Reorganisation of Wnt-response pathways in colorectal tumorigenesis

British Journal of Cancer

Volumn 98, Issue 8, 2008, Pages 1437-1442

  Caldwell, G M ^a   Jones, C E ^a   Soon, Y ^a   Warrack, R ^a   Morton, D G ^a   Matthews, G M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

catenin independent signalling; Colorectal carcinogenesis; NKD1; Wnt signalling

Indexed keywords

BETA CATENIN; FRIZZLED PROTEIN; LITHIUM CHLORIDE; MEMBRANE PROTEIN; PROTEIN FZD3; PROTEIN FZD6; UNCLASSIFIED DRUG; WNT PROTEIN;

ADULT; AGED; ARTICLE; CARCINOGENESIS; COLORECTAL ADENOMA; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOMA; ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; CALCIUM; CARRIER PROTEINS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; FRIZZLED RECEPTORS; HUMANS; MIDDLE AGED; PROTEIN KINASE C; RECEPTORS, G-PROTEIN-COUPLED; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 42149174215     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6604327     Document Type: Article

References (27)

1. Blanc E, Roux GL, Benard J, Raguenez G (2005) Low expression of Wnt-5a gene is associated with high-risk neuroblastoma. Oncogene 24: 1277-1283
2. Boutros M, Paricio N, Strutt DI, Mlodzik M (1998) Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell 94: 109-118
3. Caldwell GM, Jones C, Gensberg K, Jan S, Hardy RG, Byrd P, Chughtai S, Wallis Y, Matthews GM, Morton DG (2004) The Wnt antagonist sFRP1 in colorectal tumorigenesis. Cancer Res 64: 883-888
4. Caldwell GM, Jones CE, Taniere P, Warrack R, Soon Y, Matthews GM, Morton DG (2006) Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas. Br J Cancer 94: 922-927
5. DeAlmeida VI, Miao L, Ernst JA, Koeppen H, Polakis P, Rubinfeld B (2007) The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res 67: 5371-5379
6. Dejmek J, Dejmek A, Safholm A, Sjolander A, Andersson T (2005) Wnt-5a protein expression in primary dukes B colon cancers identifies a subgroup of patients with good prognosis. Cancer Res 65: 9142-9146
7. Hardy RG, Tselepis C, Hoyland J, Wallis Y, Pretlow TP, Talbot I, Sanders DS, Matthews G, Morton D, Jankowski JA (2002) Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Gut 50: 513-519
8. Huang CL, Liu D, Nakano J, Ishikawa S, Kontani K, Yokomise H, Ueno M (2005) Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor - an expression in non-small-cell lung cancer. J Clin Oncol 23: 8765-8773
9. Kahl-Rainer P, Sedivy R, Marian B (1996) Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control. Gastroenterology 110: 1753-1759
10. Kim SE, Choi KY (2007) EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation. Cell Signal 19: 1554-1564
11. Kirikoshi H, Sekihara H, Katoh M (2001) Expression profiles of 10 members of Frizzled gene family in human gastric cancer. Int J Oncol 9: 767-771
12. Klein PS, Melton DA (1996) A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA 93: 8455-8459
13. Kremenevskaja N, von Wasielewski R, Rao AS, Schofl C, Andersson T, Brabant G (2005) Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene 24: 2144-2154
14. Kurayoshi M, Oue N, Yamamoto H, Kishida M, Inoue A, Asahara T, Yasui W, Kikuchi A (2006) Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res 66: 10439-10448
15. Liang H, Chen Q, Coles AH, Anderson SJ, Pihan G, Bradley A, Gerstein R, Jurecic R, Jones SN (2003) Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue. Cancer Cell 4: 349-360
16. Mikels AJ, Nusse R (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol 4: e115
17. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, Kinzler KW (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275: 1787-1790
18. Nateri AS, Spencer-Dene B, Behrens A (2005) Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437: 281-285
19. Owens RB, Smith HS, Nelson-Rees WA, Springer EL (1976) Epithelial cell cultures from normal and cancerous human tissues. J Natl Cancer Inst 56: 843-849
20. Ripka S, Konig A, Buchholz M, Wagner M, Sipos B, Kloppel G, Downward J, Gress T, Michl P (2007) WNT5A - target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer. Carcinogenesis 28: 1178-1187
21. Rozen S, Skaletsky HJ (1996) Primer3. Code available at http://www.genome.wi.mit.edu/genome_software/other/primer3.html
22. Schlange T, Matsuda Y, Lienhard S, Huber A, Hynes NE (2007) Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res 9: R63
23. Sheldahl LC, Park M, Malbon CC, Moon RT (1999) Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr Biol 9: 695-698
24. Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, Van Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG, Baylin SB (2004) Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet 36: 417-422
25. Torres MA, Yang-Snyder JA, Purcell SM, DeMarais AA, McGrew LL, Moon RT (1996) Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development. J Cell Biol 133: 1123-1137
26. Toualbi K, Güller MC, Mauriz JL, Labalette C, Buendia MA, Mauviel A, Bernuau D (2007) Physical and functional cooperation between AP-1 and beta-catenin for the regulation of TCF-dependent genes. Oncogene 26: 3492-3502
27. Yan D, Wiesmann M, Rohan M, Chan V, Jefferson AB, Guo L, Sakamoto D, Caothien RH, Fuller JH, Reinhard C, Garcia PD, Randazzo FM, Escobedo J, Fantl WJ, Williams LT (2001) Elevated expression of axin2 and hnkd mRNA provides evidence that WNT/beta-catenin signaling is activated in human colon tumors. Proc Natl Acad Sci USA 98: 14973-14978