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Volumn 213, Issue 2, 2007, Pages 403-406

Tumor suppressor pRb2/p130 gene and its derived product Spa310 spacer domain as perspective candidates for cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLINE; PROTEIN P105; PROTEIN P107; PROTEIN P130; RETROVIRUS VECTOR; SPA310 PROTEIN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 34848898446     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21225     Document Type: Short Survey
Times cited : (14)

References (55)
  • 2
    • 33947498211 scopus 로고    scopus 로고
    • A small molecule based on the pRb2/P130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo
    • Bagella L, Sun A, Tonini T, Abbadessa G, Cottone G, Paggi M, De Luca A, Claudio PP, Giordano A. 2007. A small molecule based on the pRb2/P130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo. Oncogene 26:1829-1839.
    • (2007) Oncogene , vol.26 , pp. 1829-1839
    • Bagella, L.1    Sun, A.2    Tonini, T.3    Abbadessa, G.4    Cottone, G.5    Paggi, M.6    De Luca, A.7    Claudio, P.P.8    Giordano, A.9
  • 4
    • 0028039027 scopus 로고
    • CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1
    • Bates S, Bonetta L, MacAllan D, Parry D, Holder A, Dickson C. 1994. CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene 9:71-79.
    • (1994) Oncogene , vol.9 , pp. 71-79
    • Bates, S.1    Bonetta, L.2    MacAllan, D.3    Parry, D.4    Holder, A.5    Dickson, C.6
  • 5
    • 0024439444 scopus 로고
    • The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
    • Buchklovich K, Duffy LA, Harlow E. 1989, The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell 58:1097-1105.
    • (1989) Cell , vol.58 , pp. 1097-1105
    • Buchklovich, K.1    Duffy, L.A.2    Harlow, E.3
  • 7
    • 0024429019 scopus 로고
    • Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation
    • Chen PL, Scully P, Shew JY, Wang JY, Lee WH. 1989. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell 58:1193-1198.
    • (1989) Cell , vol.58 , pp. 1193-1198
    • Chen, P.L.1    Scully, P.2    Shew, J.Y.3    Wang, J.Y.4    Lee, W.H.5
  • 11
    • 0031726412 scopus 로고    scopus 로고
    • Virocrine transformation: The intersection between viral transforming proteins and cellular signal transduction pathways
    • DiMaio D, Lai CC, Klein O. 1998. Virocrine transformation: The intersection between viral transforming proteins and cellular signal transduction pathways. Annu Rev Microbiol 52:397-421.
    • (1998) Annu Rev Microbiol , vol.52 , pp. 397-421
    • DiMaio, D.1    Lai, C.C.2    Klein, O.3
  • 13
    • 0025785484 scopus 로고
    • Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein
    • Ewen ME, Xing YG, Lawrence JB, Livingston DM. 1991. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell 66:1155-1164.
    • (1991) Cell , vol.66 , pp. 1155-1164
    • Ewen, M.E.1    Xing, Y.G.2    Lawrence, J.B.3    Livingston, D.M.4
  • 14
    • 0038685911 scopus 로고    scopus 로고
    • CDK inhibitors in clinical development for the treatment of cancer
    • Fischer PM, Giannella-Borradori A. 2003. CDK inhibitors in clinical development for the treatment of cancer. Expert Opin Invest Drugs 12:955-970.
    • (2003) Expert Opin Invest Drugs , vol.12 , pp. 955-970
    • Fischer, P.M.1    Giannella-Borradori, A.2
  • 17
    • 0024414901 scopus 로고
    • A 60 kd cdc2-associated polypetide complexes with the E1A proteins in adenovirus-infected cells
    • Giordano A, Whyte P, Harlow E, Franza BR Jr, Beach D, Draetta G. 1989. A 60 kd cdc2-associated polypetide complexes with the E1A proteins in adenovirus-infected cells. Cell 58:981-990.
    • (1989) Cell , vol.58 , pp. 981-990
    • Giordano, A.1    Whyte, P.2    Harlow, E.3    Franza Jr, B.R.4    Beach, D.5    Draetta, G.6
  • 18
    • 0025994793 scopus 로고
    • Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A
    • Giordano A, Lee JH, Scheppler JA, Herrmann C, Harlow E, Deuschle U. 1991. Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A. Science 253:1271-1275.
    • (1991) Science , vol.253 , pp. 1271-1275
    • Giordano, A.1    Lee, J.H.2    Scheppler, J.A.3    Herrmann, C.4    Harlow, E.5    Deuschle, U.6
  • 19
    • 34347263739 scopus 로고    scopus 로고
    • Carcinogenesis and environment: The cancer stem cell hypothesis and implicationsforthe development of novel therapeutics and diagnostics
    • Giordano A, Fucito A, Romano G, Marino IR. 2007. Carcinogenesis and environment: The cancer stem cell hypothesis and implicationsforthe development of novel therapeutics and diagnostics. Front Biosci 12:3475-3482.
    • (2007) Front Biosci , vol.12 , pp. 3475-3482
    • Giordano, A.1    Fucito, A.2    Romano, G.3    Marino, I.R.4
  • 20
    • 0026713875 scopus 로고
    • Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
    • Gu Y, Rosenblatt J, Morgan DO. 1992. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J 11:3995-4005.
    • (1992) EMBO J , vol.11 , pp. 3995-4005
    • Gu, Y.1    Rosenblatt, J.2    Morgan, D.O.3
  • 21
    • 0027142956 scopus 로고
    • Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins
    • Hannon GJ, Demetrick D, Beach D. 1993. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev 7:2378-2391.
    • (1993) Genes Dev , vol.7 , pp. 2378-2391
    • Hannon, G.J.1    Demetrick, D.2    Beach, D.3
  • 22
    • 1842477408 scopus 로고    scopus 로고
    • Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells
    • Harwell RM, Mull B, Porter DC, Keyomarsi K. 2004. Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells. J Biol Chem 279:12695-12705.
    • (2004) J Biol Chem , vol.279 , pp. 12695-12705
    • Harwell, R.M.1    Mull, B.2    Porter, D.C.3    Keyomarsi, K.4
  • 23
    • 0024234852 scopus 로고
    • Suppression of the neoplastic phenotype by replacement of the retinoblastoma gene product in human cancer cells
    • Huang HJ, Yee JK, Shew JY, Chen PL, Bookstein R, Friedman T, Lee EY, Lee WH. 1988. Suppression of the neoplastic phenotype by replacement of the retinoblastoma gene product in human cancer cells. Science 242:1563-1566.
    • (1988) Science , vol.242 , pp. 1563-1566
    • Huang, H.J.1    Yee, J.K.2    Shew, J.Y.3    Chen, P.L.4    Bookstein, R.5    Friedman, T.6    Lee, E.Y.7    Lee, W.H.8
  • 26
    • 0026649165 scopus 로고
    • Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle
    • Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S. 1992. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257:1689-1694.
    • (1992) Science , vol.257 , pp. 1689-1694
    • Koff, A.1    Giordano, A.2    Desai, D.3    Yamashita, K.4    Harper, J.W.5    Elledge, S.6
  • 27
    • 0023106062 scopus 로고
    • Human retinoblastoma susceptibility gene: Cloning, identification, and sequence
    • Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY. 1987. Human retinoblastoma susceptibility gene: Cloning, identification, and sequence. Science 235:1394-1399.
    • (1987) Science , vol.235 , pp. 1394-1399
    • Lee, W.H.1    Bookstein, R.2    Hong, F.3    Young, L.J.4    Shew, J.Y.5    Lee, E.Y.6
  • 28
    • 0026039676 scopus 로고
    • The retinoblastoma protein is phosphorylated on multiple sites by human cdk2
    • Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E. 1991. The retinoblastoma protein is phosphorylated on multiple sites by human cdk2. EMBO J 10:4279-4290.
    • (1991) EMBO J , vol.10 , pp. 4279-4290
    • Lees, J.A.1    Buchkovich, K.J.2    Marshak, D.R.3    Anderson, C.W.4    Harlow, E.5
  • 29
    • 0027135209 scopus 로고
    • The adenovirus E1a-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E
    • Li Y, Graham C, Lacy S, Duncan AM, Whyte P. 1993. The adenovirus E1a-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E. Genes Dev 7:2366-2377.
    • (1993) Genes Dev , vol.7 , pp. 2366-2377
    • Li, Y.1    Graham, C.2    Lacy, S.3    Duncan, A.M.4    Whyte, P.5
  • 30
    • 34848836235 scopus 로고    scopus 로고
    • Induction of growth inhibition and apoptosis in prostate cancer cells by flavopiridol
    • Li Y, Chinni SR, Senderowicz AM, Sarkar FH. 2000. Induction of growth inhibition and apoptosis in prostate cancer cells by flavopiridol. Int J Cancer 108:654-664.
    • (2000) Int J Cancer , vol.108 , pp. 654-664
    • Li, Y.1    Chinni, S.R.2    Senderowicz, A.M.3    Sarkar, F.H.4
  • 31
    • 0347285407 scopus 로고    scopus 로고
    • Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors
    • Liao C, Li S, Wang X, Muhlrad S, Bjartell A, Wolgemuth DJ. 2004. Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors. Int J Cancer 108:654-664.
    • (2004) Int J Cancer , vol.108 , pp. 654-664
    • Liao, C.1    Li, S.2    Wang, X.3    Muhlrad, S.4    Bjartell, A.5    Wolgemuth, D.J.6
  • 32
    • 0028880855 scopus 로고
    • Cyclins, cyclin-dependent kinases and cdk inhibitors: Implications in cell cycle control and cancer
    • MacLachlan TK, Sang N, Giordano A. 1995. Cyclins, cyclin-dependent kinases and cdk inhibitors: Implications in cell cycle control and cancer. Crit Rev Eukaryot Gene Expr 5:127-156.
    • (1995) Crit Rev Eukaryot Gene Expr , vol.5 , pp. 127-156
    • MacLachlan, T.K.1    Sang, N.2    Giordano, A.3
  • 33
    • 27544470656 scopus 로고    scopus 로고
    • Mammalian cyclin-dependent kinases
    • Malumbers M, Barbacid M. 2005. Mammalian cyclin-dependent kinases. Trends Biochem Sci 30:630-641.
    • (2005) Trends Biochem Sci , vol.30 , pp. 630-641
    • Malumbers, M.1    Barbacid, M.2
  • 34
    • 12044258811 scopus 로고
    • Cloning of a new member ofthe retinoblastoma gene family (pRb2), which binds to the E1A transforming domain
    • Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A. 1993. Cloning of a new member ofthe retinoblastoma gene family (pRb2), which binds to the E1A transforming domain. Oncogene 8:2561-2566.
    • (1993) Oncogene , vol.8 , pp. 2561-2566
    • Mayol, X.1    Grana, X.2    Baldi, A.3    Sang, N.4    Hu, Q.5    Giordano, A.6
  • 36
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori T, Miura K, Wu DJ, Takabayashi K, Carson DA. 1994. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368:753-756.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Takabayashi, K.4    Carson, D.A.5
  • 37
  • 38
    • 0034935026 scopus 로고    scopus 로고
    • Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukemia
    • Pepper C, Thomas A, Hoy T, Fegan C, Bentley P. 2001. Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukemia. Br J Haematol 114:70-77.
    • (2001) Br J Haematol , vol.114 , pp. 70-77
    • Pepper, C.1    Thomas, A.2    Hoy, T.3    Fegan, C.4    Bentley, P.5
  • 40
    • 0029009876 scopus 로고
    • Different roles for cyclins D1 and E in regulation of the G1-to-S transition
    • Resnitzky D, Reed SI. 1995. Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol Cell Biol 15:3463-3469.
    • (1995) Mol Cell Biol , vol.15 , pp. 3463-3469
    • Resnitzky, D.1    Reed, S.I.2
  • 41
    • 0344013487 scopus 로고    scopus 로고
    • The complex biology of the receptor for the insulin-like growth factor-1
    • Romano G. 2003. The complex biology of the receptor for the insulin-like growth factor-1. Drug News & Perspect 16:525-531.
    • (2003) Drug News & Perspect , vol.16 , pp. 525-531
    • Romano, G.1
  • 42
    • 32844465160 scopus 로고    scopus 로고
    • The role of adult stem cells in carcinogenesis
    • Romano G. 2005. The role of adult stem cells in carcinogenesis. Drug News Perspect 18:555-559.
    • (2005) Drug News Perspect , vol.18 , pp. 555-559
    • Romano, G.1
  • 43
    • 33646501754 scopus 로고    scopus 로고
    • The controversial role of adenoviral-derived vectors in gene therapy programs: Where do we stand?
    • Romano G. 2006a. The controversial role of adenoviral-derived vectors in gene therapy programs: Where do we stand? Drug News Perspect 19:99-106.
    • (2006) Drug News Perspect , vol.19 , pp. 99-106
    • Romano, G.1
  • 44
    • 33748799734 scopus 로고    scopus 로고
    • Advances and perspectives in the field of gene transfer technology
    • Romano G. 2006b. Advances and perspectives in the field of gene transfer technology. Drug News Perspect 19:359-368.
    • (2006) Drug News Perspect , vol.19 , pp. 359-368
    • Romano, G.1
  • 45
    • 34548351286 scopus 로고    scopus 로고
    • The standpoint of gene therapy programs: A report on the tenth annual meeting of the American Society of Gene Therapy
    • in press
    • Romano G. 2007. The standpoint of gene therapy programs: A report on the tenth annual meeting of the American Society of Gene Therapy. Drug News Perspect (in press).
    • (2007) Drug News Perspect
    • Romano, G.1
  • 46
    • 0033556163 scopus 로고    scopus 로고
    • Dissociation between resistance from apoptosis and the transformed cell phenotype in IGF-1 receptor signaling
    • Romano G, Prisco M, Zanocco-Marani T, Peruzzi F, Valentinis B, Baserga R. 1999. Dissociation between resistance from apoptosis and the transformed cell phenotype in IGF-1 receptor signaling. J Cell Biochem 72:294-310.
    • (1999) J Cell Biochem , vol.72 , pp. 294-310
    • Romano, G.1    Prisco, M.2    Zanocco-Marani, T.3    Peruzzi, F.4    Valentinis, B.5    Baserga, R.6
  • 47
    • 34848816954 scopus 로고    scopus 로고
    • Gene therapy for cancer: What have we done and where are we going?
    • Roth JA, Cristiano RJ. 1997. Gene therapy for cancer: What have we done and where are we going? J Natl Cancer Inst 85:546-553.
    • (1997) J Natl Cancer Inst , vol.85 , pp. 546-553
    • Roth, J.A.1    Cristiano, R.J.2
  • 48
    • 0026530730 scopus 로고
    • The transcription factor E2F interacts with the retinoblastoma product and p107 cyclin A complex in a cell cycle regulated manner
    • Shirodkar S, Ewen M, DeCaprio JA, Morgan J, Livingston DM, Chittenden T. 1992. The transcription factor E2F interacts with the retinoblastoma product and p107 cyclin A complex in a cell cycle regulated manner. Cell 68:157-166.
    • (1992) Cell , vol.68 , pp. 157-166
    • Shirodkar, S.1    Ewen, M.2    DeCaprio, J.A.3    Morgan, J.4    Livingston, D.M.5    Chittenden, T.6
  • 49
    • 0030669074 scopus 로고    scopus 로고
    • P53 role in DNA re pair and tumorigenesis
    • Soddu S, Sacchi A. 1997. P53 role in DNA re pair and tumorigenesis. J Exp Clin Cancer Res 16:237-242.
    • (1997) J Exp Clin Cancer Res , vol.16 , pp. 237-242
    • Soddu, S.1    Sacchi, A.2
  • 50
    • 1642401132 scopus 로고    scopus 로고
    • Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene: Induction of cyclin A and enhanced CDK2 activity
    • Sunters A, Thomas DP, Yeudall WA, Grigoriadis AE. 2004. Accelerated cell cycle progression in osteoblasts overexpressing the c-fos proto-oncogene: Induction of cyclin A and enhanced CDK2 activity. J Biol Chem 279:9882-9891.
    • (2004) J Biol Chem , vol.279 , pp. 9882-9891
    • Sunters, A.1    Thomas, D.P.2    Yeudall, W.A.3    Grigoriadis, A.E.4
  • 51
    • 26244434392 scopus 로고    scopus 로고
    • A study on the prognostic value of cyclins D1 and E expression levels in respectable gastric cancer and on some correlations between cyclins expression, histoclinical parameters and selected protein products of cell-cycle regulatory genes
    • Tenderenda M. 2005. A study on the prognostic value of cyclins D1 and E expression levels in respectable gastric cancer and on some correlations between cyclins expression, histoclinical parameters and selected protein products of cell-cycle regulatory genes. J Exp Clin Cancer 24:405-414.
    • (2005) J Exp Clin Cancer , vol.24 , pp. 405-414
    • Tenderenda, M.1
  • 52
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA. 1995. The retinoblastoma protein and cell cycle control. Cell 81:323-330.
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 53
    • 0030575526 scopus 로고    scopus 로고
    • Why are there so many CDK inhibitors?
    • Xiong Y. 1996. Why are there so many CDK inhibitors? Biochim Biophys Acta 1288:1-5.
    • (1996) Biochim Biophys Acta , vol.1288 , pp. 1-5
    • Xiong, Y.1


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