Induction of interleukin 6 by ionizing radiation in a human epithelial cell line: Control by corticosteroids

International Journal of Radiation Biology

Volumn 72, Issue 1, 1997, Pages 33-43

  Beetz, A ^b   Messer, G ^c   Oppel, T ^b   Van Beuningen, D ^b   Peter, R U ^a,b,c   Kind, P ^c  

^a UNIVERSITY OF ULM   (Germany)

^b Sanitatsakademie der Bundeswehr   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTEROID; DACTINOMYCIN; DEXAMETHASONE; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 6; MOMETASONE FUROATE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; HELA CELL; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOREACTIVITY; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN INDUCTION; RADIATION DERMATITIS; X IRRADIATION;

ADRENAL CORTEX HORMONES; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; DOWN-REGULATION; EPITHELIUM; HELA CELLS; HUMANS; INTERLEUKIN-6; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION, GENETIC; UP-REGULATION; X-RAYS;

EID: 0030796909     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530097143518     Document Type: Article

References (68)

1. AKIRA, S., HIRANO, T., TAGA, T. and KISHIMOTO, T., 1990, Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF). FASEB Journal, 4, 2860-2867.
2. AUPHAN, N., DIDONATO, J. A., ROSETTE, C., HELMBERG, A. and KARIN, M., 1995, Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis. Science, 270, 286-290.
3. BAEUERLE, P. A. and HENKEL, T., 1994, Function and activation of NF-κB in the immune system. Annual Review of Immunology, 12, 141-179.
4. BAKER, W. H., LIMANNI, A., CHANG, C. M., JACKSON, W. E., SEEMANN, R. and PATCHEN, M. L., 1995, Comparison of interleukin-1α gene expression and protein levels in the murine spleen after lethal and sublethal total-body irradiation. Radiation Research, 143, 320-326.
5. BARTON, B. E., JAKWAY, J. P., SMITH, S. R. and SIEGEL, M. I., 1991, Cytokine inhibition by a novel steroid, mometasone furoate. Immunopharmacology and Immunotoxicology, 13, 251-261.
6. BELSITO, D. V., BAER, R. L., SCHULTZ, J. M. and THORBECKE, G. J., 1988, Relative lack of systemic effects of mometasone furoate on Langerhans cells of mice after topical administration as compared with other glucocorticosteroids. Journal of Investigative Dermatology, 91, 219-223.
7. BOOTHMAN, D. A., LEE, I. W. and SAHIJDAK, W. M., 1994, Isolation of an X-ray-responsive element in the promoter region of tissue-type plasminogen activator: potential uses of X-ray-responsive elements for gene therapy. Radiation Research, 138, S68-S71.
8. BOS, J. D. and KAPSENBERG, M. L., 1993, The skin immune system: progress in cutaneous biology. Immunology Today, 14, 75-78.
9. BRACH, M. A., GRUSS, H. J., KAISHO, T., ASANO, Y., HIRANO, T. and HERRMANN, F., 1993, Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-κB. Journal of Biological Chemistry, 268, 8466-8472.
10. CHAI, Z., GATTI, S., TONIATTI, C., POLI, V. and BARTFAI, T., 1996, Interleukin (IL)-6 gene expression in the central nervous system is necessary for fever response to lipopolisaccharide or IL-1β: a study on IL-6 deficient mice. Journal of Experimental Medicine, 183, 311-316.
11. CHOMCZYNSKI, P. and SACCHI, N., 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Analytical Biochemistry, 162, 156-159.
12. CHUNG, J., SONG, C. W., TAMAGUCHI, T. and TABACHNICK, J., 1972, Effect of anti-inflammatory compounds on γ-irradiation induced radiodermatitis. Dermatologica, 144, 97-107.
13. CHUNG, J. H., YOUN, S. H., KOH, W. S., EUN, H. C., CHO, K. H., PARK, K. C. and YOUN, J. I., 1996, Ultraviolet B irradiation-enhanced interleukin (IL)-6 production and mRNA expression are mediated by IL-1α in cultured human keratinocytes. Journal of Investigative Dermatology, 106, 715-720.
14. DEVARY, Y., GOTTLIEB, R. A., SMEAL, T. and KARIN, M., 1992, The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell, 71, 1081-1091.
15. DE VOS, S., BRACH, M., BUDNIK, A., GREWE, M., HERRMANN, F. and KRUTMANN, J., 1994, Post-transcriptional regulation of interleukin-6 gene expression in human keratinocytes by ultraviolet B radiation. Journal of Investigative Dermatology, 103, 92-96.
16. FATTORI, E., CAPPELLETTI, M., COSTA, P., SELLITTO, C., CANTONI, L., CARELLI, M., FAGGIONI, R., FANTUZZI, G., GHEZZI, P. and POLI, V., 1994, Detective inflammatory response in interleukin 6-deficient mice. Journal of Experimental Medicine, 180, 1243-1250.
17. HAIMOVITZ FRIEDMAN, A., KAN, C. C., EHLEITER, D., PERSAUD, R. S., MCLOUGHLIN, M., FUKS, Z. and KOLESNICK, R. N., 1994, Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis. Journal of Experimental Medicine, 180, 525-535.
18. HALLAHAN, D. E., GIUS, D., KUCHIBHOTLA, J., SUKHATME, V., KUFE, D. W. and WEICHSELBAUM, R. R., 1993, Radiation signaling mediated by Jun activation following dissociation from a cell type-specific repressor. Journal of Biological Chemistry, 268, 4903-4907.
19. HALLAHAN, D. E., SPRIGGS, D. R., BECKETT, M. A., KUFE, D. W. and WEICHSELBAUM, R. R., 1989, Increased tumor necrosis factor a after cellular exposure to ionizing radiation. Proceedings of the National Acadamy of Sciences, USA, 86, 10104-10107.
20. HALLIWELL, B. and GUTTERIDGE, J. M., 1985, Free Radicals in Biology and Medicine (Oxford: Oxford University Press).
21. HERRLICH, P. and RAHMSDORF, H. J., 1994, Transcriptional and post-transcriptional responses to DNA-damaging agents. Current Opinion in Cell Biology, 6, 425-431.
22. HONG, J. H., CHIANG, C. S., CAMPBELL, I. L., SUN, J. R., WITHERS, H. R. and MCBRIDE, W. H., 1995, Induction of acute phase gene expression by brain irradiation. International Journal of Radiation Oncology, Biology, Physics, 33, 619-626.
23. ISHIHARA, H., TANAKA, I., NEMOTO, K., TSUNEOKA, K., CHEERAMAKARA, C., YOSHIDA, K. and OHTSU, H., 1995, Immediate-early, transient induction of the interleukin-1β gene in mouse spleen macrophages by ionizing radiation. Journal of Radiation Research, 36, 112-124.
24. IWAMOTO, G. K., KONICEK, S. A. and TWIGG, H., 1994, Modulation of accessory cell function and interleukin-6 production by the HIV-1 tat gene. American Journal of Respiratory Cell and Molecular Biology, 10, 580-585.
25. KATZ, H. I., PRAWER, S. E., WATSON, M. J., SCULL, T. A. and PEETS, E. A., 1989, Mometasone furoate ointment 0·1% vs. hydrocortisone ointment 1·0% in psoriasis. Atrophogenic potential. International Journal of Dermatology, 28, 342-344.
26. KEYSE, S. M., 1993, The induction of gene expression in mammalian cells by radiation. Cancer Biology, 4, 119-128.
27. KHARBANDA, S., YUAN, Z. M., RUBIN, E., WEICHSELBAUM, R. and KUFE, D., 1994, Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation. Journal of Biological Chemistry, 269, 20739-20743.
28. KICK, G., MESSER, G., GOETZ, A., PLEWIG, G. and KIND, P., 1995, Photodynamic therapy induces expression of interleukin 6 by activation of AP-1 but not NF-κB DNA binding. Cancer Research, 55, 2373-2379.
29. KICK, G., MESSER, G., PLEWIG, G., KIND, P. and GOETZ, A., 1996, Strong and prolonged induction of c-jun and c-fos proto-oncogenes by photodynamic therapy. British Journal of Cancer, 74, 30-36.
30. KIRNBAUER, R., KÖCK, A., NEUNER, P., FÖRSTER, E., KRUTMANN, J., URBANSKI, A., SCHAUER, E., ANSEL, J. C., SCHWARZ, T. and LUGER, T. A., 1991, Regulation of epidermal cell interleukin-6 production by UV light and corticosteroids. Journal of Investigative Dermatology, 96, 484-489.
31. KÖNIG, H., PONTA, H., RAHMSDORF, H. J. and HERRLICH, P., 1992, Interference between pathway-specific transcription factors: glucocorticoids antagonize phorbol ester-induced AP-1 activity without altering AP-1 site occupation in vivo. EMBO Journal, 11, 2241-2246.
32. KUPPER, T. S., 1990, The activated keratinocyte: a model for inducible cytokine production by non-bone-marrow-derived cells in cutaneous inflammatory and immune responses. Journal of Investigative Dermatology, 94, 146S-150S.
33. LADEROUTE, K. R., AUSSERER, W. A., KNAPP, A. M., GRANT, T. D. and SUTHERLAND, R. M., 1994, Epidermal growth factor modifies cell cycle control in A431 human squamous carcinoma cells damaged by ionizing radiation. Cancer Research, 54, 1407-1411.
34. LE, P. T., LAZORICK, S., WHICHARD, L. P., HAYNES, B. F. and SINGER, K. H., 1991, Regulation of cytokine production in the human thymus: epidermal growth factor and transforming growth factor α regulate mRNA levels of interleukin 1 α (IL-1 α), IL-1 β, and IL-6 in human thymic epithelial cells at a post-transcriptional level. Journal of Experimental Medicine, 174, 1147-1157.
35. LEVINE, S. J., LARIVEE, P., LOGUN, C., ANGUS, C. W. and SHELHAMER, J. H., 1993, Corticosteroids differentially regulate secretion of IL-6, IL-8, and G-CSF by a human bronchial epithelial cell line. American Journal of Physiology, 265, L360-L368.
36. LIBERMANN, T. A. and BALTIMORE, D., 1990, Activation of interleukin-6 gene expression through the NF-κB transcription factor. Molecular and Cellular Biology, 10, 2327-2334.
37. LINKER ISRAELI, M., DEANS, R. J., WALLACE, D. J., PREHN, J., OZERI CHEN, T. and KLINENBERG, J. R., 1991, Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. Journal of Immunology, 147, 117-123.
38. MAGIC, Z., MATIC IVANOVIC, S., SAVIC, J. and POZNANOVIC, G., 1995, Ionizing radiation-induced expression of the genes associated with the acute response to injury in the rat. Radiation Research, 143, 187-193.
39. MARGULIES, L. and SEHGAL, P. B., 1993, Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP β (NF-IL6) activity by p53 species. Journal of Biological Chemistry, 268, 15096-15100.
40. MICHEL, G., NOWOK, K., BEETZ, A., RIED, G., KEMENY, L. and RUZICKA, T., 1995, Novel steroid derivative modulates gene expression of cytokines and growth regulators. Skin Pharmacology, 8, 215-220.
41. MULE, J. J., CUSTER, M. G., TRAVIS, W. D. and ROSENBERG, S. A., 1992, Cellular mechanisms of the antitumor activity of recombinant IL-6 in mice. Journal of Immunology, 148, 2622-2629.
42. MULE, J. J., MCINTOSH, J. K., JABLONS, D. M. and ROSENBERG, S. A., 1990, Antitumor activity of recombinant interleukin 6 in mice. Journal of Experimental Medicine, 171, 629-636.
43. NEUNER, P., URBANSKI, A., TRAUTINGER, F., MOLLER, A., KIRNBAUER, R., KAPP, A., SCHOPF, E., SCHWARZ, T. and LUGER, T. A., 1991, Increased IL-6 production by monocytes and keratinocytes in patients with psoriasis. Journal of Investigative Dermatology, 97, 27-33.
44. PETER, R. U., BEETZ, A., RIED, C., MICHEL, G., VAN BEUNINGEN, D. and RUZICKA, T., 1993, Increased expression of the epidermal growth factor receptor in human epidermal keratinocytes after exposure to ionizing radiation. Radiation Research, 136, 65-70.
45. PETER, R. U., BRAUN-FALCO, O., BIRIOUKOV, A., HACKER, N., KERSCHER, M., PETERSEIM, U., RUZICKA, T., KONZ, B. and PLEWIG, G., 1994, Chronic cutaneous radiation damage after accidental exposure to ionizing radiation: the Chernobyl experience. Journal of the American Academy of Dermatology, 30, 719-723.
46. RAY, A., LAFORGE, K. S. and SEHGAL, P. B., 1990, On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (inr motif) occlusion. Molecular and Cellular Biology, 10, 5736-5746.
47. RAY, A. and PREFONTAINE, K. E., 1994, Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proceedings of the National Academy of Sciences, USA, 91, 752-756.
48. RAY, A., SASSONE CORSI, P. and SEHGAL, P. B., 1989, A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation. Molecular and Cellular Biology, 9, 5537-5547.
49. RUPEC, R. A. and BAEUERLE, P. A., 1995, The genomic response of tumor cells to hypoxia and reoxygenation: differential activation of transcription factors AP-1 and NF-κB. European Journal of Biochemistry, 234, 632-640.
50. SACHSENMAIER, C., RADLER-POHL, A., ZINCK, R., NORDHEIM, A., HERRLICH, P. and RAHMSDORF, H. J., 1994, Involvement of growth factor receptors in the mammalian UVC response. Cell, 78, 963-972.
51. SAHIJDAK, W. M., YANG, C. R., ZUCKERMAN, J. S., MEYERS, M. and BOOTHMAN, D. A., 1994, Alterations in transcription factor binding in radioresistant human melanoma cells after ionizing radiation. Radiation Research, 138, S47-S51.
52. SCHEINMAN, R. I., COGSWELL, P. C., LOFQUIST, A. K. and BALDWIN, A. S., 1995, Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science, 270, 283-286.
53. SCHEINMAN, R. I., GUALBERTO, A., JEWELL, C. M., CIDLOWSKI, J. A. and BALDWIN, A. S., 1995, Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Molecular and Cellular Biology, 15, 943-953.
54. SCHIEVEN, G. L. and LEDBETTER, J. A., 1994, Activation of tyrosine kinase signal pathways by radiation and oxidative stress. Trends in Endocrinological Metabolism, 5, 383-388.
55. SCHMIDT-ULLRICH, R. K., VALERIE, K., FOGLEMAN, P. B. and WALTERS, J., 1996, Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells. Radiation Research, 145, 81-85.
56. SCHRECK, R., RIEBER, P. and BAEUERLE, P. A. 1991, Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO Journal, 10, 2247-2258.
57. SHERMAN, M. L., DATTA, R., HALLAHAN, D. E., WEICHSELBAUM, R. R. and KUFE, D. W., 1991, Regulation of tumor necrosis factor gene expression by ionizing radiation in human myeloid leukemia cells and peripheral blood monocytes. Journal of Clinical Investigation, 87, 1794-1797.
58. SHIMIZU, H., MITOMO, K., WATANABE, T., OKAMOTO, S. and YAMAMOTO, K. I., 1990, Involvement of a NF-κB-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines. Molecular and Cellular Biology, 10, 561-568.
59. TROTT, K. R. and KUMMERMEHR, J., 1991, Radiation effects in skin. In: Radiopathology of Organs and Tissues, edited by E. Scherer, C. Streffer and K. R. Trott (Berlin: Springer), pp. 33-66.
60. URBANSKI, A., SCHWARZ, T., NEUNER, P., KRUTMANN, J., KIRNBAUER, R., KÖCK, A. and LUGER, T. A., 1990, Ultraviolet light induces increased circulating interleukin-6 in humans. Journal of Investigative Dermatology, 94, 808-811.
61. VAN SNICK, J., 1990, Interleukin-6: an overview. Annual Review of Immunology, 8, 253-278.
62. WAAGE, A., SLUPPHAUG, G. and SHALABY, R., 1990, Glucocorticoids inhibit the production of IL-6 from monocytes, endothelial cells and fibroblasts. European Journal of Immunology, 20, 2439-2443.
63. WEICHSELBAUM, R. R., HALLAHAN, D. E., SUKHATME, V., DRITSCHILO, A., SHERMAN, M. L. and KUFE, D. W., 1991, Biological consequences of gene regulation after ionizing radiation exposure. Journal of the National Cancer Institute, 83, 480-484.
64. WLASCHEK, M., BOLSEN, K., HERRMANN, G., SCHWARZ, A., WILMROTH, F., HEINRICH, P. C., GOERZ, G. and SCHARFFETTER-KOCHANEK, K., 1993, UVA-induced autocrine Stimulation of fibroblast-derived-collagenase by IL-6: a possible mechanism in dermal photodamage? Journal of Investigative Dermatology, 101, 164-168.
65. YAMASHITA, I., KATAMINE, S., MORIUCHI, R., NAKAMURA, Y., MIYAMOTO, T., EGUCHI, K. and NAGATAKI, S., 1994, Transactivation of the human interleukin-6 gene by human T-lymphotropic virus type 1 Tax protein. Blood, 84, 1573-1578.
66. YANG YEN, H. F., CHAMBARD, J. C., SUN, Y. L., SMEAL, T., SCHMIDT, T. J., DROUIN, J. and KARIN, M., 1990, Transcriptional interference between c-jun and the glucocorticoid receptor: mutual inhibition of DNA-binding due to direct protein-protein interaction. Cell, 62, 1205-1215.
67. ZHANG, Y., LIN, J. X. and VILCEK, J., 1990, Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a κB-like sequence. Molecular and Cellular Biology, 10, 3818-3823.
68. ZHU, Z., TANG, W., RAY, A., WU, Y., EINARSSON, O., LANDRY, M. L., GWALTNEY, J. and ELIAS, J. A., 1996, Rhinovirus stimulation of interleukin-6 in vivo and in vitro. Journal of Clinical Investigation, 97, 421-430.