Expression of genes in normal human monocytes in response to Aspergillus fumigatus

Medical Mycology

Volumn 46, Issue 4, 2008, Pages 327-336

  Rødland, Ernst ^a,b   Mattingsdal, Morten ^a   Olstad, Ole ^c   Øvstebø, Reidun ^c   Kierulf, Peter ^c   Müller, Fredrik ^b   Frøland, Stig ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Aspergillus fumigatus; Microarray; Monocyte

Indexed keywords

ACYLGLYCEROL LIPASE; BETA 2 MICROGLOBULIN; CASPASE 8; CATHEPSIN B; CD1D ANTIGEN; CD22 ANTIGEN; CD30 LIGAND; CHEMOKINE RECEPTOR CCR2; CHOLESTEROL ACYLTRANSFERASE; CXCL9 CHEMOKINE; GAMMA INTERFERON; HERPESVIRUS ENTRY MEDIATOR LIGAND; INHIBIN A; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 18 BINDING PROTEIN; KRUPPEL LIKE FACTOR 6; LEUKOTRIENE A4 HYDROLASE; LIPOPOLYSACCHARIDE; MANGANESE SUPEROXIDE DISMUTASE; PROLACTIN RECEPTOR; PROTEIN BCL 6; SPHINGOSINE KINASE 1; SUPPRESSOR OF CYTOKINE SIGNALING 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 8; TRANSCRIPTION FACTOR FKHRL1;

APOPTOSIS; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CELL STIMULATION; CELLULAR IMMUNITY; CONIDIUM; CONTROLLED STUDY; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; GENETIC REGULATION; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE GENE; MICROARRAY ANALYSIS; MONOCYTE; NONHUMAN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TH1 CELL;

ASPERGILLUS; ASPERGILLUS FUMIGATUS;

EID: 42349108461     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.1080/13693780701874507     Document Type: Article

References (35)

1. Denning, DW. (1998) Invasive aspergillosis. Clin Infect Dis, 26, pp. 781-803.
2. Hope, WW and Denning, DW. (2004) Invasive aspergillosis: Current and future challenges in diagnosis and therapy. Clin Microbiol Infect, 10, pp. 2-4.
3. Schneemann, M. and Schaffner, A. (1999) Host defense mechanism in Aspergillus fumigatus infections. Contrib Microbiol, 2, pp. 57-68.
4. Medzhitov, R. (2001) Toll-like receptors and innate immunity. Nat Rev Immunol, 1, pp. 135-145.
5. Romani, L. (2004) Immunity to fungal infections. Nat Rev Immunol, 4, pp. 1-13.
6. Meier, A., Kirschning, CJ and Nikolaus, T. (2003) Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol, 5, pp. 561-570.
7. Netea, MG, Warris, A. and Van der Meer, JW (2003) Aspergillus fumigatus evades immune recognition during germination through loss of toll-like receptor-4-mediated signal transduction. J Infect Dis, 188, pp. 320-326.
8. Cortez, KJ, Lyman, CA and Kottilil, S. (2006) Functional genomics of innate host defense molecules in normal human monocytes in response to Aspergillus fumigatus. Infect Immun, 74, pp. 2353-2365.
9. Lund, PK, Joo, GB, Westvik, AB, Ovstebo, R. and Kierulf, P. (2000) Isolation of monocytes from whole blood by density gradient centrifugation and counter-current elutriation followed by cryopreservation: Six years' experience. Scand J Clin Lab Invest, 60, pp. 357-365.
10. Sturtevant, J. and Latge, JP. (1992) Participation of complement in the phagocytosis of the conidia of Aspergillus fumigatus by human polymorphonuclear cells. J Infect Dis, 166, pp. 580-586.
11. Philippe, B., Ibrahim-Granet, O. and Prevost, MC (2003) Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates. Infect Immun, 71, pp. 3034-3042.
12. Ibrahim-Granet, O., Philippe, B. and Boleti, H. (2003) Phagocytosis and intracellular fate of Aspergillus fumigatus conidia in alveolar macrophages. Infect Immun, 71, pp. 891-903.
13. The R Foundation for Statistical Computing (2005) R: A Language and Environment for Statistical Computing.
14. Gentleman, RC, Carey, VJ and Bates, DM (2004) Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol, 5, p. R80.
15. Wu, Z., Irizarry, RA, Gentleman, R., Murillo, FM and Spencer, F. A Model Based Background Adjustment for Oligonucleotide Expression Arrays.
16. Gautier, L., Cope, L., Bolstad, BM and Irizarry, RA. (2004) Affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics, 20, pp. 307-315.
17. Smyth, GK. (2004) Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Applic Genet Molec Biol, 3:1
18. McClintick, JN and Edenberg, HJ. (2006) Effects of filtering by present call on analysis of microarray experiments. BMC Bioinformatics, 7, p. 49.
19. Ashburner, M., Ball, CA and Blake, JA (2000) Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet, 25, pp. 25-29.
20. Livak, KJ and Schmittgen, TD. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25, pp. 402-408.
21. Li, C. and Wong, WH. (2001) Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection. Proc Natl Acad Sci USA, 98, pp. 31-36.
22. Dubourdeau, M., Athman, R. and Balloy, V. (2006) Aspergillus fumigatus induces innate immune responses in alveolar macrophages through the MAPK pathway independently of TLR2 and TLR4. J Immunol, 177, pp. 3994-4001.
23. Marr, KA, Balajee, SA and Hawn, TR (2003) Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens. Infect Immun, 71, pp. 5280-5286.
24. Hayashi, F., Smith, KD and Ozinsky, A. (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature, 410, pp. 1099-1103.
25. Cabral, ES, Gelderblom, H. and Hornung, RL (2006) Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes. J Infect Dis, 193, pp. 849-859.
26. Oshikawa, K. and Sugiyama, Y. (2003) Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage. Biochem Biophys Res Commun, 305, pp. 649-655.
27. Crellin, NK, Garcia, RV and Hadisfar, O. (2005) Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 + CD25+ T regulatory cells. J Immunol, 175, pp. 8051-8059.
28. Montagnoli, C., Fallarino, F. and Gaziano, R. (2006) Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism. J Immunol, 176, pp. 1712-1723.
29. Doyle, SL and O'Neill, LA. (2006) Toll-like receptors: From the discovery of NFkappaB to new insights into transcriptional regulations in innate immunity. Biochem Pharmacol, 72, pp. 1102-1113.
30. Zhao, J., Kong, HJ and Li, H. (2006) IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways. J Biol Chem, 281, pp. 10073-10080.
31. Bonecchi, R., Bianchi, G. and Bordignon, PP (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med, 187, pp. 129-134.
32. Tomee, JF and Kauffman, HF. (2000) Putative virulence factors of Aspergillus fumigatus. Clin Exp Allergy, 30, pp. 476-484.
33. Coma, G., Pena, R. and Blanco, J. (2006) Treatment of monocytes with interleukin (IL)-12 plus IL-18 stimulates survival, differentiation and the production of CXC chemokine ligands (CXCL)8, CXCL9 and CXCL10. Clin Exp Immunol, 145, pp. 535-544.
34. Ma, J., Chen, T. and Mandelin, J. (2003) Regulation of macrophage activation. Cell Mol Life Sci, 60, pp. 2334-2346.
35. Bootcov, MR, Bauskin, AR and Valenzuela, SM (1997) MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci USA, 94, pp. 11514-11519.