Cationic Lipid Complexes to Target Tumor Endothelium

Vascular-Targeted Therapies in Oncology

Volumn , Issue , 2006, Pages 221-245

  Michaelis, Uwe ^a   Teifel, Michael ^b  

^a MediGene AG   (Germany)

^b Zentaris GmbH   (Germany)

Author keywords

Cationic lipid and gene transfer; Cationic lipid complexes targeting tumor endothelium; Cationic liposomes as drug carriers; Cationic liposome based vascular targeting agents; Chemotherapeutic drugs and proteins; Intravenously administered cationic lipid complexes; Low molecular weight cytotoxic drugs; Tumor vascular targeting and cationic liposomes; Vascular disrupting agents (VDAs)

Indexed keywords

EID: 42149115569     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/0470035439.ch13     Document Type: Chapter

References (89)

1. Arndt, D., Fichtner, I., Reszka, R. and Elbe, B. (1983). Preparation, properties and therapeutic effect of Daunorubicin-containing liposomes. Pharmazie 38 (5), 331-335.
2. Audouy, S.A., de Leij, L.F., Hoekstra, D. and Molema, G. (2002). In vivo characteristics of cationic liposomes as delivery vectors for gene therapy. Pharm Res 19 (11), 1599-1605.
3. Augustin, H.G., Braun, K., Telemenakis, I., Modlich, U. and Kuhn, W. (1995). Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression. Am J Pathol 147 (2), 339-351.
4. Augustin, H.G., Kozian, D.H. and Johnson, R.C. (1994). Differentiation of endothelial cells: analysis of the constitutive and activated endothelial cell phenotypes. Bioessays 16 (12), 901-906.
5. Baldwin, A.L., Wu, N.Z. and Stein, D.L. (1991). Endothelial surface charge of intestinal mucosal capillaries and its modulation by dextran. Microvasc Res 42 (2), 160-178.
6. Bangham, A.D., Standish, M.M. and Watkins, J.C. (1965). Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 13 (1), 238-252.
7. Behr, J.P., Demeneix, B., Loeffler, J.P. and Perez-Mutul, J. (1989). Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc Natl Acad Sci USA 86 (18), 6982-6986.
8. Brigham, K.L., Meyrick, B., Christman, B., Magnuson, M., King, G. and Berry, L.C. Jr. (1989). In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle. Am J Med Sci 298 (4), 278-281.
9. Brill, B., Werner, A., Brunner, C., Michaelis, U., Teifel, M. and Groner, B. (2004). Neovascular targeting by EndoTAG-2 (MBT-0312) inhibits growth of subcutaneous mouse tumors. Angiogenesis 7 (1), 29.
10. Campbell, R.B., Fukumura, D., Brown, E.B., Mazzola, L.M., Izumi, Y., Jain, R.K., Torchilin, V.P. and Munn, L.L. (2002). Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res 62 (23), 6831-6836.
11. Chonn, A., Cullis, P.R. and Devine, D.V. (1991). The role of surface charge in the activation of the classical and alternative pathways of complement by liposomes. J Immunol 146 (12), 4234-4241.
12. Christian, S., Ahorn, H., Novatchkova, M., Garin-Chesa, P., Park, J.E., Weber, G., Eisenhaber, F., Rettig, W.J. and Lenter, M.C. (2001). Molecular cloning and characterization of EndoGlyx-1, an EMILIN-like multisubunit glycoprotein of vascular endothelium. J Biol Chem 276 (51), 48588-48595.
13. Cunningham, C.M., Kingzette, M., Richards, R.L., Alving, C.R., Lint, T.F. and Gewurz, H. (1979). Activation of human complement by liposomes: a model for membrane activation of the alternative pathway. J Immunol 122 (4), 1237-1242.
14. Dass, C.R. (2003). Improving anti-angiogenic therapy via selective delivery of cationic liposomes to tumour vasculature. Int J Pharm 267 (1/2), 1-12.
15. Dass, C.R. (2004). Lipoplex-mediated delivery of nucleic acids: factors affecting in vivo transfection. J Mol Med 82 (9), 579-591.
16. Denekamp, J. (1993). Review article: angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy. Br J Radiol 66 (783), 181-196.
17. Echtermeyer, F., Streit, M., Wilcox-Adelman, S., Saoncella, S., Denhez, F., Detmar, M. and Goetinck, P. (2001). Delayed wound repair and impaired angiogenesis in mice lacking syndecan-4. J Clin Invest 107 (2), R9-R14.
18. Eichhorn, M.E., Becker, S., Strieth, S., Werner, A., Sauer, B., Ruhstorfer, H., Michaelis, U., Griebel, J., Brix, G., Jauch, K.W. and Dellian, M. Dynamic magnet resonance tomography for monitoring the efficacy of an anti-vascular tumor therapy by paclitaxel encapsulating cationic lipid complexes (MBT-0206). Proc AACR 45, March 2004a, Abstract 1310.
19. Eichhorn, M.E., Becker, S., Strieth, S., Werner, A., Sauer, B., Ruhstorfer, H., Michaelis, U., Griebel, J., Brix, G., Jauch, K.W. and Dellian, M. (2004b). Dynamic magnetic resonance tomography for monitoring the efficacy of an anti-vascular tumor therapy by paclitaxel encapsulating cationic lipid complexes. Angiogenesis 7 (1), 18.
20. Eichhorn, M.E., Strieth, S. and Dellian, M. (2004). Anti-vascular tumor therapy: recent advances, pitfalls and clinical perspectives. Drug Resist Updat 7 (2), 125-138.
21. Eichhorn, M.E., Strieth, S., Krasnici, S., Sauer, B., Teifel, M., Michaelis, U., Naujoks, K. and Dellian, M. (2004c). Protamine enhances uptake of cationic liposomes in angiogenic microvessels. Angiogenesis 7 (2), 133-141.
22. Felgner, P.L., Gadek, T.R., Holm, M., Roman, R., Chan, H.W., Wenz, M., Northrop, J.P., Ringold, G.M. and Danielsen, M. (1987). Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 84 (21), 7413-7417.
23. Gallo, R., Kim, C., Kokenyesi, R., Adzick, N.S. and Bernfield, M. (1996). Syndecans-1 and-4 are induced during wound repair of neonatal but not fetal skin. J Invest Dermatol 107 (5), 676-683.
24. Gao, X. and Huang, L. (1991). A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem Biophys Res Commun 179 (1), 280-285.
25. Gregoriadis, G. and Ryman, B.E. (1971). Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases. Biochem J 124 (5), 58P.
26. Gregoriadis, G. and Ryman, B.E. (1972). Fate of protein-containing liposomes injected into rats. An approach to the treatment of storage diseases. Eur J Biochem 24 (3), 485-491.
27. Gregoriadis, G., Wills, E.J., Swain, C.P. and Tavill, A.S. (1974). Drug-carrier potential of liposomes in cancer chemotherapy. Lancet 1 (7870), 1313-1316.
28. Hirko, A., Tang, F. and Hughes, J.A. (2003). Cationic lipid vectors for plasmid DNA delivery. Curr Med Chem 10 (14), 1185-1193.
29. Horstmann, E., McCabe, M.S., Grochow, L., Yamamoto, S., Rubinstein, L., Budd, T., Shoemaker, D., Emanuel, E.J. and Grady, C. (2005). Risks and benefits of phase 1 oncology trials, 1991 through 2002. N Engl J Med 352 (9), 895-904.
30. Iozzo, R.V. and San Antonio, J.D. (2001). Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena. J Clin Invest 108 (3), 349-355.
31. Ito, A., Miyazoe, R., Mitoma, J., Akao, T., Osaki, T. and Kunitake, T. (1990). Synthetic cationic amphiphiles for liposome-mediated DNA transfection. Biochem Int 22 (2), 235-241.
32. Kirkpatrick, A.P., Kaiser, T.A., Shepherd, R.D. and Rinker, K.D. (2003). Biochemical mediated glycocalyx modulation in human umbilical vein endothelial cells (HUVEC). Summer Bioengineering Conference.
33. Knüchel, R., Bartelheim, K., Reich, O., Oberneder, R., Stepp, H., Michaelis, U., Naujoks, K. and Sauer, B. (2003). Cationic liposomes for tumor imaging: first clinical results. Proc Am Assoc Cancer Res (2nd edn), 44, 5397.
34. Krasnici, S., Werner, A., Eichhorn, M.E., Schmitt-Sody, M., Pahernik, S.A., Sauer, B., Schulze, B., Teifel, M., Michaelis, U., Naujoks, K. and Dellian, M. (2003). Effect of the surface charge of liposomes on their uptake by angiogenic tumor vessels. Int J Cancer 105 (4), 561-567.
35. Kunstfeld, R., Wickenhauser, G., Michaelis, U., Teifel, M., Umek, W., Naujoks, K., Wolff, K. and Petzelbauer, P. (2003). Paclitaxel encapsulated in cationic liposomes diminishes tumor angiogenesis and melanoma growth in a 'humanized' SCID mouse model. J Invest Dermatol 120 (3), 476-482.
36. Lee, C.M., Tanaka, T., Murai, T., Kondo, M., Kimura, J., Su, W., Kitagawa, T., Ito, T., Matsuda, H. and Miyasaka, M. (2002). Novel chondroitin sulfate-binding cationic liposomes loaded with cisplatin efficiently suppress the local growth and liver metastasis of tumor cells in vivo. Cancer Res 62 (15), 4282-4288.
37. Magee, W.E., Goff, C.W., Schoknecht, J., Smith, M.D. and Cherian, K. (1974). The interaction of cationic liposomes containing entrapped horseradish peroxidase with cells in culture. J Cell Biol 63 (2 Pt 1), 492-504.
38. Magee, W.E. and Miller, O.V. (1972). Liposomes containing antiviral antibody can protect cells from virus infection. Nature 235 (5337), 339-341.
39. McLean, J.W., Fox, E.A., Baluk, P., Bolton, P.B., Haskell, A., Pearlman, R., Thurston, G., Umemoto, E.Y. and McDonald, D.M. (1997). Organ-specific endothelial cell uptake of cationic liposome-DNA complexes in mice. Am J Physiol 273 (1 Pt 2), H387-H404.
40. Mold, C. and Gewurz, H. (1980). Activation of human complement by liposomes: serum factor requirement for alternative pathway activation. J Immunol 125 (2), 696-700.
41. Mounkes, L.C., Zhong, W., Cipres-Palacin, G., Heath, T.D. and Debs, R.J. (1998). Proteoglycans mediate cationic liposome-DNA complex-based gene delivery in vitro and in vivo. J Biol Chem 273 (40), 26164-26170.
42. Nabel, E.G., Plautz, G. and Nabel, G.J. (1990). Site-specific gene expression in vivo by direct gene transfer into the arterial wall. Science 249 (4974), 1285-1288.
43. Nabel, G.J., Nabel, E.G., Yang, Z.Y., Fox, B.A., Plautz, G.E., Gao, X., Huang, L., Shu, S., Gordon, D. and Chang, A.E. (1993). Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci USA 90 (23), 11307-11311.
44. Nelimarkka, L., Salminen, H., Kuopio, T., Nikkari, S., Ekfors, T., Laine, J., Pelliniemi, L. and Jarvelainen, H. (2001). Decorin is produced by capillary endothelial cells in infl ammation-associated angiogenesis. Am J Pathol 158 (2), 345-353.
45. Nishikawa, M. and Huang, L. (2001). Nonviral vectors in the new millennium: delivery barriers in gene transfer. Hum Gene Ther 12 (8), 861-870.
46. Oh, P., Li, Y., Yu, J., Durr, E., Krasinska, K.M., Carver, L.A., Testa, J.E. and Schnitzer, J.E. (2004). Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature 429 (6992), 629-635.
47. Opavsky, R., Haviernik, P., Jurkovicova, D., Garin, M.T., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Bies, J., Garfield, S., Pastorekova, S., Oue, A. and Wolff, L. (2001). Molecular characterization of the mouse Tem1/endosialin gene regulated by cell density in vitro and expressed in normal tissues in vivo. J Biol Chem 276 (42), 38795-38807.
48. Papyan, A., Werner, A., Ischenko, I., Teifel, M., Michaelis, U., Jauch, K.W. and Bruns, C.J. (2004). Combination of standard chemotherapy with MBT-0206 enhances the anti-tumor efficacy in a highly metastatic human pancreatic cancer mouse model. Angiogenesis 7 (1), 22.
49. Pilat, M.J., McCormick, J. and LoRusso, P.M. (2004). Vascular targeting agents. Curr Oncol Rep 6 (2), 103-110.
50. Plank, C., Mechtler, K., Szoka, F.C. Jr. and Wagner, E. (1996). Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery. Hum Gene Ther 7 (12), 1437-1446.
51. Pries, A.R., Secomb, T.W. and Gaehtgens, P. (2000). The endothelial surface layer. Pfl ugers Arch 440, 653-666.
52. Qiao, D., Meyer, K., Mundhenke, C., Drew, S.A. and Friedl, A. (2003). Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 signaling in brain endothelial cells. Specific role for glypican-1 in glioma angiogenesis. J Biol Chem 278 (18), 16045-16053.
53. Ran, S., Downes, A. and Thorpe, P.E. (2002). Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res 62, 6132-6140.
54. Ran, S., He, J., Huang, X., Soares, M., Scothorn, D. and Thorpe, P.E. (2005). Antitumor effects of a monoclonal antibody that binds anionic phospholipids on the surface of tumor blood vessels in mice. Clin Cancer Res 11 (4), 1551-1562.
55. Ran, S. and Thorpe, P.E. (2002). Phosphatidylserine is a marker for tumor vasculature and a potential target for cancer imaging and therapy. Int J Radiat Oncol Biol Phys 54 (5), 1479-1484.
56. Rose, J.K., Buonocore, L. and Whitt, M.A. (1991). A new cationic liposome reagent mediating nearly quantitative transfection of animal cells. Biotechniques 10 (4), 520-525.
57. Sakurai, F., Nishioka, T., Saito, H., Baba, T., Okuda, A., Matsumoto, O., Taga, T., Yamashita, F., Takakura, Y. and Hashida, M. (2001a). Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid. Gene Ther 8, 677-686.
58. Sakurai, F., Nishioka, T., Yamashita, F., Takakura, Y. and Hashida, M. (2001b). Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system. Eur J Pharm Biopharm 52, 165-172.
59. Sangare, L., Morisset, R., Gaboury, L. and Ravaoarinoro, M. (2001). Effects of cationic liposome-encapsulated doxycycline on experimental Chlamydia trachomatis genital infection in mice. J Antimicrob Chemother 47 (3), 323-331.
60. Schmitt-Sody, M., Strieth, S., Krasnici, S., Sauer, B., Schulze, B., Teifel, M., Michaelis, U., Naujoks, K. and Dellian, M. (2003). Neovascular targeting therapy: paclitaxel encapsulated in cationic liposomes improves antitumoral efficacy. Clin Cancer Res 9 (6), 2335-2341.
61. Schönherr, E., Sunderkotter, C., Schaefer, L., Thanos, S., Grassel, S., Oldberg, A., Iozzo, R. V., Young, M.F. and Kresse, H. (2004). Decorin deficiency leads to impaired angiogenesis in injured mouse cornea. J Vasc Res 41 (6), 499-508.
62. Sengupta, S., Tyagi, P., Chandra, S., Kochupillai, V. and Gupta, S.K. (2001). Encapsulation in cationic liposomes enhances antitumour efficacy and reduces the toxicity of etoposide, a topo-isomerase II inhibitor. Pharmacology 62 (3), 163-171.
63. Sengupta, S., Tyagi, P., Velpandian, T., Gupta, Y.K. and Gupta, S.K. (2000). Etoposide encapsulated in positively charged liposomes: pharmacokinetic studies in mice and formulation stability studies. Pharmacol Res 42 (5), 459-464.
64. Senior, J.H., Trimble, K.R. and Maskiewicz, R. (1991). Interaction of positively-charged liposomes with blood: implications for their application in vivo. Biochim Biophys Acta 1070 (1), 173-179.
65. Siemann, D.W., Chaplin, D.J. and Horsman, M.R. (2004). Vascular-targeting therapies for treatment of malignant disease. Cancer 100 (12), 2491-2499.
66. Simberg, D., Weisman, S., Talmon, Y. and Barenholz, Y. (2004). DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst 21 (4), 257-317.
67. Smyth-Templeton, N. (2003). Cationic liposomes as in vivo delivery vehicles. Curr Med Chem 10 (14), 1279-1287.
68. St Croix, B., Rago, C., Velculescu, V., Traverso, G., Romans, K.E., Montgomery, E., Lal, A., Riggins, G.J., Lengauer, C., Vogelstein, B. and Kinzler, K.W. (2000). Genes expressed in human tumor endothelium. Science 289 (5482), 1197-1202.
69. Stamatatos, L., Leventis, R., Zuckermann, M.J. and Silvius, J.R. (1988). Interactions of cationic lipid vesicles with negatively charged phospholipid vesicles and biological membranes. Biochemistry 27 (11), 3917-3925.
70. Strieth, S., Eichhorn, M.E., Sauer, B., Schulze, B., Teifel, M., Michaelis, U. and Dellian, M. (2004). Neovascular targeting chemotherapy: encapsulation of paclitaxel in cationic liposomes impairs functional tumor microvasculature. Int J Cancer 110 (1), 117-124.
71. Szebeni, J. (2001). Complement activation-related pseudoallergy caused by liposomes, micellar carriers of intravenous drugs, and radiocontrast agents. Crit Rev Ther Drug Carrier Syst 18 (6), 567-606.
72. Szebeni, J. (2004). Hypersensitivity reactions to radiocontrast media: the role of complement activation. Curr Allergy Asthma Rep 4 (1), 25-30.
73. Szebeni, J., Baranyi, L., Savay, S., Bodo, M., Morse, D.S., Basta, M., Stahl, G.L., Bunger, R. and Alving, C.R. (2000). Liposome-induced pulmonary hypertension: properties and mechanism of a complement-mediated pseudoallergic reaction. Am J Physiol Heart Circ Physiol 279 (3), H1319-1328.
74. Szebeni, J., Baranyi, L., Savay, S., Milosevits, J., Bunger, R., Laverman, P., Metselaar, J.M., Storm, G., Chanan-Khan, A., Liebes, L., Muggia, F.M., Cohen, R., Barenholz, Y. and Alving, C.R. (2002). Role of complement activation in hypersensitivity reactions to doxil and hynic PEG liposomes: experimental and clinical studies. J Liposome Res 12 (1/2), 165-172.
75. Szebeni, J., Fontana, J.L., Wassef, N.M., Mongan, P.D., Morse, D.S., Dobbins, D.E., Stahl, G.L., Bunger, R. and Alving, C.R. (1999). Hemodynamic changes induced by liposomes and liposome-encapsulated hemoglobin in pigs: a model for pseudoallergic cardiopulmonary reactions to liposomes. Role of complement and inhibition by soluble CR1 and anti-C5a antibody. Circulation 99 (17), 2302-2309.
76. Szebeni, J., Muggia, F.M. and Alving, C.R. (1998). Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study. J Natl Cancer Inst 90 (4), 300-306.
77. Szebeni, J., Wassef, N.M., Spielberg, H., Rudolph, A.S. and Alving, C.R. (1994). Complement activation in rats by liposomes and liposome-encapsulated hemoglobin: evidence for antilipid antibodies and alternative pathway activation. Biochem Biophys Res Commun 205 (1), 255-263.
78. Thorpe, P.E. (2004). Vascular targeting agents as cancer therapeutics. Clin Cancer Res 10 (2), 415-427.
79. Thurston, G., McLean, J.W., Rizen, M., Baluk, P., Haskell, A., Murphy, T.J., Hanahan, D. and McDonald, D.M. (1998). Cationic liposomes target angiogenic endothelial cells in tumors and chronic infl ammation in mice. J Clin Invest 101 (7), 1401-1413.
80. Tousignant, J.D., Gates, A.L., Ingram, L.A., Johnson, C.L., Nietupski, J.B., Cheng, S.H., Eastman, S.J. and Scheule, R.K. (2000). Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid: plasmid DNA complexes in mice. Hum Gene Ther 11 (18), 2493-2513.
81. Trowbridge, J.M. and Gallo, R.L. (2002). Dermatan sulfate: new functions from an old glycosaminoglycan. Glycobiology 12 (9), 117R-125R.
82. Tsujimoto, M., Inoue, K. and Nojima, S. (1981). Reactivity of human C-reactive protein with positively charged liposomes. J Biochem (Tokyo) 90 (5), 1507-1514.
83. Vitas, A.I., Diaz, R. and Gamazo, C. (1997). Protective effect of liposomal gentamicin against systemic acute murine brucellosis. Chemotherapy 43 (3), 204-210.
84. Webb, M.S., Wheeler, J.J., Bally, M.B. and Mayer, L.D. (1995). The cationic lipid stearylamine reduces the permeability of the cationic drugs verapamil and prochlorperazine to lipid bilayers: implications for drug delivery. Biochim Biophys Acta 1238 (2), 147-155.
85. Yao, V.J., Ozawa, M.G., Trepel, M., Arap, W., McDonald, D.M. and Pasqualini, R. (2005). Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection. Am J Pathol 166 (2), 625-636.
86. Yew, N.S., Wang, K.X., Przybylska, M., Bagley, R.G., Stedman, M., Marshall, J., Scheule, R.K. and Cheng, S.H. (1999). Contribution of plasmid DNA to infl ammation in the lung after administration of cationic lipid: pDNA complexes. Hum Gene Ther 10 (2), 223-234.
87. Zhang, J.S., Liu, F. and Huang, L. (2005). Implications of pharmacokinetic behavior of lipoplex for its infl ammatory toxicity. Adv Drug Deliv Rev 57 (5), 689-698.
88. Zhu, N., Liggitt, D., Liu, Y. and Debs, R. (1993). Systemic gene expression after intravenous DNA delivery into adult mice. Science 261 (5118), 209-211.
89. Zurita, A.J., Arap, W. and Pasqualini, R. (2003). Mapping tumor vascular diversity by screening phage display libraries. J Control Release 91 (1/2), 183-186.