Reishi or Ling Zhi (Ganoderma lucidum)

Encyclopedia of Dietary Supplements

Volumn , Issue , 2004, Pages 603-622

  Wasser, Solomon P ^a  

^a UNIVERSITY OF HAIFA   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84894234338     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1081/E-EDS-120022119     Document Type: Chapter

References (68)

1. Wasson, R.G. Soma: Divine Mushroom of Immortality; Harcourt Brace Jovanovich, Inc.: Los Angeles, CA, USA, 1968; 80–92.
2. Moncalvo, J.-M.; Ryvarden, L. A Nomenclatural study of the Ganodermataceae Donk; Synopsis Fungorum 11; Fungiflora: Oslo, Norway, 1997; 114.
3. Wasser, S.P.; Weis, A.L. Medicinal Mushrooms. Ganoderma lucidum, (Curtis: Fr.), P. Karst; Nevo, E., Eds.; Peledfus Publ House: Haifa, Israel, 1997; 39.
4. Chen, A.W. Cultivation of the medicinal mushroom Ganoderma lucidum (Curtis: Fr.), P. Karst (Reishi) in North America. Int. J. Med. Mushrooms 1999; 1 (3), 263–282.
5. Stamets, P. Growing Gourmet and Medicinal Mushrooms, 3rd Ed.; Ten Speed Press: CA, USA, 2000.
6. Chang, S.T.; Buswell, J.A. Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromyceti-deae)—a mushrooming medicinal mushroom. Int. J. Med. Mushrooms 1999, 1 (2), 139–146.
7. Zhou, Sh.; Gao, Y. The immunomodulating effects of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, reishi mushroom) (Aphyllo-phoromycetideae). Int. J. Med. Mushrooms 2002, 4 (1), 1–11.
8. Ying, J.; Mao, X.; Ma, Q.; Zong, Z.; Wen, H. Icons of Medicinal Fungi from China; Yuehan, X., Ed.; Science Press: Beijing, 1987. Translated.
9. Jong, S.C.; Birmingham, J.M. Medicinal benefits of the mushroom Ganoderma. Adv. Appl. Micro-biol. 1992, 37, 101–134. Translated.
10. Hobbs, Ch. Medicinal Mushrooms: An Exploration of Tradition, Healing, and Culture, 2nd Ed.; Botanica Press, Inc.: Santa Cruz, CA, USA, 1995.
11. McKenna, D.J; Jones, K.; Hughes, K. Reishi Botanical Medicines. The Desk reference for Major Herbal Supplements, 2nd Ed.; The Haworth Herbal Press: New York, London, Oxford, 2002; 825–855.
12. Hikino, H. Traditional remedies and modern assessment: the case of ginseng. In The Medicinal Plant Industry; Wijesekera, R.O.B., Ed.; CRC Press: Boca Raton, FL, USA; 149–166.
13. Liu, G.T. Recent advances in research of pharmacology and clinical applications of Ganoderma P. Karst. species (Aphyllophoromycetideae) in China. Int. J. Med. Mushrooms 1999, 1 (1), 63–68.
14. Zhou, Sh.; Kestell, P.; Baguley, B.C.; Paxton, J.W. 5,6-Dimethylxanthenone-4-acetic acid: a novel biological response modifier for cancer therapy. Invest. New Drugs 2002, 20, 281–295.
15. Zhou, Sh.; Gao, Y.; Chen, G.; Dai, X.; Ye, J.; Gao, H. A phase I/II study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, reishi mushroom) extract in patients with chronic hepatitis B. Int. J. Med. Mushrooms 2002, 4 (4), 321–328.
16. Gao, Y.; Zhou, Sh.; Chen, G.; Dai, X.; Ye, J. A phase I/II study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. extract (ganopoly) in patients with advanced cancer. Int. J. Med. Mushrooms 2002, 4 (3), 207–214.
17. Gao, Y.; Zhou, Sh.; Huang, M.; Xu, A. Antibacterial and antiviral value of the genus Ganoderma P. Karst. species (Aphyllophoro-mycetideae): a review. Int. J. Med. Mushrooms 2003, 5 (3), 235–246.
18. Gao, Y.; Lan, J.; Dai, X.; Ye, J.; Zhou, Sh. A phase I/II study of Ling Zhi mushroom Ganoderma lucidum. (W. Curt.: Fr.) Lloyd (Aphyllophoromycetideae) extract in patients with type II diabetes mellitus. Int. J. Med. Mushrooms 2004, 6 (1).
19. Hsu, H.Y., Chen, Y.P., Shen, S.J., Hsu, C.S., Chen, C.C., Chang, H.C., Eds.; Oriental Materia Medica: A Concise Guide, Oriental Healing Arts Institute: Long Beach, CA, USA, 1985; 640–641.
20. Mizuno, T. Reishi, Ganoderma lucidum and Ganoderma tsugae: bioactive substances and medicinal effects. Food Rev. Int. 1995, 11 (1), 151–166.
21. Kim, H.W.; Kim, B.K. Biomedical triterpenoids of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae). Int. J. Med. Mushrooms 1999, 1 (2), 121–138.
22. Min, B.S.; Nakamura, N.; Miyashiro, H.; Bae, K.W.; Hattori, M. Triterpens from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem. Pharm. Bull. 1999, 46, 1607–1612.
23. Min, B.S.; Gao, J.J.; Nakamura, N.; Hattori, M. Triterpenes from the spores of Ganoderma lucidum and their cytotoxicity against meth-A and LLC tumor cells. Chem. Pharm. Bull. 2000, 48, 1026–1033.
24. Chen, J.H.; Zhou, J.P.; Zhang, L.N.; Nakumura, Y.; Norisuye, T. Chemical structure of the water-insoluble polysaccharide isolated from the fruiting body of Ganoderma lucidum. Poly. J. 1998, 30, 838–842.
25. Wasser, S.P.; Weis, A.L. Medicinal properties of substances occurring in higher Basidiomycetes mushrooms: current perspectives (review). Int. J. Med. Mushrooms 1999, 1 (1), 31–62.
26. Cheong, J.; Jung, W.; Park, W. Characterization of an alkali-extracted peptidoglycan from Korean Ganoderma lucidum. Arch. Pharm. Res. 1999, 22, 515–519.
27. Ooi, V.E.C.; Liu, F. Immunomodulation and anti-cancer activity of polysaccharide–protein complexes. Curr. Med. Chem. 2000, 7, 715–729.
28. Wang, Y.Y.; Khoo, K.H.; Chen, S.T.; Lin, C.C.; Wong, C.H.; Lin, C.H. Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorg. Med. Chem. 2002, 10, 1057–1062.
29. Kawagishi, H.; Mitsunaga, S.; Yamawaki, M.; Ido, M.; Shimada, A.; Kinoshita, T.; Murata, T.; Usui, T.; Kimura, A.; Chiba, S. A lectin from mycelia of the fungus Ganoderma lucidum. Phytochemistry 1997, 44, 7–10.
30. Wasser, S.P. Medicinal mushrooms as a source of antitumor and immunomodulating polysac-charides. Appl. Microbiol. Biotechnol. 2002, 60, 258–274.
31. Toth, J.O.; Luu, B.; Ourisson, G. Ganoderic acid T and Z: cytotoxic triterpenes from Gano-derma lucidum (Polyporaceae). Tetrahedron Lett. 1983, 24, 1081–1084.
32. Lin, C.N.; Tome, W.P.; Won, S.J. Novel cytotoxic principles of Formosan Ganoderma lucidum. J. Nat. Prod. 1991, 54, 998–1002.
33. Konopski, Z.; Smedsrod, B.; Seljelid, R.; Eskelend, T. A novel immunomodulator soluble aminated b-1,3-D-glucan: binding characteristics to mouse peritoneal macrophages. Biochim. Biophys. Acta Mol. Cell. Res. 1994, 1221, 61–65.
34. Battle, J.; Ha, T.Z.; Li, C.F.; Dellabeffa, V.; Rice, P.; Kalbfleisch, J.; Browder, W.; Williams, D. Ligand binding to the (1,3)-beta-D-glucan receptor stimulates NF-kappa B activation, but not apoptosis in U937 cells. Biochem. Biophys. Res. Commun. 1998, 249, 499–504.
35. Mueller, A.; Raptis, J.; Rice, P.J.; Kalbfleisch, J.H.; Stout, R.D.; Ensley, H.E.; Browder, W.; Williams, D.L. The influence of glucan polymer structure and solution conformation on binding to (1,3)-beta-D-glucan receptors in a human monocyte-like cell line. Glycobiology 2000, 10, 339–346.
36. Zhong, L.; Jiang, D.Z.; Wang, Q.R. Effects of Ganoderma lucidum (Leyss ex Fr.) Karst. compound on the proliferation and differentiation of K652 leukemic cells. J. Hunan Med. Univ. 1999, 24, 521–524.
37. Wang, S.Y.; Hsu, M.L.; Hsu, H.C.; Tzeng, H.C.; Lee, S.S.; Shiao, M.S.; Ho, C.K. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int. J. Cancer 1997, 70, 699–705.
38. Mizushina, Y.; Hanashima, L.; Yamaguchi, T.; Takemura, M.; Sugawara, F.; Saneyoshi, M.; Matsukage, A.; Yoshida, S.; Sakagushi, K. A mushroom fruiting body-inducing substance inhibits activities of replicative DNA polymerases. Biochem. Biophys. Res. Commun. 1998, 249, 17–22.
39. Chiu, S.W.; Wang, Z.M.; Leung, T.M.; Moore, D. Nutritional value of Ganoderma extract and assessment of its genotoxicity and antigenotoxi-city using comet assays of mouse lymphocytes. Food Chem. Toxicol. 2000, 38, 173–178.
40. Lu, Z.W. Psychoneuroimmunological effects of morphine and the immunoprotection of Gano-derma polysaccharides peptide in morphine-dependent mice. Chin. J. Physiol. 1995, 26, 45–49.
41. Lee, S.; Park, S.; Oh, J.W.; Yang, C.H. Natural inhibitors for protein prenyltransferase. Planta Med. 1998, 54, 303–308.
42. Van der Hem, L.G.; van der Vliet, J.A.; Bocken, C.F.; Kino, K.; Hoitsma, A.J.; Tax, W.J. Ling Zhi-8: studies of a new immunomodulating agent. Transplantation 1995, 60, 438–443.
43. Mao, T.; van De Water, J.; Keen, C.L.; Stern, J.S.; Hackman, R.; Gershwin, M.E. Two mushrooms, Grifola frondosa and Ganoderma lucidum, can stimulate cytokine gene expression and proliferation in human T lymphocytes. Int. J. Immuno-ther. 1999, 15, 13–22.
44. Haak-Frendscho, M.; Kino, K.; Sone, T.; Jardieu, P. Ling Zhi-8: a novel T cell mutagen induces cytokine production and upregulation of ICAM-1 expression. Cell Immunol. 1993, 150, 101–113.
45. Han, M.D.; Lee, E.S.; Kim, Y.K.; Lee, J.W.; Jeong, H.; Yoon, K.H. Production of nitric oxide in RAW 264.7 macrophages treated with gano-deran, the beta-glucan of Ganoderma lucidum. Korean J. Mycol. 1998, 26, 246–255.
46. Oh, J.Y.; Cho, K.J.; Chung, S.H.; Kim, J.H.; Lillehoj, H.S.; Chung, K.S. Activation of macrophages by GLB, a protein–polysaccharide of the growing tips of Ganoderma lucidum. Yakhak Hoeji 1998, 42, 302–306.
47. Pandha, H.S.; Kirby, R.S. PC-SPES: phyto-therapy for prostate cancer. Lancet 2002, 359, 2213–2215.
48. Pfeifer, B.L.; Pirani, J.F.; Hamann, S.R.; Klippel, K.F. PC-SPES, a dietary supplement for the treatment of hormone-refractory prostate cancer. BJU Int. 2000, 85, 481–485.
49. Small, E.J.; Frohlich, M.W.; Bok, R.; Shinohara, K.; Grossfield, G.; Rozenblat, Z.; Kelly, W.K.; Corry, M.; Reese, D.M. Prospective trial of the herbal supplement PC-SPES in patients with progressive prostate cancer. J. Clin. Oncol. 2000, 18, 3595–3603.
50. Smith, D.C.; Redman, B.G.; Flaherty, L.E.; Li, L.; Strawderman, M.; Pienta, K.J. A phase II trial of oral diethylstilbesterol as a second line hormonal agent in advanced prostate cancer. Urology 1998, 52, 257–260.
51. Kabir, Y.; Kimura, S.; Tamura, T. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). J. Nutr. Sci. Vitaminol. 1988, 34, 433–438.
52. Soo, T.S. Effective dosage of the extract of Ganoderma lucidum in the treatment of various ailments. In Mushroom Biology and Mushroom Products; Royse, Ed.; The Pennsylvania State University, 1996; 177–185.
53. Lee, S.Y.; Rhee, H.M. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem. Pharm. Bull. (Tokyo) 1990, 38, 1359–1364.
54. Jin, H.; Zhang, G.; Cao, X.; Zhang, M.; Long, J.; Luo, B.; Chen, H.; Qian, S.; Mori, M.; Wang, Z. Treatment of hypertension by Linzhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure microcirculation. In Microcirculatory Approach to Asian Traditional Medicine: Strategy for the Scientific Evaluation; Excerpta Medica, International Congress Series 1117; Elsevier: Amsterdam, NY, 1996; 131–138.
55. Smith, J.; Rowan, N.; Sullivan, R. Medicinal Mushrooms. Their Therapeutic Properties and Current Medical Usage with Special Emphasis on Cancer Treatment; Special Report Commissioned by Cancer Research UK; The University of Strathclyde in Glasgow, 2002; 256.
56. Suay, I.; Arenal, F.; Asensio, F.J.; Basilio, A.; Cabello, M.A.; Diez, M.T.; Garcia, J.B.; del Val, A.G.; Corrochategui, J.; Hernandez, P.; Pelaez, F.; Vicente, M.F. Screening of Basidiomycetes for antimicrobial activities. Antonie van Leeu-wenhoek 2000, 78, 129–139.
57. Yoon, S.Y.; Eo, S.K.; Kim, Y.S.; Lee, C.K.; Han, S.S. Antimicrobial activity of Ganoderma lucidum extract alone and in combination with some antibiotics. Arch. Pharm. Res. 1994, 17, 438–442.
58. Kim, D.H.; Bae, E.A.; Jang, I.S.; Han, M.J. Anti-Helicobacter pylori activity of mushrooms. Arch. Pharm. Res. 1996, 19, 447–449.
59. Barre-Sinoussi, F.; Chermann, J.C.; Rey, F.; Nugeyre, M.T.; Chamaret, S.; Gruest, J.; Dauguet, C.; Axler-Blin, C.; Vezinet-Brun, F.; Rouzioux, C.; Rozenbaum, W.; Montagnier, L. Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 1983, 220, 868–971.
60. Matsushita, S.; Kimura, T. Advance in treatment strategy and immune reconstruction against HIV1 infection. Microbiol. Immunol. 2002, 46, 231–239.
61. Menendez-Arias, L. Targeting HIV: antiretroviral therapy and development of drug resistance. Trends Pharmacol. Sci. 2002, 23, 381–388.
62. Vermani, K.; Garg, S. Herbal medicines for sexually transmitted diseases and AIDS. J. Ethno-pharmacol. 2002, 80, 49–66.
63. Kim H.W.; Shim, M.J.; Choi, E.C.; Kim, B.K. Inhibition of cytopathic effect of human immunodeficiency virus-1 by water-soluble extract of Ganoderma lucidum. Arch. Pharm. Res. 1997, 20, 425–431.
64. Eo, S.K.; Kim, Y.S.; Lee, C.K.; Han, S.S. Anti-herpetic activities of various protein bound poly-saccharides isolated from Ganoderma lucidum. J. Ethnopharmacol. 1999, 68, 175–181.
65. Eo, S.K.; Kim, Y.S.; Lee, C.K.; Han, S.S. Possible mode of antiviral activity of acidic protein bound polysaccharide isolated from Ganoderma lucidum on herpes simplex viruses. J. Ethno-pharmacol. 2000, 72, 475–481.
66. Mizushina, Y.; Takahashi, N.; Hanashima, L.; Koshino, H.; Esumi, Y.; Uzawa, J.; Sugawara, F.; Sakagushi, K. Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum. Bioorg. Med. Chem. 1999, 7, 2047–2052.
67. Wills, R.B.H.; Bone, K.; Morgan, M. Herbal products: active constituents, modes of action and quality control. Nutr. Res. Rev. 2000, 13, 47–77.
68. Chen, A.W.; Miles, Ph. Biomedical research and the application of mushroom nutriceuticals from Ganoderma lucidum. In Mushroom Biology and Mushroom Products; Royse, Ed.; 1996, 161–175.