Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: New insights from X-ray diffraction and mass spectrometry studies

Journal of Inorganic Biochemistry

Volumn 102, Issue 5-6, 2008, Pages 995-1006

  Casini, Angela ^a   Guerri, Annalisa ^a   Gabbiani, Chiara ^a   Messori, Luigi ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Anticancer drugs; Mass spectrometry; Mechanism of action; Metal complexes; Proteins; X ray crystallography

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; CYTOCHROME C; GOLD; IMIDAZOLE; METAL COMPLEX; OXALIPLATIN; PLATINUM; PROTEIN DERIVATIVE; RUTHENIUM; UBIQUITIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG PROTEIN BINDING; ELECTROSPRAY MASS SPECTROMETRY; HEALTH SURVEY; MEDICAL RESEARCH; PROTEIN DEGRADATION; PROTEIN STRUCTURE; X RAY DIFFRACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTOCHROMES C; DIMETHYL SULFOXIDE; GOLD COMPOUNDS; HUMANS; METALS; MODELS, MOLECULAR; MURAMIDASE; ORGANOMETALLIC COMPOUNDS; PLATINUM COMPOUNDS; PROTEIN BINDING; PROTEINS; RUTHENIUM; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUPEROXIDE DISMUTASE; UBIQUITIN;

EID: 41949140548     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2007.12.022     Document Type: Article

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