메뉴 건너뛰기




Volumn 2, Issue 1, 2008, Pages 24-28

From dual peroxisome proliferator activated receptor agonists to selective peroxisome proliferator activated receptor modulators

Author keywords

AMG131; Atherosclerosis; Dual PPAR agonists; FK614; FMOC L leucine; GW0072; Metabolic syndrome; nTZDpa; Peroxisome proliferator activated receptors; SPPARMs; Type 2 diabetes

Indexed keywords

5 (2,4 DIOXO 5 THIAZOLIDINYLMETHYL) 2 METHOXY N [4 (TRIFLUOROMETHYL)BENZYL]BENZAMIDE; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; BEZAFIBRATE; CLOFIBRATE; FARGLITAZAR; FENOFIBRATE; GEMFIBROZIL; GLUCOSE; GW 625019; GW 766954; IMIGLITAZAR; LIPID; METAGLIDASEN; MURAGLITAZAR; NAVEGLITAZAR; NETOGLITAZONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PLX 204; RAGAGLITAZAR; RIVOGLITAZONE; ROSIGLITAZONE; SIPOGLITAZAR; TESAGLITAZAR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 42149144739     PISSN: 18722148     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221408783421273     Document Type: Review
Times cited : (2)

References (32)
  • 1
    • 33751502151 scopus 로고    scopus 로고
    • International Union of Pharmacology. LXVI. Orphan nuclear receptors
    • Benoit G, Cooney A, Giguere V, et al. International Union of Pharmacology. LXVI. Orphan nuclear receptors. Pharmacol Rev 2006; 58: 798-836.
    • (2006) Pharmacol Rev , vol.58 , pp. 798-836
    • Benoit, G.1    Cooney, A.2    Giguere, V.3
  • 2
    • 0033542873 scopus 로고    scopus 로고
    • Medical significance of peroxisome proliferator-activated receptors
    • Vamecq J, Latruffe N. Medical significance of peroxisome proliferator-activated receptors. Lancet 1999; 354: 141-148.
    • (1999) Lancet , vol.354 , pp. 141-148
    • Vamecq, J.1    Latruffe, N.2
  • 3
    • 33847122993 scopus 로고    scopus 로고
    • Dual PPAR alpha/ gamma agonists: Promises and pitfalls in type 2 diabetes
    • Ahmed I, Furlong K, Flood J, Treat VP, Goldstein BJ. Dual PPAR alpha/ gamma agonists: promises and pitfalls in type 2 diabetes. Am J Ther 2007; 14: 49-62.
    • (2007) Am J Ther , vol.14 , pp. 49-62
    • Ahmed, I.1    Furlong, K.2    Flood, J.3    Treat, V.P.4    Goldstein, B.J.5
  • 5
    • 36749047983 scopus 로고    scopus 로고
    • The metabolic syndrome - a global challenge for prevention
    • Schwarz PE, Reiman M, Li J, et al. The metabolic syndrome - a global challenge for prevention. Horm Metab Res 2007; 39: 777-780.
    • (2007) Horm Metab Res , vol.39 , pp. 777-780
    • Schwarz, P.E.1    Reiman, M.2    Li, J.3
  • 6
    • 0347133334 scopus 로고    scopus 로고
    • Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes
    • Saydah SH, Fradkin J, Cowie CC. Poor control of risk factors for vascular disease among adults with previously diagnosed diabetes. JAMA 2004; 291: 335-342.
    • (2004) JAMA , vol.291 , pp. 335-342
    • Saydah, S.H.1    Fradkin, J.2    Cowie, C.C.3
  • 7
    • 26844431513 scopus 로고    scopus 로고
    • Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: The bezafibrate lessons
    • Tenenbaum A, Motro M, Fisman EZ. Dual and pan-peroxisome proliferator-activated receptors (PPAR) co-agonism: the bezafibrate lessons. Cardiovasc Diabetol 2005; 4: 14-16.
    • (2005) Cardiovasc Diabetol , vol.4 , pp. 14-16
    • Tenenbaum, A.1    Motro, M.2    Fisman, E.Z.3
  • 8
    • 12344317202 scopus 로고    scopus 로고
    • Pleitropic effects of thiazolidinediones: Taking a look beyond antidiabetic activity
    • Giannini S, Serio M, Gali A. Pleitropic effects of thiazolidinediones: taking a look beyond antidiabetic activity. J Endocrinol Invest 2004; 27, 982-991.
    • (2004) J Endocrinol Invest , vol.27 , pp. 982-991
    • Giannini, S.1    Serio, M.2    Gali, A.3
  • 9
    • 34250213233 scopus 로고    scopus 로고
    • Evolution of peroxisome proliferator-activator receptor agonists
    • Chang F, Jaber LA, Berlie HD, O'Connel MB. Evolution of peroxisome proliferator-activator receptor agonists. Ann Pharmacother 2007; 41, 973-983.
    • (2007) Ann Pharmacother , vol.41 , pp. 973-983
    • Chang, F.1    Jaber, L.A.2    Berlie, H.D.3    O'Connel, M.B.4
  • 10
    • 33646255424 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma: Novel therapeutic target linking adiposity, insulin resistance, and atherosclerosis
    • Kepez A, Oto A, Dagdelen S. Peroxisome proliferator-activated receptor-gamma: novel therapeutic target linking adiposity, insulin resistance, and atherosclerosis. BioDrugs 2006; 20: 121-135.
    • (2006) BioDrugs , vol.20 , pp. 121-135
    • Kepez, A.1    Oto, A.2    Dagdelen, S.3
  • 11
    • 4444272941 scopus 로고    scopus 로고
    • Combination therapy with fenofibrate and rosiglitazone paradoxically lowers serum HDL cholesterol
    • Normen L, Frohlich J, Montaner J, Harris M, Elliott T, Bondy G. Combination therapy with fenofibrate and rosiglitazone paradoxically lowers serum HDL cholesterol. Diabetes Care 2004; 27: 2241-2242.
    • (2004) Diabetes Care , vol.27 , pp. 2241-2242
    • Normen, L.1    Frohlich, J.2    Montaner, J.3    Harris, M.4    Elliott, T.5    Bondy, G.6
  • 12
    • 29244437857 scopus 로고    scopus 로고
    • The effect of dual PPAR alpha/ gamma stimulation with combination of rosiglitazone and fenofibrate on metabolic parameters in type 2 diabetic patients
    • Seber S, Ucak S, Basat O, Altuntas Y. The effect of dual PPAR alpha/ gamma stimulation with combination of rosiglitazone and fenofibrate on metabolic parameters in type 2 diabetic patients. Diabetes Res Clin Pract 2006; 71: 52-58.
    • (2006) Diabetes Res Clin Pract , vol.71 , pp. 52-58
    • Seber, S.1    Ucak, S.2    Basat, O.3    Altuntas, Y.4
  • 13
    • 34447114640 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus
    • Bajaj M, Suraamornkul S, Hardies LJ, Glass L, Musi N, DeFronzo RA. Effects of peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus. Diabetologis 2007; 50: 1723-1731
    • (2007) Diabetologis , vol.50 , pp. 1723-1731
    • Bajaj, M.1    Suraamornkul, S.2    Hardies, L.J.3    Glass, L.4    Musi, N.5    DeFronzo, R.A.6
  • 14
    • 34347333419 scopus 로고    scopus 로고
    • PPAR ligands: Are they potential agents for cardiovascular disorders?
    • Balakumar P, Rose M, Singh M. PPAR ligands: are they potential agents for cardiovascular disorders? Pharmacology 2007; 80: 177-184.
    • (2007) Pharmacology , vol.80 , pp. 177-184
    • Balakumar, P.1    Rose, M.2    Singh, M.3
  • 15
    • 34547625616 scopus 로고    scopus 로고
    • The next generation of PPAR drugs: Do we have the tools to find them?
    • Shearer BG, Billin AN. The next generation of PPAR drugs: do we have the tools to find them? Biochim Biophys Acta 2007; 1771: 1082-1093.
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 1082-1093
    • Shearer, B.G.1    Billin, A.N.2
  • 17
    • 30144436299 scopus 로고    scopus 로고
    • Characterization of compound mechanisms and secondary activities by BioMAP analysis
    • Berg EL, Kunkel EJ, Hytopoulos E, Plavec I. Characterization of compound mechanisms and secondary activities by BioMAP analysis. J Pharmacol Toxicol Methods 2006; 53: 67-74.
    • (2006) J Pharmacol Toxicol Methods , vol.53 , pp. 67-74
    • Berg, E.L.1    Kunkel, E.J.2    Hytopoulos, E.3    Plavec, I.4
  • 18
    • 13044286786 scopus 로고    scopus 로고
    • A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation
    • Oberfield JL, Collins JL, Holmes CP, et al. A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation. Proc Natl Acad Sci USA 1999; 96: 6102-6106.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6102-6106
    • Oberfield, J.L.1    Collins, J.L.2    Holmes, C.P.3
  • 19
    • 33845405222 scopus 로고    scopus 로고
    • ADOPT Study Group. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • Kahn SE, Haffner SM, Heise MA, et al. ADOPT Study Group. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 2006; 355: 2427-2443.
    • (2006) N Engl J Med , vol.355 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3
  • 20
    • 0036090467 scopus 로고    scopus 로고
    • Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation
    • Lecka-Czernik B, Moerman EJ, Grant DF, Lehmann JM, Manolagas SC, Jilka RL. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology 2002; 143: 2376-2384.
    • (2002) Endocrinology , vol.143 , pp. 2376-2384
    • Lecka-Czernik, B.1    Moerman, E.J.2    Grant, D.F.3    Lehmann, J.M.4    Manolagas, S.C.5    Jilka, R.L.6
  • 21
    • 13644257646 scopus 로고    scopus 로고
    • PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: Indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist
    • Bishop-Bailey D, Warner TD. PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist. FASEB J 2003; 17: 1925-1927.
    • (2003) FASEB J , vol.17 , pp. 1925-1927
    • Bishop-Bailey, D.1    Warner, T.D.2
  • 22
    • 2642557181 scopus 로고    scopus 로고
    • A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity
    • Rocchi S, Picard F, Vamecq J, et al. A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity. Mol Cell 2001; 8: 731-747.
    • (2001) Mol Cell , vol.8 , pp. 731-747
    • Rocchi, S.1    Picard, F.2    Vamecq, J.3
  • 23
  • 24
    • 12444273748 scopus 로고    scopus 로고
    • Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator
    • Berger JP, Petro AE, Macnaul KL, et al. Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. Mol Endocrinol 2003; 17: 662-676.
    • (2003) Mol Endocrinol , vol.17 , pp. 662-676
    • Berger, J.P.1    Petro, A.E.2    Macnaul, K.L.3
  • 25
    • 0346668393 scopus 로고    scopus 로고
    • A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth
    • Bruemmer D, Berger JP, Liu J, et al. A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth. Eur J Pharmacol 2003; 466, 225-234.
    • (2003) Eur J Pharmacol , vol.466 , pp. 225-234
    • Bruemmer, D.1    Berger, J.P.2    Liu, J.3
  • 26
    • 29144474215 scopus 로고    scopus 로고
    • FK614, a novel peroxisome proliferator-activated receptor gamma modulator, induces differential transactivation through a unique ligand-specific interaction with transcriptional coactivators
    • Fujimura T, Sakuma H, Konishi S, et al. FK614, a novel peroxisome proliferator-activated receptor gamma modulator, induces differential transactivation through a unique ligand-specific interaction with transcriptional coactivators. J Pharmacol Sci 2005; 99: 342-352.
    • (2005) J Pharmacol Sci , vol.99 , pp. 342-352
    • Fujimura, T.1    Sakuma, H.2    Konishi, S.3
  • 27
    • 27744523803 scopus 로고    scopus 로고
    • Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist, on insulin resistance in Zucker fatty rat
    • Minoura H, Takeshita S, Yamamoto T, et al. Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor gamma agonist, on insulin resistance in Zucker fatty rat. Eur J Pharmacol 2005; 519: 182-190.
    • (2005) Eur J Pharmacol , vol.519 , pp. 182-190
    • Minoura, H.1    Takeshita, S.2    Yamamoto, T.3
  • 28
    • 42149110461 scopus 로고    scopus 로고
    • Malecha, J.W., Lindstrom, A.K., Duron, S.G., Govek, S.P.: WO07047432 ( 2007).
    • Malecha, J.W., Lindstrom, A.K., Duron, S.G., Govek, S.P.: WO07047432 ( 2007).
  • 29
    • 42149087309 scopus 로고    scopus 로고
    • Kalypsys, I., Zhao, C.: WO07109577 (2007).
    • Kalypsys, I., Zhao, C.: WO07109577 (2007).
  • 30
    • 42149175127 scopus 로고    scopus 로고
    • Lin, J., Womack, P., Lee, B., Shi, S., Zhang, C., Zuckerman, R., Artis, D.R., Ibrahim, P.N., Wang, W.: WO07030559 (2007).
    • Lin, J., Womack, P., Lee, B., Shi, S., Zhang, C., Zuckerman, R., Artis, D.R., Ibrahim, P.N., Wang, W.: WO07030559 (2007).
  • 31
    • 42149116512 scopus 로고    scopus 로고
    • Malecha, J.W., Lindstrom, A.K., Duron, S.G., Thomas, D.J.: WO07047431 (2007).
    • Malecha, J.W., Lindstrom, A.K., Duron, S.G., Thomas, D.J.: WO07047431 (2007).
  • 32
    • 42149191591 scopus 로고    scopus 로고
    • Epple, R., Cow, C.: WO07089557 (2007).
    • Epple, R., Cow, C.: WO07089557 (2007).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.