Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 4035-4051

  Song, Kwang Seop ^a   Lee, Sung Han ^a   Chun, Hyun Ji ^b   Kim, Jong Yup ^a   Jung, Myung Eun ^a   Ahn, Kwangwoo ^a   Kim, Soo Un ^c   Kim, Jeongmin ^a   Lee, Jinhwa ^a  

^a Green Cross Company   (South Korea)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c Seoul National University   (South Korea)

Author keywords

1 Benzhydrylpiperazine; Anti obesity; Cannabinoid receptor; CB1 receptor antagonists; Piperazine; Rimonabant; SAR study

Indexed keywords

1 [4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZIN 1 YL] 2 ETHYLBUTAN 1 ONE; 1 [4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZIN 1 YL](FURAN 2 YL)METHANONE; 1 [4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZIN 1 YL](THIOPHEN 2 YL)METHANONE; 1 [4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZIN 1 YL]2 METHYLPROPAN 1 ONE; 1 [4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZIN 1 YL]BUTAN 1 ONE; 1 [4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZIN 1 YL]HEXAN 1 ONE; 1 [BIS(4 CHLOROPHENYL)METHYL] 4 (BUTYLSULFONYL)PIPERAZINE; 1 [BIS(4 CHLOROPHENYL)METHYL] 4 (ETHYLSULFONYL)PIPERAZINE; 1 [BIS(4 CHLOROPHENYL)METHYL] 4 (OCTYLSULFONYL)PIPERAZINE; 1 [BIS(4 CHLOROPHENYL)METHYL] 4 TOSYLPIPERAZINE; 4 [BIS(4 CHLOROPHENYL)METHYL] N CYCLOHEXYLPIPERAZINE 1 CARBOXAMIDE; 4 [BIS(4 CHLOROPHENYL)METHYL] N PHENYLPIPERAZINE 1 CARBOXAMIDE; 4 [BIS(4 CHLOROPHENYL)METHYL] N TERT BUTYLPIPERAZINE 1 CARBOXAMIDE; 4 [BIS(CHLOROPHENYL)METHYL] N (4 CHLOROPHENYL)PIPERAZINE 1 CARBOXAMIDE; [4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZIN 1 YL](CYCLOBUTYL)METHANONE; [4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZIN 1 YL](CYCLOHEXYL)METHADONE; [4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZIN 1 YL](CYCLOPENTYL)METHADONE; [4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZIN 1 YL](CYCLOPROPYL)METHANONE; BENZYL 4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZINE 1 CARBOXYLATE; BUTYL 4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZINE 1 CARBOXYLATE; CANNABINOID 1 RECEPTOR ANTAGONIST; CANNABINOID 2 RECEPTOR; N BENZYL 4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZINE 1 CARBOXAMIDE; NEOPENTYL 4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZINE 1 CARBOXYLATE; PHENYL 4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZINE 1 CARBOXYLATE; PIPERAZINE DERIVATIVE; RIMONABANT; TERT BUTYL 4 [BIS(4 CHLOROPHENYL)METHYL]PIPERAZINE 1 CARBOXYLATE; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; MALE; NONHUMAN; OBESITY; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; DRUG DESIGN; HUMANS; LIGANDS; MALE; MOLECULAR STRUCTURE; PIPERAZINES; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 41649118733     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.023     Document Type: Article

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