Effects of pentoxifylline on the vascular response to injury after angioplasty in rabbit iliac arteries

Basic Research in Cardiology

Volumn 103, Issue 3, 2008, Pages 257-264

  Busk, Martin ^a   Mertz, Henrik ^a   Espersen, Geert T ^a   Rasmussen, Klaus ^a   Maeng, Michael ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Adventitia; Angioplasty; Collagen; Neointima; Pentoxifylline; Remodeling; Smoothelin

Indexed keywords

COLLAGEN; PENTOXIFYLLINE; PLACEBO; SMOOTHELIN;

ANGIOPLASTY; ANIMAL CELL; ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTERY INJURY; ARTERY INTIMA; ARTERY INTIMA PROLIFERATION; ARTERY MEDIA; ARTICLE; BLOOD VESSEL INJURY; BLOOD VESSEL WALL; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; ELASTIC TISSUE; EXPERIMENTAL RABBIT; ILIAC ARTERY; MYOFIBROBLAST; NONHUMAN; PHENOTYPE; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANGIOPLASTY, BALLOON; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLLAGEN; HYPERPLASIA; ILIAC ARTERY; IMMUNOHISTOCHEMISTRY; MODELS, ANIMAL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PENTOXIFYLLINE; RABBITS; TIME FACTORS;

EID: 42249106187     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-007-0694-8     Document Type: Article

References (37)

1. Andersen HR, Maeng M, Thorwest M, Falk E (1996) Remodeling rather than neointimal formation explains luminal narrowing after deep vessel wall injury: Insights from a porcine coronary (re)stenosis model. Circulation 93: 1716-1724
2. Bar H, Wende P, Watson L, Denger S, van EG, Kreuzer J, Jahn L (2002) Smoothelin is an indicator of reversible phenotype modulation of smooth muscle cells in balloon-injured rat carotid arteries. Basic Res Cardiol 97:9-16
3. Berman B, Duncan MR (1990) Pentoxifylline inhibits the proliferation of human fibroblasts derived from keloid, scleroderma and morphoea skin and their production of collagen, glycosaminoglycans and fibronectin. Br J Dermatol 123:339-346
4. Bernard C, Barnier P, Merval R, Esposito B, Tedgui A (1995) Pentoxifylline selectivity inhibits tumor necrosis factor synthesis in the arterial wall. J Cardiovasc Pharmacol 25(Suppl 2): S30-S33
5. Bilder G, Wentz T, Leadley R, Amin D, Byan L, O'Conner B, Needle S, Galczenski H, Bostwick J, Kasiewski C, Myers M, Spada A, Merkel L, Ly C, Persons P, Page K, Perrone M, Dunwiddie C (1999) Restenosis following angioplasty in the swine coronary artery is inhibited by an orally active PDGF-receptor tyrosine kinase inhibitor, RPR101511A. Circulation 99:3292-3299
6. Chen YM, Wu KD, Tsai TJ, Hsieh BS (1999) Pentoxifylline inhibits PDGF-induced proliferation of and TGF-beta-stimulated collagen synthesis by vascular smooth muscle cells. J Mol Cell Cardiol 31:773-783
7. Christen T, Verin V, Bochaton-Piallat M, Popowski Y, Ramaekers F, Debruyne P, Camenzind E, van EG, Gabbiani G (2001) Mechanisms of neointima formation and remodeling in the porcine coronary artery. Circulation 103:882-888
8. Coats WD Jr., Whittaker P, Cheung DT, Currier JW, Han B, Faxon DP (1997) Collagen content is significantly lower in restenotic versus nonrestenotic vessels after balloon angioplasty in the atherosclerotic rabbit model. Circulation 95:1293-1300
9. Courtman DW, Franco CD, Meng Q, Bendeck MP (2004) Inward remodeling of the rabbit aorta is blocked by the matrix metalloproteinase inhibitor doxycycline. J Vasc Res 41:157-165
10. Dawson DL (2001) Comparative effects of cilostazol and other therapies for intermittent claudication. Am J Cardiol 87:19D-27D
11. Durand E, Al Haj ZA, Addad F, Brasselet C, Caligiuri G, Vinchon F, Lemarchand P, Desnos M, Bruneval P, Lafont A (2005) Adenovirus-mediated gene transfer of superoxide dismutase and catalase decreases restenosis after balloon angioplasty. J Vasc Res 42:255-265
12. Fang CC, Yen CJ, Chen YM, Shyu RS, Tsai TJ, Lee PH, Hsieh BS (2000) Pentoxifylline inhibits human peritoneal mesothelial cell growth and collagen synthesis: Effects on TGF-beta. Kidney Int 57:2626-2633
13. Fishbein I, Waltenberger J, Banai S, Rabinovich L, Chorny M, Levitzki A, Gazit A, Huber R, Mayr U, Gertz SD, Golomb G (2000) Local delivery of platelet-derived growth factor receptor-specific tyrphostin inhibits neointimal formation in rats. Arterioscler Thromb Vasc Biol 20:667-676
14. Guzman LA, Mick MJ, Arnold AM, Forudi F, Whitlow PL (1996) Role of intimal hyperplasia and arterial remodeling after balloon angioplasty: an experimental study in the atherosclerotic rabbit model. Arterioscler Thromb Vasc Biol 16:479-487
15. Hansen PR, Holm AM, Qi JH, Ledet T, Rasmussen LM, Andersen CB (1999) Pentoxifylline inhibits neointimal formation and stimulates constrictive vascular remodeling after arterial injury. J Cardiovasc Pharmacol 34:683-689
16. Hsu HY, Saadati HG, Mishra A, Heller KB, Sadun AA (2000) Plasma levels of orally and subcutaneously administered pentoxifylline in rabbits. J Med 31:149-166
17. Kingston PA, Sinha S, David A, Castro MG, Lowenstein PR, Heagerty AM (2001) Adenovirus-mediated gene transfer of a secreted transforming growth factor-beta type II receptor inhibits luminal loss and constrictive remodeling after coronary angioplasty and enhances adventitial collagen deposition. Circulation 104:2595-2601
18. Krasinski K, Spyridopoulos I, Kearney M, Losordo DW (2001) In vivo blockade of tumor necrosis factor-alpha accelerates functional endothelial recovery after balloon angioplasty. Circulation 104:1754-1756
19. Lafont A, Guzman LA, Whitlow PL, Goormastic M, Cornhill JF, Chisolm GM (1995) Restenosis after experimental angioplasty. Intimal, medial, and adventitial changes associated with constrictive remodeling. Circ Res 76:996-1002
20. Lafont A, Durand E, Samuel JL, Besse B, Addad F, Levy BI, Desnos M, Guerot C, Boulanger CM (1999) Endothelial dysfunction and collagen accumulation: Two independent factors for restenosis and constrictive remodeling after experimental angioplasty. Circulation 100:1109-1115
21. Maeng M, Olesen PG, Emmertsen NC, Thorwest M, Nielsen TT, Kristensen BO, Falk E, Andersen HR (2001) Time course of vascular remodeling, formation of neointima and formation of neoadventitia after angioplasty in a porcine model. Coron Artery Dis 12:285-293
22. Maeng M, Mertz H, Nielsen S, van Eys GJ, Rasmussen K, Espersen GT (2003) Adventitial myofibroblasts play no major role in neointima formation after angioplasty. Scand Cardiovasc J 37:34-42
23. Mintz GS, Popma JJ, Pichard AD, Kent KM, Satler LF, Wong C, Hong MK, Kovach JA, Leon MB (1996) Arterial remodeling after coronary angioplasty: A serial intravascular ultrasound study. Circulation 94:35-43
24. Pasterkamp G, de Kleijn DP, Borst C (2000) Arterial remodeling in atherosclerosis, restenosis and after alteration of blood flow: potential mechanisms and clinical implications. Cardiovasc Res 45:843-852
25. Post MJ, de Smet BJ, van der Helm Y, Borst C, Kuntz RE (1997) Arterial remodeling after balloon angioplasty or stenting in an atherosclerotic experimental model. Circulation 96:996-1003
26. Preaux AM, Mallat A, Rosenbaum J, Zafrani ES, Mavier P (1997) Pentoxifylline inhibits growth and collagen synthesis of cultured human hepatic myofibroblast-like cells. Hepatology 26:315-322
27. Rectenwald JE, Moldawer LL, Huber TS, Seeger JM, Ozaki CK (2000) Direct evidence for cytokine involvement in neointimal hyperplasia. Circulation 102:1697-1702
28. Schmidt MR, Maeng M, Kristiansen SB, Andersen HR, Falk E (2004) The natural history of collagen and alpha-actin expression after coronary angioplasty. Cardiovasc Pathol 13:260-267
29. Schwartz RS, Edelman ER, Carter A, Chronos N, Rogers C, Robinson KA, Waksman R, Weinberger J, Wilensky RL, Jensen DN, Zuckerman BD, Virmani R (2002) Drug-eluting stents in preclinical studies: Recommended evaluation from a consensus group. Circulation 106:1867-1873
30. Sierevogel MJ, Pasterkamp G, Velema E, de Jaegere PP, de Smet BJ, Verheijen JH, de Kleijn DP, Borst C (2001) Oral matrix metalloproteinase inhibition and arterial remodeling after balloon dilation: An intravascular ultrasound study in the pig. Circulation 103:302-307
31. Sierevogel MJ, Velema E, van der Meer FJ, Nijhuis MO, Smeets M, de Kleijn DP, Borst C, Pasterkamp G (2002) Matrix metalloproteinase inhibition reduces adventitial thickening and collagen accumulation following balloon dilation. Cardiovasc Res 55:864-869
32. Sliwa K, Skudicky D, Candy G, Wisenbaugh T, Sareli P (1998) Randomised investigation of effects of pentoxifylline on left-ventricular performance in idiopathic dilated cardiomyopathy. Lancet 351:1091-1093
33. Smith JD, Bryant SR, Couper LL, Vary CP, Gotwals PJ, Koteliansky VE, Lindner V (1999) Soluble transforming growth factor-beta type II receptor inhibits negative remodeling, fibroblast transdifferentiation, and intimal lesion formation but not endothelial growth. Circ Res 84:1212-1222
34. Stefanovich V, Von Poelnitz M, Reiser M (1974) Inhibition of various cyclic AMP phosphodiesterases by pentifylline and theophylline. Arzneim - Forsch Drug Res 24:1747-1751
35. Tanner FC, van der Loo B, Shaw S, Greutert H, Bachschmid MM, Berrozpe M, Rozenberg I, Blau N, Siebenmann R, Schmidli J, Meyer P, Luscher TF (2007) Inactivity of nitric oxide synthase gene in the atherosclerotic human carotid artery. Basic Res Cardiol 102:308-317
36. Tsai TJ, Lin RH, Chang CC, Chen YM, Chen CF, Ko FN, Teng CM (1995) Vasodilator agents modulate rat glomerular mesangial cell growth and collagen synthesis. Nephron 70:91-99
37. Yamamoto K, Morishita R, Tomita N, Shimozato T, Nakagami H, Kikuchi A, Aoki M, Higaki J, Kaneda Y, Ogihara T (2000) Ribozyme oligonucleotides against transforming growth factor-beta inhibited neointimal formation after vascular injury in rat model: Potential application of ribozyme strategy to treat cardiovascular disease. Circulation 102:1308-1314