Study of DHPS and DHFR genes of Pneumocystis jirovecii in Thai HIV-infected patients

Medical Mycology

Volumn 46, Issue 4, 2008, Pages 389-392

  Siripattanapipong, Suradej ^a   Leelayoova, Saovanee ^b   Mungthin, Mathirut ^b   Worapong, Jeerapun ^c   Tan Ariya, Peerapan ^a  

^a Mahidol University ^*  (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c MAHIDOL UNIVERSITY   (Thailand)

Author keywords

Dihydrofolate reductase; Dihydropteroate synthase; Mutations; Pneumocystis jirovecii

Indexed keywords

DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE;

ARTICLE; CODON; CONTROLLED STUDY; FUNGAL GENETICS; FUNGUS ISOLATION; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MUTATIONAL ANALYSIS; NONHUMAN; PNEUMOCYSTIS JIROVECI; SAMPLING; THAILAND;

AIDS-RELATED OPPORTUNISTIC INFECTIONS; DIHYDROPTEROATE SYNTHASE; DNA, FUNGAL; HUMANS; MUTATION; PNEUMOCYSTIS JIROVECII; PNEUMONIA, PNEUMOCYSTIS; POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TETRAHYDROFOLATE DEHYDROGENASE; THAILAND;

PNEUMOCYSTIS; PNEUMOCYSTIS JIROVECII;

EID: 42349089614     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.1080/13693780701883722     Document Type: Article

References (26)

1. Hughes, WT. (1991) Prevention and treatment of Pneumocystis carinii pneumonia. Ann Rev Med, 42, pp. 287-295.
2. Fishman, JA. (1998) Prevention of infection due to Pneumocystis carinii. Antimicrob Agents Chemother, 42, pp. 995-1004.
3. Klein, NC, Duncanson, FP and Lenox, TH (1992) Trimethoprim-sulfamethoxazole versus pentamidine for Pneumocystis carinii pneumonia in AIDS patients: Results of a large prospective randomized treatment trial. AIDS, 6, pp. 301-305.
4. Hardy, WD, Feinberg, J. and Finkelstein, DM (1992) A controlled trial of trimethoprim-sulfamethoxazole or aerosolized pentamidine for secondary prophylaxis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. AIDS Clinical Trials Group Protocol 021. N Engl J Med, 327, pp. 1842-1848.
5. Bozzette, SA, Finkelstein, DM and Spector, SA (1995) A randomized trial of three antipneumocystis agents in patients with advanced human immunodeficiency virus infection. NIAID AIDS Clinical Trials Group. N Engl J Med, 332, pp. 693-699.
6. Saah, AJ, Hoover, DR and Peng, Y. (1995) Predictors for failure of Pneumocystis carinii pneumonia prophylaxis. Multicenter AIDS cohort study. JAMA, 273, pp. 1197-1202.
7. Bonora, S., Perri, G Di, Vento, S., Cazzadori, A. and Concia, E. (1998) Failure of prophylaxis against PCP in patients with HIV infection. AIDS Patient Care STDS, 12, pp. 843-848.
8. Ma, L., Borio, L., Masur, H. and Kovacs, JA. (1999) Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use. J Infect Dis, 180, pp. 1969-1978.
9. Takahashi, T., Endo, T. and Nakamura, T. (2002) Dihydrofolate reductase gene polymorphisms in Pneumocystis carinii f. sp. hominis in Japan. J Med Microbiol, 51, pp. 510-515.
10. Siripattanapipong, S., Worapong, J., Mungthin, M., Leelayoova, S. and Tan-ariya, P. (2005) Genotypic study of Pneumocystis jirovecii in human immunodeficiency virus-positive patients in Thailand. J Clin Microbiol, 43, pp. 2104-2110.
11. Takahashi, T., Hosoya, N. and Endo, T. (2000) Relationship between mutations in dihydropteroate synthase of Pneumocystis carinii f. sp. hominis isolates in Japan and resistance to sulfonamide therapy. J Clin Microbiol, 38, pp. 3161-3164.
12. Kazanjian, P., Locke, AB and Hossler, PA (1998) Pneumocystis carinii mutations associated with sulfa and sulfone prophylaxis failures in AIDS patients. AIDS, 12, pp. 873-878.
13. Lane, BR, Ast, JC and Hossler, PA (1997) Dihydropteroate synthase polymorphisms in Pneumocystis carinii. J Infect Dis, 175, pp. 482-485.
14. Totet, A., Latouche, S. and Lacube, P. (2004) Pneumocystis jirovecii dihydropteroate synthase genotypes in immunocompetent infants and immunosuppressed adults, Amiens, France. Emerg Infect Dis, 10, pp. 667-673.
15. Higgins, DG, Thompson, JD and Gibson, TJ. (1996) Using CLUSTAL for multiple sequence alignments. Methods Enzymol, 266, pp. 383-402.
16. Thompson, JD, Gibson, TJ, Plewniak, F., Jeanmougin, F. and Higgins, DG. (1997) The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res, 25, pp. 4876-4882.
17. Nahimana, A., Rabodonirina, M., Bille, J., Francioli, P. and Hauser, PM. (2004) Mutations of Pneumocystis jirovecii dihydrofolate reductase associated with failure of prophylaxis. Antimicrob Agents Chemother, 48, pp. 4301-4305.
18. Robberts, FJ, Chalkley, LJ, Weyer, K., Goussard, P. and Liebowitz, LD. (2005) Dihydropteroate synthase and novel dihydrofolate reductase gene mutations in strains of Pneumocystis jirovecii from South Africa. J Clin Microbiol, 43, pp. 1443-1444.
19. Costa, MC, Esteves, F., Antunes, F. and Matos, O. (2006) Genetic characterization of the dihydrofolate reductase gene of Pneumocystis jirovecii isolates from Portugal. J Antimicrob Chemother, 58, pp. 1246-1249.
20. Kazanjian, P., Armstrong, W. and Hossler, PA (2000) Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients. J Infect Dis, 182, pp. 551-557.
21. Navin, TR, Beard, CB and Huang, L. (2001) Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P. carinii pneumonia in patients with HIV-1: A prospective study. Lancet, 358, pp. 545-549.
22. Huang, L., Beard, CB and Creasman, J. (2000) Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene. J Infect Dis, 182, pp. 1192-1198.
23. Helweg-Larsen, J., Benfield, TL, Eugen-Olsen, J., Lundgren, JD and Lundgren, B. (1999) Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia. Lancet, 354, pp. 1347-1351.
24. Visconti, E., Ortona, E. and Mencarini, P. (2001) Mutations in dihydropteroate synthase gene of Pneumocystis carinii in HIV patients with Pneumocystis carinii pneumonia. Int J Antimicrob Agents, 18, pp. 547-551.
25. Nahimana, A., Rabodonirina, M. and Zanetti, G. (2003) Association between a specific Pneumocystis jiroveci dihydropteroate synthase mutation and failure of pyrimethamine/sulfadoxine prophylaxis in human immunodeficiency virus-positive and -negative patients. J Infect Dis, 188, pp. 1017-1023.
26. Ma, L., Kovacs, JA and Cargnel, A. (2002) Mutations in the dihydropteroate synthase gene of human-derived Pneumocystis carinii isolates from Italy are infrequent but correlate with prior sulfa prophylaxis. J Infect Dis, 185, pp. 1530-1532.