Ciliary neurotrophic factor receptor α subunit-modulated multiple downstream signaling pathways in hepatic cancer cell lines and their biological implications

Hepatology

Volumn 47, Issue 4, 2008, Pages 1298-1308

  Hu, Xin ^a,b   Zhao, Yingjun ^a,b   He, Xianghuo ^b   Li, Jinjun ^b   Wang, Tao ^a,b   Zhou, Weiping ^c   Wan, Dafang ^b   Wang, Hongyang ^b   Gu, Jianren ^b  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Eastern Institute of Hepatobiliary Surgery   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA; GLUCOSE TRANSPORTER 4; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ARTICLE; BIOLOGY; CELL CYCLE ARREST; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; ENZYME ACTIVITY; GLUCOSE TRANSPORT; HEPATOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CARCINOMA; LIVER CELL CARCINOMA; METABOLIC DISORDER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR ALPHA SUBUNIT; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; HEPATOBLASTOMA; HUMANS; JANUS KINASES; LIVER; LIVER NEOPLASMS; PLASMIDS; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR CROSS-TALK; RNA INTERFERENCE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS;

EID: 42249083200     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22163     Document Type: Article

References (28)

1. Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ. The ciliary neurorrophic facror and its receptor, CNTFR alpha. Pharm Acta Helv 2000;74:265-272.
2. Febbraio MA. gp130 receptor ligands as potential therapeutic targets for obesity. J Clin Invest 2007;117:841-849.
3. Lambert PD, Anderson KD, Sleeman MW, Wong V, Tan J, Hijarunguru A, Corcoran TL, et al. Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity. Proc Natl Acad Sci U S A 2001;98:4652-4657.
4. Sleeman MW, Garcia K, Liu R, Murray JD, Malinova L, Moncrieffe M, et al. Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice. Proc Natl Acad Sci U S A 2003;100:14297-14302.
5. Watt MJ, Dzamko N, Thomas WG, Rose-John S, Ernst M, Carling D, et al. CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nat Med 2006;12:541-548.
6. Lesser SS, Lo DC. CNTF II, I presume? Nat Neurosci 2000;3:851-852.
7. Man D, He W, Sze KH, Gong K, Smith DK, Zhu G, et al. Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. J Biol Chem 2003;278:23285-23294.
8. Ozog MA, Bernier SM, Bates DC, Chatterjee B, Lo CW, Naus CC. The complex of ciliary neurotrophic factor-ciliary neurotrophic factor receptor alpha up-regulates connexin43 and intercellular coupling in astrocytes via the Janus tyrosine kinase/signal transducer and activator of transcription pathway. Mol Biol Cell 2004;15:4761-4774.
9. Alonzi T, Middleton G, Wyatt S, Buchman V, Betz UA, Muller W, et al. Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Mol Cell Neurosci 2001;18:270-282.
10. Kokoeva MV, Yin H, Flier JS. Neurogenesis in the hypothalamus of adult mice: potential role in energy balance. Science 2005;310:679-683.
11. Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, et al. Large-scale cDNA transfection screening for genes related to cancer development and progression. Proc Natl Acad Sci USA 2004;101:15724-15729.
12. He C, Chen J, Ao S, Lu C. Preparation and a structure-function analysis of human ciliary neurotrophic factor. Neurosci Res 1995;23:327-333.
13. Yamada E, Okada S, Saito T, Ohshima K, Sato M, Tsuchiya T, et al. Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles. J Cell Biol 2005;168:921-928.
14. Jia Y, Takimoto K. Mitogen-activated protein kinases control cardiac KChIP2 gene expression. Circ Res 2006;98:386-393.
15. Zaheer A, Zhong W, Lim R. Expression of mRNAs of multiple growth factors and receptors by neuronal cell lines: detection with reverse transcription PCR. Neurochem Res 1995;20:1457-1463.
16. Guo M, Li J, Wan D, Gu J. KIAA0101 (OEACT-1), an expressionally down-regulated and growth-inhibitory gene in human hepatocellular carcinoma. BMC Cancer 2006;6:109.
17. Huang P, Altshuller YM, Hou JC, Pessin JE, Frohman MA. Insulin-stimulated plasma membrane fusion of Glut4 glucose transporter-containing vesicles is regulated by phospholipase D1. Mol Biol Cell 2005;16:2614-2623.
18. Bogan JS, McKee AE, Lodish HF. Insulin-responsive compartments containing GLUT4 in 3T3-L1 and CHO cells: regulation by amino acid concentrations. Mol Cell Biol 2001;21:4785-4806.
19. Auguste P, Robledo O, Olivier C, Froger J, Praloran V, Pouplard-Barthelaix A, et al. Alanine substitution for Thr268 and Asp269 of soluble ciliary neurotrophic factor (CNTF) receptor alpha component defines a specific antagonist for the CNTF response. J Biol Chem 1996;271:26049-26056.
20. Yamaguchi S, Katahira H, Ozawa S, Nakamichi Y, Tanaka T, Shimoyama T, et al. Activators of AMP-activated protein kinase enhance GLUT4 translocation and its glucose transport activity in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 2005;289:E643-649.
21. De Vos J, Jourdan M, Tarte K, Jasmin C, Klein B. JAK2 tyrosine kinase inhibitor tyrphostin AG490 downregulares the mitogen-activated protein kinase (MAPK) and signal transducer and activator of transcription (STAT) pathways and induces apoptosis in myeloma cells. Br J Haematol 2000;109:823-828.
22. Banerjee R, Caruccio L, Zhang YJ, McKercher S, Santella RM. Effects of carcinogen-induced transcription factors on the activation of hepatitis B virus expression in human heparoblastoma HepG2 cells and its implication on hepatocellular carcinomas. HEPATOLOGY 2000;32:367-374.
23. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004;4:891-899.
24. Riedl CC, Akhurst T, Larson S, Stanziale SF, Tuorto S, Bhargava A, et al. 18F-FDG PET scanning correlates with tissue markers of poor prognosis and predicts mortality for patients after liver resection for colorectal metastases. J Nucl Med 2007;48:771-775.
25. Wilhelm SM, Carter C, Tang L, Wilkie D, McNabola A, Rong H, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-7109.
26. Garcia Z, Kumar A, Marques M, Cortes I, Carrera AC. Phosphoinositide 3-kinase controls early and late events in mammalian cell division. EMBO J 2006;25:655-661.
27. Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 2000;19:2548-2556.
28. Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, et al. Signaling of human ciliary neurotrophic factor (CNTF) revisited: the interleukin-6 receptor can serve as an alpha-receptor for CTNF. J Biol Chem 2003;278:9528-9535.