Technology Insight: Water diffusion MRI - A potential new biomarker of response to cancer therapy

Nature Clinical Practice Oncology

Volumn 5, Issue 4, 2008, Pages 220-233

  Patterson, Daniel M ^a   Padhani, Anwar R ^a,b   Collins, David J ^c  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b SYNARC INC   (United States)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; WATER;

CANCER THERAPY; CELL MEMBRANE; CELL ORGANELLE; DIAGNOSTIC IMAGING; DIAGNOSTIC PROCEDURE; DIFFUSION WEIGHTED IMAGING; EXTRACELLULAR SPACE; HUMAN; IMAGE PROCESSING; MACROMOLECULE; MALIGNANT NEOPLASTIC DISEASE; MOTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; TREATMENT RESPONSE; WATER FLOW;

APOPTOSIS; BIOLOGICAL MARKERS; CELL MEMBRANE; DIFFUSION MAGNETIC RESONANCE IMAGING; EXTRACELLULAR SPACE; HUMANS; NEOPLASMS;

EID: 41849147484     PISSN: 17434254     EISSN: 17434262     Source Type: Journal    
DOI: 10.1038/ncponc1073     Document Type: Review

References (87)

1. Tanner JE (1979) Self diffusion of water in frog muscle. Biophys J 28: 107-116
2. Parker GJ (2004) Analysis of MR diffusion weighted images. Br J Radiol 77 (Suppl): S176-S185
3. Ross BD et al. (2003) Evaluation of cancer therapy using diffusion magnetic resonance imaging. Mol Cancer Ther 2: 581-587
4. Szafer A et al. (1995) Theoretical model for water diffusion in tissues. Magn Reson Med 33: 697-712
5. Sykova E et al. (1994) Extracellular volume fraction and diffusion characteristics during progressive ischemia and terminal anoxia in the spinal cord of the rat. J Cereb Blood Flow Metab 14: 301-311
6. Norris DG et al. (1994) Health and infarcted brain tissues studied at short diffusion times: The origins of apparent restriction and the reduction in apparent diffusion coefficient. NMR Biomed 7: 304-310
7. Lyng H et al. (2000) Measurement of cell density and necrotic fraction in human melanoma xenografts by diffusion weighted magnetic resonance imaging. Magn Reson Med 43: 828-836
8. Cheng KH and Hernandez M (1992) Magnetic resonance diffusion imaging detects structural damage in biological tissues upon hyperthermia. Cancer Res 52: 6066-6073
9. Dzik-Jurasz AS (2003) Molecular imaging in vivo: An introduction. Br J Radiol 76 (Suppl): S98-S109
10. Guo AC et al. (2002) Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology 224: 177-183
11. Stejskal EO and Tanner J (1965) Spin diffusion measurements: Spin echoes in the presence of a time-dependent field gradient. J Chem Phys 42: 288-292
12. Le Bihan D et al. (1986) Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging. Radiology 168: 497-505
13. Turner R et al. (1990) Echo-planar imaging of intravoxel incoherent motion. Radiology 177: 407-414
14. Turner R et al. (1991) Echo-planar imaging of diffusion and perfusion. Magn Reson Med 19: 247-253
15. Morvan D (1995) In vivo measurement of diffusion and pseudo-diffusion in skeletal muscle at rest and after exercise. Magn Reson Imaging 13: 193-199
16. Thoeny HC et al. (2004) Diffusion-weighted imaging of the parotid gland: Influence of the choice of b-values on the apparent diffusion coefficient value. J Magn Reson Imaging 20: 786-790
17. Niendorf T et al. (1996) Biexponential diffusion attenuation in various states of brain tissue: Implications for diffusion-weighted imaging. Magn Reson Med 36: 847-857
18. Mulkern RV et al. (2005) Magnetization transfer studies of the fast and slow tissue water diffusion components in the human brain. NMR Biomed 18: 186-194
19. Thoeny HC et al. (2005) Effect of vascular targeting agent in rat tumor model: Dynamic contrast-enhanced versus diffusion-weighted MR imaging. Radiology 237: 492-499
20. Schaefer PW et al. (2000) Diffusion-weighted MR imaging of the brain. Radiology 217: 331-345
21. Ries M et al. (2001) Diffusion tensor MRI of the human kidney. J Magn Reson Imaging 14: 42-49
22. Bammer R (2003) Basic principles of diffusion-weighted imaging. Eur J Radiol 45: 169-184
23. Yamada I et al. (1999) Diffusion coefficients in abdominal organs and hepatic lesions: Evaluation with intravoxel incoherent motion echo-planar MR imaging. Radiology 210: 617-623
24. Taouli B et al. (2003) Evaluation of liver diffusion isotropy and characterization of focal hepatic lesions with two single-shot echo-planar MR imaging sequences: Prospective study in 66 patients. Radiology 226: 71-78
25. Padhani AR (2003) MRI for assessing antivascular cancer treatments. Br J Radiol 76 (Suppl): S60-S80
26. Leach MO et al. (2005) The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: Issues and recommendations. Br J Cancer 92 1599-1610
27. O'Connor JP et al. (2007) DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. Br J Cancer 96: 189-195
28. Thoeny HC et al. (2005) Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats. Radiology 234: 756-764
29. Chaplin DJ and Hill SA (2002) The development of combretastatin A4 phosphate as a vascular targeting agent. Int J Radiat Oncol Biol Phys 54: 1491-1496
30. Beauregard DA et al. (1998) Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status. Br J Cancer 77: 1761-1767
31. Jordan BF et al. (2005) Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1 alpha using PX-478. Neoplasia 7 475-485
32. Fan G et al. (2005) Usefulness of diffusion/perfusion-weighted MRI in rat gliomas: Correlation with histopathology. Acad Radiol 12 640-651
33. Herneth AM et al. (2003) Apparent diffusion coefficient: A quantitative parameter for in vivo tumor characterization. Eur J Radiol 45: 208-213
34. Sugahara T et al. (1999) Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomas. J Magn Reson Imaging 9: 53-60
35. Yabuuchi H et al. (2006) Phyllodes tumor of the breast: correlation between MR findings and histologic grade. Radiology 241: 702-709
36. Higano S et al. (2006) Malignant astrocytic tumors: Clinical importance of apparent diffusion coefficient in prediction of grade and prognosis. Radiology 241: 839-846
37. Ichikawa T et al. (1998) Diffusion-weighted MR imaging with a single-shot echoplanar sequence: Detection and characterization of focal hepatic lesions. AJR Am J Roentgenol 170: 397-402
38. Okada Y et al. (1998) Breath-hold T2-weighted MRI of hepatic tumors: Value of echo planar imaging with diffusion-sensitizing gradient. J Comput Assist Tomogr 22: 364-371
39. Sato C et al. (2005) Differentiation of noncancerous tissue and cancer lesions by apparent diffusion coefficient values in transition and peripheral zones of the prostate. J Magn Reson Imaging 21 258-262
40. Ichikawa T et al. (2007) High-b value diffusion-weighted MRI for detecting pancreatic adenocarcinoma: Preliminary results. AJR Am J Roentgenol 188: 409-414
41. Nakayama T et al. (2004) Usefulness of the calculated apparent diffusion coefficient value in the differential diagnosis of retroperitoneal masses. J Magn Reson Imaging 20: 735-742
42. Sarty GE et al. (2004) Magnetic resonance diffusion imaging of ovarian masses: A first experience with 12 cases. MAGMA 16: 182-193
43. Kuroki Y et al. (2004) Diffusion-weighted imaging of breast cancer with the sensitivity encoding technique: Analysis of the apparent diffusion coefficient value. Magn Reson Med Sci 3: 79-85
44. Habermann CR et al. (2005) Diffusion-weighted echo-planar MRI: A valuable tool for differentiating primary parotid gland tumors? [German] Rofo 177: 940-945
45. White ML et al. (2006) Evaluating tumors and tumorlike lesions of the nasal cavity, the paranasal sinuses, and the adjacent skull base with diffusion-weighted MRI. J Comput Assist Tomogr 30: 490-495
46. Sumi M et al. (2006) MR microimaging of benign and malignant nodes in the neck. AJR Am J Roentgenol 186: 749-757
47. deSouza NM et al. (2007) Magnetic resonance imaging in prostate cancer: Value of apparent diffusion coefficients for identifying malignant nodules. Br J Radiol 80: 90-95
48. Maeda M et al. (2005) Usefulness of the apparent diffusion coefficient in line scan diffusion-weighted imaging for distinguishing between squamous cell carcinomas and malignant lymphomas of the head and neck. AJNR Am J Neuroradiol 26: 1186-1192
49. Kozlowski P et al. (2006) Combined diffusion-weighted and dynamic contrast-enhanced MRI for prostate cancer diagnosis - correlation with biopsy and histopathology. J Magn Reson Imaging 24: 108-113
50. Reinsberg SA et al. (2007) Combined use of diffusion-weighted MRI and 1H MR spectroscopy to increase accuracy in prostate cancer detection. AJR Am J Roentgenol 188: 91-98
51. Takahara T et al. (2004) Diffusion weighted whole body imaging with background body signal suppression (DWIBS): Technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med 22: 275-282
52. Ballon D et al. (2004) Imaging therapeutic response in human bone marrow using rapid whole-body MRI. Magn Reson Med 52: 1234-1238
53. Brizel D et al. (1996) Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56: 941-943
54. Swinson DE et al. (2002) Tumour necrosis is an independent prognostic marker in non-small cell lung cancer: Correlation with biological variables. Lung Cancer 37:235-240
55. Gray LH et al. (1953) The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 26: 638-648
56. Leek RD et al. (1999) Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast. Br J Cancer 79: 991-995
57. Lemaire L et al. (1999) Assessment of induced rat mammary tumour response to chemotherapy using the apparent diffusion coefficient of tissue water as determined by diffusion-weighted 1H-NMR spectroscopy in vivo. MAGMA 8: 20-26
58. Roth Y et al. (2004) High-b-value diffusion-weighted MR imaging for pretreatment prediction and early monitoring of tumor response to therapy in mice. Radiology 232:685-692
59. Dzik-Jurasz A et al. (2002) Diffusion MRI for prediction of response of rectal cancer to chemoradiation. Lancet 380: 307-308
60. DeVries AF et al. (2003) Tumor microcirculation and diffusion predict therapy outcome for primary rectal carcinoma. Int J Radiat Oncol Biol Phys 56: 958-965
61. Chen KC and Nicholson C (2000) Changes in brain cell shape create residual extracellular space volume and explain tortuosity behavior during osmotic challenge. Proc Natl Acad Sci USA 97: 8306-8311
62. Schlaug G et al. (1997) Time course of the apparent diffusion coefficient (ADC) abnormality in human stroke. Stroke 49: 113-119
63. Hortelano S et al. (2001) Intracellular water motion decreases in apoptotic macrophages after caspase activation. Cell Death Differ 8: 1022-1028
64. + influx is required for volume loss during programmed cell death. J Biol Chem 278: 39176-39184
65. Desjardins LM and MacManus JP (1995) An adherent cell model to study different stages of apoptosis. Exp Cell Res 216: 380-387.
66. Akagi Y et al. (1993) Radiation-induded apoptosis and necrosis in Molt-4 cells: A study of dose-effect relatiooships and their modification. Int J Radiat-Biol 64: 47-56
67. Plaks V et al. (2004) Photodynamic therapy of established prostatic adenocarcinoma with TOOKAD: A biphasic apparent diffusion coefficient change as potential early MRI response marker. Neoplasia 6: 224-233
68. Mardor Y et al. (2001) Monitoring response to convection-enhanced taxol delivery in brain tumor patients using diffusion-weighted magnetic resonance imaging. Cancer Res 61: 4971-4973
69. Hein PA et al. (2003) Diffusion-welighted-magnetio resonance imaging for monitoring diffusion changes in rectal carcinoma during combined, preoperative chemoradiation: Preliminary results of a prospective study. Eur J Radio 45: 214-222
70. Zhao M et al. (1996) Early detection of treatment response by diffusion-weighted 1H-HMR spectroscopy in a murine tumour in vivo. Br J Cancer 73: 61-64
71. Zhao M and Evelhoch 3L (1996) Detection of response to 5-fluorouracil by diffusion-weighted. 1H-NMR spectroscopy in murine tumours in vivo. Proc Int Soc Magn Reson Med Sci Meet Exhib 2. 118
72. Chenevert TL et al. (1997) Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. Clin Cancer Res 3: 1457-1466
73. Chenevert TL et al. (2000) Diffusion magnetic resonance imaging: an early surrogate marker of therapeutic efficacy in brain tumors. J Natl Cancer Inst 92: 2029-2036
74. Hall DE et al. (2004) Therapeutic efficacy of DTI-015 using diffusiorr magnetic resonance imaging as an early surrogate marker. Clin Cancer Res 10: 7852-7859
75. Galons JP et al. (1999) Early increases in breast tumor xenograft water mobility in response to paclitaxel therapy detected by non-invasive diffusion magnetic resonance imaging. Neoplasia 1 113-117
76. Jennings D et al. (2002) Early response of prostate carcinoma xenografts to docetaxel chemotherapy monitored with diffusion MRI. Neoplasia 4: 255-262
77. Thoeny HC et al. (2005) Difftision-weighted magnetic resonance imaging allows noninvasive in vivo monitoring of the effects of combretastatin a-4 phosphate after repeated administration. Neoplasia 7: 779-787
78. Moffat BA et al. (2005) Functional diffusion map: A noninvasive MRI biomarker for early stratification of clinical brain tumor response. Proc Natl Acad Sci USA 102: 5524-5529
79. Hamstra DA et al. (2005) Evaluation of the functional diffusion map as an early biomarker of time-to-progression and overall survival in-high-grade glioma. Proc Natl Acad Sci USA 102: 16759-16764
80. Theilmann RJ et al. (2004) Changes in water mobility measured by diffusion MRI predict response of metastatic breast cancer to chemotherapy. Neoplasia 6: 831-837
81. Chen CY et al. (2006) Early response of hepatocellular carcinoma to transcatheter arterial chemoembolization: Choline levels and MR diffusion constants - initial experience. Radiology 239: 448-456
82. Naganawa S et al. (2005) Apparent diffusion coefficient in cervical cancer of the uterus: Comparison with the normal uterine cervix. Eur Radiol 15: 71-78
83. Einarsdottir H et al. (2004) Diffusion-weighted MRI of soft tissue tumours. Eur Radiol 14: 959-963
84. Pickles MD et al. (2006) Diffusion changes precede size reduction in neoadjuvant treatment of breast cancer. Magn Reson Imaging 24: 843-847
85. Manton DJ et al. (2006) Neoadjuvant chemotherapy in breast cancer: early response prediction with quantitative MR imaging and spectroscopy. Br J Cancer 94: 427-435
86. Mardor Y et al. (2003) Early detection of response to radiation therapy in patients with brain malignancies using conventional and high b-value diffusion-weighted magnetic resonance imaging. J Clin Oncol 21: 1094-1100
87. Jacobs MA et al. (2005) Uterine fibroids: Diffusion weighted MR imaging for monitoring theraphy with focused ultrasound surgery - preliminary study. Radiology 236: 196-203