Radioprotection of normal tissues in tumor-bearing mice by troxerutin

Journal of Radiation Research

Volumn 45, Issue 2, 2004, Pages 221-228

  Maurya, Dharmendra Kumar ^a   Salvi, Veena Prakash ^a   Krishnan Nair, Cherupally Krishnan ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

Comet assay; DNA damage; Lipid peroxidation; Membrane damage; Radioprotection; Radiotherapy; Troxerutin

Indexed keywords

CELL DEATH; CELL MEMBRANES; DNA; GAMMA RAYS; HISTOLOGY; IRRADIATION; LIPIDS; MAMMALS; MITOCHONDRIA; OXIDATION; OXIDATIVE STRESS; RADIATION EFFECTS; TUMORS;

CELLULARS; COMET ASSAYS; DNA DAMAGES; LIPID PEROXIDATION; MEMBRANE DAMAGE; NORMAL TISSUE; RADIATION-INDUCED; RADIOPROTECTION; TROXERUTIN; Γ-RADIATION;

FLAVONOIDS;

FLAVANOID; TROXERUTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CANCER RADIOTHERAPY; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; GAMMA IRRADIATION; IN VITRO STUDY; LEUKOCYTE; LIPID PEROXIDATION; LIVER; LIVER MICROSOME; MALE; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; RADIATION DOSE; RADIATION INJURY; RADIATION PROTECTION; RADIATION RESPONSE; RADIOSENSITIVITY; TUMOR; WHOLE BODY RADIATION;

ANIMALIA;

EID: 4544230202     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.45.221     Document Type: Article

References (45)

1. Nair, C. K. K., Parida, D. K. and Nomura, T. (2001) Radioprotectors in radiotherapy. J. Radiat. Res. 42: 21-37.
2. Bors, W., Heller, W. Michel, C. and Sarn, M. (1990) Flavonoids as anioxidants: Determination of radical scavenging efficiencies. Methods Enzymol.186: 343-355.
3. Uma, Devi, P., Ganasoundari, A., Rao, B. S. S. and Srinivasan, K. K. (1999) In vivo radioprotection by Ocimum flavonoids: survival of mice. Radiat. Res. 151: 74-78.
4. Uma, Devi, P. and Ganasoundari, A. (1999) Modulation of antioxidant enzyme by Ocimum sanctum and it role in protection against radiation injury. Ind. J. Exp. Biol. 37: 262-268.
5. Samarth, R. M. and Kumar, A. (2003) Radioprotection of Swiss albino mice by plant extract Mentha piperita (Linn). J. Radiat. Res. 44: 101-109.
6. Nishimura, Y., Kim, H. S., Ikota, N., Arima, H., Bom, H. S., Kim, Y. H., Watanabe, Y., Yukawa, M. and Ozawa, T. (2003) Radioprotective effect of chitosan in sub-lethally X-ray irradiated mice. J. Radiat. Res. 44: 53-58.
7. Hosseinimehr, S. J., Safiee, A., Mozdarani, H. and Akhlagpour, S. (2001) Radioprotective effects of 2-iminothiazolidine derivatives against lethal doses of gamma radiation in mice. J. Radiat. Res. 42: 401-808.
8. Bardhan, K. D. (1981) Histamine H2 receptor antagonists. In: Prespective in Duodenal Ulcer, 2nd. Ed., Ed, S., pp. 73-84, Kline and French, Hertfordshire.
9. Mozdarani, H. (2003) Radioprotective properties of histamine H2 receptor antagonists: present and future prospects. J. Radiat. Res. 44: 145-149.
10. Uma, Devi, P., Ganasoundari, A., Vrinda, B., Srinivasan, K. K. and Unnikrishnan, M. K. (2000) Radiation protection by ocimum flavonoids orientin and vicenin: mechanism of action. Radiat. Res 154: 455-460.
11. Konopacka, M. (1996) Vitamines as radioprotector of normal cells. Postepy Hig. Med. Dosw. 50: 145-156.
12. Rehn, D., Golden, G., Nocker, W., Diebschlag, W. and Lehmacher, W. (1993) Comparision between the efficacy and tolerability of oxerutins and troxerutin in the treatment of patients with chronic venous insufficiency. Lrzneimittelforschung. 43(10): 1060-1063.
13. Boisseu, M. R., Taccoen, A., Garreau, C., Vergnes, C., Roudaut, M. F. and Garreau-Gomez, B. (1995) Fibrinolysis and hemorheology in chronic venous insufficiency: a double blind study of troxerutin efficiency. J. Cardiovasc. Surg. (Torino) 36: 369-374.
14. Vin, F., Chabanel, A., Taccoen, A., Ducros, J., Gruffaz, J., Hutinel, B., Maillet, P. and Samama, M. (1992) Action of the troxerutin on clinical parameters, plethysmographics and rheologics of venous insufficiency of the lower limbs: A placebo-controled trial. Arteres et. Veines 11: 333-342.
15. Vin, F., Chabanel, A., Taccoen, A., Ducros, J., Gruffaz, J., Hutinel, B., Maillet, P. and Samama, M. (1994) Double blind trial of the efficacy of troxerutin in chronic venous insufficiency. Phlebology 9: 71-78.
16. Incandela, L., De, Sanctis, M. T., Cesarone, M. R., Laurora, G., Belcaro, G., Taccoen, A. and Gerentes, I. (1996) Efficacy of troxerutin in patients with chronic venous insufficiency: a double-blind, placebo-controlled study. Advances in Therapy 13(3): 161-166.
17. Biosseau, M., Freyburger, G., Beylot, C. and Busquet, M. (1986) Erythrocyte aggregation and parameters hemorheologic at the insufficiency venous influence of the troxerutin. Arteries et veins. 5(3): 231-234.
18. Wadworth, A. and Faulds, D. (1992) Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders. Drugs 44: 1013-1032.
19. Auteri, A., Blardi, P., Frigerio, C., de, Lillo, L. and di, Perri, T. (1990) Pharmacodynamics of troxerutine in patients with chronic venous insufficiency: correlations with plasma drug levels. Int. J. Clin. Pharmacol. Res. 10: 235-41.
20. Schuller-Petrovic, S., Wolzt, M., Bohler, K., Jilma, B. and Eichler, H. G. (1994) Studies on the effect of short-term oral dihydroergotamine and troxerutin in patients with varicose veins. Clin. Pharmacol. Ther. 56: 452-459.
21. Glacet-Bernard, A., Coscas, G., Chabanel, A., Zourdani, A., Lelong, F. and Samama, M. M. (1994) A randomized, double-masked study on the treatment of retinal vein occlusion with troxerutin. Am. J. Ophthalmol. 118: 421-429.
22. Krupinski, K., Giedrojc, J. and Bielawiec, M. (1996) Effect of troxerutin on laser-induced thrombus formation in rat mesenteric vessels, coagulation parameter and platelet function. Pol. J. Pharmacol. 48: 335-339.
23. Gueguen-Duchesne, M., Durand, F., Le, Goff, M. C. and Genetet, B. (1988) Effects of troxerutin on the hemorhhological parameters of patients with moderate arterial hypertension. Prog. Clin. Biol. Res. Centre 280: 401-406.
24. Vanscheidt, W., Rabe, E., Naser-Hijazi, B., Ramelet, A. A., Partsch, H., Diehm, C, Schultz-Ehrenburg, U., Spengel, F., Wirsching, M., Gotz, V., Schnitker, J. and Henneicke-von, Zepelin, H. H. (2002) The efficacy and safety of a coumarin-/troxerutin-combination (SB-LOT) in patients with chronic venous insufficiency: a double blind placebo-controlled randomized study. Vasa 31: 185-190.
25. Kessler, M., Ubeaud, G., Walter, T., Sturm, F. and Jung, L. (2002) Free radical scavenging and skin penetration on troxerutin and vitamin derivatives. Dermatolog. Treat. 13: 133-141.
26. Blasig, I. E., Loewe, H. and Elbert, B. (1987) Radical trapping and lipid peroxidation during myocardial reperfusion injury - radical scavenging by troxerutin in comprision to mannitol. Biomed. Biochim. Acta. 47: S539-S544.
27. Blasig, I. E., Loewe, H. and Elbert, B. (1988) Effect of troxerutin and methionine on spin trapping of free oxy-radicals. Biomed. Biochim. Acta. 47: S252-S255.
28. Wenisch, C. (2001) Effect of bioflavonoids (trihydroxyethylrutin and disodium flavodate) in vitro on neutrophil reactive oxygen production and phagocytotic ability to assessed by flow cytometry. Curr. Med. Res. Opan. 17: 123-127.
29. Grotz, A. A., Henneicke-vonZepelin, H. H., Khnen, R., al-Nawas, B., Bockisch, A., Kutzner, J., Wustenberg, P., Naser-Hijazi, B., Belz, G. G. and Wagner, W. (1999) Prospective double-blind study of radioxerostomia with coumarin/troxerutine in patients with head and neck cancer. Strahlenther. Onkol. 175: 397-404.
30. Waravdekar, S. S. and Ranadive, K. J. (1957) Biological testing of sulfur isosteres of carcinogenic hydrocarbons. J. Natl. Cancer Inst. 18: 555-559.
31. Gandhi, N. M., Gopalaswamy, U. V. and Nair, C. K. K. (2003) Radiation protection by Disulfiram. J. Radiat. Res. 44: (In Press)
32. Shetty, T. K., Satav, J. G. and Nair, C. K. K. (2002) Protection of DNA and microsomal membranes in vitro by Glycyrrhizia glabra L., against gamma irradiation. Phytother. Res. 16: 576-578.
33. Lowry, O. H., Rosenbrough, N. J., Farr, A. L. and Randall, R. J. (1951) Protein measurement with the Folin phenol reasent. J. Biol. Chem. 193: 265-275.
34. Beuge, J. A. and Aust, S. D. (1978) Microsomal lipid peroxidation. Meth. Enzymol. 52: 302-310.
35. Singh, N. P. (2000) Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis. Mutat. Res. 455: 111-127.
36. Chaubey, R. C., Bhilwade, H. N., Rajagopalan, R. and Bannur, S. V. (2001) Gamma ray-induced DNA damage in human and mouse leukocytes measured by SCGE-Pro: a software developed for automated image analysis and data processing for comet assay. Mutat. Res. 490: 187-197.
37. Marzin, D., Phi, H. V., Olivier, P. and Sauzieres, J. (1987) Study of the mutagenic activity of troxerutin, a flavonoid derivatives. Toxicol. Lett. 35(2-3): 297-305.
38. Glacet-Bernard, A., Coscas, G., Chabanel, A., Zaurdani, A., Lelong, F. and Samama, M. M. (1994) A randomized double-masked study on the treatment of retinal vein occlusion with troxerutin. Am. J. Ophthalmol. 15: 421-429.
39. Marhic, C. (1991) Clinical and rheological efficacy of troxerutin in obstetric gynecology. Gynecol. Obstet. 86: 209-212.
40. Wijayanegara, H., Moses, J. C., Achmad, L., Sobama, R. and Permadi, W. (1992) A clinical trial of hydroxyethylrotusides in treatment of hemorrhoids of pregnancy. J. Int. Med. Res. 20: 54-60.
41. Patwardhan, A., Carlsson, K., Poullain, J. C., Taccoen, A. and Gerentes, I. (1995) The affinity of troxerutin for the venous wall measured by laser scanning microscopy. J. Cardiovascular. Surg. (Torino) 36: 381-385.
42. Carlson, K., Patwardhan, A., Poullain, J. C. and Gerentes, I. (1996) Transport et fixation de la troxerutine dans la paroi veineuse. J. Mal. Vasc. 21 (Suppl C): 270-274.
43. Basile, M., Gidaro, S., Pacella, M., Biffignandi, P. M. and Gidaro, G. S. (2001) Parental troxerutin and carbazochrome-combination in the treatment of post-hemorrhoidectomy status: A randomized, double blind, placebo-controlled, phase IV study. Curr. Med. Res. Opin. 17: 256-261.
44. Belli, M., Sapora, O. and, Antonella, M. (2002) Molecular targets in cellular response to ionizing radiation and implications in space radiation protection. J. Radiat. Res. 43: S13-S19.
45. Tannehill, S. P. and Mehta, M. P. (1996) Amifostine and radiation therapy: past, present and future. Semin. Oncol. 23 (Suppl. 8): 69-77.