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Volumn 11, Issue 3, 2008, Pages 320-328

Dietary approaches to the prevention of food allergy

Author keywords

Cow's milk allergy; Elimination diet; Formula; Infant; Prevention

Indexed keywords

ALPHA TOCOPHEROL; AMINO ACID; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CALCITRIOL; COLECALCIFEROL; DOCOSAHEXAENOIC ACID; FISH OIL; FOOD ALLERGEN; FRUCTOSE OLIGOSACCHARIDE; GALACTOSE OLIGOSACCHARIDE; GARLIC EXTRACT; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; PLACEBO; PREBIOTIC AGENT; PROBIOTIC AGENT; RETINOL; SELENIUM; SOYBEAN PROTEIN; TRACE ELEMENT; VITAMIN D; ZINC;

EID: 42149191215     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e3282fbf589     Document Type: Review
Times cited : (20)

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    • Kukkonen K, Savilahti E, Haahtela T, et al. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 2007; 119:192-198. The combined supplementation of mother and infant with prebiotics and probiotics was not effective in preventing eczema at 2 years of age.
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    • This is the 7-year follow-up of the pioneering study demonstrating sustained reduction in eczema after supplementation of mother and infant during late pregnancy and lactation with LGG
    • Kalliomäki M, Salminen S, Poussa T, Isolauri E. Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial. J Allergy Clin Immunol 2007; 119:1019-1021. This is the 7-year follow-up of the pioneering study demonstrating sustained reduction in eczema after supplementation of mother and infant during late pregnancy and lactation with LGG.
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    • Kalliomäki, M.1    Salminen, S.2    Poussa, T.3    Isolauri, E.4
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    • Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization
    • This animal study used a novel bioengineered, IL-10 producing Lactococcus lactis strain and demonstrated a reduction in IgE-sensitization to β-lactoglobulin in treated mice
    • Frossard CP, Steidler L, Eigenmann PA. Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization. J Allergy Clin Immunol 2007; 119:952-959. This animal study used a novel bioengineered, IL-10 producing Lactococcus lactis strain and demonstrated a reduction in IgE-sensitization to β-lactoglobulin in treated mice.
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    • Osborn DA, Sinn JK. Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev 2007; CD006475. This Cochrane review summarizes the complex field of probiotic interventions for atopy prevention and concludes that current data are insufficient to recommend probiotics for allergy prevention. Further studies are recommended.
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    • Osborn DA, Sinn JK. Prebiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev 2007; CD006474. Although this Cochrane review found some preliminary evidence for an immune modulating effect of prebiotic oligosaccharides, the quality of studies did not allow firm conclusions with regard to allergy prevention, and further research was recommended.
    • Osborn DA, Sinn JK. Prebiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev 2007; CD006474. Although this Cochrane review found some preliminary evidence for an immune modulating effect of prebiotic oligosaccharides, the quality of studies did not allow firm conclusions with regard to allergy prevention, and further research was recommended.
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    • Dunstan JA, Mitoulas LR, Dixon G, et al. The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial. Pediatr Res 2007; 62:689-694. This study demonstrates that maternal fish oil supplementation during pregnancy increases DHA levels in breast milk during early lactation, and in the serum of infants at 1 year of age.
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    • Krauss-Etschmann S, Hartl D, Rzehak P, et al. Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. J Allergy Clin Immunol 2008; 121:464-470. This well designed study showed a decrease in Th-2 cytokines and increase in tolerogenic TGF-β in cord blood after maternal supplementation with EPA/DHA during pregnancy. The clinical significance of this finding in terms of allergy prevention is unknown, and long-term follow-up data are needed.
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    • Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years
    • This longitudinal study found no evidence of a preventive effect of omega-3 or omega-6 fatty acids for eczema, asthma or atopy. Although maternal omega-3 LCPUFA supplementation during pregnancy may be protective, postnatal supplementation of the infant appears to be ineffective
    • Almqvist C, Garden F, Xuan W, et al. Omega-3 and omega-6 fatty acid exposure from early life does not affect atopy and asthma at age 5 years. J Allergy Clin Immunol 2007; 119:1438-1444. This longitudinal study found no evidence of a preventive effect of omega-3 or omega-6 fatty acids for eczema, asthma or atopy. Although maternal omega-3 LCPUFA supplementation during pregnancy may be protective, postnatal supplementation of the infant appears to be ineffective.
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    • Almqvist, C.1    Garden, F.2    Xuan, W.3
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