Molecular mechanisms underlying IL-4-induced leukocyte recruitment in vivo: A critical role for the α4 integrin

Journal of Immunology

Volumn 163, Issue 6, 1999, Pages 3441-3448

  Hickey, Michael J ^a   Granger, D Neil ^b   Kubes, Paul ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTEGRIN; INTERLEUKIN 4; L SELECTIN; MONOCLONAL ANTIBODY; PADGEM PROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CAPILLARY; CELL INTERACTION; CONTROLLED STUDY; CREMASTER MUSCLE; ENDOTHELIUM CELL; LEUKOCYTE ADHERENCE; LEUKOCYTE MIGRATION; MALE; MOLECULAR DYNAMICS; MONONUCLEAR CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; VENULE;

ANIMALS; ANTIGENS, CD; CELL ADHESION; CELL MOVEMENT; E-SELECTIN; EOSINOPHILS; INJECTIONS, INTRADERMAL; INTEGRIN ALPHA4; INTEGRINS; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROCIRCULATION; MICROSCOPY, VIDEO; P-SELECTIN; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0033568296     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Bradding, P., I. H. Feather, S. Wilson, P. G. Bardin, C. H. Heusser, S. T. Holgate, and P. H. Howarth. 1993. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects: the mast cell as a source of IL-4, IL-5 and IL-6 in human allergic mucosal inflammation. J. Immunol. 151:3853.
2. Brown, M. A., and J. M. Hanifin. 1990. Atopic dermatitis. Curr. Opin. Immunol. 2:531.
3. Robinson, D. S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A. M. Bentley, C. Corrigan, S. R. Durham, and A. B. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N. Engl. J. Med. 326:298.
4. Coyle, A. J., G. Le Gros, C. Bertrand, S. Tsuyuki, C. H. Heusser, M. Kopf, and G. P. Anderson. 1995. Interleukin-4 is required for induction of lung Th2 mucosal immunity. Am. J. Respir. Cell Mol. Biol. 13:54.
5. Kopf, M., G. Le Gros, A. J. Coyle, M. Kosco-Vilbois, and F. Brombacher. 1995. Immune responses of IL-4, IL-5, IL-6 deficient mice. Immunol. Rev. 148:45.
6. + T cell infiltration. J. Immunol. 149: 2954.
7. Gundel, R., D. Lindell, P. Harris, M. Fournel, G. Jesmok, and M. E. Gerritsen. 1996. IL-4 induced leukocyte trafficking in cynomolgous monkeys: correlation with expression of adhesion molecules and chemokine generation. Clin. Exp. Allergy 26:719.
8. Moser, R., P. Groscurth, J. M. Carballido, P. L. B. Bruijnzeel, K. Blaser, C. H. Heusser, and J. Fehr. 1993. Interleukin-4 induces tissue eosinophilia in mice: correlation with its in vitro capacity to stimulate the endothelial cell-dependent selective transmigration of human eosinophils. J. Lab. Clin. Med. 122: 567.
9. 4 integrin/VCAM-1 adhesion pathways. J. Immunol. 160:5367.
10. 4 integrins mediate lymphocyte attachment and rolling under physiologic flow. Cell 80:413.
11. Alon, R., P. D. Kassner, M. W. Carr, E. B. Finger, M. E. Hemler, and T. A. Springer. 1995. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell Biol. 128:1243.
12. 2-integrins. J. Cell Biol. 125:1417.
13. + T lymphocytes on tumor necrosis factor α-activated vascular endothelium under flow. J. Exp. Med. 181:1179.
14. Luscinskas, F. W., H. Ding, P. Tan, D. Cumming, T. F. Tedder, and M. E. Gerritsen. 1996. L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-α-activated vascular endothelium under flow in vitro. J. Immunol. 156:326.
15. 4-integrin supports leukocyte rolling and adhesion in chronically inflamed postcapillary venules in vivo. J. Exp. Med. 183:1995.
16. 4-integrin, P-selectin, and E-selectin in an allergic model of inflammation. J. Exp. Med. 185: 1077.
17. Thornhill, M. H., and D. O. Haskard. 1990. IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-γ. J. Immunol. 145:865.
18. Schleimer, R. P., S. A. Sterbinsky, J. Kaiser, C. A. Bickel, D. A. Klunk, K. Tomioka, W. Newman, F. W. Luscinskas, M. A. J. Gimbrone, B. W. McIntyre, and B. S. Bochner. 1992. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium: association with expression of VCAM-1. J. Immunol. 148:1086.
19. 4 integrin-dependent adhesion are differentially regulated. J. Immunol. 157:5061.
20. Patel, K. D. 1998. Eosiriophil tethering to interleukin-4-activated endothelial cells requires both P-selectin and vascular cell adhesion molecule-1. Blood 92:3904.
21. Melrose, J., N. Tsurushita, G. Liu, and E. L. Berg. 1998. IFN-γ inhibits activation-induced expression of E- and P-selectin on endothelial cells. J. Immunol. 161:2457.
22. Bullard, D. C., E. J. Kunkel, H. Kubo, M. J. Hicks, I. Lorenzo, N. A. Doyle, C. M. Doerschuk, K. Ley, and A. L. Beaudet. 1996. Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice. J. Exp. Med 183:2329.
23. Hickey, M. J., K. A. Sharkey, E. G. Sihota, P. H. Reinhardt, J. D. MacMicking, C. Nathan, and P. Kubes. 1997. Inducible nitric oxide synthase (iNOS)-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB J. 11:955.
24. House, S. D., and H. H. Lipowsky. 1987. Leukocyte-endothelium adhesion: microhemodynamics in mesentery of the cat. Microvasc. Res. 34:363.
25. Eppihimer, M. J., B. Wolitzky, D. C. Anderson, M. A. Labow, and D. N. Granger. 1996. Heterogeneity of expression of E- and P-selectins in vivo. Circ. Res. 79:560.
26. Henninger, D. D., J. Panes, M. J. Eppihimer, J. Russell, M. E. Gerritsen, D. C. Anderson, and D. N. Granger. 1997. Cytokine-induced VCAM-1 and ICAM-1 expression in different organs of the mouse. J. Immunol. 158:1825.
27. Hickey, M. J., S. Kanwar, D. McCafferty, D. N. Granger, M. J. Eppihimer, and P. Kubes. 1999. Varying roles of E-selectin and P-selectin in different microvascular beds in response to antigen. J. Immunol. 162:1137.
28. Hickey, M. J., A. C. Issekutz, P. H. Reinhardt, R. N. Fedorak, and P. Kubes. 1998. Endogenous interleukin-10 regulates hemodynamic parameters, leukocyte-endothelial cell interactions and microvascular permeability during endotoxemia. Circ. Res. 83:1124.
29. Mizgerd, J. P., B. B. Meek, G. J. Kutkoski, D. C. Bullard, A. L. Beaudet, and C. M. Doerschuk. 1996. Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungs. J. Exp. Med. 184:639.
30. Larbi, K., A. Allen, R. R. Lobb, P. M. R. Silva, and S. Nourshargh. 1999. A tissue specific role for VCAM-1 in IL-4-induced eosinophil accumulation in vivo. FASEB J. 13:A670 (Abstr.).
31. Reinhardt, P. H., and P. Kubes. 1998. Differential leukocyte recruitment from whole blood via endothelial adhesion molecules under shear conditions. Blood 92:4691.
32. Rothenberg, M. E., A. D. Luster, and P. Leder. 1995. Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. Proc. Natl. Acad. Sci. USA 92:8960.
33. 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4. J. Immunol. 160:3569.
34. Swerlick, R. A., K. H. Lee, L. Li, N. T. Sepp, S. W. Caughman, and T. J. Lawley. 1992. Regulation of vascular cell adhesion molecule-1 on human dermal microvascular endothelial cells. J. Immunol. 149:698.
35. Haraldsen, G., G. Kvale, B. Lien, I. N. Farstad, and P. Brandtzaeg. 1996. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human intestinal microvascular endothelial cells. J. Immunol. 156:2558.
36. Jahnsen, F. L., P. Brandtzaeg, R. Haye, and G. Haraldsen. 1997. Expression of functional VCAM-1 by cultured nasal polyp-derived microvascular endothelium. Am. J. Pathol. 150:2113.
37. Kanwar, S., R. C. Woodman, M.-C. Poon, T. Murohara, A. M. Lefer, K. L. Davenpeck, and P. Kubes. 1995. Desmopressin induces endothelial P-selectin expression and leukocyte rolling in post-capillary venules. Blood 86:2760.