Pentoxifylline inhibits neointimal formation and stimulates constrictive vascular remodeling after arterial injury

Journal of Cardiovascular Pharmacology

Volumn 34, Issue 5, 1999, Pages 683-689

  Hansen, Peter Riis ^a,d   Holm, Anne Mette ^a   Qi, Jian Hua ^b   Ledet, Thomas ^c   Rasmussen, Lars Melholt ^c   Andersen, Claus Bøgelund ^a  

^a Rigshospital ^*  (Denmark)

^b UPPSALA UNIVERSITY   (Sweden)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d Heart Center   (Denmark)

Author keywords

Apoptosis; Collagen; Neointima; Pentoxifylline; Remodeling; Vascular smooth muscle cell

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 4; COLLAGEN TYPE 6; CYCLINE; PENTOXIFYLLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY; CELL DENSITY; CELL MIGRATION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOPTOSIS; BLOOD PRESSURE; CAROTID ARTERY INJURIES; CELL DIVISION; CELL MOVEMENT; COLLAGEN; DISEASE MODELS, ANIMAL; MALE; MUSCLE, SMOOTH, VASCULAR; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; TUNICA INTIMA; VASOCONSTRICTION;

EID: 0032736726     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199911000-00009     Document Type: Article

References (44)

1. Schwartz SM, deBois D, O'Brien ERM. The intima: soil for atherosclerosis and restenosis. Circ Res 1995;77:445-65.
2. Bauters C, Meurice T, Hamon M, McFadden E, Lablanche J-M, Bertrand ME. Mechanisms and prevention of restenosis: from experimental models to clinical practice. Cardiovasc Res 1996;31: 835-16.
3. Currier JW, Faxon DP. Restenosis after percutaneous transluminal coronary angioplasty: have we been aiming at the wrong target? J Am Coll Cardiol 1995;25:516-20.
4. Birnbaum Y, Fishbein MC, Luo H, Nishioka T, Siegel RJ. Regional remodeling of atherosclerotic arteries: a major determinant of clinical manifestations of disease. J Am Coll Cardiol 1997;30: 1149-64.
5. Strauss BH, Chisholm RJ, Keeley FW, Gotlieb AI, Logan RA, Armstrong PW. Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. Circ Res 1994;75: 650-8.
6. Galis ZS, Muszynski M, Sukhova GK, et al. Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ Res 1994;75:181-9.
7. Coats WD, Whittaker P, Cheung DT, Currier JW, Han B, Faxon DP. Collagen content is significantly lower in restenotic versus nonrestenotic vessels after balloon angioplasty in the atherosclerotic rabbit model. Circulation 1997;95:1293-300.
8. Ward A, Clissold SP. Pentoxifylline: a review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs 1987;34:50-97.
9. Gillings DB. Pentoxifylline and intermittent claudication: review of clinical trials and cost-effectiveness analyses. J Cardiovasc Pharmacol 1995;25(suppl 2):S44-50.
10. Strohschneider T, Kling D, Betz E. The effect of pentoxifylline on endothelial permeability of rabbit carotid artery wall. Eur J Pharmacol 1988;150:287-93.
11. Lilly CM, Sandhu JS, Ishizaka A, et al. Pentoxifylline prevents tumor necrosis factor-induced lung injury. Am Rev Respir Dis 1989;139:1361-8.
12. Dauber IM, Lesnefsky EJ, Ashmore RC, et al. Coronary vascular injury due to ischemia-reperfusion is reduced by pentoxifylline. J Pharmacol Exp Ther 1992;260:1250-6.
13. Nenci G, Gresele P, Agnelli G, Ballatori E. Effect of pentoxifylline on platelet aggregation. Pharmatherapeutica 1981;2:532-8.
14. Pan X, Arauz E, Krzanowski JJ, Fitzpatrick DF, Poison JB. Synergistic interactions between selective pharmacological inhibitors of phosphodiesterase isoenzyme families PDE III and PDE IV to attenuate proliferation of rat vascular smooth muscle cells. Biochem Pharmacol 1994;48:827-35.
15. Bellas RE, Lee JS, Sonenshein GE. Expression of a constitutive NF-KB-like activity is essential for proliferation of cultured bovine vascular smooth muscle cells. J Clin Invest 1995;96:2521-7.
16. Belloc F, Jaloustre C, Dumain P, Lacombe F, Lenoble M, Boisseau MR. Effect of pentoxifylline on apoptosis of cultured cells. J Cardiovasc Pharmacol 1995;25(suppl 2):S71-4.
17. Strieter RM, Remick DG, Ward PA, et al. Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun 1988;155:1230-6.
18. Bernard C, Barnier P, Merval R, Esposito B, Tedgui A. Pentoxifylline selectively inhibits tumor necrosis factor synthesis in the arterial wall. J Cardiovasc Pharmacol 1995;25(suppl 2):S30-3.
19. Berman B, Duncan MR. Pentoxifylline inhibits normal human dermal fibroblast in vitro proliferation, collagen glycosaminoglycan, and fibronectin production, and increases collagenase activity. J Invest Dermatol 1989;92:605-10.
20. Berman B, Wietzerbin J, Sanceau J, Merlin G, Duncan MR. Pentoxifylline inhibits certain constitutive and tumor necrosis factor-alpha-induced activities of human normal dermal fibroblasts. J Invest Dermatol 1992;98:706-12.
21. Peterson TC. Pentoxifylline prevents fibrosis in an animal model and inhibits platelet-derived growth factor-driven proliferation of fibroblasts. Hepatology 1993;17:486-93.
22. Clowes AW, Reidy MA, Clowes MM. Mechanisms of stenosis after arterial injury. Lab Invest 1983;49:208-15.
23. Berkenboom G, Unger P, Goldman M, Fang Z, Fontaine J. Prevention of cyclosporine A-induced vascular toxicity by pentoxifylline. J Cardiovasc Pharmacol 1991;18:761-8.
24. Zeymer U, Fishbein MC, Forrester JS, Cercek B. Proliferating cell nuclear antigen immunohistochemistry in rat aorta after balloon denudation: comparison with thymidine and bromodeoxyuridine labeling. Am J Pathol 1992;141:685-9.
25. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
26. Rizvi MAD, Myers PR. Nitric oxide modulates basal and endothelin-induced coronary artery vascular smooth muscle cell proliferation and collagen levels. J Mol Cell Cardiol 1997;29:1779-89.
27. Auerbach R, Auerbach W, Polakowski I. Assays for angiogenesis: a review. Pharmacol Ther 1991;51:1-11.
28. Garg UC, Hassid A. Nitric oxide-generation vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 1989;83:1774-7.
29. Iyengar R. Gating by cyclic AMP: expanded role for an old signaling pathway. Science 1996;271:461-3.
30. Rybalkin SD, Bornfeldt KE, Sonnenburg WK, et al. Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype. J Clin Invest 1997;100:2611-21.
31. Indolfi C, Avvedimento EV, Di Lorenzo E, et al. Activation of cAMP-PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury. Nature Med 1997;3:775-9.
32. Souness JE, Hassall GA, Parrott DP. Inhibition of pig aortic smooth muscle cell DNA synthesis by selective type III and type IV cyclic AMP phosphodiesterase inhibitors. Biochem Pharmacol 1992;44:857-66.
33. Bochaton-Piallat M-L, Gabbiani F, Redard M, Desmoulière A, Gabbiani G. Apoptosis participates in cellularity regulation during rat aortic intima thickening. Am J Pathol 1995;146:1059-64.
34. Perlman H, Maillard L, Krasinski K, Walsh K. Evidence for the rapid onset of apoptosis in medial smooth muscle cells after balloon injury. Circulation 1997;95:981-7.
35. Malik N, Francis SE, Holt CM, et al. Apoptosis and cell proliferation after porcine coronary angioplasty. Circulation 1998;98: 1657-65.
36. Isner JM, Keamey M, Bortman S, Passeri J. Apoptosis in human atherosclerosis and restenosis. Circulation 1995;91:2703-11.
37. McCullagh KA, Balian G. Collagen characterization and cell transformation in human atherosclerosis. Nature 1975;258:73-5.
38. Kakuta T, Currier JW, Haudenschild CC, Ryan TJ, Faxon DP. Differences in compensatory vessel enlargement, not intimal formation, account for restenosis after angioplasty in the hypercholesterolemic rabbit model. Circulation 1994;89:2809-15.
39. Lafont A, Guzman LA, Whitlow PL, Goormastic M, Cornhill JF, Chisolm GM. Restenosis after experimental angioplasty: intimal, medial, and adventitial changes associated with constrictive remodeling. Circ Res 1995;76:996-1002.
40. Le Tourneau T, Van Belle E, Corseaux D, et al. Role of nitric oxide in restenosis after experimental balloon angioplasty in the hypercholesterolemic rabbit: effects on neointimal hyperplasia and vascular remodeling. J Am Coll Cardiol 1999;33:876-82.
41. Casscells W. Migration of smooth muscle and endothelial cells: critical events in restenosis. Circulation 1992;86:723-9.
42. 1 receptor antagonist: effects on smooth muscle cell migration and proliferation after balloon catheter injury. Am J Pathol 1991;139:1291-6.
43. Grasl-Kraupp B, Ruttkay-Nedecky B, Koudelka H, Bukowska K, Bursch W, Schulte-Hermann R. In situ detection of fragmented DNA (TUNEL) assay fails to discriminate among apoptosis, necrosis and autolytic cell death: a cautionary note. Hepatology 1995; 21:1465-8.
44. Kockx MM, Muhring J, Knaapen MWM, De Meyer GRY. RNA synthesis and splicing interferes with DNA in situ end labeling techniques used to detect apoptosis. Am J Pathol 1998;152:885-8.