Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: A prospective study

Lancet

Volumn 358, Issue 9281, 2001, Pages 545-549

  Navin, Thomas R ^a,b,f   Beard, Charles B ^a   Huang, Laurence ^c   Del Rio, Carlos ^d   Lee, Sherline ^a   Pieniazek, Norman J ^a   Carter, Jane L ^a   Le, Thuy ^a   Hightower, Allen ^a   Rimland, David ^d,e  

^a NATL CENTER FOR INFECTIOUS DISEASES   (United States)

^b CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINDAMYCIN; COTRIMOXAZOLE; DAPSONE; DIHYDROPTEROATE SYNTHASE; PENTAMIDINE; PRIMAQUINE; TRIMETHOPRIM;

ADULT; AGE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; DRUG CHOICE; DRUG RESPONSE; FEMALE; GENE LOCUS; GENE MUTATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; PNEUMOCYSTIS CARINII; PNEUMOCYSTIS PNEUMONIA; PRIORITY JOURNAL; PROGNOSIS; TREATMENT FAILURE; TREATMENT OUTCOME;

PNEUMOCYSTIS CARINII;

EID: 0035908750     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(01)05705-1     Document Type: Article

References (15)

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3. Dihydropteroate synthase polymorphism in Pneumocystis carinii
4. Failure of co-trimoxazole in Pneumocystis carinii infection and mutations in dihydropteroate synthase gene
5. Dihydropteroate synthase mutations in Pneumocystis carinii associated with sulfa prophylaxis failures
6. Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P carinii pneumonia
7. Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use
8. Pneumocystis carinii mutations are associated with duration of sulfa or sulfone prophylaxis exposure in AIDS patients
9. Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene
10. Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase
11. Sulfonamide resistance in Neisseria meningitidis as defined by site-directed mutagenesis could have its origins in other species
12. Sulfonamide resistance in Streptococcus pneumoniae: DNA sequence of the gene encoding dihydropteroate synthase and characterization of the enzyme
13. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: Dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfa
14. Genetic variation in Pneumocystis carinii isolates from different geographic regions: Implications for transmission