메뉴 건너뛰기




Volumn 52, Issue 1, 2008, Pages 48-57

Lack of skeletal effect of soy isoflavones in intact growing, female rats may be explained by constant serum estrogenic activity despite reduced serum estradiol

Author keywords

Adolescence; Bone; Estrogenic activity; Growth; Skeletal effects; Soy

Indexed keywords

CASEIN; GENISTEIN; ISOFLAVONE DERIVATIVE; SOYBEAN PROTEIN;

EID: 42149104976     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000118630     Document Type: Article
Times cited : (6)

References (50)
  • 1
    • 0024423180 scopus 로고
    • Nutritional factors in bone health in elderly subjects: Methodological and contextual problems
    • Heaney RP: Nutritional factors in bone health in elderly subjects: methodological and contextual problems. Am J Clin Nutr 1989;50:1182-1189.
    • (1989) Am J Clin Nutr , vol.50 , pp. 1182-1189
    • Heaney, R.P.1
  • 2
    • 0031741906 scopus 로고    scopus 로고
    • Phytoestrogens: The biochemistry, physiology, and implications for human health of soy isoflavones
    • Setchell KD: Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. Am J Clin Nutr 1998;68:1333S-1346S.
    • (1998) Am J Clin Nutr , vol.68
    • Setchell, K.D.1
  • 3
    • 3142755432 scopus 로고    scopus 로고
    • Isoflavones in soy infant formula: A review of evidence for endocrine and other activity in infants
    • Chen A, Rogan WJ: Isoflavones in soy infant formula: a review of evidence for endocrine and other activity in infants. Annu Rev Nutr 2004;24:33-54.
    • (2004) Annu Rev Nutr , vol.24 , pp. 33-54
    • Chen, A.1    Rogan, W.J.2
  • 4
    • 0023877656 scopus 로고
    • Vitamin D metabolism, mineral homeostasis, and bone mineralization in term infants fed human milk, cow milk-based formula, or soy-based formula
    • Hillman LS, Chow W, Salmons SS, Weaver E, Erickson M, Hansen, J: Vitamin D metabolism, mineral homeostasis, and bone mineralization in term infants fed human milk, cow milk-based formula, or soy-based formula. J Pediatr 1988;112:864-874.
    • (1988) J Pediatr , vol.112 , pp. 864-874
    • Hillman, L.S.1    Chow, W.2    Salmons, S.S.3    Weaver, E.4    Erickson, M.5    Hansen, J.6
  • 5
    • 0042785118 scopus 로고    scopus 로고
    • Dietary phytoestrogens and their effect on bone: Evidence from in vitro and in vivo, human observational, and dietary intervention studies
    • Setchell KD, Lydeking-Olsen E: Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies. Am J Clin Nutr 2003;78:593S-609S.
    • (2003) Am J Clin Nutr , vol.78
    • Setchell, K.D.1    Lydeking-Olsen, E.2
  • 6
    • 0033847870 scopus 로고    scopus 로고
    • Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women
    • Alekel DL, Germain AS, Peterson CT, Hanson KB, Stuart JW, Toda T: Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr 2000;72:844-852.
    • (2000) Am J Clin Nutr , vol.72 , pp. 844-852
    • Alekel, D.L.1    Germain, A.S.2    Peterson, C.T.3    Hanson, K.B.4    Stuart, J.W.5    Toda, T.6
  • 8
    • 0031772172 scopus 로고    scopus 로고
    • Soy protein and isoflavones: Their effects on blood lipids and bone density in postmenopausal women
    • Potter SM, Baum JA, Teng H, Stillman RJ, Shay NF, Erdman JW Jr: Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 1998;68:1375S-1379S.
    • (1998) Am J Clin Nutr , vol.68
    • Potter, S.M.1    Baum, J.A.2    Teng, H.3    Stillman, R.J.4    Shay, N.F.5    Erdman Jr, J.W.6
  • 9
    • 0000428012 scopus 로고    scopus 로고
    • Bone mineral acquisition in utero and during infancy and childhood
    • Marcus R, Feldman D, Kelsey J eds, San Diego, Academic Press
    • Hillman LS: Bone mineral acquisition in utero and during infancy and childhood; in Marcus R, Feldman D, Kelsey J (eds): Osteoporosis. San Diego, Academic Press, 1996.
    • (1996) Osteoporosis
    • Hillman, L.S.1
  • 10
    • 0028920667 scopus 로고
    • Alterations in calcium intake on peak bone mass in the female rat
    • Peterson CA, Eurell JA, Erdman JW Jr: Alterations in calcium intake on peak bone mass in the female rat. J Bone Miner Res 1995;10:81-95.
    • (1995) J Bone Miner Res , vol.10 , pp. 81-95
    • Peterson, C.A.1    Eurell, J.A.2    Erdman Jr, J.W.3
  • 11
    • 0002752419 scopus 로고
    • Monitoring of the estrous cycle in the laboratory rodent by vaginal lavage
    • Heindel JJ, Chapin RE eds, Chapt 4. San Diego, Academic Press
    • Cooper RL, Goldman JM, Vandenbergh JG: Monitoring of the estrous cycle in the laboratory rodent by vaginal lavage; in Heindel JJ, Chapin RE (eds): Female Reproductive Toxicology, Chapt 4. San Diego, Academic Press, 1993, pp 45-56.
    • (1993) Female Reproductive Toxicology , pp. 45-56
    • Cooper, R.L.1    Goldman, J.M.2    Vandenbergh, J.G.3
  • 13
    • 0032866285 scopus 로고    scopus 로고
    • Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS
    • Holder CL, Churchwell MI, Doerge DR: Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS. J Agric Food Chem 1999;47:3764-3770.
    • (1999) J Agric Food Chem , vol.47 , pp. 3764-3770
    • Holder, C.L.1    Churchwell, M.I.2    Doerge, D.R.3
  • 14
    • 0031065967 scopus 로고    scopus 로고
    • Follicular function in lactating dairy cows treated with sustained-release bovine somatotropin
    • Kirby CJ, Smith MF, Keisler DH, Lucy MC: Follicular function in lactating dairy cows treated with sustained-release bovine somatotropin. J Dairy Sci 1997;80:273-285.
    • (1997) J Dairy Sci , vol.80 , pp. 273-285
    • Kirby, C.J.1    Smith, M.F.2    Keisler, D.H.3    Lucy, M.C.4
  • 15
    • 0025721873 scopus 로고
    • pH-dependent cytotoxicity of contaminants of phenol red for MCF-7 breast cancer cells
    • Grady LH, Nonneman DJ, Rottinghaus GE, Welshons WV: pH-dependent cytotoxicity of contaminants of phenol red for MCF-7 breast cancer cells. Endocrinology 1991;129:3321-3330.
    • (1991) Endocrinology , vol.129 , pp. 3321-3330
    • Grady, L.H.1    Nonneman, D.J.2    Rottinghaus, G.E.3    Welshons, W.V.4
  • 16
    • 0028322045 scopus 로고
    • Adaptation of the diphenylamine (DPA) assay to a 96-well plate tissue culture format and comparison with the MTT assay
    • Natarajan N, Shambaugh GE III, Elseth KM, Haines GK, Radosevich JA: Adaptation of the diphenylamine (DPA) assay to a 96-well plate tissue culture format and comparison with the MTT assay. Biotechniques 1994;17:166-171.
    • (1994) Biotechniques , vol.17 , pp. 166-171
    • Natarajan, N.1    Shambaugh III, G.E.2    Elseth, K.M.3    Haines, G.K.4    Radosevich, J.A.5
  • 18
    • 0015303973 scopus 로고    scopus 로고
    • Direct method for determining inorganic phosphate in serum with 'centrifichem'
    • Daly J, Ertingshausen G: Direct method for determining inorganic phosphate in serum with 'centrifichem'. Clin Chem 2000;18:263-265.
    • (2000) Clin Chem , vol.18 , pp. 263-265
    • Daly, J.1    Ertingshausen, G.2
  • 19
    • 0002864903 scopus 로고
    • Fleming Melsen Modification
    • Masson PJ: Fleming Melsen Modification. J Tech Methods 1929;12:75-90.
    • (1929) J Tech Methods , vol.12 , pp. 75-90
    • Masson, P.J.1
  • 20
    • 0003357591 scopus 로고    scopus 로고
    • Modification of the 'Vegetable Protein Products' Requirements for the National School Lunch Program, School Breakfast Program, Summer Food Service Program and Child and Adult Care Food Program
    • Food and Nutrition Service
    • Food and Nutrition Service: Modification of the 'Vegetable Protein Products' Requirements for the National School Lunch Program, School Breakfast Program, Summer Food Service Program and Child and Adult Care Food Program. Federal Register 2000;65:12429-12442.
    • (2000) Federal Register , vol.65 , pp. 12429-12442
  • 21
    • 14544297097 scopus 로고    scopus 로고
    • US Department of Health and Human Service and US Department of Agriculture, 6th ed. 1-12-2005. Washington, US Government Printing Office
    • US Department of Health and Human Service and US Department of Agriculture. Dietary Guidelines for Americans 2005, 6th ed. 1-12-2005. Washington, US Government Printing Office, 2005.
    • (2005) Dietary Guidelines for Americans 2005
  • 22
    • 0026721750 scopus 로고
    • Influence of diets containing cow's milk or soy protein beverage on plasma lipids in children with familial hypercholesterolemia
    • Jacques H, Laurin D, Moorjani S, Stienke FH, Cagne C, Brun D, Lupien PJ: Influence of diets containing cow's milk or soy protein beverage on plasma lipids in children with familial hypercholesterolemia. J Am Coll Nutr 1992;11(suppl):69S-73S.
    • (1992) J Am Coll Nutr , vol.11 , Issue.SUPPL.
    • Jacques, H.1    Laurin, D.2    Moorjani, S.3    Stienke, F.H.4    Cagne, C.5    Brun, D.6    Lupien, P.J.7
  • 23
    • 0033667684 scopus 로고    scopus 로고
    • Bitter taste, phytonutrients, and the consumer: A review
    • Drewnowski A, Gomez-Carneros C: Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr 2000;72:1424-1435.
    • (2000) Am J Clin Nutr , vol.72 , pp. 1424-1435
    • Drewnowski, A.1    Gomez-Carneros, C.2
  • 24
    • 19844376597 scopus 로고    scopus 로고
    • Estrogen receptor-related receptor alpha: A mediator of estrogen response in bone
    • Bonnelye E, Aubin JE: Estrogen receptor-related receptor alpha: a mediator of estrogen response in bone. J Clin Endocrinol Metab 2005;90:3115-3121.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 3115-3121
    • Bonnelye, E.1    Aubin, J.E.2
  • 26
    • 18844408031 scopus 로고    scopus 로고
    • Role of oestrogen in the regulation of bone turnover at the menarche
    • Eastell R: Role of oestrogen in the regulation of bone turnover at the menarche. J Endocrinol 2005;185:223-234.
    • (2005) J Endocrinol , vol.185 , pp. 223-234
    • Eastell, R.1
  • 27
    • 0031424333 scopus 로고    scopus 로고
    • The association of platelet-derived growth factor receptor tyrosine phosphorylation to mitogenic response of human osteoblastic cells in vitro
    • Nakanishi H, Yamanouchi K, Gotoh Y, Magayama M: The association of platelet-derived growth factor receptor tyrosine phosphorylation to mitogenic response of human osteoblastic cells in vitro. Oral Dis 1997;3:236-242.
    • (1997) Oral Dis , vol.3 , pp. 236-242
    • Nakanishi, H.1    Yamanouchi, K.2    Gotoh, Y.3    Magayama, M.4
  • 28
    • 0031846604 scopus 로고    scopus 로고
    • Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells
    • Sandy J, Davies M, Prime S, Farndale R: Signal pathways that transduce growth factor-stimulated mitogenesis in bone cells. Bone 1998;23:17-26.
    • (1998) Bone , vol.23 , pp. 17-26
    • Sandy, J.1    Davies, M.2    Prime, S.3    Farndale, R.4
  • 30
    • 0032170032 scopus 로고    scopus 로고
    • Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo
    • Hsieh CY, Santell RC, Haslam SZ, Helferich WZ: Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res 1998;58:3833-3838.
    • (1998) Cancer Res , vol.58 , pp. 3833-3838
    • Hsieh, C.Y.1    Santell, R.C.2    Haslam, S.Z.3    Helferich, W.Z.4
  • 31
    • 16244392961 scopus 로고    scopus 로고
    • Dietary soy protein and isoflavones have no significant effect on bone and a potentially negative effect on the uterus of sexually mature intact Sprague-Dawley female rats
    • Nakai M, Cook L, Pyter LM, Black M, Sibona J, Turner RT, Jeffery EH, Bahr JM: Dietary soy protein and isoflavones have no significant effect on bone and a potentially negative effect on the uterus of sexually mature intact Sprague-Dawley female rats. Menopause 2005;12:291-298.
    • (2005) Menopause , vol.12 , pp. 291-298
    • Nakai, M.1    Cook, L.2    Pyter, L.M.3    Black, M.4    Sibona, J.5    Turner, R.T.6    Jeffery, E.H.7    Bahr, J.M.8
  • 32
    • 16244373391 scopus 로고    scopus 로고
    • Dietary soy protein and isoflavones: No effect on the reproductive tract and minimal positive effect on bone resorption in the intact female Fischer 344 rat
    • Nakai M, Black M, Jeffery EH, Bahr JM: Dietary soy protein and isoflavones: no effect on the reproductive tract and minimal positive effect on bone resorption in the intact female Fischer 344 rat. Food Chem Toxicol 2005;43:945-949.
    • (2005) Food Chem Toxicol , vol.43 , pp. 945-949
    • Nakai, M.1    Black, M.2    Jeffery, E.H.3    Bahr, J.M.4
  • 33
    • 0036620979 scopus 로고    scopus 로고
    • Isoflavones and bone: Animal and human evidence of efficacy
    • Chen X, Anderson JJ: Isoflavones and bone: animal and human evidence of efficacy. J Musculoskelet Neuronal Interact 2002;2:352-359.
    • (2002) J Musculoskelet Neuronal Interact , vol.2 , pp. 352-359
    • Chen, X.1    Anderson, J.J.2
  • 34
    • 14844282847 scopus 로고    scopus 로고
    • Skeletal benefits of soy isoflavones: A review of the clinical trial and epidemiologic data
    • Messina M, Ho S, Alekel DL: Skeletal benefits of soy isoflavones: a review of the clinical trial and epidemiologic data. Curr Opin Clin Nutr Metab Care 2004;7:649-658.
    • (2004) Curr Opin Clin Nutr Metab Care , vol.7 , pp. 649-658
    • Messina, M.1    Ho, S.2    Alekel, D.L.3
  • 35
    • 2442476606 scopus 로고    scopus 로고
    • Not all soy products are created equal: Caution needed in interpretation of research results
    • Erdman JW Jr, Badger TM, Lampe JW, Setchell, KD, Messina M: Not all soy products are created equal: caution needed in interpretation of research results. J Nutr 2004;134:1229S-1233S.
    • (2004) J Nutr , vol.134
    • Erdman Jr, J.W.1    Badger, T.M.2    Lampe, J.W.3    Setchell, K.D.4    Messina, M.5
  • 36
    • 0036073599 scopus 로고    scopus 로고
    • Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability
    • Setchell KD, Brown NM, Zimmer-Nechemias L, Brashear WT, Wolfe BE: Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am J Clin Nutr 2002;76:447-453.
    • (2002) Am J Clin Nutr , vol.76 , pp. 447-453
    • Setchell, K.D.1    Brown, N.M.2    Zimmer-Nechemias, L.3    Brashear, W.T.4    Wolfe, B.E.5
  • 37
    • 0030068459 scopus 로고    scopus 로고
    • Absorption and excretion of the soy isoflavone genistein in rats
    • King RA, Broadbent JL, Head RJ: Absorption and excretion of the soy isoflavone genistein in rats. J Nutr 1996;126:176-182.
    • (1996) J Nutr , vol.126 , pp. 176-182
    • King, R.A.1    Broadbent, J.L.2    Head, R.J.3
  • 38
    • 0030849952 scopus 로고
    • Intestinal uptake and biliary excretion of the isoflavone genistein in rats
    • Sfakianos J, Coward L, Kirk M, Barnes S: Intestinal uptake and biliary excretion of the isoflavone genistein in rats. J Nutr 1991;127:1260-1268.
    • (1991) J Nutr , vol.127 , pp. 1260-1268
    • Sfakianos, J.1    Coward, L.2    Kirk, M.3    Barnes, S.4
  • 39
    • 0037401122 scopus 로고    scopus 로고
    • Metabolism of isoflavones and lignans by the gut microflora: A study in germ-free and human flora associated rats
    • Bowey E, Adlercreutz H, Rowland I: Metabolism of isoflavones and lignans by the gut microflora: a study in germ-free and human flora associated rats. Food Chem Toxicol 2003:41:631-636.
    • (2003) Food Chem Toxicol , vol.41 , pp. 631-636
    • Bowey, E.1    Adlercreutz, H.2    Rowland, I.3
  • 40
    • 16244389982 scopus 로고    scopus 로고
    • Comparison of regulative functions between dietary soy isoflavones aglycone and glucoside on lipid metabolism in rats fed cholesterol
    • Kawakami Y, Tsurugasaki W, Nakamura S, Osada K: Comparison of regulative functions between dietary soy isoflavones aglycone and glucoside on lipid metabolism in rats fed cholesterol. J Nutr Biochem 2005;16:205-212.
    • (2005) J Nutr Biochem , vol.16 , pp. 205-212
    • Kawakami, Y.1    Tsurugasaki, W.2    Nakamura, S.3    Osada, K.4
  • 41
    • 0036203612 scopus 로고    scopus 로고
    • Hypolipidemic action of the soybean isoflavones genistein and genistin in glomerulonephritic rats
    • Kojima T, Uesugi T, Toda T, Miura Y, Yagasaki K: Hypolipidemic action of the soybean isoflavones genistein and genistin in glomerulonephritic rats. Lipids 2002;37:261-265.
    • (2002) Lipids , vol.37 , pp. 261-265
    • Kojima, T.1    Uesugi, T.2    Toda, T.3    Miura, Y.4    Yagasaki, K.5
  • 43
    • 0031886079 scopus 로고    scopus 로고
    • Anabolic effect of genistein and genistin on bone metabolism in the femoral-metaphyseal tissues of elderly rats: The genistein effect is enhanced by zinc
    • Yamaguchi M, Gao YH: Anabolic effect of genistein and genistin on bone metabolism in the femoral-metaphyseal tissues of elderly rats: the genistein effect is enhanced by zinc. Mol Cell Biochem 1998;178:377-382.
    • (1998) Mol Cell Biochem , vol.178 , pp. 377-382
    • Yamaguchi, M.1    Gao, Y.H.2
  • 44
    • 0031430951 scopus 로고    scopus 로고
    • Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women
    • Nagata C, Kabuto M, Kurisu Y, Shimizu H: Decreased serum estradiol concentration associated with high dietary intake of soy products in premenopausal Japanese women. Nutr Cancer 1997;29:228-233.
    • (1997) Nutr Cancer , vol.29 , pp. 228-233
    • Nagata, C.1    Kabuto, M.2    Kurisu, Y.3    Shimizu, H.4
  • 45
    • 0032407033 scopus 로고    scopus 로고
    • Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women
    • Xu X, Duncan AM, Merz BE, Kurzer MS: Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev 1998;7:1101-1108.
    • (1998) Cancer Epidemiol Biomarkers Prev , vol.7 , pp. 1101-1108
    • Xu, X.1    Duncan, A.M.2    Merz, B.E.3    Kurzer, M.S.4
  • 46
    • 0030893546 scopus 로고    scopus 로고
    • Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol
    • Nagel SC, vom Saal FS, Thayer KA, Dhar MG, Boechler M, Welshons WV: Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ Health Perspect 1997;105:70-76.
    • (1997) Environ Health Perspect , vol.105 , pp. 70-76
    • Nagel, S.C.1    vom Saal, F.S.2    Thayer, K.A.3    Dhar, M.G.4    Boechler, M.5    Welshons, W.V.6
  • 47
    • 0031935548 scopus 로고    scopus 로고
    • The effective free fraction of estradiol and xenoestrogens in human serum measured by whole cell uptake assays: Physiology of delivery modifies estrogenic activity
    • Nagel SC, vom Saal FS, Welshons WV: The effective free fraction of estradiol and xenoestrogens in human serum measured by whole cell uptake assays: physiology of delivery modifies estrogenic activity. Proc Soc Exp Biol Med 1998;217:300-309.
    • (1998) Proc Soc Exp Biol Med , vol.217 , pp. 300-309
    • Nagel, S.C.1    vom Saal, F.S.2    Welshons, W.V.3
  • 48
    • 0031039888 scopus 로고    scopus 로고
    • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    • Kuiper GG, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 1997;138:863-870.
    • (1997) Endocrinology , vol.138 , pp. 863-870
    • Kuiper, G.G.1    Carlsson, B.2    Grandien, K.3    Enmark, E.4    Haggblad, J.5    Nilsson, S.6
  • 50
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
    • Reeves PG, Nielsen FH, Fahey GC Jr: AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 1993;123:1939-1951.
    • (1993) J Nutr , vol.123 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey Jr, G.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.