-
1
-
-
0028800331
-
Colorectal cancer biology: Clinical implications
-
Johnston PG, Allegra CJ (1995) Colorectal cancer biology: clinical implications. Semin Oncol 22:418-432
-
(1995)
Semin Oncol
, vol.22
, pp. 418-432
-
-
Johnston, P.G.1
Allegra, C.J.2
-
2
-
-
0037364351
-
Thymidylate synthase protein expression in primary colorectal cancer: Lack of correlation with outcome and response to fluorouracil in metastatic disease sites
-
Johnston PG, Benson AB III, Catalano P, Rao MS, O'Dwyer PJ, Allegra CJ (2003) Thymidylate synthase protein expression in primary colorectal cancer: lack of correlation with outcome and response to fluorouracil in metastatic disease sites. J Clin Oncol 21:815-819
-
(2003)
J Clin Oncol
, vol.21
, pp. 815-819
-
-
Johnston, P.G.1
Benson III, A.B.2
Catalano, P.3
Rao, M.S.4
O'Dwyer, P.J.5
Allegra, C.J.6
-
3
-
-
0032949446
-
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Result from four National surgical adjuvant breast and bowel project adjuvant studies C-01, C-02, C-03, & C-04)
-
Mamounas E, Wieand S, Wolmark N, Bear HD, Atkins JN, Song K, Jones J, Rockette H (1999) Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: result from four National surgical adjuvant breast and bowel project adjuvant studies C-01, C-02, C-03, & C-04). J Clin Oncol 17:1349-1355
-
(1999)
J Clin Oncol
, vol.17
, pp. 1349-1355
-
-
Mamounas, E.1
Wieand, S.2
Wolmark, N.3
Bear, H.D.4
Atkins, J.N.5
Song, K.6
Jones, J.7
Rockette, H.8
-
4
-
-
1442290323
-
Thymidylate synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis
-
Popat S, Matakidou A, Houlston R (2004) Thymidylate synthase expression and prognosis in colorectal cancer: a systematic review and meta-analysis. J Clin Oncol 22:529-536
-
(2004)
J Clin Oncol
, vol.22
, pp. 529-536
-
-
Popat, S.1
Matakidou, A.2
Houlston, R.3
-
6
-
-
0029036377
-
The catalytic mechanism and structure of thymidylate synthase
-
Carreras CW, Santi DV (1995) The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem 64:721-762
-
(1995)
Annu Rev Biochem
, vol.64
, pp. 721-762
-
-
Carreras, C.W.1
Santi, D.V.2
-
7
-
-
0026795489
-
Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil sensitive and resistant human cancer cell lines
-
Johnston PG, Drake JC, Trepel J, Allegra CL (1992) Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil sensitive and resistant human cancer cell lines. Cancer Res 52:4306-4312
-
(1992)
Cancer Res
, vol.52
, pp. 4306-4312
-
-
Johnston, P.G.1
Drake, J.C.2
Trepel, J.3
Allegra, C.L.4
-
8
-
-
0029930070
-
Resistance to Tomudex (ZD1694): Multifactorial in human breast and colon carcinoma cell lines
-
Drake JC, Allegra CJ, Moran RG, Johnston PG (1996) Resistance to Tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines. Biochem Pharmacol 51:1349-1355
-
(1996)
Biochem Pharmacol
, vol.51
, pp. 1349-1355
-
-
Drake, J.C.1
Allegra, C.J.2
Moran, R.G.3
Johnston, P.G.4
-
9
-
-
0032729240
-
Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: Results from National Surgical Adjuvant Breast and Bowel Project C-04
-
Wolmark N, Rockette H, Mamounas E, Jones J, Wieand S, Wickerham DL, Bear HD, Atkins JA, Dimitrov NV, Glass AG, Fisher ER, Fisher B (1999) Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project C-04. J Clin Oncol 17:3553-3559
-
(1999)
J Clin Oncol
, vol.17
, pp. 3553-3559
-
-
Wolmark, N.1
Rockette, H.2
Mamounas, E.3
Jones, J.4
Wieand, S.5
Wickerham, D.L.6
Bear, H.D.7
Atkins, J.A.8
Dimitrov, N.V.9
Glass, A.G.10
Fisher, E.R.11
Fisher, B.12
-
10
-
-
0000068297
-
Fluorouracil, leucovorin and levamisole adjuvant therapy for colon cancer: Five-year final report of INT-0089
-
Haller DG, Catalano PJ, Macdonald JS, Mayer RJ (1998) Fluorouracil, leucovorin and levamisole adjuvant therapy for colon cancer: five-year final report of INT-0089. Proc Am Soc Clin Oncol 17:256a
-
(1998)
Proc Am Soc Clin Oncol
, vol.17
-
-
Haller, D.G.1
Catalano, P.J.2
MacDonald, J.S.3
Mayer, R.J.4
-
12
-
-
0035209477
-
Thymidylate synthase expression in stage II and III colon cancer: A retrospective review
-
Tomiak A, Vincent M, Earle CC, Johnston PG, Kocha W, Taylor M, Maroun J, Eidus L, Whiston F, Stitt L (2001) Thymidylate synthase expression in stage II and III colon cancer: a retrospective review. Am J Clin Oncol 24:597-602
-
(2001)
Am J Clin Oncol
, vol.24
, pp. 597-602
-
-
Tomiak, A.1
Vincent, M.2
Earle, C.C.3
Johnston, P.G.4
Kocha, W.5
Taylor, M.6
Maroun, J.7
Eidus, L.8
Whiston, F.9
Stitt, L.10
-
13
-
-
0034048729
-
Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
-
Salonga D, Danenberg KD, Johnson M, Metzger R, Groshen S, Tsao-Wei DD, Lenz HJ, Leichman CG, Leichman L, Diasio RB, Danenberg PV (2000) Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 6:1322-1327
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1322-1327
-
-
Salonga, D.1
Danenberg, K.D.2
Johnson, M.3
Metzger, R.4
Groshen, S.5
Tsao-Wei, D.D.6
Lenz, H.J.7
Leichman, C.G.8
Leichman, L.9
Diasio, R.B.10
Danenberg, P.V.11
-
14
-
-
0033975032
-
Thymidylate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients
-
Paradiso A, Simone G, Petroni S, Leone B, Vallejo C, Lacava J, Romero A, Machiavelli M, De Lena M, Allegra CJ, Johnston PG (2000) Thymidylate synthase and p53 primary tumour expression as predictive factors for advanced colorectal cancer patients. Br J Cancer 82:560-567
-
(2000)
Br J Cancer
, vol.82
, pp. 560-567
-
-
Paradiso, A.1
Simone, G.2
Petroni, S.3
Leone, B.4
Vallejo, C.5
Lacava, J.6
Romero, A.7
MacHiavelli, M.8
De Lena, M.9
Allegra, C.J.10
Johnston, P.G.11
-
15
-
-
1642472091
-
Thymidylate synthase expression as a predictor of the prognosis of curatively resected colon carcinoma in patients registered in an adjuvant immunochemotherapy clinical trial
-
Sakamoto J, Hamashima H, Susuki H, Ito K, Mai M, Saji S, Fukushima M, Matsushita Y, Nakazato H (2003) Thymidylate synthase expression as a predictor of the prognosis of curatively resected colon carcinoma in patients registered in an adjuvant immunochemotherapy clinical trial. Oncl Rep 10:1081-1090
-
(2003)
Oncl Rep
, vol.10
, pp. 1081-1090
-
-
Sakamoto, J.1
Hamashima, H.2
Susuki, H.3
Ito, K.4
Mai, M.5
Saji, S.6
Fukushima, M.7
Matsushita, Y.8
Nakazato, H.9
-
16
-
-
0034087575
-
Thymidylate synthase expression: An independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer
-
Edler D, Hallstrom M, Johnston PG, Magnusson I, Ragnhammar P, Blomgren H (2000) Thymidylate synthase expression: an independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer. Clin Cancer Res 6:1378-1384
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1378-1384
-
-
Edler, D.1
Hallstrom, M.2
Johnston, P.G.3
Magnusson, I.4
Ragnhammar, P.5
Blomgren, H.6
-
17
-
-
0033981858
-
Immunohistochemically detected thymidylate synthase in colorectal cancer: An independent prognostic factor of survival
-
Edler D, Kressner U, Ragnhammar P, Johnston PG, Magnusson I, Glimelius B, Påhlman L, Lindmark G, Blomgren H (2000) Immunohistochemically detected thymidylate synthase in colorectal cancer: an independent prognostic factor of survival. Clin Cancer Res 6:488-492
-
(2000)
Clin Cancer Res
, vol.6
, pp. 488-492
-
-
Edler, D.1
Kressner, U.2
Ragnhammar, P.3
Johnston, P.G.4
Magnusson, I.5
Glimelius, B.6
Påhlman, L.7
Lindmark, G.8
Blomgren, H.9
-
18
-
-
15444349773
-
P53 and thymidylate synthase expression in untreated stage II colon cancer: Associations with recurrence, survival, and site
-
Lenz HJ, Danenberg KD, Leichman CG, Florentine B, Johnston PG, Groshen S, Zhou L, Xiong YP, Danenberg PV, Leichman LP (1998) p53 and thymidylate synthase expression in untreated stage II colon cancer: associations with recurrence, survival, and site. Clin Cancer Res 4:1227-1234
-
(1998)
Clin Cancer Res
, vol.4
, pp. 1227-1234
-
-
Lenz, H.J.1
Danenberg, K.D.2
Leichman, C.G.3
Florentine, B.4
Johnston, P.G.5
Groshen, S.6
Zhou, L.7
Xiong, Y.P.8
Danenberg, P.V.9
Leichman, L.P.10
-
19
-
-
4243755966
-
Thymidylate synthase expression predict prognosis of curatively resected colorectal carcinoma patients registered in an adjuvant immunochemotherapy clinical trial
-
Sakamoto J, Fukushima M, Hamashima H (1999) Thymidylate synthase expression predict prognosis of curatively resected colorectal carcinoma patients registered in an adjuvant immunochemotherapy clinical trial. Proc ASCO 18:268a
-
(1999)
Proc ASCO
, vol.18
-
-
Sakamoto, J.1
Fukushima, M.2
Hamashima, H.3
-
20
-
-
0031856639
-
The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer
-
Sanguedolce R, Vultaggio G, Sanguedolce F, Modica G, Li Volsi F, Diana G, Guereio G, Bellanca L, Rausa L (1998) The role of thymidylate synthase levels in the prognosis and the treatment of patients with colorectal cancer. Anticancer Res 18:1515-1520
-
(1998)
Anticancer Res
, vol.18
, pp. 1515-1520
-
-
Sanguedolce, R.1
Vultaggio, G.2
Sanguedolce, F.3
Modica, G.4
Li Volsi, F.5
Diana, G.6
Guereio, G.7
Bellanca, L.8
Rausa, L.9
-
21
-
-
0007644491
-
Limited prognostic importance of immunohistochemical parameters (IHP) [thymidylate synthase (TS), KI-67, and P53] in 465 patients with Dukes' B2 and C colon cancer enrolled on North Central Cancer Treatment Group (NCCTG) trials
-
Goldberg RM, Sargent D, Mahoney MR (1998) Limited prognostic importance of immunohistochemical parameters (IHP) [thymidylate synthase (TS), KI-67, and P53] in 465 patients with Dukes' B2 and C colon cancer enrolled on North Central Cancer Treatment Group (NCCTG) trials. Proc ASCO 18:267a
-
(1998)
Proc ASCO
, vol.18
-
-
Goldberg, R.M.1
Sargent, D.2
Mahoney, M.R.3
-
22
-
-
0000798692
-
P53, p21 and thymidylate synthase protein expression: Associations with recurrence in stage II and III rectal cancer
-
Elwell A, Xiong YP, Chang M (1997) p53, p21 and thymidylate synthase protein expression: associations with recurrence in stage II and III rectal cancer. Proc ASCO 16:258a
-
(1997)
Proc ASCO
, vol.16
-
-
Elwell, A.1
Xiong, Y.P.2
Chang, M.3
-
23
-
-
0028151449
-
The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
-
Johnston PG, Fisher ER, Rockette HE, Fisher B, Wolmark N, Drake JC, Chabner BA, Allegra CJ (1994) The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J Clin Oncol 12:2640-2647
-
(1994)
J Clin Oncol
, vol.12
, pp. 2640-2647
-
-
Johnston, P.G.1
Fisher, E.R.2
Rockette, H.E.3
Fisher, B.4
Wolmark, N.5
Drake, J.C.6
Chabner, B.A.7
Allegra, C.J.8
-
24
-
-
0031426423
-
Immunohistochemical determination of thymidylate synthase in colorectal cancer-methodological studies
-
Edler D, Blomgren H, Allegra CJ, Johnston PG, Lagerstedt U, Magnusson I, Ragnhammar P (1997) Immunohistochemical determination of thymidylate synthase in colorectal cancer-methodological studies. Eur J Cancer 33:2278-2281
-
(1997)
Eur J Cancer
, vol.33
, pp. 2278-2281
-
-
Edler, D.1
Blomgren, H.2
Allegra, C.J.3
Johnston, P.G.4
Lagerstedt, U.5
Magnusson, I.6
Ragnhammar, P.7
-
25
-
-
0030775486
-
Behavioral research contributions and needs in cancer prevention and control: Tobacco use prevention and cessation
-
Lichtenstein E (1997) Behavioral research contributions and needs in cancer prevention and control: Tobacco use prevention and cessation. Prev Med 26:S57-S63
-
(1997)
Prev Med
, vol.26
-
-
Lichtenstein, E.1
-
26
-
-
0028171292
-
G1 phase progression: Cycling on cue
-
Sherr CJ (1994) G1 phase progression: cycling on cue. Cell 79:551-555
-
(1994)
Cell
, vol.79
, pp. 551-555
-
-
Sherr, C.J.1
-
27
-
-
0028181760
-
Identification of G1 kinase activity for cdk6, a novel cyclin D partner
-
Meyerson M, Harlow E (1994) Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol 14:2077-2086
-
(1994)
Mol Cell Biol
, vol.14
, pp. 2077-2086
-
-
Meyerson, M.1
Harlow, E.2
-
28
-
-
0026698263
-
Association of human cyclin e with a periodic G1-S phase protein kinase
-
Dulic V, Lees E et al (1992) Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257:1958-1961
-
(1992)
Science
, vol.257
, pp. 1958-1961
-
-
Dulic, V.1
Lees, E.2
-
29
-
-
0026552630
-
Cdk2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before Cdc2 in the cell cycle
-
Elledge SJ, Richman R, Hall FL, Williams RT, Lodgson N, Harper JW (1992) Cdk2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before Cdc2 in the cell cycle. Proc Natl Acad Sci USA 89:2907-2911
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 2907-2911
-
-
Elledge, S.J.1
Richman, R.2
Hall, F.L.3
Williams, R.T.4
Lodgson, N.5
Harper, J.W.6
-
30
-
-
0028909645
-
Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
-
Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M (1995) Human cyclin E, a nuclear protein essential for the G1-to-S phase transition. Mol Cell Biol 15:2612-2624
-
(1995)
Mol Cell Biol
, vol.15
, pp. 2612-2624
-
-
Ohtsubo, M.1
Theodoras, A.M.2
Schumacher, J.3
Roberts, J.M.4
Pagano, M.5
-
31
-
-
0027717617
-
P21 is a universal inhibitor of cyclin kinases
-
Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993) p21 is a universal inhibitor of cyclin kinases. Nature 366:701-704
-
(1993)
Nature
, vol.366
, pp. 701-704
-
-
Xiong, Y.1
Hannon, G.J.2
Zhang, H.3
Casso, D.4
Kobayashi, R.5
Beach, D.6
-
32
-
-
0035176182
-
Characterization of a thymidylate synthase (TS)-inducible cell line
-
Longley DB, Ferguson PR, Boyer J, Latif T, Lynch M, Maxwell P, Harkin DP, Johnston PG (2001) Characterization of a thymidylate synthase (TS)-inducible cell line. Clin Cancer Res 7:3533-3539
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3533-3539
-
-
Longley, D.B.1
Ferguson, P.R.2
Boyer, J.3
Latif, T.4
Lynch, M.5
Maxwell, P.6
Harkin, D.P.7
Johnston, P.G.8
-
33
-
-
0033602038
-
Cyclin E-Cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex
-
Yin MB, Guo B, Panadero A, Frank C, Wrzosek C, Slocum HK, Rustum YM (1999) Cyclin E-Cdk2 activation is associated with cell cycle arrest and inhibition of DNA replication induced by the thymidylate synthase inhibitor Tomudex. Exp Cell Res 247:189-199
-
(1999)
Exp Cell Res
, vol.247
, pp. 189-199
-
-
Yin, M.B.1
Guo, B.2
Panadero, A.3
Frank, C.4
Wrzosek, C.5
Slocum, H.K.6
Rustum, Y.M.7
-
34
-
-
4344710221
-
16INK4a- mediated cellular arrest as an indicator of chemosensitivity to 5-fluorouracil
-
16INK4a-mediated cellular arrest as an indicator of chemosensitivity to 5-fluorouracil. Pathol Int 54:564-575
-
(2004)
Pathol Int
, vol.54
, pp. 564-575
-
-
Kamoshida, S.1
Matsuoka, H.2
Shiogama, K.3
Matsuyama, A.4
Shimomura, R.5
Inada, K.6
Maruta, M.7
Tsutsumi, Y.8
-
37
-
-
0034097872
-
Expression of thymidylate synthase in human gastric and colorectal adenocarcinomas is upregulated by p16/INK4
-
Omura K, Uno Y, Kawakami K, Kanehira E, Tawaraya K, Tsukayama M, Hiranuma C, Watanabe Y (2000) Expression of thymidylate synthase in human gastric and colorectal adenocarcinomas is upregulated by p16/INK4. Hepatogastroenterology 47:742-745
-
(2000)
Hepatogastroenterology
, vol.47
, pp. 742-745
-
-
Omura, K.1
Uno, Y.2
Kawakami, K.3
Kanehira, E.4
Tawaraya, K.5
Tsukayama, M.6
Hiranuma, C.7
Watanabe, Y.8
-
38
-
-
0036209688
-
Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases
-
Backus HHJ, van Groeningen CJ, Vos W, Dukers DF, Bloemena E, Wouters D, Pinedo HM, Reters GJ (2002) Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases. J Clin Pathol 55:206-211
-
(2002)
J Clin Pathol
, vol.55
, pp. 206-211
-
-
Backus, H.H.J.1
Van Groeningen, C.J.2
Vos, W.3
Dukers, D.F.4
Bloemena, E.5
Wouters, D.6
Pinedo, H.M.7
Reters, G.J.8
-
39
-
-
0034743398
-
Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer
-
Backus HH, van Riel JM, van Groeningen CJ, Vos W, Dukers DF, Bloemena E, Wouters D, Pinedo HM, Reters GJ (2001) Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer. Ann Oncol 12:779-785
-
(2001)
Ann Oncol
, vol.12
, pp. 779-785
-
-
Backus, H.H.1
Van Riel, J.M.2
Van Groeningen, C.J.3
Vos, W.4
Dukers, D.F.5
Bloemena, E.6
Wouters, D.7
Pinedo, H.M.8
Reters, G.J.9
-
40
-
-
10244261646
-
Tumor marker utility grading system: A framework to evaluate clinical utility of tumor markers
-
Hayes DF, Bast RC, Desch CE, Fritsche H, Kemeny NE Jr., Jessup JM, Locker GY, Macdonald JS, Mennel RG, Norton L, Ravdin P, Taube S, Winn RJ (1996) Tumor marker utility grading system: a framework to evaluate clinical utility of tumor markers. J Natl Cancer Inst 88:1456-1466
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 1456-1466
-
-
Hayes, D.F.1
Bast, R.C.2
Desch, C.E.3
Fritsche, H.4
Kemeny Jr., N.E.5
Jessup, J.M.6
Locker, G.Y.7
MacDonald, J.S.8
Mennel, R.G.9
Norton, L.10
Ravdin, P.11
Taube, S.12
Winn, R.J.13
|