Microdomain pH gradient and kinetics inside composite polymeric membranes of pH and glucose sensitivity

Pharmaceutical Research

Volumn 25, Issue 5, 2008, Pages 1150-1157

  Huang, Hui Yu ^a   Shaw, James ^b   Yip, Christopher ^b   Wu, Xiao Yu ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Fluorescence ratiometry; Glucose dependent internal pH; Internal pH mapping and kinetics; pH responsive nano hydrogels; Polymeric composite membranes

Indexed keywords

BUFFER; CATALASE; FLUORESCENT DYE; GLUCOSE; GLUCOSE OXIDASE; N ISOPROPYLACRYLAMIDE METHACRYLIC ACID COPOLYMER; NANOPARTICLE; POLY(N ISOPROPYLACRYLAMIDE); POLYMETHACRYLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; COMPOSITE MATERIAL; CONFOCAL LASER MICROSCOPY; DRUG SYNTHESIS; FLUORESCENCE; HYDROGEL; MATERIALS TESTING; PH; PRIORITY JOURNAL;

ACRYLAMIDES; ALGORITHMS; BUFFERS; COMPOSITE RESINS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; GLUCOSE; HYDROGEN-ION CONCENTRATION; INSULIN INFUSION SYSTEMS; KINETICS; MEMBRANES, ARTIFICIAL; METHACRYLATES; MICROSCOPY, CONFOCAL; NANOPARTICLES; REFERENCE STANDARDS; XANTHENES;

EID: 42049123035     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9507-x     Document Type: Article

References (40)

1. J. Kost, and R. Langer. Responsive polymeric delivery systems. Adv. Drug Deliv. Rev. 46:125-148 (2001).
2. Y. Qiu, and K. Park. Environment-sensitive hydrogels for drug delivery. Adv. Drug Deliv. Rev. 53:321-339 (2001).
3. T. Miyata, T. Uragami, and K. Nakamae. Biomolecule-sensitive hydrogels. Adv. Drug Deliv. Rev. 54:79-98 (2002).
4. A. Chi, and T. Okano. Pulsatile drug release control using hydrogels. Adv. Drug Deliv. Rev. 54:53-77 (2002).
5. X. Y. Wu, Q. Zhang, and R. Arshady. Stimuli sensitive hydrogels. Polymer structure and phase transition. In R. Arshady (ed.), Polymeric biomaterials, Citus Books, London, UK, 2003, pp. 157-194.
6. X. Y. Wu, Q. Zhang, and R. Arshady. Stimuli sensitive hydrogels. Response and release modulation. In R. Arshady (ed.), Polymeric biomaterials, Citus Books, London, UK, 2003, pp. 195-231.
7. T. Traitel, Y. Cohen, and J. Kost. Characterization of glucose-sensitive insulin release systems in simulated in vivo conditions. Biomaterials 21:1679-1687 (2000).
8. W. G. Albin, A. T. Horbett, R. S. Miller, and L. N. Ricker. Theoretical and experimental studies of glucose sensitive membranes. J. Control. Release 6:267-291 (1987).
9. K. Ishihara, and K. J. Matsui. Glucose-responsive insulin release from polymer capsule. Polym. Sci. Polym. Lett. Ed. 24:413-417 (1986).
10. R. A. Siegel, and B. A. Firestone. Mechanochemical approaches to self-regulating insulin pump design. J. Control. Release 11:181-192 (1990).
11. K. Podual, F. J. Doyle III, and N. A. Peppas. Glucoes-sensitivity of glucose oxidase-containing cationic copolymer hydrogels having poly(ethylene glycol) grafts. J. Control. Release 67:9-17 (2000).
12. Y. Ito, M. Casolaro, K. Kano, and T. Imanishi. An insulin-releasing system that is responsive to glucose. J. Control. Release 10:195-203 (1989).
13. E. Kokufuta, S. Matsukawa, T. Ebihara, and K. Matsuda. Construction of biochemo-mechanical systems using polyelectrolyte gels. In K. S. Schmitz (ed.), Macro-ion characterization, from dilute solutions to complex fluids, ACS Symp. Series 548, ACS, Washington, DC, 1994, pp. 507-516.
14. J. Heller, A. C. Chang, G. Rodd, and G. M. Grodsky. Release of insulin from pH-sensitive poly(ortho esters). J. Control. Release 13:295-302 (1990).
15. L. Ying, E. T. Kang, and K. G. Neoh. Covalent immobilization of glucose oxidase on microporous membranes prepared from poly(vinylidene fluoride) with grafted poly(acrylic acid) side chains. J. Memb. Sic. 208:361-374 (2002).
16. K. Zhang, and X. Y. Wu. Modulated insulin permeation across a glucose-sensitive polymeric composite membrane. J. Control. Release 80:169-178 (2000).
17. F. Yam and X. Y. Wu. A novel composite membrane for temperature responsive permeation. Polymer Preprint 40:312-313 (1999).
18. F. Yam, X. Y. Wu, and Q. Zhang. A novel composite membrane for temperature and pH responsive permeation. In K. Park (ed.), Controlled drug delivery: designing technology for the future, ACS, Washington, DC, 2000, pp. 263-272.
19. X. Y. Wu and F. Yam. Polymer System for Drug Delivery and Solute Separation, US patent, 2003, US 6,565,872.
20. K. Zhang, and X. Y. Wu. Temperature- and pH-responsive polymeric composite membranes for regulated delivery of peptide and protein drugs. Biomaterials 25:5281-5291 (2004).
21. K. Zhang, H. Y. Huang, G. C. Yang, J. Shaw, C. Yip, and X. Y. Wu. Characterization of nanostructure of stimuli-responsive polymeric composite membranes. Biomacromolecules 5:1248-1255 (2004).
22. K. Zhang, C. Quan, H. Huang, N. Taulier, and X. Y. Wu. On the stability of insulin delivered by a new glucose-responsive polymeric composite membrane. J. Pharm. Pharmacol. 56:611-620 (2004).
23. X. Y. Wu, and P. I. Lee. Preparation and characterization of thermal- and pH-sensitive nanospheres. Pharm. Res. 10:1544-1547 (1993).
24. J. Huang, and X. Y. Wu. Effect of pH, salt, surfactant and composition on phase transition of poly(NIPAm/MAA) nanoparticles. J. Poly. Sci: Poly. Chem. 37:2667-2676 (1999).
25. J. Moselhy, X. Y. Wu, R. Nicholov, and K. Kodaria. In vitro characterization of interaction of poly(NIPAm/MAA) nanoparticles with proteins and cells. J. Biomater. Sci. Polymer Edn. 11(2):123-147 (2000).
26. M. Abdekhodaie, and X. Y. Wu. Modeling of a glucose-sensitive cationic membrane. J. Memb. Sci. 254:119-127 (2005).
27. R. P. Haugland. Molecular probes handbook of fluorescent probes and research products. 9th edition. Molecular Probes, Eugene, Oregon, 2002.
28. J. Zhang, R. E. Campbell, A. Y. Ting, and R. Y. Tsien. Creating new fluorescent probes for cell biology. Nat. Rev. Mol. Cell Biol. 3:906-918 (2002).
29. M. D. Burke, J. O. Park, M. Srinivasarao, and S. A. Khan. Diffusion of macromolecules in polymer solutions and gels: A laser scanning confocal microscopy study. Mcromolecules 33:7500-7507 (2000).
30. K. Fu, D. W. Pack, A. M. Klibanov, and R. Langer. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm. Res. 17:100-106 (2000).
31. Y. Hirokawa, H. Jinnai, Y. Nishikawa, T. Okamoto, and T. Hashimoto. Direct observation of internal structures in poly(N-isopropylacrylamide) chemical gels. Macromolecules 32:7093-7099 (1999).
32. A. Shenderova, T. G. Burke, and S. P. Shwendeman. The acidic microclimate in poly(lactic-co-glycolic) microspheres stabilizes camptothecins. Pharm. Res. 16:241-248 (1999).
33. D. P. Taylor, J. Slattery, and A. C. Leopold. Apoplastic pH in corn root gravitropsim: a laser scanning confocal microscopy measurement. Physiol. Plant 97:35-38 (1996).
34. Q. Yu, J. Kuo, and C. Tang. Using confocal laser scanning microscopy to measure apoplastic pH change in roots of Lupinus angustifolius L. in response to high pH. Ann. Bot. 87:47-52 (2001).
35. S. Cope, S. Hibberd, J. Whetstone, R. MacRae, and C. Melia. Measurement and mapping of pH in hydrating pharmaceutical pellets using confocal laser scanning microscopy. Pharm. Res. 19:1554-1563 (2002).
36. E. Kuwana, F. Liang, and E. Sevick-Muraca. Fluorescence lifetime spectroscopy of a pH-sensitive dye encapsulated in hydrogel beads. Biotechnol. Prog. 20:1561-1566 (2004).
37. X. Y. Wu, R. H. Pelton, A. E. Hamielec, D. R. Woods, and W. McPhee. The kinetics of poly(N-isopropylacrylamide) microgel latex formation. Colloid Polym. Sci. 272:467-477 (1994).
38. R. A. Siegel. Hydrophobic weak polyelectrolyte gels: Studies of swelling equilibria and kinetics. Adv. Poly. Sci. 109:233 (1993).
39. H. W. Blanch, and D. S. Clark. Biochemical Engineering. Marcel Dekker, New York, NY, 1996, p. 118.
40. Y. Zhou, and X. Y. Wu. Finite element analysis of diffusional drug release from complex matrix systems, I. Complex geometries and composite structures. J. Control. Release 49:277-288 (1997).