Do nonmelanoma skin cancers develop from extra-cutaneous stem cells?

International Journal of Cancer

Volumn 122, Issue 10, 2008, Pages 2173-2177

  Simka, Marian ^a  

^a Department of Angiology ^*  (Poland)

Author keywords

Bone marrow cells; Epidermis; Hematopoietic stem cells; Keratinocytes; Skin neoplasms

Indexed keywords

BASAL CELL CARCINOMA; CANCER MODEL; CELL DIFFERENTIATION; CELL FUSION; CELL LINEAGE; EPIDERMIS; HEMATOPOIETIC STEM CELL; HUMAN; IMMUNE DEFICIENCY; KERATINOCYTE; KIDNEY GRAFT; MALIGNANT TRANSFORMATION; MULTIPOTENT STEM CELL; PRECANCER; PRIORITY JOURNAL; RECIPIENT; REVIEW; SKIN CANCER; SKIN CARCINOGENESIS; SKIN INFLAMMATION; STEM CELL; TISSUE INJURY; WOUND HEALING; ANIMAL; BONE MARROW CELL; CELL TRANSFORMATION; CYTOLOGY; METABOLISM; PATHOLOGY; SKIN TUMOR;

ANIMALS; BONE MARROW CELLS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; KERATINOCYTES; SKIN NEOPLASMS; STEM CELLS;

EID: 42149107393     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.23373     Document Type: Review

References (65)

1. Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TCl. Gastric cancer originating from bone marrow-derived cells. Science 2004;306:1568-71.
2. Aractingi S, Kanitakis J, Euvrard S, Le Danff C, Peguillet I, Khosrotehrani K, Lantz O, Carosella ED. Skin carcinoma arising from donor cells in a kidney transplant recipient. Cancer Res 2005;65:1755-60.
3. Lindelöf B, Sigurgeirsson B, Gäbel H, Stern RS. Incidence of skin cancer in 5356 patients following organ transplantation. Br J Dermatol 2000;143:513-19.
4. Ferrandiz C, Fuente MJ, Ribera M, Bielsa I, Fernandez MT, Lauzurica R, Roca J. Epidermal dysplasia and neoplasia in kidney transplant recipients. J Am Acad Dermatol 1995;33:590-6.
5. Otley CC, Pittelkow MR. Skin cancer in liver transplant recipients. Liver Transplant 2000;6:253-62.
6. Ong CS, Keogh AM, Kossard S, Macdonald PS, Spratt PM. Skin cancer in Australian heart transplant recipients. J Am Acad Dermatol 1999;40:27-34.
7. Jensen P, Hansen S, Møller B, Leivestad T, Pfeffer P, Geiran O, Fauchald P, Simonsen S. Skin cancer in kidney and heart transplant recipients and different long-term immunosuppressive therapy regimens. J Am Acad Dermatol 1999;40:177-86.
8. Leisenring W, Friedman DL, Flowers ME, Schwartz JL, Deeg HJ. Nonmelanoma skin and mucosal cancers after hematopoietic cell transplantation. J Clin Oncol 2006;24:1119-26.
9. Martinez JC, Otley CC, Stasko T, Euvrard S, Brown C, Schanbache CF. Defining the clinical course of metastatic skin cancer in organ transplant recipients. Arch Dermatol 2003;139:301-6.
10. Borue X, Lee S, Grove J, Herzog EL, Harris R, Diflo T, Glusac E, Hyman K, Theise ND, Krause DS. Bone marrow-derived cells contribute to epithelial engraftment during wound repair. Am J Pathol 2004;165:1767-72.
11. Potten CS, Booth C. Keratinocyte stem cells: a commentary. J Invest Dermatol 2002;119:888-99.
12. Simka M. Delayed healing of chronic leg ulcers can result from impaired trafficking of bone marrow-derived precursors of keratinocytes to the skin. Med Hypothes 2007;69:637-41.
13. Rizvi AZ, Wong MH. Epithelial stem cells and their niche: there's no place like home. Stem Cells 2005;23:150-65.
14. Raj D, Brash DE, Grossman D. Keratinocyte apoptosis in epidermal development and disease. J Invest Dermatol 2006:126:243-57.
15. Coussens LM, Tinkle CL, Hanahan D, Werb Z. MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis. Cell 2000;103:48190.
16. Zhang W, Remenyik E, Zelterman D, Brash DE, Wikonkal NM. Escaping the stem cell compartment: sustained UVB exposure allows p53-mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations. Proc Natl Acad Sci USA 2001;20:13948-53.
17. Rebel H, Kram N, Westerman A, Banus S, Kranen van HJ, Gruijl de FR. Relationship between UV-induced mutant p53 patches and skin tumours, analysed by mutation spectra and by induction kinetics in various DNA-repair-deficient mice. Carcinogenesis 2005;26:2123-30.
18. Kramata P, Lu YP, Lou YR, Singh RN, Kwon SM, Conney AH. Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB irradiation harbour the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH- mice. Cancer Res 2005;65:3577-85.
19. Inokuma D, Abe R, Fujita Y, Sasaki M, Shibaki A, Nakamura H, McMillan JR, Shimizu T, Shimizu H. CTACK/CCL27 accelerates skin regeneration via accumulation of bone marrow derived-keratinocytes. Stem Cells 2006;24:2810-16.
20. Fathke C, Wilson L, Hutter J, Kapoor V, Smith A, Hocking A, Isik F. Contribution of bone marrow-derived cells to skin: collagen deposition and wound repair. Stem Cells 2004;22:812-22.
21. Boukamp P. Non-melanoma skin cancer: what drives tumor development and progression? Carcinogenesis 2005;26:1657-67.
22. Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, Halperin AJ, Ponten J. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA 1991;88:10124-8.
23. Einspahr JG, Xu MJ, Warneke J, Saboda K, Ranger-Moore J, Bozzo P, Duckett L, Goldman R, Lin P, Buckmeier J, Alberts DS. Reproducibility and expression of skin biomarkers in sun-damaged skin and actinic keratoses. Cancer Epidemiol Biomarkers Prev 2006;15:1841-8.
24. Brash DE. Roles of the transcription factor p53 in keratinocyte carcinomas. Br J Dermatol 2006;154 (Suppl. 1):8-10.
25. Bolshakov S, Walker CM, Strom SS, Selvan MS, Clayman GL, El-Naggar A, Lippman SM, Kripke ML, Ananthaswamy HN. p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas. Clin Cancer Res 2003;9:228-34.
26. Queille S, Luron L, Spatz A, Avril MF, Ribrag V, Duvillard P, Hiesse C, Sarasin A, Armand JP, Daya-Grosjean L. Analysis of skin cancer risk factors in immunosuppressed renal transplant patients shows high levels of UV-specific tandem CC to TT mutations of the p53 gene. Carcinogenesis 2007;28:724-31.
27. Rambhatla L, Ram-Mohan S, Cheng JJ, Sherley JL. Immortal DNA strand cosegregation requires p53/IMPDH-dependent asymmetric self-renewal associated with adult stem cells. Cancer Res 2005; 65:3155-61.
28. Bäckvall H, Strömberg S, Gustafsson A, Asplund A, Sivertsson A, Lundberg J, Ponten F. Mutation spectra of epidermal p53 clones adjacent to basal cell carcinoma and squamous cell carcinoma. Exp Dermatol 2004;13:643-50.
29. Bäckvall H, Wolf O, Hermelin H, Weitzberg E, Ponten F. The density of epidermal p53 clones is higher adjacent to squamous cell carcinoma in comparison with basal cell carcinoma. Br J Dermatol 2004; 150:259-66.
30. Brash DE, Zhang W, Grossman D, Takeuchi S. Colonisation of adjacent stem cell compartments by mutant keratinocytes. Semin Cancer Biol 2005;15:97-102.
31. Zhang W, Hanks AN, Boucher K, Florell SR, Allen SM, Alexander A, Brash DE, Grossman D. UVB-induced apoptosis drives clonal expansion during skin tumor development. Carcinogenesis 2005; 26:249-57.
32. Wicha MS, Liu S, Dontu G. Cancer stem cells: an old idea - a paradigm shift. Cancer Res 2006;66:1883-90.
33. Kucia M, Reca R, Miekus K, Wanzeck J, Wojakowski W, Janowska-Wieczorek A, Ratajczak J, Ratajczak MZ. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005;23:879-94.
34. Morris RJ. Keratinocyte stem cells: targets for cutaneous carcinogens. J Clin Invest 2000;106:3-8.
35. Dean M. Cancer stem cells: redefining the paradigm of cancer treatment strategies. Mol Intervent 2006;6:140-8.
36. Ratajczak MZ, Zuba-Surma E, Kucia M, Reca R, Wojakowski W, Ratajczak J. The pleiotropic effects of the SDF-1-CXCR4 axis in organogenesis, regeneration and tumorigenesis. Leukemia 2006;20:1915-24.
37. Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-11.
38. Braun KM, Watt FM. Epidermal label-retaining cells: background and recent applications. J Invest Dermatol Symp Proc 2004;9:196-201.
39. El-Omar EM, Rabkin CS, Gammon MD, Vaughan TL, Risch HA, Schoenberg JB, Stanford JL, Mayne ST, Goedert J, Blot WJ, Fraumeni JF, Jr, Chow WH. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphism. Gastroenterology 2003;124:1193-201.
40. Marx J. Inflammation and cancer: the link grows stronger. Science 2004;306:966-8.
41. Herzog EL, Chai L, Krause DS. Plasticity of marrow-derived stem cells. Blood 2003;102:3483-93.
42. Schwartz RE, Reyes M, Koodie L, Jiang Y, Blackstad M, Lund T, Lenvik T, Johnson S, Hu W-S, Verfaillie CM. Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells. J Clin Invest 2002;109:1291-302.
43. Li HC, Stoicov C, Rogers AB, Houghton JM. Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers. World J Gastroenterol 2006;21:363-71.
44. Deng W, Han Q, Liao L, Li C, Ge W, Zhao Z, You S, Deng H, Murad F, Zhao RCH. Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue. Tissue Eng 2005;11:110-19.
45. Brittan M, Braun KM, Reynolds LE, Conti FJ, Reynolds AR, Poulsom R, Alison MR, Wright NA, Hodivala-Dilke KM. Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion. J Pathol 2005;205:1-13.
46. Herzog EL, Krause DS. Engraftment of marrow-derived epithelial cells. The role of fusion. Proc Am Thorac Soc 2006;3:691-5.
47. Rizvi AZ, Swain JR, Davies PS, Bailey AS, Decker AD, Willenbring H, Grompe M, Fleming WH, Wong. Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. Proc Natl Acad Sci USA 2006;103:6321-5.
48. He X, Tsang TC, Pipes BL, Ablin RJ, Harris DT. A stem cell fusion model of carcinogenesis. J Exp Ther Oncol 2005;5:101-9.
49. Pawelek J, Chakraborty A, Lazova R, Yilmaz Y, Cooper D, Brash D, Handerson T. Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion? Contrib Microbiol 2006;13:138-55.
50. Pawelek JM. Tumour-cell fusion as a source of myeloid traits in cancer. Lancet Oncol 2005;6:916-18.
51. Yilmaz Y, Lazova R, Qumsiyeh M, Cooper D, Pawelek J. Donor Y chromosome in renal carcinoma cells of a female BMT recipient: visualisation of putative BMT-tumor hybrids by FISH. Bone Marrow Transplant 2005;35:1021-4.
52. Chakraborty A, Lazova R, Davies S, Bäckvall H, Ponten F, Brash D, Pawelek J. Donor DNA in a renal cell carcinoma metastasis from a bone marrow transplant recipient. Bone Marrow Transplant 2004; 34:183-6.
53. Hematti P, Sloand EM, Carvallo CA, Albert MR, Yee CL, Fuehrer MM, Blancato JK, Kearns WG, Barrett JA, Childs RW, Vogel JC, Dunbar CE. Absence of donor-derived keratinocyte stem cells in skin tissues cultured from patients after mobilized peripheral blood hematopoietic stem cell transplantation. Exp Hematol 2002;30:943-9.
54. Smits T, Olthuis D, Blokx WA, Kleinpenning MM, Kerkhof van de PC, Erp van PE, Gerritsen MJ. Aneuploidy and proliferation in keratinocytic intraepidermal neoplasias. Exp Dermatol 2007;16:81-6.
55. Pilch H, Weiss J, Heubner C, Heine M. Differential diagnosis of keratoacanthomas and squamous cell carcinomas: diagnostic value of DNA image cytometry and p53 expression. J Cutan Pathol 1994; 21:507-13.
56. Simka M, Januszewski K. Squamous cell carcinoma in longstanding venous ulceration - clinical case. Przeg Flebol 2003;11:117-18.
57. Baldursson B, Sigurgeirsson B, Lindelöf B. Venous leg ulcers and squamous cell carcinoma a large-scale epidemiological study. Br J Dermatol 1995;133:571-4.
58. Fortina AB, Piaserico S, Caforio AL, Abeni D, Alaibac M, Angelini A, Iliceto S, Peserico A. Immunosuppressive level and other risk factors for basal cell carcinoma and squamous cell carcinoma in heart transplant recipients. Arch Dermatol 2004;140:1079-85.
59. Penn I. Post-transplant malignancy: the role of immunosuppression. Drug Saf 2000;23:101-13.
60. Moodycliffe AM, Nghiem D, Clydesdale G, Ullrich SE. Immune suppression and skin cancer development: regulation by NKT cells. Nat Immunol 2000;1:521-5.
61. Aractingi S, Kanitakis J, Euvrard S, Le Danff C, Carosella ED. Selective expression of HLA-G in malignant and premalignant skin specimens in kidney transplant recipients. Int J Cancer 2003;106:232-5.
62. Marshall SE, Bordea C, Haldar NA, Mullighan CG, Wojnarowska F, Morris PJ, Welsh KI. Glutathione S-transferase polymorphisms and skin cancer after renal transplantation. Kidney Int 2000;58:2186-93.
63. Harwood CA, Surentheran T, McGregor JM, Spink PJ, Leigh IM, Breuer J, Proby CM. Human papillomavirus infection and non-melanoma skin cancer in immunosuppressed and immunocompetent individuals. J Med Virol 2000;61:289-97.
64. Tolar J, O'Shaughnessy MJ, Panoskaltsis-Mortari A, McElmurry RT, Bell S, Riddle M, McIvor RS, Yant SR, Kay MA, Krause D, Verfaillie CM, Blazar BR. Host factors that impact the biodistribution and persistence of multipotent adult progenitor cells. Blood 2006;107:4182-8.
65. Murata H, Janin A, Leboeuf C, Soulier J, Gluckman E, Meignin V, Socie G. Donor-derived cells and human graft-versus-host disease of the skin. Blood 2007;109:2663-5.