Non-oxidative glucose disposal is reduced in type 2 diabetes, but can be restored by aerobic exercise

Diabetes, Obesity and Metabolism

Volumn 10, Issue 5, 2008, Pages 400-407

  Yokoyama, H ^a   Mori, K ^a   Emoto, M ^a   Araki, T ^a   Teramura, M ^a   Mochizuki, K ^a   Tashiro, T ^a   Motozuka, K ^a   Inoue, Y ^a   Nishizawa, Y ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Exercise; Glucose clamp; Insulin resistance; Intramyocellular lipid; Type 2 diabetes mellitus

Indexed keywords

ALPHA GLUCOSIDASE INHIBITOR; GLUCOSE; INSULIN; LIPID; SULFONYLUREA;

ADULT; AEROBIC EXERCISE; AGED; ANTHROPOMETRY; ARTICLE; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GLUCOSE INFUSION; GLUCOSE OXIDATION; GLUCOSE UTILIZATION; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTON NUCLEAR MAGNETIC RESONANCE; SOLEUS MUSCLE; STEADY STATE;

EID: 42149179911     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2007.00716.x     Document Type: Article

References (40)

1. Krssak M, Falk Petersen K, Dresner A et al. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1 H NMR spectroscopy study. Diabetologia 1999; 42: 113-116.
2. Jacob S, Machann J, Rett K et al. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 1999; 48: 1113-1119.
3. Damsbo P, Vaag A, Hother-Nielsen O et al. Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1991; 34: 239-245.
4. Bak JF, Moller N, Schmitz O et al. In vivo insulin action and muscle glycogen synthase activity in type 2 (non-insulin-dependent) diabetes mellitus: Effects of diet treatment. Diabetologia 1992; 35: 777-784.
5. Riccio A, Del Prato S, Vigili de Kreutzenberg S et al. Glucose and lipid metabolism in non-insulin-dependent diabetes. Effect of metformin. Diabete Metab 1991; 17: 180-184.
6. Petersen KF, Dufour S, Befroy D et al. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 2004; 350: 664-671.
7. Kelley DE, He J, Menshikova EV et al. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002; 51: 2944-2950.
8. Yamanouchi K, Shinozaki T, Chikada K et al. Daily walking combined with diet therapy is a useful means for obese NIDDM patients not only to reduce body weight but also to improve insulin sensitivity. Diabetes Care 1995; 18: 775-778.
9. Ligtenberg PC, Hoekstra JB, Bol E et al. Effects of physical training on metabolic control in elderly type 2 diabetes mellitus patients. Clin Sci (Lond) 1997; 93: 127-135.
10. Goodpaster BH, Katsiaras A, Kelley DE. Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity. Diabetes 2003; 52: 2191-2197.
11. Eriksson J, Tuominen J, Valle T et al. Aerobic endurance exercise or circuit-type resistance training for individuals with impaired glucose tolerance? Horm Metab Res 1998; 30: 37-41.
12. Short KR, Vittone JL, Bigelow ML et al. Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity. Diabetes 2003; 52: 1888-1896.
13. Menshikova EV, Ritov VB, Toledo FG et al. Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. Am J Physiol Endocrinol Metab 2005; 288: E818-E825.
14. The expert committee on the diagnosis and classification of diabetes mellitus. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26 (Suppl. 1): S5-S20.
15. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: A method for quantifying insulin secretion and resistance. Am J Physiol 1979; 237: E214-E223.
16. Emoto M, Nishizawa Y, Maekawa K et al. Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care 1999; 22: 818-822.
17. Yokoyama H, Emoto M, Fujiwara S et al. Quantitative insulin sensitivity check index and he reciprocal index of homeostasis model assessment in normal range-weight and moderately obese type 2 diabetic patients. Diabetes Care 2003; 26: 2426-2432.
18. Frayn KN. Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 1983; 55: 628-634.
19. Boesch C, Slotboom J, Hoppeler H et al. In vivo determination of intra-myocellular lipids in human muscle by means of localized 1 H-MR-spectroscopy. Magn Reson Med 1997; 37: 484-493.
20. Wasserman K, Whipp BJ, Koyl SN et al. Anaerobic threshold and respiratory gas exchange during exercise. J Appl Physiol 1973; 35: 236-243.
21. Paolisso G, D'Amore A, Giugliano D et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 1993; 57: 650-656.
22. Yokoyama H, Emoto M, Mori K et al. Plasma adiponectin level is associated with insulin-stimulated nonoxidative glucose disposal. J Clin Endocrinol Metab 2006; 91: 290-294.
23. Berrish TS, Hetherington CS, Alberti KG et al. Peripheral and hepatic insulin sensitivity in subjects with impaired glucose tolerance. Diabetologia 1995; 38: 699-704.
24. Vestergaard H, Lund S, Larsen FS et al. Glycogen synthase and phosphofructokinase protein and mRNA levels in skeletal muscle from insulin-resistant patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1993; 91: 2342-2350.
25. Wells AM, Sutcliffe IC, Johnson AB et al. Abnormal activation of glycogen synthesis in fibroblasts from NIDDM subjects. Evidence for an abnormality specific to glucose metabolism. Diabetes 1993; 42: 583-589.
26. Golay A, DeFronzo RA, Ferrannini E et al. Oxidative and non-oxidative glucose metabolism in non-obese type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1988; 31: 585-591.
27. Vaag A, Alford F, Henriksen FL et al. Multiple defects of both hepatic and peripheral intracellular glucose processing contribute to the hyperglycaemia of NIDDM. Diabetologia 1995; 38: 326-336.
28. Yeaman SJ, Armstrong JL, Bonavaud SM et al. Regulation of glycogen synthesis in human muscle cells. Biochem Soc Trans 2001; 29: 537-541.
29. Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W et al. Increased insulin receptor signaling and glycogen synthase activity contribute to the synergistic effect of exercise on insulin action. J Appl Physiol 2003; 95: 2519-2529.
30. Dela F, Ploug T, Handberg A et al. Physical training increases muscle GLUT4 protein and mRNA in patients with NIDDM. Diabetes 1994; 43: 862-865.
31. Hayashi T, Wojtaszewski JF, Goodyear LJ. Exercise regulation of glucose transport in skeletal muscle. Am J Physiol 1997; 273: E1039-E1051.
32. Fujii N, Hayashi T, Hirshman MF et al. Exercise induces isoform-specific increase in 5′AMP-activated protein kinase activity in human skeletal muscle. Biochem Biophys Res Commun 2000; 273: 1150-1155.
33. Ruderman NB, Park H, Kaushik VK et al. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. Acta Physiol Scand 2003; 178: 435-442.
34. Virkamaki A, Korsheninnikova E, Seppala-Lindroos A et al. Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle. Diabetes 2001; 50: 2337-2343.
35. Randle PJ, Garland PB, Hales CN et al. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; 1: 785-789.
36. Larson-Meyer DE, Newcomer BR, Hunter GR. Influence of endurance running and recovery diet on intramyocellular lipid content in women: A 1H NMR study. Am J Physiol Endocrinol Metab 2002; 282: E95-E106.
37. Gan SK, Kriketos AD, Ellis BA et al. Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men. Diabetes Care 2003; 26: 1706-1713.
38. He J, Goodpaster BH, Kelley DE. Effects of weight loss and physical activity on muscle lipid content and droplet size. Obes Res 2004; 12: 761-769.
39. Schrauwen-Hinderling VB, Schrauwen P, Hesselink MK et al. The increase in intramyocellular lipid content is a very early response to training. J Clin Endocrinol Metab 2003; 88: 1610-1616.
40. Tamura Y, Tanaka Y, Sato F et al. Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab 2005; 90: 3191-3196.