Expression of dominant negative c-jun inhibits ultraviolet B-induced squamous cell carcinoma number and size in an SKH-1 hairless mouse model

Molecular Cancer Research

Volumn 1, Issue 11, 2003, Pages 848-854

  Cooper, Simon J ^a   MacGowan, Jacalyn ^a   Ranger Moore, James ^b   Young, Matthew R ^c   Colburn, Nancy H ^c   Bowden, G Tim ^a,d  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; LUCIFERASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREEDING; CARCINOGENESIS; CONTROLLED STUDY; DNA BINDING; EPIDERMIS; GENE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MOUSE; MOUSE STRAIN; NONHUMAN; NUDE MOUSE; ONCOGENE C JUN; PRIORITY JOURNAL; RADIATION EXPOSURE; SIGNAL TRANSDUCTION; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; SUNLIGHT; TAM67 GENE; TRANSGENE; TRANSGENIC MOUSE; ULTRAVIOLET B RADIATION;

ANIMALS; CARCINOMA, SQUAMOUS CELL; CYCLIN D1; DISEASE MODELS, ANIMAL; GENES, JUN; HYPERPLASIA; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; NEOPLASMS, RADIATION-INDUCED; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-JUN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN NEOPLASMS; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSGENES; ULTRAVIOLET RAYS;

ANIMALIA; MUS MUSCULUS;

EID: 0141430912     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Shea, C. R. and Parrish, J. A. Nonionizing radiation and the skin. In: G. L. A. (ed.), Physiology, Biochemistry and Molecular Biology of the Skin, pp. 910-927. New York: Oxford University Press, 1991.
2. Cole, C. A., Forbes, P. D., and Davies, R. E. An action spectrum for UV photocarcinogenesis. Photochem. Photobiol., 43: 275-284, 1986.
3. de Gruijl, F. R., Sterenborg, H. J., Forbes, P. D., Davies, R. E., Cole, C., Kelfkens, G., van Weelden, H., Slaper, H., and van der Leun, J. C. Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice. Cancer Res., 53: 53-60, 1993.
4. Bender, K., Gottlicher, M., Whiteside, S., Rahmsdorf, H. J., and Herrlich, P. Sequential DNA damage-independent and -dependent activation of NF-κB by UV. EMBO J., 17: 5170-5181, 1998.
5. Chen, W., Borchers, A. H., Dong, Z., Powell, M. B., and Bowden, G. T. UVB irradiation-induced activator protein-1 activation correlates with increased c-fos gene expression in a human keratinocyte cell line. J. Biol. Chem., 273: 32176-32181, 1998.
6. Shaulian, E. and Karin, M. AP-1 in cell proliferation and survival. Oncogene, 20: 2390-2400, 2001.
7. Jochum, W., Passegue, E., and Wagner, E. F. AP-1 in mouse development and tumorigenesis. Oncogene, 20: 2401-2412, 2001.
8. Schreiber, M., Kolbus, A., Piu, F., Szabowski, A., Mohle-Steinlein, U., Tian, J., Karin, M., Angel, P., and Wagner, E. F. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev., 13: 607-619, 1999.
9. Bernstein, L. R. and Colburn, N. H. AP1/jun function is differentially induced in promotion-sensitive and resistant JB6 cells. Science, 244: 566-569, 1989.
10. Domann, F. E., Jr., Levy, J. P., Finch, J. S., and Bowden, G. T. Constitutive AP-1 DNA binding and transactivating ability of malignant but not benign mouse epidermal cells. Mol. Carcinog., 9: 61-66, 1994.
11. Brown, P. H., Alani, R., Preis, L. H., Szabo, E., and Birrer, M. J. Suppression of oncogene-induced transformation by a deletion mutant of c-jun. Oncogene, 8: 877-886, 1993.
12. Domann, F. E., Levy, J. P., Birrer, M. J., and Bowden, G. T. Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice. Cell Growth & Differ., 5: 9-16, 1994.
13. Young, M. R., Li, J. J., Rincon, M., Flavell, R. A., Sathyanarayana, B. K., Hunziker, R., and Colburn, N. Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. Proc. Natl. Acad. Sci. USA, 96: 9827-9832, 1999.
14. Thompson, E. J., MacGowan, J., Young, M. R., Colburn, N., and Bowden, G. T. A dominant negative c-jun specifically blocks okadaic acid-induced skin tumor promotion. Cancer Res., 62: 3044-3047, 2002.
15. Lu, Y. P., Lou, Y. R., Yen, P., Mitchell, D., Huang, M. T., and Conney, A. H. Time course for early adaptive responses to ultraviolet B light in the epidermis of SKH-1 mice. Cancer Res., 59: 4591-4602, 1999.
16. Robles, A. I., Rodriguez-Puebla, M. L., Glick, A. B., Trempus, C., Hansen, L., Sicinski, P., Tennant, R. W., Weinberg, R. A., Yuspa, S. H., and Conti, C. J. Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev., 12: 2469-2474, 1998.
17. Kim, A. L., Athar, M., Bickers, D. R., and Gautier, J. Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development. Photochem. Photobiol., 75: 58-67, 2002.
18. Yamamoto, H., Ochiya, T., Takeshita, F., Toriyama-Baba, H., Hirai, K., Sasaki, H., Sakamoto, H., Yoshida, T., Saito, I., and Terada, M. Enhanced skin carcinogenesis in cyclin D1-conditional transgenic mice: cyclin D1 alters keratinocyte response to calcium-induced terminal differentiation. Cancer Res., 62: 1641-1647, 2002.
19. Dong, Z., Birrer, M. J., Watts, R. G., Matrisian, L. M., and Colburn, N. H. Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc. Natl. Acad. Sci. USA, 91: 609-613, 1994.
20. Dong, Z., Crawford, H. C., Lavrovsky, V., Taub, D., Watts, R., Matrisian, L. M., and Colburn, N. H. A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate-induced invasion in mouse keratinocytes. Mol. Carcinog., 19: 204-212, 1997.
21. Young, M. R., Farrell, L., Lambert, P., Awasthi, P., and Colburn, N. H. Protection against human papillomavirus type 16-E7 oncogene-induced tumorigenesis by in vivo expression of dominant-negative c-jun dagger. Mol. Carcinog., 34: 72-77, 2002.
22. Rodriguez-Puebla, M. L., Robles, A. I., and Conti, C. J. ras activity and cyclin D1 expression: an essential mechanism of mouse skin tumor development. Mol. Carcinog., 24: 1-6, 1999.
23. Wisdom, R., Johnson, R. S., and Moore, C. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J., 18: 188-197, 1999.
24. Hennigan, R. F. and Stambrook, P. J. Dominant negative c-jun inhibits activation of the cyclin D1 and cyclin E kinase complexes. Mol. Biol. Cell, 12: 2352-2363, 2001.
25. Soh, J. W. and Weinstein, I. B. Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. J. Biol. Chem., 2003.
26. Soh, J. W. and Weinstein, I. B. Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. J. Biol. Chem., in press, 2003.
27. Pahl, H. L. Activators and target genes of Re1/NF-κB transcription factors. Oncogene, 18: 6853-6866, 1999.
28. Stein, B., Baldwin, A. S., Jr., Ballard, D. W., Greene, W. C., Angel, P., and Herrlich, P. Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J., 12: 3879-3891, 1993.
29. Li, J. J., Westergaard, C., Ghosh, P., and Colburn, N. H. Inhibitors of both nuclear factor-κB and activator protein-1 activation block the neoplastic transformation response. Cancer Res., 57: 3569-3576, 1997.
30. Hsu, T. C., Nair, R., Tulsian, P., Camalier, C. E., Hegamyer, G. A., Young, M. R., and Colburn, N. H. Transformation nonresponsive cells owe their resistance to lack of p65/nuclear factor-κB activation. Cancer Res., 61: 4160-4168, 2001.
31. Li, J. J., Cao, Y., Young, M. R., and Colburn, N. H. Induced expression of dominant-negative c-jun downregulates NFκB and AP-1 target genes and suppresses tumor phenotype in human keratinocytes. Mol. Carcinog., 29: 159-169, 2000.
32. Rincon, M. and Flavell, R. A. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J., 13: 4370-4381, 1994.