Human fibroblast growth factor 20 (FGF-20; CG53135-05): A novel cytoprotectant with radioprotective potential

International Journal of Radiation Biology

Volumn 81, Issue 8, 2005, Pages 567-579

  Maclachlan, T ^a   Narayanan, B ^a   Gerlach, V L ^a   Smithson, G ^a   Gerwien, R W ^a   Folkerts, O ^a   Fey, E G ^b   Watkins, B ^b   Seed, T ^c   Alvarez, E ^d  

^a CURAGEN CORPORATION   (United States)

^b Biomodels LLC   (United States)

^c CATHOLIC UNIVERSITY OF AMERICA   (United States)

^d PharmaMar USA Inc   (United States)

Author keywords

Cytokine; Fibroblast growth factor; Mucositis; Oxygen radical scavenging; Radioprotection

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOOXYGENASE 2; GA BINDING PROTEIN; GLUTATHIONE PEROXIDASE 1; HYDROGEN PEROXIDE; INTESTINAL TREFOIL FACTOR; INTESTINAL TREFOIL FACTOR 3; MANGANESE SUPEROXIDE DISMUTASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; RECOMBINANT FIBROBLAST GROWTH FACTOR; RECOMBINANT HUMAN FIBROBLAST GROWTH FACTOR 20; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; CELL PROTECTION; CELL STRAIN 3T3; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; ENDOTHELIUM CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; IRRADIATION; LETHALITY; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; RADIATION PROTECTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; UPREGULATION; WHOLE BODY RADIATION;

ANIMALS; CELL SURVIVAL; CYCLOOXYGENASE 2; ENDOTHELIAL CELLS; FIBROBLAST GROWTH FACTORS; FREE RADICAL SCAVENGERS; GENE EXPRESSION PROFILING; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED C3H; OXIDATIVE STRESS; PEPTIDES; RADIATION INJURIES; RADIATION-PROTECTIVE AGENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; WHOLE-BODY IRRADIATION;

ANIMALIA; LOTUS;

EID: 28944454134     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000500211091     Document Type: Article

References (29)

1. Alvarez E, Gerlach V, Gerwien R, Fey EG, Watkins BA, Hahne WF, Sonis ST. Single-dose prevention or short-term treatment with Fibroblast Growth Factor-20 (CG53135-05) reduces the severity and duration of oral mucositis. Supportive Cancer Therapy./122-127/2005/vol2.
2. Alvarez E, Fey EG, Valax P, Yim Z, Peterson JD, Mesri M, Jeffers M, Dindinger M, Twomlow N, Ghatpande A, LaRochelle WJ, Sonis ST, Lichenstein HS. 2003. Preclinical characterization of CG53135(FGF-20) in radiation and concomitant chemotherapy/radiation-induced oral mucositis. Clinical Cancer Research 9: 3454-3461.
3. Coleman CN, Blakely WF, Fike JR, MacVittie TJ, Metting NF, Mitchell JB, Moulder JE, Preston RJ, Seed TM, Stone HB, Tofilon PJ, Wong RS. 2003. Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001. Radiation Research 159: 812-834.
4. Ding I, Huang K, Wang X, Greig JR, Miller RW, Okunieff P. 1997. Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments Acta Oncologica 36: 337-340.
5. Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF. 2004. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proceedings of the National Academy of Sciences, USA 101: 2452-2457.
6. Gutteridge JM, Halliwell B. 2000. Free radicals and antioxidants in the year 2000. A historical look to the future. Annals of the New York Academy of Sciences 899: 136-147.
7. Hall EJ. 2000. Radiobiology for the radiologist, 5th Edn. Philadelphia, PA: Lippincott Williams & Wilkins. p. 32-50.
8. Huang TT, Yasunami M, Carlson EJ, Gillespie AM, Reaume AG, Hoffman EK, Chan PH, Scott RW, Epstein CJ. 1997. Superoxide-mediated cytotoxicity in superoxide dismutase-deficient fetal fibroblasts. Archives of Biochemistry and Biophysics 344: 424-432.
9. Itoh N, Ornitz DM. 2004. Evolution of the Fgf and Fgfr gene families. Trends in Genetics 20: 563-569.
10. Jeffers M, McDonald WF, Chillakuru RA, Yang M, Nakase H, Deegler LL, Sylander ED, Rittman B, Bendele A, Sartor RB, Lichenstein HS. 2002. A novel human fibroblast growth factor treats experimental intestinal inflammation. Gastroenterology 123: 1151-1162.
11. Jeffers M, Shimkets R, Prayaga S, Boldog F, Yang M, Burgess C, Fernandes E, Rittman B, Shimkets J, LaRochelle WJ, Lichenstein HS. 2001. Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis. Cancer Research 61: 3131-3138.
12. Kang SK, Rabbani ZN, Folz RJ, Golson ML, Huang H, Yu D, Samulski TS, Dewhirst MW, Anscher MS, Vujaskovic Z. 2003. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. International Journal Radiation Oncology, Biology, Physics 57: 1056-1066.
13. Lee JM, Johnson JA. 2004. An important role of Nrf2-ARE pathway in the cellular defense mechanism. Journal Biochemistry Molecular Biology 37: 139-143.
14. Li Q, Sanlioglu S, Li S, Ritchie T, Oberley L, Engelhardt JF. 2001. GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex. Antioxidants and Redox Signaling 3: 415-432.
15. Maddens S, Charruyer A, Plo I, Dubreuil P, Berger S, Salles B, Laurent G, Jaffrezou JP. 2002. Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect. Blood 100: 1294-1301.
16. Mashimo H, Wu DC, Podolsky DK, Fishman MC. 1996. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 274: 262-265.
17. Mikkelsen RB, Wardman P. 2003. Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms. Oncogene 22: 5734-5754.
18. Moulder JE. 2004. Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents: a review. International Journal Radiation Biology 80: 3-10.
19. Okunieff P, Li M, Liu W, Sun J, Fenton B, Zhang L, Ding I. 2001. Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma. American Journal of Clinical Oncology 24: 491-495.
20. Powers CJ, McLeskey SW, Wellstein A. 2000. Fibroblast growth factors, their receptors and signaling. Endocrine-Related Cancer 7: 165-197.
21. Riley PA. 1994. Free radicals in biology: oxidative stress and the effects of ionizing radiation. International Journal of Radiation Biology 65: 27-33.
22. Shonai T, Adachi M, Sakata K, Takekawa M, Endo T, Imai K, Hareyama M. 2002. MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells. Cell Death and Differentiation 9: 963-971.
23. Slupphaug G, Kavli B, Krokan HE. 2003. The interacting pathways for prevention and repair of oxidative DNA damage. Mutation Research 531: 231-251.
24. Sun J, Chen Y, Li Y, Ge Z. 1998. Role of antioxidant enzymes on ionizing radiation resistance. Free Radical Biology and Medicine 24: 586-593.
25. Suresh A, Tung F, Moreb J, Zucali JR. 1994. Role of manganese superoxide dismutase in radioprotection using gene transfer studies. Cancer Gene Therapy 1: 85-90.
26. Szebenyi G, Fallon JF. 1999. Fibroblast growth factors as multifunctional signaling factors. International Review of Cytology 185: 45-106.
27. Tanaka H, Matsumura I, Ezoe S, Satoh Y, Sakamaki T, Albanese C, Machii T, Pestell RG, Kanakura Y. 2002. E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination. Molecular Cell 9: 1017-1029.
28. Terry NH, Brinkley J, Doig AJ, Ma J, Patel N, White RA, Mahajan N, Kang Y. 2004. Cellular kinetics of murine lung: model system to determine basis for radioprotection with keratinocyte growth factor. International Journal Radiation Oncology Biology, Physics 58: 435-444.
29. Waselenko JK, MacVittie TJ, Blakely WF, Pesik N, Wiley AL, Dickerson WE, Tsu H, Confer DL, Coleman CN, Seed T, Lowry P, Armitage JO, Dainiak N. 2004. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Annals of Internal Medicine 140: 1037-1051.