of the removal of sulfur-mustard-induced cross-links. Biochem. Biophys. Acta. 179: 179-188, 1969.
259. RENSHAW, B.: Observations on the role of water in the susceptibility of human skin to vesicant vapors. In: National Defense Research Committee, Washington, DC, Division 9, Report OSRD No. 5169, June 1, 1945.
260. RENSHAW, B.: Mechanisms in production of sutaneous injuries by sulfur and nitrogen mustard. In: Chemical Warfare Agents, and Related Problems, Parts III-VI, vol. 1, Chap. 23, pp. 479-518, U. S. Office of Scientific Research and Development, National Defense Research Committee, Washington, DC, 1946.
261. RHOADS, C. P.: The sword and the ploughshare. J. Mt. Sinai. Hospital 13: 299-309, 1947.
262. RICH, A. R., AND GINZLER, A. M.: Pathologic changes in tissues of victims of the Bari incident. MRL(EA) Report No. 20, Medical Research Laboratory, Edgewood Arsenel, Edgewood, MD, May 18, 1944.
263. RIM, W. R., AND BAHN, C. F.: Vesicant injury to the eye. In: Proceedings of the Vesicant Workshop, Columbia, MD, Feb. 1987, pp. 25-33, AD A188222, USAMRICD-SP-87-03, U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, 1987.
264. ROBERTS, J. J., AND WARWICK, G. P.: Studies of the mode of action of tumour-growth-inhibiting alkylating agents. IV. In vitro reactions of 2-chloroethylarylamines. Biochem. Pharmacol. 12: 1315-1319, 1963a.
265. ROBERTS, J. J., AND WARWICK, G. P.: Studies of the mode of action of alkylating agents. VI. The metabolism of bis-2-chloroethyl sulphide (mustard gas) and related compounds. Biochem. Pharmacol. 12: 1329-1334, 1963b.
266. ROBERTS, J. J., CRATHORN, A. R., AND BRENT, T. P.: Repair of allkkylated DNA in mammalian cells. Nature (Lond.) 218: 970-972, 1968.
267. ROBERTS, J. J., BRENT, T. P., AND CRATHORN, A. R.: Evidents for the inactivation and repair of the mammalian DNA template after alkylation by mustard gas and half mustard gas. Europ. J. Cancer 7: 515-524, 1971.
268. ROITT, I. M.: The inhibition of carbohydrate metabolism in ascites-tumour cells by ethyleneimines. Biochem. J. 63: 300-307, 1956.
269. ROMMEREIM, R. L., AND HACKETT. P. L.: Evaluation of the teratogenic potential of orally administered sulfur mustard in rats and rabbits. Teratology 33: 70C, (Abstract P66), 1986.
270. ROSENBLATT, D. H., MILLER, T. A., DACRE, J. C., MUUL, I., AND COGLEY, D. R.: Problem definition studies of potential environmental pollutants. II. Physical, chemical, toxicological and biological properties of 16 substances. Technical Report 7509, AD A030428, U. S. Army Medical Bioengineering Research and Development Laboratory, Fort Detrick, Frederick, MD, 1975.
271. ROZMAN, R. S., BLISS, L. AND SMITH, P. K.: Studies on the metabolic fate of bis(2-choroethyl)sulfide (mustard gas) in the mouse and human. Proc. Amer. Assoc. Cancer Res. 2: 195, 1957.
272. ROZMIAREK, H., CAPIZZI, R. L., PAPIRMEISTER, B., FUHRMAN, W. H., AND SMITH, W. J.: Mutagenic activity in somatic and germ cells following chronic inhalation of sulfur mustard. Mutation Res. 21: 13-14, 1973.
273. RUDIN, D. O.: A review of the biological actions of mustard as a basis for therapy. Medical Laboratories Special Report No. 21, CMLRE-ML-52, Chemical Corps Medical Laboratories, Army Chemical Center, MD, May 1953.
274. SASSER, L. B., MILLER, R. A., CUSHING, J. A., AND DACRE, J. C.: Subchronic oral toxicity study of sulfur mustard in rats.Toxicologist 8: 225 (Abstract 898), 1988.
275. SASSER, L. B., CUSHING, J. A., BUSCHBOM, R. L., AND DACRE, J. C.: Two generation reproduction study of sulfur mustard in rats. Toxicologist 9: 274 (Abstract 1097), 1989a.
276. SASSER, L. B., CUSHING, J. A., KALKWARF, D. R., AND BUSCHBOM, R. L.: Toxicological studies on lewisite and sulfur mustard agents: modified dominant lethal study of sulfur mustard in rats. Final Report. Project Order No. 84PP4865, U.S. Army Medical Research and Development Command, Fort Detrick, Frederick, MD, May 1989b.
277. SASSER, L. B., MILLER, R. A., KALKWARF, D. R., BUSCHBOM, R. L., AND CUSHING, J. A.: Toxicology studies on lewisite and sulfur mustard agents: subchronic toxicity of sulfur mustard (HD) in rats. Final Report. Project Order No. 84PP4865, U. S. Army Medical Research and Development Command, Fort Detrick, Frederick, MD, June 1989c.
278. SASSER, L. B., CUSHING, J. A., AND DACRE, J C.: Dominant lethal study of sulfur mustard in male and female rats. J. Appl. Toxicol. 13: 359-368, 1993.
279. SASSER, L. B., MILLER, R. A., KALKWARF, D. R., CUSHING, J. A., AND DACRE, J. C.: Subchronic toxicity evaluation of sulfur mustard in rats. J. Appl. Toxicol. 16: 5-13, 1996.
280. SASSER, L. B., CUSHING, J. A., MILLER, R. A., KALKWARF, D. R., AND DACRE, J. C.: Two-generation reproduction study of sulfur mustard in rats. Reprod. Toxicol. 10: in press, 1996.
281. SCARBOROUGH, D. E., AND THOMAS, C. G.: In vivo detoxification of nitrogen mustard. Proc. Am. Assoc. Cancer Res. 3: 358, (Abstract 235), 1962.
282. SCHANNE, F. A. X., KANE, A. B., YOUNG, E. E., AND FARMER, J. L.: Calcium dependence of toxic cell death: a final common pathway. Science (Wash. DC) 206: 700, 1979.
283. SCHULTZ, P. E., BONUS, R. L., SALKIN, M. S., AND SCANLON, E. F.: The in vivo and in vitro neutralization of nitrogen mustard for use in cancer chemotherapy perfusion. Surg. Gynecol. Obstet, 115: 91-100, 1962.
284. SCIANOWSKI, J.: The influence of ββ′-diclorodiethyl sulfide on lactate dehydrogenase (E.C.1.1.1.27) and its isoenzymes in the internal organs of rats. Acta Med. Pol. 18: 97-112, 1977.
285. SCOTT, D.: Chromosome aberrations, DNA post-replication repair and lethality of tumour cells with a differential sensitivity to alkylating agents. Chromosomes Today 6: 391-401, 1977.
286. SCOTT, D., FOX, M., AND FOX, B. W.: Differential induction of aberrations in mammalian cell lines. Mutation Res. 29: 201-202, 1975.
287. SEGAL, D.: The Soviet Union's mightly chemical warfare machine. Army Magazine 37: 26-38, 1987.
288. SHIGENOBU, T.: Occupational cancer of the lungs - cancer of the respiratory tract among workers manufacturing poisonous gases. Jap. J. Thoracic Dis. 18: 880-885, 1980 (Japanese with English abstract).
289. SHIMKIN, M. B.: Pulmonary-tumor induction in mice with chemical agents used in the clinical management of lymphomas. Cancer 7: 410-413, 1954.
290. SHIMKIN, M. B., WEISBURGER, J. H., WEISBERGER, E. K., GUBNAREFF, N., AND SUNTZEFF, V.: Bioassay of 29 alkylating chemicals by the pulmonary-tumor response in strain A mice. J. Nat. Cancer Inst. 36: 915-935, 1966.
291. SHIMURA, K., NOMURA, H., NIIMOTO, M., HATTORI, T., KAMITSUNA, A., SHIGENOBU, T., NISHIMOTO, Y., HAYASHI, Y., AND TOKUOKA, S.: Pathohistologic studies on four cases of gastric carcinoma in Okuno-jima poison gas workers. J. Hiroshima Med. Ass. 31: 277-281, 1978 (In Japanese).
292. SINCLAIR, D. C.: Disability produced by exposure of skin to mustard-gas vapour. Brit. Med. J. 1: 346-349, 1950.
293. STOCKHOLM INTERNATIONAL PEACE RESEARCH INSTITUTE: GB Weapons today. In The problem of chemical and biological warfare, ed. by J. P. Robinson, C. G., Heden, and H. Von Schreeb, vol. 2, chapter 1, pp. 27-89, Stockholm International Peace Research Institute, Stockholm, Sweden, 1973.
294. SMITH, H. W.: Review of the literature on the systemic action of mustard gas. National Defense Research Committee of the Office of Scientific Research and Development, OSRD No. 1717, Aug. 16, 1943.
295. SMITH, H. W., GEORGE, T., CLOWES, H. A., AND MARSHALL, E. K., JR.: On dichloroethylsulfide (mustard gas). IV. The mechanism of absorption by the skin. J. Pharmacol. Exp. Therap. 15: 1-30, 1919.
296. SMITH, P. K., NADKARNI, M. V., TRAMS, E. G., AND DAVISON, C.: Distribution and fate of alkylating agents. Ann. NY Acad. Sci. 68: 834-852, 1958.
297. SOLLMANN, M. T.: A manual of pharmacology and its application to therapeutics and toxicology, 8th ed., W. B. Saunders Co., Philadelphia, PA, 1957.
298. SOUTHERN RESEARCH INSTITUTE, BIRMINGHAM, AL: Comparative actions of CW agents as vapors and aerosols. Quarterly Progress Report 14, Contract No. DA18-108-CML-2561, Army Chemical Center, MD July 13, 1953.
299. SPIEGEBERG, U.: Psychopathologisch-neurologische schaden nach einwirkung synthetischer gifte. In Wehrdienst und gesundheit, vol. 3, pp. 1-103, Wehr und Wissen Verlagsgesellshaft MBH, Darmstadt, Germany, 1961.
300. STEVENS, C. M. AND MYLROIE, A.: Mutagenic activity of beta-chloroalkyl amines and sulphides. Nature (Lond.) 166: 1019, 1950.
301. STEVENS, C. M., AND MYLROIE, A.: Mutagenic activity of compounds related to mustard gas. Biochem. Biophy. Acta 8: 325-331, 1952.
302. STEVENS, C. M. AND MYLROIE, A.: Production and reversion of biochemical mutants of Neurospora crassa with mustard compounds. Am. J. Botany 40: 424-429, 1953.
303. STEWART, D. L.: Mutagenicity study of sulfur mustard in the Salmonella histidine reversion test. Environ. Mutag. 8 (suppl. 8): 103-104, (Abstract 269), 1987.
304. STEWART, D. L., SASS, E. J., FRITZ, L. K., AND SASSER, L. B.: Toxicological studies of lewisite and sulfur mustard agents: Mutagenicity of sulfur mustard in the Salmonella histidine reversion assay. Final Report, Project Order No. 84PP4865, U.S. Army Medical Research and Development Command, Fort Detrick, Frederick, MD, July 31, 1989.
305. THOR, H., SMITH, M. T., HARTZELL, P., BELLOMO, G., JEWELL, S. A., AND ORRENIUS, S.: The metabolism of menadione(2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells. J. Biol. Chem. 257: 12419-12425, 1982.
306. 2+ sequestration by toxic agents. Biochem. Pharmacol. 34: 3717-3723, 1985.
307. TOKUOKA, S., HAYASHI, Y., INAI, K., EGAWA, H., AOKI, Y., AKAMIZU, H., ETO, R., NISHIDA, T., OHE, K., KOBUKE, T., NAMBU, S., TAKEMOTO, T., KOU, E., NISHINA, H., FUJIHARA, M., YONEHARA, S., TSUYA, T., SUEHIRO, S., AND HORIUCHI, K.: Early cancer and related lesions in the bronchial epithelium in former workers of mustard gas factory. Act. Pathol. Jpn. 36: 533-542, 1986.
308. TRAPP, R.: The detoxification and natural degradation of chemical warfare agents. Stockholm International Peace Research Institute, Taylor & Francis, London and Philadelphia, PA, 1985.
309. TURNBULL, J. D., ALOYO, V. J., AND PAPIRMEISTER, B.: Induction of axon growth and increased acetylcholinesterase production in mouse neuorblastema by sulfur mustards. Edgewood Arsenal Technical Report EATR 4735 (AD 7654261, Biomedical Laboratory, Edgewood Arsenal, Aberdeen Proving Ground, MD, Jan. 1973.
310. U.S. Department of the Army; Military Specification. Chemical agent, mustard, distilled (HD). MIL-C-12051B (MU) (Superseding MIL-M-12051A, 29 October 1952). Department of the Army. 23 June 1969.
311. U.S. Department of the Army: Military Chemistry and Chemical Compounds, FM 3-9/AFR 355-7, 1974.
312. VAN DUUREN, B. L., WITZ, G., AND SIVAK, V.: Chemical carcinogenesis. In The physiopathology of cancer, ed. by F. Homburger, vol. 1, 3rd ed., pp. 1-63, Biology and Biochemistry, Karger, Basel, 1974.
313. VAN HOOIDONK, C., CEULEN, B. I., BOCK, J., AND VAN GENDEREN, J.: CW agents and the skin. Penetration and decontamination. Proc. Int. Symp. Protection Against Chemical Warfare Agents, Stockholm, Sweden, 6-9 June 1983, pp. 153-160, 1983.
314. VEDDER, E. B.: The medical aspects of chemical warfare, p. 326. Williams & Wilkins Co., Baltimore, MD, 1925.
315. VELDEN R. VON DEN: Uber kampfgaivergeftungen. X. Klinek der erkrankungennach dichlordiethylsulfidverguftung. Z. ges exptl. Med. 14: 1-27, 1921.
316. s-1 and their removal by the resistant strain. Biochem. Biophys. Res. Commun. 31: 355-360, 1968.
317. VOGT, R. F., JR., DANNENBERG, A. M., JR., SCHOFIELD, B. H., HYNES, N. A., AND PAPIRMEISTER, B.: Pathogeneses of skin lesions caused by sulfur mustard. Fund. Appl. Toxicol. 4: S71-S83, 1984.
318. VOJVODIC, V., MILOSAVLJEVIC, Z., BOSKOVIC, B., AND BOJANIC, N.: The protective effect of different drugs in rats poisoned by sulfur and nitrogen mustards. Fund. Appl. Toxicol. 5: S160-S168, 1985.
319. VYCUDILIK, W.: Detection of bis (2-chloroethyl)-sulfide (Yperite) in urine by high resolution gas chromatography-mass spectrometry. Forensic Sci. Int. 35: 67-71, 1987.
320. WADA, S., AND MIYANISHI, M.: A case report of bronchogenic carcinoma seen following chronic mustard gas exposure. Diagnosis and Teatment 42: 791-794, 1954 (in Japanese).
321. WADA, S., YAMADA, A., NISHIMOTO, Y., TAKUOKA, S., MIYANISHI, M., KATSUTA, S., AND UMISA, H.: Neoplasms of the respiratory tract among poison gas workers. J. Hiroshima Med. Assn. 16: 728-745, 1963.
322. WADA, S., NISHIMOTO, Y., MIYANISKI, M., KAMBE, S., AND MILLER, R. W.: Mustard gas as a cause of respiratory neoplasia in man. Lancet 1: 1161-1163, 1968.
323. WALKER, I. G., AND HELLEINER, C. W.: The sensitivity of cultured mammalian cells in different stages of the division cycle to nitrogen and sulfur mustard. Cancer Res. 23: 734-738, 1963.
324. WALPOLE, A. L.: Carcinogenic action of alkylating agents. Ann. NY Acad. Sci. 68: 750-761, 1958.
325. WARTHIN, A. S., AND WELLER, C. V.: The pathology of the skin lesions produced by mustard gas (dichloroethylsulphide). J. Lab. Clin. Med. 3: 447-479, 1918.
326. WARTHIN, A. S., AND WELLER, C. V.: The lesions of the respiratory and gastrointestinal tracts produced by mustard gas (dichloroethyl sulphide). J. Lab. Clin. Med. 4: 229-264, 1919a.
327. WARTHIN, A. S., AND WELLER, C. V.: The general pathology of mustard gas (dichloroethyl sulphide) poisoning. J. Lab. Clin. Med. 4: 265-306, 1919b.
328. WARTHIN, A. S., WELLER, C. V., AND HERRMANN, G. R.: The ocular lesions produced by dichloroethylsulphide "mustard gas". J. Lab. Clin. Med. 4: 785-832, 1918.
329. WATKINS, D. K.: Lysosomes and radiation injury. In Lysosomes in biology and pathology, ed. by J. T. Dingle and R. T. Dean, vol. 4, pp. 147-166, North Holland, Amsterdam, 1975.
330. WEGNER, N.: Therapie der S., Lost-vergiftung. Fortschr. Med. 16: 811-812, 1975a.
331. WEGNER, N.: Massnahmen gegen Lost-vergiftung. Selecta 27: 2462, 2464, 1975b.
332. WEISS, A.: Kampfstoffe als karzinogene Substanzen. Verh. nordwestdtsch Ges. Inn. Med. 51: 23, 1958.
333. WEISS, A., AND WEISS B.: Karzinogenese durch lost-esposition beim menschen ein wichtiger hinweis fur die alkylantien-therapie. Dtsch. Med. Wochenschr. 100: 919-923, 1975.
334. WHEELER, G. P.: Studies related to the mechanism of action of cytotoxic alkylating agents: a review. Cancer Res. 22: 651-688, 1962.
335. WHEELER, L. A., ASWAD, A., CONNOR, M. J., AND LOWE, N.: Depletion of cutaneous glutathione and the induction of inflammation by 8-methoxypsoralan plus UVA radiation. J. Invest. Dermatol. 87: 658, 1986.
336. WILLEMS, J. L.: Clinical management of mustard gas casualties. Ann. Med. Milit. (Belg.) 3 (suppl. S1): 1-16, 1989a.
337. WILLEMS, J. L.: Controversies regarding diagnosis and treatment of Iranian chemical war casualties brought to Europe. Proc. 3rd Symposium Protection Against Chemical warfare Agents, Umea, Sweden, 11-16 June 1989, pp. 149-150, 1989b.
338. WILS, E. R. J., HULST, A. G., AND VAN LAAR, J.: Analysis of thiodiglycol in urine of victims of an alleged attack with mustard gas. Part II. J. Anal. Toxicol. 12: 15-19, 1988.
339. WULF, H. C., AASTED, A., DARRE, E., AND NEIBUHR, E.: Sister chromatid exchantges in fishermen exposed to leaking mustard gas shells. Lancet 1: 690-691, 1985.
340. YAMADA, A.: Patho-anatomical studies on respiratory cancers developed in workers with occupational exposure to mustard gas. Hiroshima Med. J. 7: 719-761, 1959 (In Japanese with English Abstract).
341. YAMADA, A.: On the late injuries following occupational inhalation of mustard gas, with special reference to carcinoma of the respiratory tract. Acta Pathol. Jap. 13: 131-155, 1963.
342. YAMADA, A., HIROSE, F., AND MIYANISHI, M.: An autopsy case of bronchial carcinoma found in a patient succumbed to occupational mustard gas poisoning. Gann (J. Cancer Res.) 44: 216-218, 1953 (In Japanese).
343. YAMADA, A., HIROSE, F., NAGAI, M. AND NAKAMURA, T.: Five cases of cancer of the larynx found in persons who suffered from occupational mustard gas poisoning. Gann (Japanese J. Cancer Res.) 48: 366-368, 1957.
344. YAMADA, A., TAMURA, H, AND HARADA, Y.: A case of carcinoma of the hypopharynx found in a male following the prolonged occupational exposure to mustard gas. Hiroshima Med. J. 9: 1427-1432, 1961 (In Japanese).
345. YAMAKIDO, M., NISHIMOTO, Y., SHIGENOBU, T., ONARI, K., SATOH, C., GORIKI, K., AND FUJITA, M.: Study of genetic effects of sulfur mustard gas on former workers of Ohkunojima poison gas factory and their offspring. Hiroshima J. Med. Sci. 34: 311-322. 1985a.
346. YAMAKIDO, M., SHIGENOBU, T., KAMITUNA, A., NISHIMOTO, Y., AND YUKUTAKE, M.: The causes of death in the retired workers of Okuno-jima poison gas factory. Jap. J. Med. 24: 394, (Abstract P137), 1985b.
347. YOUNG, L.: Observations on the effects of mustard gas on the rat. Canadian J. Res. 25: 141-151, 1947.
348. ZAMENHOF, S., LEIDY, G., HAHN, E., AND ALEXANDER, H. E.: Inactivation and unstabilization of the transforming principle of mutagenic agents. J. Bacteriol. 72: 1-11, 1956.
349. ZANETTI, J. E.: Accident at Salaise with yperite dissolved in alcohol. Letter to Deputy Chief of Chemical Warfare Service, (AD 499340), Feb. 21, 1919.