Overexpression of E2F5/p130, but not E2F5 alone, can inhibit E2F-induced cell cycle entry in transgenic mice

Molecular Vision

Volumn 14, Issue , 2008, Pages 602-614

  Chen, Qin ^a   Liang, Dongcai ^b   Overbeek, Paul A ^b  

^a UNIVERSITY OF HOUSTON   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; BROXURIDINE; COMPLEMENTARY DNA; PROTEIN P130; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F3; TRANSCRIPTION FACTOR E2F3A; TRANSCRIPTION FACTOR E2F5; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION; GENE OVEREXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VIVO STUDY; LENS FIBER; MICROINJECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

ANIMALS; CELL CYCLE; CELL DIFFERENTIATION; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; E2F3 TRANSCRIPTION FACTOR; E2F5 TRANSCRIPTION FACTOR; HUMANS; LENS, CRYSTALLINE; MICE; MICE, TRANSGENIC; RETINOBLASTOMA-LIKE PROTEIN P130;

EID: 42149186405     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Cobrinik D. Pocket proteins and cell cycle control. Oncogene 2005; 24:2796-809.
2. Giordano A, Rossi A, Romano G, Bagella L. Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy. J Cell Physiol 2007; 213:403-6.
3. Clarke AR, Maandag ER, van Roon M, van der Lugt NM, van der Valk M, Hooper ML, Berns A, te Riele H. Requirement for a functional Rb-1 gene in murine development. Nature 1992; 359:328-30.
4. Lee EY, Chang CY, Hu N, Wang YC, Lai CC, Herrup K, Lee WH. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 1992; 359:288-94.
5. Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev 1996; 10:1633-44.
6. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev 1998; 12:2245-62.
7. Zhang HS, Postigo AA, Dean DC. Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p161NK4a, TGFbeta, and contact inhibition. Cell 1999; 97:53-61.
8. Hijmans EM, Voorhoeve PM, Beijersbergen RL, van't Veer LJ, Bernards R. E2F-5, a new E2F family member that interacts with p130 in vivo. Mol Cell Biol 1995; 15:3082-9.
9. DeGregori J, Johnson DG. Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr Mol Med 2006; 6:739-48.
10. Dimova DK, Dyson NJ. The E2F transcriptional network: old acquaintances with new faces. Oncogene 2005; 24:2810-26.
11. DeGregori J, Leolne G, Miron A, Jakoi L, Nevins JR. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci USA 1997; 94:7245-50.
12. Lukas J, Petersen BO, Holm K, Bartek J, Helin K. Deregulated expression of E2F family members induces S-phase entry and overcomes p161NK4A-mediated growth suppression: Mol Cell Biol 1996; 16:1047-57.
13. Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev 1998; 12:2120-30.
14. Wells J, Boyd KE, Fry CJ, Bartley SM, Farnham PJ. Target gene specificity of E2F and pocket protein family members in living cells. Mol Cell Biol 2000; 20:5797-807.
15. Chen Q, Liang P, Yang T, Leone G, Overbeek PA. Distinct capacities of individual E2Fs to induce cell cycle reentry in postmitotic lens fiber cells of transgenic mice. Dev Neurosci 2004; 26:435-45.
16. Claudio PP, Howard CM, Baldi A, De Luca A, Fu Y, Condorelli G, Sun Y, Colburn N, Calabretta B, Giordano A. P130/pRb2 has growth suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res 1994; 54:5556-60.
17. Claudio PP, Howard CM, Pacilio C, Cinti C, Romano G, Minimo C, Maraldi NM, Minna JD, Gelbert L, Leoncini L, Tosi GM, Hicheli P, Caputi M, Giordano GG, Giordano A. Mutations in the retinoblastoma-related gene RB2/p130 in lung tumors and suppression of tumor growth in vivo by retrovirus-mediated gene transfer. Cancer Res 2000; 60:372-82.
18. Vairo G, Livingston DM, Ginsberg D. Functional interaction between E2F-4 and p130: Evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev 1995; 9:869-81.
19. Iavarone A, Massagué J. E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest. Mol Cell Biol 1999; 19:916-22.
20. Takahashi Y, Rayman JB, Dynlacht BD. Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Genes Dev 2000; 14:804-16.
21. Gaubatz S, Lindeman GJ, Ishida S, Jakoi L, Nevins JR, Livingston DM, Rempel RE. E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell 2000; 6:729-35.
22. Cvekl A, Piatigorsky J. Lens development and crystallin gene expression: many roles for Pax-6. Bioessays 1996; 18:621-30.
23. Rampalli AM, Gao CY, Chauthaiwale VM, Zelenka PS. pRb and p107 regulate E2F activity during lens fiber cell differentiation. Oncogene 1998; 16:399-408.
24. Chen Q, Ash JD, Branton P, Fromm L, Overbeek PA. Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice. Oncogene 2002; 21:1028-37.
25. Fromm L, Shawlot W, Gunning K, Butel. JS, Overbeek PA. The retinoblastoma protein-binding region of simian virus 40 large T antigen alters cell cycle regulation in lenses of transgenic mice. Mol Cell Biol 1994; 14:6743-54.
26. Pan H, Griep AE. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev 1994; 8:12S5-99.
27. Morgenbesser SD, Williams BO, Jacks T, DePinho RA. P53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 1994; 371:72-4.
28. Saavedra HI, Wu L, de Bruin A, Timmers C, Rosol TJ, Weinstein M, Robinson ML, Leone G. Specificity of E2F1, E2F2, and E2F3 in mediating phenotypes induced by loss of Rb. Cell Growth Differ 2002; 13:215-25.
29. Chen Q, Hung F, Fromm L, Overbeek PA. Induction of cell cycle entry and cell death in postmitotic lens fiber cells by overexpression of E2F1 or E2F2. Invest Ophthalmol Vis Sci 2000; 41:4223-31.
30. Reneker LW, Chen Q, Bloch A, Xie L, Schuster G, Overbeek PA. Chick delta1-crystallin enhancer influences mouse alphaA-crystallin promoter activity in transgenic mice. Invest Ophthalmol Vis Sci 2004; 45:4083-90.
31. Hogan BF, Costantini F, Lacy E, Beddington R. Manipulating the Mouse Embryo: A Laboratory Manual. 2nd ed. 1994; Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
32. Taketo M, Schroeder AC, Mobraaten LE. FVB/N: an inbred mouse strain preferable for transgenic analyses. Proc Natl Acad Sci USA 1991; 88:2065-9.
33. Fromm L, Overbeek PA. Regulation of cyclin and cyclin-dependent kinase gene expression during lens differentiation requires the retinoblastoma protein. Oncogene 1996; 12:69-75.
34. Helmbold H, Deppert W, Bohn W. Regulation of cellular senescence by Rb2/ p130. Oncogene 2006; 25:5257-62.
35. Araki K, Nakajima Y, Eto K, Ikeda MA. Distinct recruitment of E2F family members to specific E2F-binding sites mediates activation and repression of the E2F1 promoter. Oncogene 2003; 22:7632-41.
36. Trimarchi JM, Lees JA. Sibling rivalry in the E2F family. Nat Rev Mol Cell Biol 2002; 3:11-20.
37. Rempel RE, Saenz-Robles MT, Storms R, Morham S, Ishida S, Engel A, Jakoi L, Melhem MF, Pipas JM, Smith C, Nevins JR. Loss of E2F4 activity leads to abnormal development and multiple cellular lineages. Mol Cell 2000; 6:293-306.
38. Lindeman GJ, Dagnino L, Gaubatz S, Xu Y, Bronson RT, Warren HB, Livingston DM. A specific, non-proliferation role, for E2F-5 in choroids plexus function revealed by gene targeting. Genes Dev 1998; 12:1092-8.
39. Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D. The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc Natl Acad Sci USA 1998; 95:10493-8.
40. Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA. E2F-4 and E2F-5, two novel members of the E2F family, are expressed in the early phases of the cell cycle. Proc Natl Acad Sci USA 1995; 92:2403-7.
41. E2F-5, a new E2F family member that interacts with p130 in vivo. Mol Cell Biol 1995; 15:3082-9. Voorhoeve PMBeijersbergen RLvan 't Veer LJBernards R
42. D'Andrilli G, Masciullo V, Bagella L, Tonini T, Minimo C, Zannoni, GF, Giuntoli RL 2nd, Carlson JA Jr, Soprano DR, Soprano KJ, Scambia G, Giordano A. Frequent loss of pRb2/p130 in human ovarian carcinoma. Clin Cancer Res 2004; 10:3098-103.
43. Claudio PP, Caputi M, Giordano A. The RB2/p130 gene: the latest weapon in the war against lung cancer? Clin Cancer Res 2000; 6:754-64.
44. Lipinski MM, Jacks T. The retinoblastoma gene family in differentiation and development. Oncogene 1999; 18:7873-82.
45. Macaluso M, Cinti C, Russo G, Russo A, Giordano A. PRb2/p130-E2F4/ 5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. Oncogene 2003; 22:3511-7.
46. Lazzi S, Bellan C, De Falco G, Cinti C, Ferrari F, Nyongo A, Claudio PP, Tosi GM, Vatti R, Gloghini A, Carbone A, Giordano A, Leoncini L, Tosi P. Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for disease pathogenesis. Hum Pathol 2002; 33:723-31.
47. Mutti L, De Luca A, Claudio PP, Convertino G, Carbone M, Giordano A. Simian virus 40-like DNA sequences and large-T antigen-retinoblastoma family protein pRb2/p130 interaction in human mesothelioma. Dev Biol Stand 1998; 94:47-53.
48. Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG Jr. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 2000; 407:645-8.
49. Kowalik TF, DeGregori J, Leone G, Jakoi L, Nevins JR. E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ 1998; 9:113-8.