The expression of multiple cytokines and inducible nitric oxide synthase in experimental melanin-protein-induced uveitis

Ophthalmic Research

Volumn 33, Issue 6, 2001, Pages 329-335

  Kim, Hae Sook ^a   Yoon, Sungjoo Kim ^a   Joo, Choun Ki ^a,b  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea College of Medicine   (South Korea)

Author keywords

Autoimmune uveitis; Cytokine; Experimental melanin protein induced uveitis; Nitric oxide synthase, inducible

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; MELANIN; MESSENGER RNA; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ENZYME INDUCTION; IMMUNIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UVEITIS;

ANIMALS; CATTLE; CILIARY BODY; CYTOKINES; DISEASE MODELS, ANIMAL; DNA PRIMERS; IRIS; MALE; MELANINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, INBRED LEW; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; UVEITIS, ANTERIOR;

EID: 0035672691     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000055689     Document Type: Article

References (36)

1. Experimental autoimmune anterior uveitis (EAAU), a new form of experimental uveitis. I. Induction by a detergent-insoluble, intrinsic protein fraction of the retinal pigment epithelium
2. Experimental autoimmune anterior uveitis: The preparation of uveitogenic ocular melanin
3. Experimental melanin-protein-induced uveitis in the Lewis rat
4. Immunohistochemical studies on melanin associated antigen (MAA) induced experimental autoimmune anterior uveitis (EAAU)
5. Experimental autoimmune anterior uveitis: Induction with melanin-associated antigen from the iris and ciliary body
6. Eukaryotic gene expression
7. Identification of the lymphokines, interferon-gamma and interleukin-2, in inflammatory eye diseases
8. Interferon-gamma (IFN-gamma) production in vivo in experimental autoimmune uveoretinitis
9. In vivo lymphokine production in experimental autoimmune uveoretinitis
10. Endotoxin-induced uveitis in the rat is attenuated by inhibition of nitric oxide production
11. Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity
12. The role of interleukin-10 (IL-10) in IL-15-mediated T-cell responses
13. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes
14. Synthesis of nitric oxide from L-arginine by neutrophils: Release and interaction with superoxide anion
15. Purification of nitric oxide synthase from rat macrophages
16. Nitric oxide synthase inhibitors exert differential time-dependent defects on LPS-induced uveitis
17. Molecular basis of 'suppressor' a macrophage: Arginine metabolism via the nitric oxide synthetase pathway
18. Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation: The role of IFN-r in the induction of the nitric oxide synthesizing pathway
19. Streptozotocin-induced renal hemodynamic changes in isogenic Lewis rats: A kidney transplant study
20. Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat
21. Interleukin-1alpha, interleukin-1beta, and tumor necrosis factor gene expression in endotoxin-induced uveitis
22. The kinetics of cytokine mRNA expression in the retina during experimental autoimmune uveoretinitis
23. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
24. Kinetics of cytokine production in experimental autoimmune anterior uveitis (EAAU)
25. Impaired immune and acute-phase responses in interleukin-6-deficient mice
26. Interleukin 6 is required for a protective immune response to systemic Escherichia coli infection
27. Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolysaccharide or IL-1 beta: A study on IL-6-deficient mice
28. Interleukin-6 does not mediate endotoxin-induced uveitis in mice: Studies in gene deletion animals
29. IFN-γ-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response
30. The role of nitric oxide synthase in endotoxin-induced uveitis: Effects of NG-nitro-L-arginine
31. Nitric oxide accelerates the onset and increases the severity of experimental autoimmune uveoretinitis through an IFN-gamma-dependent mechanism
32. Cyclophosphamide treatment of female non-obese diabetic mice causes enhanced expression of inducible nitric oxide synthase and interferon-gamma, but not of interleukin-4
33. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: Comparison of activating cytokines and evidence for independent production
34. Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: Initial analysis of the human NOS2 promoter
35. Inhibition of experimental melanin protein-induced uveitis (EMIU) by targeting nitric oxide via phosphatidylcholine-specific phospholipase C
36. GTP cyclohydrolase I mRNA is induced by LPS in vascular smooth muscle: Characterization, sequence and relationship to nitric oxide synthase